Genetic variation among lambs in peripheral IgE activity against the larval stages of Teladorsagia circumcincta.

Abstract:

:IgA and IgE activity against Teladorsagia circumcincta was investigated in a flock of Texel lambs following natural, mixed nematode infection among lambs. The distribution of IgA activity was similar to a gamma distribution whereas IgE activity was different. Box-Cox analysis demonstrated that X0.25 was a suitable transformation to normalise IgE responses. The transformed IgE activity was under moderate to strong genetic control. Nine different allergens were identified by proteomic analysis. Tropomyosin was selected for further analysis. IgE activity against tropomyosin was moderately heritable and associated with decreased egg counts and with reduced body weight at the time of sampling.

journal_name

Parasitology

journal_title

Parasitology

authors

Murphy L,Eckersall PD,Bishop SC,Pettit JJ,Huntley JF,Burchmore R,Stear MJ

doi

10.1017/S0031182010000028

subject

Has Abstract

pub_date

2010-07-01 00:00:00

pages

1249-60

issue

8

eissn

0031-1820

issn

1469-8161

pii

S0031182010000028

journal_volume

137

pub_type

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