Immunogenicity of a hybrid Plasmodium falciparum malaria antigen.

Abstract:

:A recombinant baculovirus-expressed hybrid protein containing epitopes for the C-terminal fragment of the Plasmodium falciparum precursor to the major merozoite surface antigens (PMMSA) and the tetrapeptide repeats of the circumsporozoite protein (CSP) was assessed for its immunogenicity. Murine MHC-II restriction of the antibody response to the CSP repeats was not overcome by the PMMSA component, the response to which showed no restriction. In an adjuvant trial the highest antibody titres in rabbits to both components of the hybrid were obtained using Freund's adjuvant. Lack of a boosting antibody response to the CSP repeats appeared to be linked to the conformation of the PMMSA component. Formulation of the hybrid protein into Iscoms gave antibody titres of only short duration to both components.

journal_name

Parasitology

journal_title

Parasitology

authors

Lockyer MJ,Cooper H,Tite J,Rowan W,Crowe JS

doi

10.1017/s0031182000076733

subject

Has Abstract

pub_date

1993-06-01 00:00:00

pages

451-7

eissn

0031-1820

issn

1469-8161

journal_volume

106 ( Pt 5)

pub_type

杂志文章
  • Rat-dietary fructose and the intestinal distribution and growth of Moniliformis (Acanthocephala).

    abstract::The numbers, distribution in the small intestine, sexual development and growth (dry weight) of 5-week-old Moniliformis dubius (Acanthocephala) were investigated experimentally in adult, female CFHB rats fed on theoretically isoenergetic diets containing known amounts of fructose in combination with either maize-oil f...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182000057176

    authors: Crompton DW,Keymer A,Singhvi A,Nesheim MC

    更新日期:1983-02-01 00:00:00

  • Capture and penetration processes of the free-living juveniles of Trichostrongylus colubriformis (Nematoda) by the nematophagous fungus, Arthrobotrys oligospora.

    abstract::The nematode-trapping fungus Arthrobotrys oligospora traps and invades all the free-living juvenile stages of the trichostrongyle nematode Trichostrongylus colubriformis. The processes of capture and invasion of the 1st-stage juveniles are described using differential interference contrast optics and 3-D reconstructio...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182000079798

    authors: Murray DS,Wharton DA

    更新日期:1990-08-01 00:00:00

  • Molecular characterization of Cystoisospora belli and unizoite tissue cyst in patients with Acquired Immunodeficiency Syndrome.

    abstract::Cystoisospora belli is a coccidian protozoan that can cause chronic diarrhoea, acalculous cholecystitis and cholangiopathy in AIDS patients. We applied molecular methods to identify Cystoisospora at species level in AIDS patients presenting with and without the presence of unizoites in lamina propria. Coprological and...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S0031182010001253

    authors: Velásquez JN,Osvaldo GA,Di Risio C,Etchart C,Chertcoff AV,Perissé GE,Carnevale S

    更新日期:2011-03-01 00:00:00

  • Enzymatic amplification of mini-exon-derived RNA gene spacers of Leishmania donovani: primers and probes for DNA diagnosis.

    abstract::The multicopy mini-exon-derived RNA (med RNA) locus of Leishmania donovani was enzymatically amplified by the polymerase chain reaction (PCR). The major 180 bp PCR product contained conserved med RNA gene sequences flanking the variable intergenic spacer from the med RNA gene tandem repeat. The oligonucleotide primers...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182000068086

    authors: Hassan MQ,Ghosh A,Ghosh SS,Gupta M,Basu D,Mallik KK,Adhya S

    更新日期:1993-12-01 00:00:00

  • An introduced pentastomid parasite (Raillietiella frenata) infects native cane toads (Rhinella marina) in Panama.

    abstract::The pentastomid parasite, Raillietiella frenata, is native to Asia where it infects the Asian House gecko, Hemidactylus frenatus. This gecko has been widely introduced and recently R. frenata was found in introduced populations of cane toads (Rhinella marina) in Australia, indicating a host-switch from introduced geck...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S0031182014001759

    authors: Kelehear C,Saltonstall K,Torchin ME

    更新日期:2015-04-01 00:00:00

  • Triggering and modulation of the host-parasite interplay by Echinococcus multilocularis: a review.

    abstract::As more facts emerge regarding the ways in which E. multilocularis-derived molecules trigger the host immune response and modulate the host-parasite interplay, it becomes possible to envisage how the parasite can survive and proliferate in its intermediate host, while in other hosts it dies out. Through effects on cel...

    journal_title:Parasitology

    pub_type: 杂志文章,评审

    doi:10.1017/S0031182009991533

    authors: Mejri N,Hemphill A,Gottstein B

    更新日期:2010-03-01 00:00:00

  • Substrate specificity of the neutral sphingomyelinase from Trypanosoma brucei.

    abstract::The kinetoplastid parasite Trypanosoma brucei causes African trypanosomiasis in both humans and animals. Infections place a significant health and economic burden on developing nations in sub-Saharan Africa, but few effective anti-parasitic treatments are currently available. Hence, there is an urgent need to identify...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S0031182018001853

    authors: Dickie EA,Young SA,Smith TK

    更新日期:2019-04-01 00:00:00

  • The epidemiology of multiple-clone Plasmodium falciparum infections in Gambian patients.

    abstract::The occurrence of multiple-clone Plasmodium falciparum haploid blood-stage infections is a pre-requisite for cross-fertilization and genetic exchange at the diploid stage in the mosquito. Using monoclonal antibodies against 3 polymorphic blood-stage antigens, a method of two-colour differential immunofluorescence allo...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182000059217

    authors: Conway DJ,Greenwood BM,McBride JS

    更新日期:1991-08-01 00:00:00

  • Biological approaches to characterize the mode of action of two 5-nitroindazolinone prototypes on Trypanosoma cruzi bloodstream trypomastigotes.

    abstract::The phenotypic activity of two 5-nitroindazolinones, i.e. 2-benzyl-1-propyl (22) and 2-benzyl-1-butyl (24) derivatives, previously proposed as anti-Trypanosoma cruzi prototypes, was presently assayed on bloodstream trypomastigotes (BT) of the moderately drug-resistant Y strain. Further exploration of putative targets ...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S0031182016001098

    authors: Fonseca-Berzal C,DA Silva CF,Menna-Barreto RF,Batista MM,Escario JA,Arán VJ,Gómez-Barrio A,Soeiro Mde N

    更新日期:2016-09-01 00:00:00

  • Parasite-host relationships during the development of Eimeria dispersa Tyzzer 1929, in the turkey (Meleagris gallopavo gallopavo) with a description of intestinal intra-epithelial leucocytes.

    abstract::An electron microscopical study was made on the development of Eimeria dispersa in the small intestine of the domestic turkey. Turkey poults, 10-14 days of age, were inoculated with oocysts and pieces of intestinal tissue were fixed at intervals between 3.5 and 114 h after inoculation. Sporozoites were occasionally se...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182000051611

    authors: Millard BJ,Lawn AM

    更新日期:1982-02-01 00:00:00

  • Synergistic antimalarial activity of ketones with rufigallol and vitamin C.

    abstract::Malaria remains a major cause of human morbidity and mortality worldwide. Plasmodium falciparum, the most virulent of the 4 human Plasmodium species causing malaria, is potentially life threatening, is increasing in prevalence and is becoming even more resistant to in-use drugs. In light of the growing problem of mult...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S0031182005008267

    authors: Mahajan SS,Kamath VR,Ghatpande SS

    更新日期:2005-10-01 00:00:00

  • The influence of health education on the prevalence of intestinal parasites in a low-income community of Campos dos Goytacazes, Rio de Janeiro State, Brazil.

    abstract::In a recent study by our group on the prevalence of intestinal parasitic infections and on the knowledge, attitudes and practices of local residents of Campos dos Goytacazes, Rio de Janeiro, Brazil, we observed that about 50% of the inhabitants were parasitized and had some knowledge of intestinal parasitic infections...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S0031182011002253

    authors: Pereira AP,Alencar MF,Cohen SC,Souza-Júnior PR,Cecchetto F,Mathias LS,Santos CP,Almeida JC,de Moraes Neto AH

    更新日期:2012-05-01 00:00:00

  • Phylogeny of snake trypanosomes inferred by SSU rDNA sequences, their possible transmission by phlebotomines, and taxonomic appraisal by molecular, cross-infection and morphological analysis.

    abstract::Blood examination by microhaematocrit and haemoculture of 459 snakes belonging to 37 species revealed 2.4% trypanosome prevalence in species of Viperidae (Crotalus durissus and Bothrops jararaca) and Colubridae (Pseudoboa nigra). Trypanosome cultures from C. durissus and P. nigra were behaviourally and morphologically...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S0031182008004253

    authors: Viola LB,Campaner M,Takata CS,Ferreira RC,Rodrigues AC,Freitas RA,Duarte MR,Grego KF,Barrett TV,Camargo EP,Teixeira MM

    更新日期:2008-04-01 00:00:00

  • Can the tea tree oil (Australian native plant: Melaleuca alternifolia Cheel) be an alternative treatment for human demodicosis on skin?

    abstract::Australian tea tree oil (TTO) and its extract terpinen-4-ol (T4O) are found to be effective in moderating demodex-related diseases. Their possible effects are lowering the mite counts, relieving the demodex-related symptoms and modulating the immune system especially the inflammatory response. This review summarizes t...

    journal_title:Parasitology

    pub_type: 杂志文章,评审

    doi:10.1017/S0031182018000495

    authors: Lam NSK,Long XX,Griffin RC,Chen MK,Doery JC

    更新日期:2018-10-01 00:00:00

  • Boophilus microplus: the effect of histamine on the attachment of cattle-tick larvae--studies in vivo and in vitro.

    abstract::Circumstantial evidence suggests that the earlier detachment of Boophilus microplus larvae from highly resistant cattle follows the release of histamine at the attachment site. In vivo and in vitro experiments show that a proportion of the larvae will detach following injection or infusion of histamine. Other mediator...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182000000950

    authors: Kemp DH,Bourne A

    更新日期:1980-06-01 00:00:00

  • Molecular identification of Taenia spp. in the Eurasian lynx (Lynx lynx) from Finland.

    abstract::Cestodes of the genus Taenia are parasites of mammals, with mainly carnivores as definitive and herbivores as intermediate hosts. Various medium-sized cats, Lynx spp., are involved in the life cycles of several species of Taenia. The aim of the present study was to identify Taenia tapeworms in the Eurasian lynx (Lynx ...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S0031182012002120

    authors: Lavikainen A,Haukisalmi V,Deksne G,Holmala K,Lejeune M,Isomursu M,Jokelainen P,Näreaho A,Laakkonen J,Hoberg EP,Sukura A

    更新日期:2013-04-01 00:00:00

  • Surface antigens of Toxoplasma gondii.

    abstract::Monoclonal antibodies reacting with pellicular antigens of Toxoplasma gondii tachyzoites have been selected among hybridomas produced against this organism by immunofluorescence assay. These antigens have been further characterized by immunofluorescence on living zoites, Western immunoblotting and immunoprecipitation ...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182000066695

    authors: Couvreur G,Sadak A,Fortier B,Dubremetz JF

    更新日期:1988-08-01 00:00:00

  • Characterization of an atypical antigen from Sarcoptes scabiei containing an MADF domain.

    abstract::We have cloned a cDNA encoding a novel antigen from a Sarcoptes scabiei (Acari) cDNA library by immunoscreening with sera from S. scabiei-infected dogs. The antigen is encoded by a 2,157 bp mRNA with a predicted open reading frame of 719 amino acids (molecular weight 79 kDa). Our sequence analysis identified the prese...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S0031182005008747

    authors: Ljunggren EL,Bergström K,Morrison DA,Mattsson JG

    更新日期:2006-01-01 00:00:00

  • In vitro influence of Theileria annulata on the functions of bovine dendritic cells for stimulation of T lymphocyte proliferation.

    abstract::The present study was performed on antigen-presenting cells (APCs) of Theileria annulata transformed dendritic cells (TaDCs) and monocyte-derived dendritic cells (MoDCs) to compare differences in antigen presentation and stimulation of T lymphocyte proliferation. Antigen presentation for T lymphocyte proliferation was...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S0031182019001227

    authors: Rashid M,Liu J,Guan G,Wang J,Li Z,Hassan MA,Rashid MI,Mukhtar MU,Luo J,Yin H

    更新日期:2020-01-01 00:00:00

  • Loss of behavioural dominance in male mice infected with Trichinella spiralis.

    abstract::Trichinella spiralis infections may lead to the loss of behavioural dominance among male mice. Reversals of dominance order first appear at the time when newborn larvae are released into the circulation of the host. The duration of dominance reversals bears no relationship to the number of muscle larvae harboured. ...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:

    authors: Rau ME

    更新日期:1984-04-01 00:00:00

  • Genetic control of immune responses to parasites: immunity to Trichuris muris in inbred and random-bred strains of mice.

    abstract::A comparison has been made of the responses of random-bred CFLP and inbred NIH mice to infection with Trichuris muris. Random-bred mice showed greater variation in worm burdens and less uniformity in worm expulsion. Irradiation prior to infection reduced variation, but did not increase the mean level of infection abov...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182000053142

    authors: Wakelin D

    更新日期:1975-08-01 00:00:00

  • Long-term epidemiology, effect on body condition and interspecific interactions of concomitant infection by nasopharyngeal bot fly larvae (Cephenemyia auribarbis and Pharyngomyia picta, Oestridae) in a population of Iberian red deer (Cervus elaphus hispan

    abstract::We studied the pattern of infection and the inter-annual variation and individual factors affecting the infection of 2 species of nasopharyngeal bot flies, Cephenemyia auribarbis and Pharyngomyia picta (Diptera: Oestridae), in a population of Iberian red deer (Cervus elaphus hispanicus) from south central Spain (10 an...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182004005578

    authors: Vicente J,Fierro Y,Martínez M,Gortázar C

    更新日期:2004-09-01 00:00:00

  • Use of clomipramine as chemotherapy of the chronic phase of Chagas disease.

    abstract::Chagas infection is a major endemic disease affecting Latin American countries. The persistence of Trypanosoma cruzi generates a chronic inflammatory reactivity that induces an immune response directed to the host's tissues. The effectiveness of the treatment in the chronic phase is still unsatisfactory due, amongst o...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S0031182013000103

    authors: Fauro R,Lo Presti S,Bazan C,Baez A,Strauss M,Triquell F,Cremonezzi D,Negrete OS,Willhuber GC,Paglini-Oliva P,Rivarola HW

    更新日期:2013-06-01 00:00:00

  • The effect of dietary sainfoin ( Onobrychis viciifolia) on local cellular responses to Trichostrongylus colubriformis in sheep.

    abstract::The effect of sainfoin (Onobrychis viciifolia) hay consumption on the pathophysiology and local cellular responses of growing lambs during infection with Trichostrongylus colubriformis was investigated. Thirty-two lambs, 16 weeks of age, were allocated to 1 of 4 treatment groups (n=8) that were offered either grass (G...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S0031182008004563

    authors: Ríos-de Alvarez L,Greer AW,Jackson F,Athanasiadou S,Kyriazakis I,Huntley JF

    更新日期:2008-08-01 00:00:00

  • Characterization of the effector mechanisms of a transmission-blocking antibody upon differentiation of Plasmodium berghei gametocytes into ookinetes in vitro.

    abstract::The transmission-blocking monoclonal antibody 13.1, which recognizes the ookinete surface antigen Pbs21 of Plasmodium berghei, and an IgG2a isotype control antibody 26.37 were purified by caprylic acid and ammonium sulphate precipitation. Fab fragments were prepared by papain digestion. IgG but not Fab from antibody 1...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s0031182000077702

    authors: Ranawaka GR,Alejo-Blanco AR,Sinden RE

    更新日期:1994-07-01 00:00:00

  • Detection of viruses in livestock.

    abstract::Diseases caused by viruses are a constant and major problem for livestock production world wide. The diseases range from highly contagious acute forms with high mortality, to chronic disabling diseases with an insidious effect on production. Such diseases cannot be regarded as static in nature due to the highly mutabl...

    journal_title:Parasitology

    pub_type: 杂志文章,评审

    doi:10.1017/s0031182099004199

    authors: Crowther JR

    更新日期:1998-01-01 00:00:00

  • Kinetics of classes and sub-classes of total immunoglobulins and specific antibodies to Schistosoma mansoni during murine infection.

    abstract::During the course of Schistosoma mansoni murine infection there is a dramatic increase of some immunoglobulins and S. mansoni-specific antibodies. The most substantial response is initiated after 40 days of infection and results in a prolonged increase of total IgG1, IgM and IgA. The maximum increase is respectively 2...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/s003118200000072x

    authors: Bout D,Rousseaux R,Carlier Y,Capron A

    更新日期:1980-04-01 00:00:00

  • Advances and challenges in barcoding of microbes, parasites, and their vectors and reservoirs.

    abstract::DNA barcoding is now a common tool in parasitology and epidemiology, which require good methods for identification not only of parasites and pathogens but vectors and reservoirs. This special issue presents some advances and challenges in barcoding of microbes, parasites, and their vectors and reservoirs. DNA barcodin...

    journal_title:Parasitology

    pub_type: 社论

    doi:10.1017/S0031182018000884

    authors: Morand S

    更新日期:2018-04-01 00:00:00

  • Genetic variation among lambs in peripheral IgE activity against the larval stages of Teladorsagia circumcincta.

    abstract::IgA and IgE activity against Teladorsagia circumcincta was investigated in a flock of Texel lambs following natural, mixed nematode infection among lambs. The distribution of IgA activity was similar to a gamma distribution whereas IgE activity was different. Box-Cox analysis demonstrated that X0.25 was a suitable tra...

    journal_title:Parasitology

    pub_type: 杂志文章

    doi:10.1017/S0031182010000028

    authors: Murphy L,Eckersall PD,Bishop SC,Pettit JJ,Huntley JF,Burchmore R,Stear MJ

    更新日期:2010-07-01 00:00:00

  • An in silico structure-based approach to anti-infective drug discovery.

    abstract::In light of the low success rate of target-based genomics and HTS (High Throughput Screening) approaches in anti-infective drug discovery, in silico structure-based drug design (SBDD) is becoming increasingly prominent at the forefront of drug discovery. In silico SBDD can be used to identify novel enzyme inhibitors r...

    journal_title:Parasitology

    pub_type: 杂志文章,评审

    doi:10.1017/S0031182013000693

    authors: Cunningham F,McPhillie MJ,Johnson AP,Fishwick CW

    更新日期:2014-01-01 00:00:00