Abstract:
:The present study was initiated to examine whether the concentration of CO in the breath is elevated in patients with inflammatory bowel disease (IBD). Twenty-three clinically stable patients with IBD in the outpatient clinic (11 with Crohn's disease, 12 with ulcerative colitis), who are non-smokers and non-passive smokers, were selected and the concentration of CO in their breath was measured using a breath gas analyser (TRI lyser mBA-3000). The concentration of CO in the breath of 23 patients with IBD was 2.5+/-0.9 (1.1-4.3) ppm. This concentration comes within the range of standard values in our previous reports (2.5+/-2.2 ppm). Any significant difference was not observed between 2.4+/-0.9 (1.5-4.3) ppm for the 11 Crohn's disease patients and the 2.6+/-1.0 (1.1-3.9) ppm for the 12 ulcerative colitis patients. The results suggest that clinically stable patients with IBD do not show high values for concentration of CO in the breath.
journal_name
Clin Exp Medjournal_title
Clinical and experimental medicineauthors
Nitta H,Kinoyama M,Teramoto F,Watanabe A,Koga H,Haruma K,Akagi R,Ueda Hdoi
10.1007/s10238-007-0129-8subject
Has Abstractpub_date
2007-06-01 00:00:00pages
77-81issue
2eissn
1591-8890issn
1591-9528journal_volume
7pub_type
杂志文章abstract::The purpose of this study was to reveal the clinical diagnostic and prognostic value of miR-768-3p in HBV-related HCC and to investigate its effect on the biological function of HCC. Quantitative real-time polymerase chain reaction was used to detect the expression level of miR-768-3p in subjects' serum. The receiver ...
journal_title:Clinical and experimental medicine
pub_type: 杂志文章
doi:10.1007/s10238-020-00646-z
更新日期:2020-11-01 00:00:00
abstract::Endotoxin is known to cause acute lung injury (ALI). Here, we investigated the effects and mechanisms of recombinant human bone morphogenetic protein-2 (rhBMP-2) on pulmonary arteriole remodeling in endotoxin-induced ALI in rats. Sixty Wistar rats were randomly divided into 3 groups (n = 20). Control group was infused...
journal_title:Clinical and experimental medicine
pub_type: 杂志文章
doi:10.1007/s10238-012-0197-2
更新日期:2013-08-01 00:00:00
abstract::Longitudinal studies have improved current diagnostics and management of metabolic associated fatty liver disease (MAFLD) patients by liver biopsy and therapeutic intervention, yet the deficiency of biomarker spectrum for dissecting subtypes largely hinders the symptomatic treatment. We originally enriched serum from ...
journal_title:Clinical and experimental medicine
pub_type: 杂志文章
doi:10.1007/s10238-020-00636-1
更新日期:2020-11-01 00:00:00
abstract::Interleukin-17A plays a role in tissue inflammation by inducing release of proinflammatory and neutrophil-mobilizing cytokines. We investigated the association between ulcerative colitis (UC) and polymorphisms of IL17A, rs2275913 (-197 G > A), and rs3748067 (*1249 C > T). The study was performed in 475 healthy subject...
journal_title:Clinical and experimental medicine
pub_type: 杂志文章
doi:10.1007/s10238-012-0206-5
更新日期:2013-11-01 00:00:00
abstract::The effect of preimmunisation with cancer procoagulant (CP) on the growth of Walker 256 carcinosarcoma cells in Wistar Lew/Han/IMP rats in vivo has been analysed. One group of rats was immunised with CP purified from human amnion-chorion membranes. The rest of the animals (control groups) were injected with 0.9% NaCl ...
journal_title:Clinical and experimental medicine
pub_type: 杂志文章
doi:10.1007/s10238-006-0106-7
更新日期:2006-10-01 00:00:00
abstract::Glioblastoma multiforme (GBM) is the most common malignancy in central nervous system. A small subpopulation of GBM cells known as GBM stem-like cells (GSLCs) were supposed to be the most malignant cells among GBM cells as they are resistant to multiple therapies including radiotherapy. In this study, we set up two GS...
journal_title:Clinical and experimental medicine
pub_type: 杂志文章
doi:10.1007/s10238-018-0504-7
更新日期:2018-08-01 00:00:00
abstract::Pancreatic cancer (PC) is a leading cause of cancer death worldwide, especially in Western societies. Its aggressive nature and poor prognosis increase the need for identifying new and more accurate diagnostic and prognostic tools. We studied 41 patients who had undergone radical surgical resection for PC, investigate...
journal_title:Clinical and experimental medicine
pub_type: 杂志文章
doi:10.1007/s10238-015-0352-7
更新日期:2016-08-01 00:00:00
abstract::Cancer stem cells (CSCs) are thought to be a major player in tumor initiation, progression, and metastasis. Targeting CSCs for elimination presents a promising therapeutic strategy; however, this approach will require a stronger understanding of CSC biology and identification of CSC-specific markers. The present study...
journal_title:Clinical and experimental medicine
pub_type: 杂志文章
doi:10.1007/s10238-020-00665-w
更新日期:2020-09-23 00:00:00
abstract::To investigate lncRNAs acting as competing endogenous RNAs (ceRNAs) involved in oncogenesis and progression of HCC. Different expressed lncRNAs, microRNAs, and mRNAs (DElncRNAs, DEmiRNAs, DEmRNAs), downloaded from The Cancer Genome Atlas (TCGA) database, were identified by edgeR package. CeRNA network was constructed ...
journal_title:Clinical and experimental medicine
pub_type: 杂志文章
doi:10.1007/s10238-020-00634-3
更新日期:2020-08-01 00:00:00
abstract::The predominance of the effector mechanisms by CD4 + T cells is a characteristic of inflammatory autoimmune diseases such as rheumatoid arthritis (RA). The CD40/CD40L costimulatory pathway contributes to these pathogenic mechanisms by promoting autoantibody production and inflammation. Aberrant expression of CD40 and ...
journal_title:Clinical and experimental medicine
pub_type: 杂志文章
doi:10.1007/s10238-019-00568-5
更新日期:2019-11-01 00:00:00
abstract::Imatinib mesylate represents the first of a new generation of molecularly targeted therapies engineered to disrupt signal transduction pathways. It is a tyrosine kinase inhibitor with relatively selective activity against the Abelson (ABL) proto-oncogene, platelet-derived growth factor receptor, and c-KIT receptor. De...
journal_title:Clinical and experimental medicine
pub_type: 杂志文章,评审
doi:10.1007/s10238-004-0032-5
更新日期:2004-09-01 00:00:00
abstract::Many tumor cells express chemokines and chemokine receptors, and these molecules can affect both tumor progression and anti-tumor immune response. Genetic polymorphisms of some chemokine receptors were found to be closely related to malignant tumors, especially in metastasis process, including breast cancer (BC). Cons...
journal_title:Clinical and experimental medicine
pub_type: 杂志文章,评审
doi:10.1007/s10238-015-0342-9
更新日期:2016-05-01 00:00:00
abstract::Familial hypercholesterolaemia is a genetic disorder characterised by high low-density lipoprotein (LDL) cholesterol concentrations, which frequently gives rise to premature coronary artery disease (CAD). The clinical expression of familial hypercholesterolaemia is highly variable even in patients carrying the same LD...
journal_title:Clinical and experimental medicine
pub_type: 杂志文章
doi:10.1007/s10238-005-0086-z
更新日期:2005-12-01 00:00:00
abstract::The sensitivity of the alkaline comet assay for the evaluation of baseline and treatment-induced DNA damage in white blood cells of breast cancer patients receiving adjuvant chemotherapy according to three conventional anthracycline- and cyclophosphamide-containing protocols was investigated. Additionally, baseline DN...
journal_title:Clinical and experimental medicine
pub_type: 杂志文章
doi:10.1007/s10238-006-0113-8
更新日期:2006-12-01 00:00:00
abstract::An in vitro skin explant model was originally developed to predict the occurrence and severity of acute graft-versus-host disease in allogeneic hematopoietic stem cell transplants. In previous studies we reported that peripheral blood mononuclear cells of patients with rheumatoid arthritis were able to induce graft-ve...
journal_title:Clinical and experimental medicine
pub_type: 杂志文章
doi:10.1007/s10238-001-8014-3
更新日期:2001-06-01 00:00:00
abstract::Staphylococcus aureus (S. aureus) is the most common bacterium in sepsis and pneumonia involving gram-positive bacteria. Lipoteichoic acid (LTA) is a cell wall component of gram-positive bacteria. It is a potent inducer of inflammatory mediators in human dendritic cells, human pulmonary epithelial cells, and murine ma...
journal_title:Clinical and experimental medicine
pub_type: 杂志文章
doi:10.1007/s10238-013-0231-z
更新日期:2014-05-01 00:00:00
abstract::We have previously found that ex vivo expanded human CD4+CD25+Treg cells suppress proliferation of lymphoma B-cell lines. Here we demonstrate that the immunomodulatory drug lenalidomide potentiates suppression of lymphoma B-cell proliferation by freshly isolated CD4+CD25+Tregs, as well as suppression by Tregs expanded...
journal_title:Clinical and experimental medicine
pub_type: 杂志文章
doi:10.1007/s10238-016-0411-8
更新日期:2017-05-01 00:00:00
abstract::It is suggested that gastric mucins, and in particular some specific glycan structures that can act as carbohydrate receptors, are involved in the interactions with Helicobacter pylori adhesins. The main aim of our study was to evaluate glycosylation pattern of glycoproteins of gastric juice before and at the end of e...
journal_title:Clinical and experimental medicine
pub_type: 杂志文章
doi:10.1007/s10238-010-0113-6
更新日期:2011-06-01 00:00:00
abstract::Apoptosis of the acinar and ductal epithelial cells of the salivary glands has been proposed as a mechanism possibly responsible for the impairment of the secretory function in Sjögren's syndrome, an organ-specific autoimmune disorder characterized by destruction of these glandular structures. The presence of serum au...
journal_title:Clinical and experimental medicine
pub_type: 杂志文章
doi:10.1007/s10238-009-0087-4
更新日期:2010-09-01 00:00:00
abstract::The aim of this work was to investigate the presence of the RHD gene in fetal cells obtained from amniotic fluid. We studied 65 samples of amniotic fluid, 11 from RhD-negative mothers sensitized with anti-D alloantibodies. The fetal origin of the DNA was confirmed with the analysis of 1 VNTR locus and 3 STR loci in DN...
journal_title:Clinical and experimental medicine
pub_type: 杂志文章
doi:10.1007/s102380200010
更新日期:2002-07-01 00:00:00
abstract::Tumor markers were used for disease monitoring in small-cell lung cancer patients. The aim of this study was to improve diagnostic efficiency in the detection of tumor progression in small-cell lung cancer patients by using fuzzy logic modeling in combination with a tumor marker panel (NSE, ProGRP, Tumor M2-PK, CYFRA ...
journal_title:Clinical and experimental medicine
pub_type: 杂志文章
doi:10.1007/s102380300005
更新日期:2003-02-01 00:00:00
abstract::The identification of chromosome 1 translocations and deletions is a rare and poorly investigated event in chronic lymphocytic leukemia (CLL). Nevertheless, the identification of novel additional molecular alterations is of great interest, opening to new prognostic and therapeutic strategies for such heterogeneous hem...
journal_title:Clinical and experimental medicine
pub_type: 杂志文章
doi:10.1007/s10238-019-00551-0
更新日期:2019-05-01 00:00:00
abstract::Alpha1-adrenoceptor antagonists (alpha1-blockers) are currently used as first-line drugs for the treatment of benign prostatic hyperplasia (BPH). However, cases of BPH are often encountered in which the efficacy of alpha1-blockers decreases and switching to surgical treatment is required. One factor responsible for th...
journal_title:Clinical and experimental medicine
pub_type: 杂志文章
doi:10.1007/s10238-009-0073-x
更新日期:2010-06-01 00:00:00
abstract::Hyperhomocysteinemia is an independent risk factor for vascular disease, frequently observed in patients with severe renal impairment. Hyperhomocysteinemia has never been considered as a possible risk factor in renal artery stenosis. We investigated plasma folate and vitamin B12, methylenetetrahydrofolate reductase (M...
journal_title:Clinical and experimental medicine
pub_type: 杂志文章
doi:10.1007/s102380100005
更新日期:2001-12-01 00:00:00
abstract::Current hepatitis C virus (HCV) genotyping techniques are often highly technical, costly, or need improvements in sensitivity and specificity. These limitations indicate the need of novel methods for HCV genotyping. The present study aimed to develop a novel genotyping method combining high-resolution melting (HRM) an...
journal_title:Clinical and experimental medicine
pub_type: 杂志文章
doi:10.1007/s10238-016-0424-3
更新日期:2017-08-01 00:00:00
abstract::Experimental, epidemiologic, and clinical trial data indicate the antineoplastic effects of calcium and vitamin D in large-bowel neoplasia. The aim of this study was to determine serum levels of vitamin D metabolites and parathormone (PTH) in patients with colorectal cancer (CRC) and to extract conclusions comparing t...
journal_title:Clinical and experimental medicine
pub_type: 杂志文章
doi:10.1007/s10238-009-0069-6
更新日期:2010-03-01 00:00:00
abstract::Gastrointestinal (GIT) cancers represent the third common cancers worldwide, characterized by rapid progression and higher mortality rate. Matrix metalloproteinases (MMPs) play an important role in cancer metastases. The present study was conducted to estimate and evaluate the role of MMP-7, -9, -10 and -12 and TGF β1...
journal_title:Clinical and experimental medicine
pub_type: 杂志文章
doi:10.1007/s10238-020-00651-2
更新日期:2020-11-01 00:00:00
abstract::High glucose plays an important role in the pathogenesis of atherosclerosis. In this study, we assessed the effects of high glucose on human umbilical vein endothelial cell (HUVEC) apoptosis. Additionally, we investigated whether alpha-lipoic acid, an antioxidant, prevents high glucose-induced apoptosis of HUVECs. HUV...
journal_title:Clinical and experimental medicine
pub_type: 杂志文章
doi:10.1007/s10238-008-0155-1
更新日期:2008-03-01 00:00:00
abstract::The most important mutation associated with Multiple Endocrine Neoplasia type 2B (MEN 2B) is the change of thymine to cytosine in codon 918 of exon 16 in the RET oncogene (ATG → ACG). The aim of this work was to develop a single oligoarray by using tandem hybridization to detect the T918C/RET mutation for MEN 2B patie...
journal_title:Clinical and experimental medicine
pub_type: 杂志文章
doi:10.1007/s10238-010-0128-z
更新日期:2011-12-01 00:00:00
abstract::STAT6 transcription factor, which has been implicated in commitment to Th2, is known to be activated by IL-4 and IL-13. Accordingly, STAT6 is primarily responsible for the transcriptional effects of IL-4 and IL-13. STAT6-deficient mice are known to have defective IL-4-mediated functions, such as B cell proliferation, ...
journal_title:Clinical and experimental medicine
pub_type: 杂志文章
doi:10.1007/s10238-009-0083-8
更新日期:2010-09-01 00:00:00