Abstract：
:Alpha1-adrenoceptor antagonists (alpha1-blockers) are currently used as first-line drugs for the treatment of benign prostatic hyperplasia (BPH). However, cases of BPH are often encountered in which the efficacy of alpha1-blockers decreases and switching to surgical treatment is required. One factor responsible for this resistance includes structural changes in prostatic tissue architecture following repeated oral administration of alpha1-blockers. Forty patients suspected of having prostate cancer, but without evidence of malignancy on prostatic biopsy were divided into two groups: an untreated group (n = 17) and an oral alpha1-blocker-treated group (n = 23). Twenty-one patients exhibiting resistance to oral alpha1-blocker therapy who underwent surgery were assigned into the surgically treated group. Each tissue sample was subjected to Masson's trichrome staining to distinguish collagen fibers from smooth muscle constituting prostatic stroma. The mean collagen fiber share was 62.2 +/- 10.4% in the untreated group, 72.1 +/- 9.1% in the oral alpha1-blocker-treated group, and 72.2 +/- 15.7% in the surgically treated group. Focusing on cases exhibiting high-collagen fiber share (70% or more), the distribution in each of the two alpha1-blocker-treated groups (16 of the 23 cases from the oral alpha1-blocker-treated group and 10 of the 21 cases from the surgically treated group) differed significantly from that in the untreated group (2 of the 17 cases). Our findings suggest that the accumulation of collagen fibers in prostatic stroma could be one of the factors responsible for alpha1-blocker treatment.
journal_name
Clin Exp Medjournal_title
Clinical and experimental medicineauthors
Imamura T,Ishii K,Kanda H,Arase S,Yoshio Y,Hori Y,Soga N,Kise H,Arima K,Sugimura Ydoi
10.1007/s10238-009-0073-xsubject
Has Abstractpub_date
2010-06-01 00:00:00pages
99-106issue
2eissn
1591-8890issn
1591-9528journal_volume
10pub_type
杂志文章abstract：:Immunophenotypic characterization of the leukemic cells has been widely used as a tool for diagnosis, classification and prognosis of leukaemia. A total of 192 Chinese patients with acute myeloid leukemia (AML) were immunophenotyped by flow cytometry using a panel of monoclonal antibodies. Among the 192 patients enrol...
journal_title：Clinical and experimental medicine
pub_type： 杂志文章
doi：10.1007/s10238-009-0030-8
更新日期：2009-06-01 00:00:00
abstract：:Mesenchymal stem cells (MSCs) have captured the attention of researchers today due to their multipotent differentiation capacity. Also, they have been successfully applied clinically, in the treatment of various diseases of the heart and musculoskeletal systems, with encouraging results. Their supportive role in haema...
journal_title：Clinical and experimental medicine
pub_type： 杂志文章,评审
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更新日期：2014-08-01 00:00:00
abstract：:Anti-tumour necrosis factor-α (TNF-α) therapy brought new hopes for treating rheumatic diseases but also increased the risk of infection, including mycobacterium tuberculosis (MTb). Conventional screening tools, such as tuberculin skin test (TST), lack sensitivity or specificity. Recently, T-SPOT.TB has been introduce...
journal_title：Clinical and experimental medicine
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journal_title：Clinical and experimental medicine
pub_type： 杂志文章
doi：10.1007/s10238-009-0049-x
更新日期：2009-12-01 00:00:00
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journal_title：Clinical and experimental medicine
pub_type： 杂志文章
doi：10.1007/s10238-006-0113-8
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journal_title：Clinical and experimental medicine
pub_type： 杂志文章,评审
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更新日期：2021-01-23 00:00:00
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journal_title：Clinical and experimental medicine
pub_type： 杂志文章
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更新日期：2001-12-01 00:00:00
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journal_title：Clinical and experimental medicine
pub_type： 杂志文章
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更新日期：2008-06-01 00:00:00
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journal_title：Clinical and experimental medicine
pub_type： 杂志文章
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更新日期：2008-09-01 00:00:00
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pub_type： 杂志文章
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更新日期：2019-02-01 00:00:00
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pub_type： 杂志文章
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更新日期：2018-05-01 00:00:00
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journal_title：Clinical and experimental medicine
pub_type： 杂志文章
doi：10.1007/s10238-015-0361-6
更新日期：2016-08-01 00:00:00
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journal_title：Clinical and experimental medicine
pub_type： 杂志文章
doi：10.1007/s10238-015-0337-6
更新日期：2016-02-01 00:00:00
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journal_title：Clinical and experimental medicine
pub_type： 杂志文章
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更新日期：2019-08-01 00:00:00
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journal_title：Clinical and experimental medicine
pub_type： 杂志文章
doi：10.1007/s10238-010-0105-6
更新日期：2011-03-01 00:00:00
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journal_title：Clinical and experimental medicine
pub_type： 杂志文章,评审
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journal_title：Clinical and experimental medicine
pub_type： 杂志文章
doi：10.1007/s10238-020-00636-1
更新日期：2020-11-01 00:00:00
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journal_title：Clinical and experimental medicine
pub_type： 杂志文章
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更新日期：2008-03-01 00:00:00
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journal_title：Clinical and experimental medicine
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更新日期：2016-11-01 00:00:00
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journal_title：Clinical and experimental medicine
pub_type： 杂志文章
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更新日期：2007-06-01 00:00:00
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journal_title：Clinical and experimental medicine
pub_type： 杂志文章
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更新日期：2020-05-01 00:00:00
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journal_title：Clinical and experimental medicine
pub_type： 杂志文章
doi：10.1007/s10238-020-00664-x
更新日期：2020-10-20 00:00:00
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journal_title：Clinical and experimental medicine
pub_type： 杂志文章
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更新日期：2012-03-01 00:00:00
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journal_title：Clinical and experimental medicine
pub_type： 临床试验,杂志文章
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更新日期：2012-12-01 00:00:00
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journal_title：Clinical and experimental medicine
pub_type： 杂志文章,评审
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更新日期：2016-05-01 00:00:00
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journal_title：Clinical and experimental medicine
pub_type： 杂志文章
doi：10.1007/s10238-013-0268-z
更新日期：2015-02-01 00:00:00
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journal_title：Clinical and experimental medicine
pub_type： 杂志文章
doi：10.1007/s102380300005
更新日期：2003-02-01 00:00:00
