Tumor-resident adenosine-producing mesenchymal stem cells as a potential target for cancer treatment.

abstract：:T helper (Th) 17 cells have a critical role in the pathogenesis of chronic hepatitis B virus (HBV) infection, and basic leucine zipper transcription factor, ATF-like (BATF) is a newly identified transcriptional factor regulating the differentiation of Th17 cells. However, its precise role in patients with chronic hepa...

journal_title：Clinical and experimental medicine

authors： Wang LY,Fan YC,Zhao J,Ji XF,Wang K

更新日期：2018-05-01 00:00:00

abstract：:The predominance of the effector mechanisms by CD4 + T cells is a characteristic of inflammatory autoimmune diseases such as rheumatoid arthritis (RA). The CD40/CD40L costimulatory pathway contributes to these pathogenic mechanisms by promoting autoantibody production and inflammation. Aberrant expression of CD40 and ...

journal_title：Clinical and experimental medicine

authors： Román-Fernández IV,García-Chagollán M,Cerpa-Cruz S,Jave-Suárez LF,Palafox-Sánchez CA,García-Arellano S,Sánchez-Zuno GA,Muñoz-Valle JF

更新日期：2019-11-01 00:00:00

abstract：:Immunophenotypic characterization of the leukemic cells has been widely used as a tool for diagnosis, classification and prognosis of leukaemia. A total of 192 Chinese patients with acute myeloid leukemia (AML) were immunophenotyped by flow cytometry using a panel of monoclonal antibodies. Among the 192 patients enrol...

journal_title：Clinical and experimental medicine

authors： Tong H,Lu C,Zhang J,Liu Z,Ma Y

更新日期：2009-06-01 00:00:00

abstract：:Gastrointestinal (GIT) cancers represent the third common cancers worldwide, characterized by rapid progression and higher mortality rate. Matrix metalloproteinases (MMPs) play an important role in cancer metastases. The present study was conducted to estimate and evaluate the role of MMP-7, -9, -10 and -12 and TGF β1...

journal_title：Clinical and experimental medicine

authors： El-Ashmawy NE,Khedr NF,Mansour MG,Al-Ashmawy GM

更新日期：2020-11-01 00:00:00

abstract：:The purpose of this study was to reveal the clinical diagnostic and prognostic value of miR-768-3p in HBV-related HCC and to investigate its effect on the biological function of HCC. Quantitative real-time polymerase chain reaction was used to detect the expression level of miR-768-3p in subjects' serum. The receiver ...

journal_title：Clinical and experimental medicine

authors： Cao C,Wang C

更新日期：2020-11-01 00:00:00

abstract：:Previous studies have implicated protective effects of vitamin D on insulin secretion and pancreas beta cell function. The goal of the present study is to determine if a combination therapy of 25-hydroxyvitamin D3 and insulin had any advantage over insulin therapy alone on lipid peroxidation and antioxidant activity i...

journal_title：Clinical and experimental medicine

authors： Noyan T,Balaharoğlu R,Kömüroğlu U

更新日期：2005-05-01 00:00:00

abstract：:β-Thalassemia is a significant public health problem in Egypt. Infectious complications represent the second most common cause of mortality and the major cause of morbidity in β-thalassemia major (BTM). The increased susceptibility of these patients to infectious diseases has been attributed to the abnormalities of th...

journal_title：Clinical and experimental medicine

authors： Elsayh KI,Mohammed WS,Zahran AM,Saad K

更新日期：2016-08-01 00:00:00

abstract：:The incidence of sepsis-associated acute kidney injury (AKI) is on the rise. Recent studies have found a correlation between antithrombin III and AKI. We established a predictive model for sepsis-associated AKI based on plasma ATIII levels. A prospective study (March 2018-January 2020) was conducted in sepsis patients...

journal_title：Clinical and experimental medicine

authors： Xie Y,Zhang Y,Tian R,Jin W,Du J,Zhou Z,Wang R

更新日期：2020-08-31 00:00:00

abstract：:The aim of this study was to discover potential biomarkers for rheumatoid arthritis (RA) using Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry combined with magnetic beads. Proteomic fingerprint technology combining magnetic beads with MALDI-TOF-MS was used to profile and compare the prote...

journal_title：Clinical and experimental medicine

authors： Zhang X,Yuan Z,Shen B,Zhu M,Liu C,Xu W

更新日期：2012-09-01 00:00:00

abstract：OBJECTIVE:Infection of prosthetic material is a major complication of vascular surgery. Therapy for it includes implantation of antimicrobial prostheses bonded with different antimicrobial agents. These agents may, however, induce an acute phase reaction following implantation in the host, thus compromising follow-up o...

journal_title：Clinical and experimental medicine

authors： Hernandez-Richter TM,Wichmann MW,Schrödl W,Angele MK,Heinritzi K,Schildberg FW

更新日期：2001-03-01 00:00:00

abstract：:SOCS3 as an important negative regulator of IL6/JAK/STAT3 signaling pathway may be early critical determinants of carcinogenesis. This study aimed to explore the aberrant promoter methylation of SOCS3 gene in circulating DNA as a noninvasive biomarker for screening hepatocellular carcinoma (HCC) high-risk individuals ...

journal_title：Clinical and experimental medicine

authors： Wei L,Huang Y,Zhao R,Zhang J,Liu Q,Liang W,Ding X,Gao B,Li B,Sun C,He J,Yu X,Liu Z,Sun A,Qin Y

更新日期：2018-02-01 00:00:00

abstract：:Tumor markers were used for disease monitoring in small-cell lung cancer patients. The aim of this study was to improve diagnostic efficiency in the detection of tumor progression in small-cell lung cancer patients by using fuzzy logic modeling in combination with a tumor marker panel (NSE, ProGRP, Tumor M2-PK, CYFRA ...

journal_title：Clinical and experimental medicine

authors： Schneider J,Peltri G,Bitterlich N,Philipp M,Velcovsky HG,Morr H,Katz N,Eigenbrodt E

更新日期：2003-02-01 00:00:00

abstract：:TNF-α plays a key role in the inflammatory cytokine cascade involved in the pathogenesis of chronic arthritis, including rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis. Systemic inflammation and the increased production of pro-inflammatory cytokines in these patients may favor the onset of metab...

journal_title：Clinical and experimental medicine

authors： Maruotti N,d'Onofrio F,Cantatore FP

更新日期：2015-11-01 00:00:00

abstract：:Rho-associated coiled-coil-containing protein kinase 2 (ROCK2) has been known as an effector for the small GTPase Rho and plays an important role in tumor progression and metastasis. However, the effect of ROCK2 in gastric cancer (GC) has not been identified. This study showed that ROCK2 expression significantly incre...

journal_title：Clinical and experimental medicine

authors： Li M,Ke J,Wang Q,Qian H,Yang L,Zhang X,Xiao J,Ding H,Shan X,Liu Q,Xiao Y,Bao B,Huang H

更新日期：2017-11-01 00:00:00

abstract：:To investigate lncRNAs acting as competing endogenous RNAs (ceRNAs) involved in oncogenesis and progression of HCC. Different expressed lncRNAs, microRNAs, and mRNAs (DElncRNAs, DEmiRNAs, DEmRNAs), downloaded from The Cancer Genome Atlas (TCGA) database, were identified by edgeR package. CeRNA network was constructed ...

journal_title：Clinical and experimental medicine

authors： Qu L,Cai X,Xu J,Wei X,Qu X,Sun L,Gong L,Su C,Zhu Y

更新日期：2020-08-01 00:00:00

abstract：:The effect of preimmunisation with cancer procoagulant (CP) on the growth of Walker 256 carcinosarcoma cells in Wistar Lew/Han/IMP rats in vivo has been analysed. One group of rats was immunised with CP purified from human amnion-chorion membranes. The rest of the animals (control groups) were injected with 0.9% NaCl ...

journal_title：Clinical and experimental medicine

authors： Kamocka M,Kaplinska K,Mielicki WP

更新日期：2006-10-01 00:00:00

abstract：:Slit2 glycoprotein has been described to regulate the inflammatory response and be involved in autoimmune diseases. Here, we investigated the expression of Slit2 and its potential significance in systemic lupus erythematosus (SLE). A total of 103 patients with SLE participated in our study. The levels of serum Slit2 w...

journal_title：Clinical and experimental medicine

authors： Zhang Y,Hu L,Li X,Chen L,Yang X

更新日期：2020-10-20 00:00:00

abstract：:Hereditary periodic fever syndromes (HPF) are a group of diseases characterised by recurrences of fever and inflammation separated by symptom-free intervals. Familial Mediterranean fever (FMF) is the most frequent entity within this group of disorders which further consists of hyperimmunoglobulinaemia D and periodic f...

journal_title：Clinical and experimental medicine

authors： van der Hilst JC,Simon A,Drenth JP

更新日期：2005-10-01 00:00:00

abstract：:Bronchoalveolar lavage (BAL) is a useful procedure for differential diagnosis of interstitial lung diseases (ILDs) and for identification of granulomatous lung diseases. We investigated a panel of biomarkers from BAL fluid of ILD patients to evaluate their utility in differentiating ILDs. Bronchoscopy with BAL was per...

journal_title：Clinical and experimental medicine

authors： d'Alessandro M,Carleo A,Cameli P,Bergantini L,Perrone A,Vietri L,Lanzarone N,Vagaggini C,Sestini P,Bargagli E

更新日期：2020-05-01 00:00:00

abstract：:Breast cancer is the most common cause of malignancy and mortality in women worldwide. This study aimed at localising homologous recombination repair (HR) genes and their chromosomal loci and correlating their nucleotide variants with susceptibility to breast cancer. In this study, authors analysed the association bet...

journal_title：Clinical and experimental medicine

authors： Romanowicz H,Strapagiel D,Słomka M,Sobalska-Kwapis M,Kępka E,Siewierska-Górska A,Zadrożny M,Bieńkiewicz J,Smolarz B

更新日期：2017-11-01 00:00:00

abstract：:Pancreatic islet transplantation has remained an effective therapy for type 1 diabetes since 2000. Its widespread use has been prohibited by the shortage of suitable donors. It is critical to explore an applicable alternative for β-cell replacement. This study was performed to generate insulin-producing cells (IPCs) f...

journal_title：Clinical and experimental medicine

authors： Guo XR,Wang XL,Li MC,Yuan YH,Chen Y,Zou DD,Bian LJ,Li DS

更新日期：2015-11-01 00:00:00

abstract：:Primary biliary cirrhosis (PBC) is a slowly progressive autoimmune disease of unknown mechanism. We established a PBC animal model by injecting C57BL/6 mice with polyinosinic-polycytidylic acid sodium (polyI:C) to investigate the therapeutic effect of bone marrow-derived mesenchymal stem cells (BM-MSC) on this model. ...

journal_title：Clinical and experimental medicine

authors： Wang D,Zhang H,Liang J,Gu Z,Ma X,Huang J,Lin J,Hou Y,Lu L,Sun L

更新日期：2011-03-01 00:00:00

abstract：:This paper describes the clinical significance of antibodies to the ribosomal P proteins in systemic lupus erythematosus. It appears that liver disease due to the lupus process and not attributable to viral infection, alcohol or drugs is associated with anti-ribosomal P. In addition, there is a strong relationship to ...

journal_title：Clinical and experimental medicine

authors： Reichlin M

更新日期：2006-06-01 00:00:00

abstract：:The sensitivity of the alkaline comet assay for the evaluation of baseline and treatment-induced DNA damage in white blood cells of breast cancer patients receiving adjuvant chemotherapy according to three conventional anthracycline- and cyclophosphamide-containing protocols was investigated. Additionally, baseline DN...

journal_title：Clinical and experimental medicine

authors： Kopjar N,Milas I,Garaj-Vrhovac V,Gamulin M

更新日期：2006-12-01 00:00:00

abstract：:Mixed-phenotype acute leukemia (MPAL) is the infrequent type of acute leukemia characterized by immunophenotypic and/or cytochemical features of both lineages, but the diagnosis of this disease still is a challenge. In this study, we analyzed immunophenotyping, cytochemistry and frequency of MPAL patients to better di...

journal_title：Clinical and experimental medicine

authors： Poopak B,Khosravi A,Bahoush-Mehdiabadi G,Madani T,Khodadi E,Farahani Z,Vahedi AA,Khosravipour G,Poopak P,Poopak AH

更新日期：2018-11-01 00:00:00

abstract：:Type I interferons are currently used for the treatment of chronic viral hepatitis, multiple sclerosis and several hematological and solid tumors. Side effects are not uncommon, and include multiple alterations in thyroid function, some of which are unrelated to autoimmunity. Review of the literature revealed an overa...

journal_title：Clinical and experimental medicine

authors： Monzani F,Caraccio N,Dardano A,Ferrannini E

更新日期：2004-04-01 00:00:00

abstract：:Alpha1-adrenoceptor antagonists (alpha1-blockers) are currently used as first-line drugs for the treatment of benign prostatic hyperplasia (BPH). However, cases of BPH are often encountered in which the efficacy of alpha1-blockers decreases and switching to surgical treatment is required. One factor responsible for th...

journal_title：Clinical and experimental medicine

authors： Imamura T,Ishii K,Kanda H,Arase S,Yoshio Y,Hori Y,Soga N,Kise H,Arima K,Sugimura Y

更新日期：2010-06-01 00:00:00

abstract：:Oxidative stress (OS) has recently been documented in hypothyroidism, a disease more prevalent in women. In general, OS is reported to be more prevalent in males. However, the effect of gender on OS and protein glycation in hypothyroidism has not been addressed. Blood samples from 37 recently diagnosed primary hypothy...

journal_title：Clinical and experimental medicine

authors： Nanda N,Bobby Z,Hamide A

更新日期：2008-06-01 00:00:00

abstract：:Although the role of cholesterol absorption by the gallbladder epithelium in gallstone formation is well established, the exact process is poorly understood. Potential candidates for regulation of transepithelial cholesterol transport are suggested to be two large membrane multiple ligand receptors, megalin and cubili...

journal_title：Clinical and experimental medicine

authors： Tsaroucha AK,Chatzaki E,Lambropoulou M,Despoudi K,Laftsidis P,Charsou C,Polychronidis A,Papadopoulos N,Simopoulos CE

更新日期：2008-09-01 00:00:00

abstract：:Experimental, epidemiologic, and clinical trial data indicate the antineoplastic effects of calcium and vitamin D in large-bowel neoplasia. The aim of this study was to determine serum levels of vitamin D metabolites and parathormone (PTH) in patients with colorectal cancer (CRC) and to extract conclusions comparing t...

journal_title：Clinical and experimental medicine

authors： Charalampopoulos A,Charalabopoulos A,Batistatou A,Golias C,Anogeianaki A,Peschos D,Iliadis I,Macheras A,Charalabopoulos K

更新日期：2010-03-01 00:00:00