Guilty bystanders: nurse-like cells as a model of microenvironmental support for leukemic lymphocytes.

abstract：:We have previously found that ex vivo expanded human CD4+CD25+Treg cells suppress proliferation of lymphoma B-cell lines. Here we demonstrate that the immunomodulatory drug lenalidomide potentiates suppression of lymphoma B-cell proliferation by freshly isolated CD4+CD25+Tregs, as well as suppression by Tregs expanded...

journal_title：Clinical and experimental medicine

authors： Grygorowicz MA,Borycka IS,Nowak E,Paszkiewicz-Kozik E,Rymkiewicz G,Błachnio K,Biernacka M,Bujko M,Walewski J,Markowicz S

更新日期：2017-05-01 00:00:00

abstract：:Hyperhomocysteinemia is an independent risk factor for vascular disease, frequently observed in patients with severe renal impairment. Hyperhomocysteinemia has never been considered as a possible risk factor in renal artery stenosis. We investigated plasma folate and vitamin B12, methylenetetrahydrofolate reductase (M...

journal_title：Clinical and experimental medicine

authors： Olivieri O,Friso S,Trabetti E,Girelli D,Pizzolo F,Faccini G,Stranieri C,Pignatti PF,Corrocher R

更新日期：2001-12-01 00:00:00

abstract：:Hereditary periodic fever syndromes (HPF) are a group of diseases characterised by recurrences of fever and inflammation separated by symptom-free intervals. Familial Mediterranean fever (FMF) is the most frequent entity within this group of disorders which further consists of hyperimmunoglobulinaemia D and periodic f...

journal_title：Clinical and experimental medicine

authors： van der Hilst JC,Simon A,Drenth JP

更新日期：2005-10-01 00:00:00

abstract：:SOCS3 as an important negative regulator of IL6/JAK/STAT3 signaling pathway may be early critical determinants of carcinogenesis. This study aimed to explore the aberrant promoter methylation of SOCS3 gene in circulating DNA as a noninvasive biomarker for screening hepatocellular carcinoma (HCC) high-risk individuals ...

journal_title：Clinical and experimental medicine

authors： Wei L,Huang Y,Zhao R,Zhang J,Liu Q,Liang W,Ding X,Gao B,Li B,Sun C,He J,Yu X,Liu Z,Sun A,Qin Y

更新日期：2018-02-01 00:00:00

abstract：:Macrophage migration inhibitory factor (MIF) has been reported to associate with increased cancer risk in several cancers. However, the role of MIF in breast cancer (BC) susceptibility remains unknown. For the first time, we conducted a case-control study to assess the potential association of three common MIF gene va...

journal_title：Clinical and experimental medicine

authors： Lin S,Wang M,Liu X,Zhu W,Guo Y,Dai Z,Yang P,Tian T,Dai C,Zheng Y,Hu C,Wei L,Dai Z

更新日期：2017-08-01 00:00:00

abstract：:Imatinib mesylate represents the first of a new generation of molecularly targeted therapies engineered to disrupt signal transduction pathways. It is a tyrosine kinase inhibitor with relatively selective activity against the Abelson (ABL) proto-oncogene, platelet-derived growth factor receptor, and c-KIT receptor. De...

journal_title：Clinical and experimental medicine

authors： Peggs K

更新日期：2004-09-01 00:00:00

abstract：:Interleukin-17A plays a role in tissue inflammation by inducing release of proinflammatory and neutrophil-mobilizing cytokines. We investigated the association between ulcerative colitis (UC) and polymorphisms of IL17A, rs2275913 (-197 G > A), and rs3748067 (*1249 C > T). The study was performed in 475 healthy subject...

journal_title：Clinical and experimental medicine

authors： Hayashi R,Tahara T,Shiroeda H,Saito T,Nakamura M,Tsutsumi M,Shibata T,Arisawa T

更新日期：2013-11-01 00:00:00

abstract：:Oxidative stress (OS) has recently been documented in hypothyroidism, a disease more prevalent in women. In general, OS is reported to be more prevalent in males. However, the effect of gender on OS and protein glycation in hypothyroidism has not been addressed. Blood samples from 37 recently diagnosed primary hypothy...

journal_title：Clinical and experimental medicine

authors： Nanda N,Bobby Z,Hamide A

更新日期：2008-06-01 00:00:00

abstract：:Arginase activity was measured in serum and biopsy from healthy individuals and colorectal cancer patients. Arginase activity in tumor samples (87 +/- 7.7 U/g tissue) was significantly higher than in controls (40.7 +/- 3.3 U/g tissue). However, serum arginase activity did not show any significant change in both groups...

journal_title：Clinical and experimental medicine

authors： del Ara RM,González-Polo RA,Caro A,del Amo E,Palomo L,Hernández E,Soler G,Fuentes JM

更新日期：2002-05-01 00:00:00

abstract：:Rho-associated coiled-coil-containing protein kinase 2 (ROCK2) has been known as an effector for the small GTPase Rho and plays an important role in tumor progression and metastasis. However, the effect of ROCK2 in gastric cancer (GC) has not been identified. This study showed that ROCK2 expression significantly incre...

journal_title：Clinical and experimental medicine

authors： Li M,Ke J,Wang Q,Qian H,Yang L,Zhang X,Xiao J,Ding H,Shan X,Liu Q,Xiao Y,Bao B,Huang H

更新日期：2017-11-01 00:00:00

abstract：:The aim of this study was to evaluate the ferric-reducing ability of serum (FRAS), paraoxonase 1 (PON1), ceruloplasmin serum oxidase activity and hsCRP level in patients with type1 diabetes mellitus without and with diabetic retinopathy. The study was performed in 76 patients with type 1 diabetes mellitus, 35 without ...

journal_title：Clinical and experimental medicine

authors： Nowak M,Wielkoszyński T,Marek B,Kos-Kudła B,Swietochowska E,Siemińska L,Karpe J,Kajdaniuk D,Głogowska-Szelag J,Nowak K

更新日期：2010-09-01 00:00:00

abstract：:The purpose of this study was to reveal the clinical diagnostic and prognostic value of miR-768-3p in HBV-related HCC and to investigate its effect on the biological function of HCC. Quantitative real-time polymerase chain reaction was used to detect the expression level of miR-768-3p in subjects' serum. The receiver ...

journal_title：Clinical and experimental medicine

authors： Cao C,Wang C

更新日期：2020-11-01 00:00:00

abstract：:STAT6 transcription factor, which has been implicated in commitment to Th2, is known to be activated by IL-4 and IL-13. Accordingly, STAT6 is primarily responsible for the transcriptional effects of IL-4 and IL-13. STAT6-deficient mice are known to have defective IL-4-mediated functions, such as B cell proliferation, ...

journal_title：Clinical and experimental medicine

authors： Kim EG,Shin HJ,Lee CG,Park HY,Kim YK,Park HW,Cho SH,Min KU,Cho ML,Park SH,Lee CW

更新日期：2010-09-01 00:00:00

abstract：:High glucose plays an important role in the pathogenesis of atherosclerosis. In this study, we assessed the effects of high glucose on human umbilical vein endothelial cell (HUVEC) apoptosis. Additionally, we investigated whether alpha-lipoic acid, an antioxidant, prevents high glucose-induced apoptosis of HUVECs. HUV...

journal_title：Clinical and experimental medicine

authors： Meng X,Li ZM,Zhou YJ,Cao YL,Zhang J

更新日期：2008-03-01 00:00:00

abstract：:Atopic dermatitis (AD) is a chronic, inflammatory skin disease which is characterized by severe pruritus and affects patients' quality of life. In recent years gamma interferon (IFN-gamma) has been accepted as a novel treatment for severe AD, however, its mechanism of action is not clearly identified. Present study ev...

journal_title：Clinical and experimental medicine

authors： Panahi Y,Davoudi SM,Madanchi N,Abolhasani E

更新日期：2012-12-01 00:00:00

abstract：:The background of this article is as follows: Few data are available about the persistence of serum-specific IgG antibodies to L. infantum after acute VL. The objective of this article is to evaluate the persistence of antibodies against L. infantum in patients healed from acute VL, and the kinetic of the same antibod...

journal_title：Clinical and experimental medicine

authors： Mansueto P,Pepe I,Seidita A,Scozzari F,Vitale G,Arcoleo F,Elvira I,Cillari E,Rini GB,Napoli N,Di Rosa S,Mansueto S,Di Fede G

更新日期：2012-06-01 00:00:00

abstract：:Anti-tumour necrosis factor-α (TNF-α) therapy brought new hopes for treating rheumatic diseases but also increased the risk of infection, including mycobacterium tuberculosis (MTb). Conventional screening tools, such as tuberculin skin test (TST), lack sensitivity or specificity. Recently, T-SPOT.TB has been introduce...

journal_title：Clinical and experimental medicine

authors： Xie X,Chen JW,Li F,Tian J,Gao JS,Zhang D

更新日期：2011-09-01 00:00:00

abstract：:The development of new therapies based on tumor biology is one of the main topics in cancer treatment. In this regard, investigating the microenvironment and cellular composition of the tumor is of particular interest. Mesenchymal stem cells (MSCs) are a major group of cells in the tumor tissue and play a critical rol...

journal_title：Clinical and experimental medicine

authors： Arab S,Alizadeh A,Asgharzade S

更新日期：2021-01-23 00:00:00

abstract：:TNF-α plays a key role in the inflammatory cytokine cascade involved in the pathogenesis of chronic arthritis, including rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis. Systemic inflammation and the increased production of pro-inflammatory cytokines in these patients may favor the onset of metab...

journal_title：Clinical and experimental medicine

authors： Maruotti N,d'Onofrio F,Cantatore FP

更新日期：2015-11-01 00:00:00

abstract：:Telomere shortening occurs with human aging in many organs and tissues and is accelerated by rapid cell turnover and oxidative injury. To clarify the clinical importance of telomere shortening in colonic mucosa in ulcerative colitis (UC), we measured average telomere length using quantitative real-time PCR in non-neop...

journal_title：Clinical and experimental medicine

authors： Tahara T,Shibata T,Okubo M,Kawamura T,Sumi K,Ishizuka T,Nakamura M,Nagasaka M,Nakagawa Y,Ohmiya N,Arisawa T,Hirata I

更新日期：2015-08-01 00:00:00

abstract：:Takayasu arteritis (TAK) is a rare granulomatous vasculitis of unknown etiology that mainly affects the aorta and its major branches. The aim is to describe the clinical features, diagnostic procedures, pathogenesis, and management of TAK in a longitudinal cohort of patients recruited within a single region of souther...

journal_title：Clinical and experimental medicine

authors： Dammacco F,Cirulli A,Simeone A,Leone P,Pulli R,Angiletta D,Rubini G,Di Palo A,Vacca A,Dammacco R

更新日期：2020-10-07 00:00:00

abstract：:Apoptosis of the acinar and ductal epithelial cells of the salivary glands has been proposed as a mechanism possibly responsible for the impairment of the secretory function in Sjögren's syndrome, an organ-specific autoimmune disorder characterized by destruction of these glandular structures. The presence of serum au...

journal_title：Clinical and experimental medicine

authors： Lisi S,Sisto M,Lofrumento D,Frassanito MA,Caprio S,Romano ML,Mitolo V,D'Amore M

更新日期：2010-09-01 00:00:00

abstract：:The aim of this work was to investigate the presence of the RHD gene in fetal cells obtained from amniotic fluid. We studied 65 samples of amniotic fluid, 11 from RhD-negative mothers sensitized with anti-D alloantibodies. The fetal origin of the DNA was confirmed with the analysis of 1 VNTR locus and 3 STR loci in DN...

journal_title：Clinical and experimental medicine

authors： Cotorruelo C,Biondi C,García Borrás S,Di Mónaco R,Racca A

更新日期：2002-07-01 00:00:00

abstract：:T helper (Th) 17 cells have a critical role in the pathogenesis of chronic hepatitis B virus (HBV) infection, and basic leucine zipper transcription factor, ATF-like (BATF) is a newly identified transcriptional factor regulating the differentiation of Th17 cells. However, its precise role in patients with chronic hepa...

journal_title：Clinical and experimental medicine

authors： Wang LY,Fan YC,Zhao J,Ji XF,Wang K

更新日期：2018-05-01 00:00:00

abstract：:Primary biliary cirrhosis (PBC) is a slowly progressive autoimmune disease of unknown mechanism. We established a PBC animal model by injecting C57BL/6 mice with polyinosinic-polycytidylic acid sodium (polyI:C) to investigate the therapeutic effect of bone marrow-derived mesenchymal stem cells (BM-MSC) on this model. ...

journal_title：Clinical and experimental medicine

authors： Wang D,Zhang H,Liang J,Gu Z,Ma X,Huang J,Lin J,Hou Y,Lu L,Sun L

更新日期：2011-03-01 00:00:00

abstract：:Alpha1-adrenoceptor antagonists (alpha1-blockers) are currently used as first-line drugs for the treatment of benign prostatic hyperplasia (BPH). However, cases of BPH are often encountered in which the efficacy of alpha1-blockers decreases and switching to surgical treatment is required. One factor responsible for th...

journal_title：Clinical and experimental medicine

authors： Imamura T,Ishii K,Kanda H,Arase S,Yoshio Y,Hori Y,Soga N,Kise H,Arima K,Sugimura Y

更新日期：2010-06-01 00:00:00

abstract：OBJECTIVE:Infection of prosthetic material is a major complication of vascular surgery. Therapy for it includes implantation of antimicrobial prostheses bonded with different antimicrobial agents. These agents may, however, induce an acute phase reaction following implantation in the host, thus compromising follow-up o...

journal_title：Clinical and experimental medicine

authors： Hernandez-Richter TM,Wichmann MW,Schrödl W,Angele MK,Heinritzi K,Schildberg FW

更新日期：2001-03-01 00:00:00

abstract：:Recently, Th17 cell-associated responses have received growing attention; however, the role of IL-22 (a cytokines also produced by Th17 cells) in the pathogenesis of systemic lupus erythematosus (SLE) has not been widely explored. In this study, we analyze the frequencies of IL-22-positive CD4+/CD8+ T cells in periphe...

journal_title：Clinical and experimental medicine

authors： Qin WZ,Chen LL,Pan HF,Leng RX,Zhai ZM,Wang C,Li RJ,Wang S,Wang HP,Ye DQ

更新日期：2011-12-01 00:00:00

abstract：:The incidence of sepsis-associated acute kidney injury (AKI) is on the rise. Recent studies have found a correlation between antithrombin III and AKI. We established a predictive model for sepsis-associated AKI based on plasma ATIII levels. A prospective study (March 2018-January 2020) was conducted in sepsis patients...

journal_title：Clinical and experimental medicine

authors： Xie Y,Zhang Y,Tian R,Jin W,Du J,Zhou Z,Wang R

更新日期：2020-08-31 00:00:00

abstract：:Familial hypercholesterolaemia is a genetic disorder characterised by high low-density lipoprotein (LDL) cholesterol concentrations, which frequently gives rise to premature coronary artery disease (CAD). The clinical expression of familial hypercholesterolaemia is highly variable even in patients carrying the same LD...

journal_title：Clinical and experimental medicine

authors： Pitsavos C,Choumerianou DM,Skoumas J,Maumus S,Stefanadis C,Dedoussis GV,Visvikis-Siest S

更新日期：2005-12-01 00:00:00