Abstract：
:Oxidative stress (OS) has recently been documented in hypothyroidism, a disease more prevalent in women. In general, OS is reported to be more prevalent in males. However, the effect of gender on OS and protein glycation in hypothyroidism has not been addressed. Blood samples from 37 recently diagnosed primary hypothyroid patients were collected before initiation of thyroxine therapy. Serum glucose, thyroid and lipid profiles were estimated. Glutathione (GSH), malondialdehyde (MDA), protein carbonylation (PCO) and fructosamine levels were analysed. GSH was found to be lower, whereas MDA, fructosamine and PCO levels were higher in male than in female patients. Level of MDA was significantly correlated with fructosamine, protein carbonyls, cholesterol, low-density and high-density lipoprotein cholesterol, triglyceride and GSH in hypothyroid patients. We found OS to be more prevalent in male hypothyroid patients. The positive association of MDA with fructosamine indicates that enhanced lipid peroxidation could be a plausible contributor for accelerated glycation of protein. Considering the negative influence of OS on health, extra attention should be paid to male hypothyroid patients in spite of the low prevalence of this disease in them.
journal_name
Clin Exp Medjournal_title
Clinical and experimental medicineauthors
Nanda N,Bobby Z,Hamide Adoi
10.1007/s10238-008-0164-0subject
Has Abstractpub_date
2008-06-01 00:00:00pages
101-8issue
2eissn
1591-8890issn
1591-9528journal_volume
8pub_type
杂志文章abstract：:Interleukin (IL)-27 is an IL-12 family cytokine and exerts a critical role in immune regulation in the context of infection, autoimmunity, and angiogenesis. In this study, we aimed to investigate the possible pathophysiological role of IL-27 and vascular endothelial growth factor (VEGF) in ankylosing spondylitis (AS)....
journal_title：Clinical and experimental medicine
pub_type： 杂志文章
doi：10.1007/s10238-014-0281-x
更新日期：2015-05-01 00:00:00
abstract：:Nasopharyngeal carcinoma (NPC) is a very common head and neck cancer in southern china. Despite advances in surgical and chemotherapeutic approaches, its prognosis is still not promising. Hedgehog signaling pathway was reported to be involved in a number of cancers including head and neck. However, it remains unclear ...
journal_title：Clinical and experimental medicine
pub_type： 杂志文章
doi：10.1007/s10238-012-0198-1
更新日期：2013-11-01 00:00:00
abstract：:Tumor markers were used for disease monitoring in small-cell lung cancer patients. The aim of this study was to improve diagnostic efficiency in the detection of tumor progression in small-cell lung cancer patients by using fuzzy logic modeling in combination with a tumor marker panel (NSE, ProGRP, Tumor M2-PK, CYFRA ...
journal_title：Clinical and experimental medicine
pub_type： 杂志文章
doi：10.1007/s102380300005
更新日期：2003-02-01 00:00:00
abstract：:Primary biliary cirrhosis (PBC) is a slowly progressive autoimmune disease of unknown mechanism. We established a PBC animal model by injecting C57BL/6 mice with polyinosinic-polycytidylic acid sodium (polyI:C) to investigate the therapeutic effect of bone marrow-derived mesenchymal stem cells (BM-MSC) on this model. ...
journal_title：Clinical and experimental medicine
pub_type： 杂志文章
doi：10.1007/s10238-010-0105-6
更新日期：2011-03-01 00:00:00
abstract：:High glucose plays an important role in the pathogenesis of atherosclerosis. In this study, we assessed the effects of high glucose on human umbilical vein endothelial cell (HUVEC) apoptosis. Additionally, we investigated whether alpha-lipoic acid, an antioxidant, prevents high glucose-induced apoptosis of HUVECs. HUV...
journal_title：Clinical and experimental medicine
pub_type： 杂志文章
doi：10.1007/s10238-008-0155-1
更新日期：2008-03-01 00:00:00
abstract：:The objective of this study was to compare between the effects of mesenchymal stem cell (MSC) and betamethasone in the treatment of rheumatoid arthritis. Sixty male albino mice were divided equally into 2 models. They are MSC model, group 1: saline control group, group 2: collagen-induced arthritis (CIA), group 3: ind...
journal_title：Clinical and experimental medicine
pub_type： 杂志文章
doi：10.1007/s10238-013-0248-3
更新日期：2014-08-01 00:00:00
abstract：:Catastrophic antiphospholipid syndrome (CAPS) is a rare disorder, characterized by the development of multiple vascular thrombosis over a short period of time, in patients with persistently detectable antiphospholipid antibodies (aPLs). The vascular occlusions predominantly affect small vessels. The overall mortality ...
journal_title：Clinical and experimental medicine
pub_type： 杂志文章
doi：10.1007/s10238-019-00565-8
更新日期：2019-08-01 00:00:00
abstract：:Endotoxin is known to cause acute lung injury (ALI). Here, we investigated the effects and mechanisms of recombinant human bone morphogenetic protein-2 (rhBMP-2) on pulmonary arteriole remodeling in endotoxin-induced ALI in rats. Sixty Wistar rats were randomly divided into 3 groups (n = 20). Control group was infused...
journal_title：Clinical and experimental medicine
pub_type： 杂志文章
doi：10.1007/s10238-012-0197-2
更新日期：2013-08-01 00:00:00
abstract：:T helper (Th) 17 cells have a critical role in the pathogenesis of chronic hepatitis B virus (HBV) infection, and basic leucine zipper transcription factor, ATF-like (BATF) is a newly identified transcriptional factor regulating the differentiation of Th17 cells. However, its precise role in patients with chronic hepa...
journal_title：Clinical and experimental medicine
pub_type： 杂志文章
doi：10.1007/s10238-017-0480-3
更新日期：2018-05-01 00:00:00
abstract：:Gastrointestinal (GIT) cancers represent the third common cancers worldwide, characterized by rapid progression and higher mortality rate. Matrix metalloproteinases (MMPs) play an important role in cancer metastases. The present study was conducted to estimate and evaluate the role of MMP-7, -9, -10 and -12 and TGF β1...
journal_title：Clinical and experimental medicine
pub_type： 杂志文章
doi：10.1007/s10238-020-00651-2
更新日期：2020-11-01 00:00:00
abstract：:Although the role of cholesterol absorption by the gallbladder epithelium in gallstone formation is well established, the exact process is poorly understood. Potential candidates for regulation of transepithelial cholesterol transport are suggested to be two large membrane multiple ligand receptors, megalin and cubili...
journal_title：Clinical and experimental medicine
pub_type： 杂志文章
doi：10.1007/s10238-008-0174-y
更新日期：2008-09-01 00:00:00
abstract：:B-cell chronic lymphocytic leukemia (B-CLL) is one of the most common leukemias among the elderly and, despite many efforts, still stays incurable. Recent studies point to the microenvironment as the critical factor providing leukemic lymphocytes with pro-survival signals. Thus, the neighboring cells appear to be a pe...
journal_title：Clinical and experimental medicine
pub_type： 杂志文章
doi：10.1007/s10238-013-0268-z
更新日期：2015-02-01 00:00:00
abstract：:The background of this article is as follows: Few data are available about the persistence of serum-specific IgG antibodies to L. infantum after acute VL. The objective of this article is to evaluate the persistence of antibodies against L. infantum in patients healed from acute VL, and the kinetic of the same antibod...
journal_title：Clinical and experimental medicine
pub_type： 杂志文章
doi：10.1007/s10238-011-0150-9
更新日期：2012-06-01 00:00:00
abstract：:Atopic dermatitis (AD) is a chronic, inflammatory skin disease which is characterized by severe pruritus and affects patients' quality of life. In recent years gamma interferon (IFN-gamma) has been accepted as a novel treatment for severe AD, however, its mechanism of action is not clearly identified. Present study ev...
journal_title：Clinical and experimental medicine
pub_type： 临床试验,杂志文章
doi：10.1007/s10238-011-0164-3
更新日期：2012-12-01 00:00:00
abstract：:Anti-inflammatory cytokine and its serological detection may have an important role in the process of cardiovascular and cerebrovascular diseases. We investigated whether serum interleukin-10 (IL-10) is associated with cerebral infarction or not in the general population. Identified comprehensive searching was perform...
journal_title：Clinical and experimental medicine
pub_type： 杂志文章,meta分析
doi：10.1007/s10238-015-0346-5
更新日期：2016-05-01 00:00:00
abstract：:We have previously found that ex vivo expanded human CD4+CD25+Treg cells suppress proliferation of lymphoma B-cell lines. Here we demonstrate that the immunomodulatory drug lenalidomide potentiates suppression of lymphoma B-cell proliferation by freshly isolated CD4+CD25+Tregs, as well as suppression by Tregs expanded...
journal_title：Clinical and experimental medicine
pub_type： 杂志文章
doi：10.1007/s10238-016-0411-8
更新日期：2017-05-01 00:00:00
abstract：:Common variable immunodeficiency (CVID) is a heterogeneous group of disorders, characterized by hypogammaglobulinemia and increased susceptibility to infections, autoimmunity and malignancies. This study was performed to analyze the Mannose-binding lectin (MBL) polymorphisms in Iranian patients with CVID. Thirty-five ...
journal_title：Clinical and experimental medicine
pub_type： 杂志文章
doi：10.1007/s10238-009-0049-x
更新日期：2009-12-01 00:00:00
abstract：:Alpha1-adrenoceptor antagonists (alpha1-blockers) are currently used as first-line drugs for the treatment of benign prostatic hyperplasia (BPH). However, cases of BPH are often encountered in which the efficacy of alpha1-blockers decreases and switching to surgical treatment is required. One factor responsible for th...
journal_title：Clinical and experimental medicine
pub_type： 杂志文章
doi：10.1007/s10238-009-0073-x
更新日期：2010-06-01 00:00:00
abstract：:Hereditary periodic fever syndromes (HPF) are a group of diseases characterised by recurrences of fever and inflammation separated by symptom-free intervals. Familial Mediterranean fever (FMF) is the most frequent entity within this group of disorders which further consists of hyperimmunoglobulinaemia D and periodic f...
journal_title：Clinical and experimental medicine
pub_type： 杂志文章,评审
doi：10.1007/s10238-005-0071-6
更新日期：2005-10-01 00:00:00
abstract：:Accurate prediction of the outcome of molecular target-based treatment in advanced renal cell carcinoma (RCC) is an important clinical problem. Positron emission tomography/computed tomography using [18F]-2-fluoro-2-deoxyglucose (FDG PET/CT) is a noninvasive tool for the assessment of glucose accumulation which can be...
journal_title：Clinical and experimental medicine
pub_type： 杂志文章
doi：10.1007/s10238-018-0539-9
更新日期：2019-02-01 00:00:00
abstract：:Familial hypercholesterolaemia is a genetic disorder characterised by high low-density lipoprotein (LDL) cholesterol concentrations, which frequently gives rise to premature coronary artery disease (CAD). The clinical expression of familial hypercholesterolaemia is highly variable even in patients carrying the same LD...
journal_title：Clinical and experimental medicine
pub_type： 杂志文章
doi：10.1007/s10238-005-0086-z
更新日期：2005-12-01 00:00:00
abstract：:The predominance of the effector mechanisms by CD4 + T cells is a characteristic of inflammatory autoimmune diseases such as rheumatoid arthritis (RA). The CD40/CD40L costimulatory pathway contributes to these pathogenic mechanisms by promoting autoantibody production and inflammation. Aberrant expression of CD40 and ...
journal_title：Clinical and experimental medicine
pub_type： 杂志文章
doi：10.1007/s10238-019-00568-5
更新日期：2019-11-01 00:00:00
abstract：:The aim of this study was to evaluate the ferric-reducing ability of serum (FRAS), paraoxonase 1 (PON1), ceruloplasmin serum oxidase activity and hsCRP level in patients with type1 diabetes mellitus without and with diabetic retinopathy. The study was performed in 76 patients with type 1 diabetes mellitus, 35 without ...
journal_title：Clinical and experimental medicine
pub_type： 杂志文章
doi：10.1007/s10238-009-0084-7
更新日期：2010-09-01 00:00:00
abstract：:The thrombin generation potential is an in vitro measure for the capacity of an individual to generate thrombin and recognized as a reflection of a hypo- or hypercoagulable status. Measurement of the in vivo thrombin activity, however, may be of clinical significance. We evaluated a new assay for in vivo thrombin acti...
journal_title：Clinical and experimental medicine
pub_type： 杂志文章
doi：10.1007/s10238-016-0417-2
更新日期：2017-05-01 00:00:00
abstract：:Recent findings suggest that cell and gene transplantation in the infarcted myocardium may improve heart function. The aim of the study was to investigate the mechanism involved in improving heart function following the co-injection of adipose-derived stem cells (ADSCs) and basic fibroblast growth factor (bFGF) in a r...
journal_title：Clinical and experimental medicine
pub_type： 杂志文章
doi：10.1007/s10238-015-0383-0
更新日期：2016-11-01 00:00:00
abstract：:Breast cancer is the most common cause of malignancy and mortality in women worldwide. This study aimed at localising homologous recombination repair (HR) genes and their chromosomal loci and correlating their nucleotide variants with susceptibility to breast cancer. In this study, authors analysed the association bet...
journal_title：Clinical and experimental medicine
pub_type： 杂志文章
doi：10.1007/s10238-016-0441-2
更新日期：2017-11-01 00:00:00
abstract：:Previous studies have implicated protective effects of vitamin D on insulin secretion and pancreas beta cell function. The goal of the present study is to determine if a combination therapy of 25-hydroxyvitamin D3 and insulin had any advantage over insulin therapy alone on lipid peroxidation and antioxidant activity i...
journal_title：Clinical and experimental medicine
pub_type： 杂志文章
doi：10.1007/s10238-005-0061-8
更新日期：2005-05-01 00:00:00
abstract：:Longitudinal studies have improved current diagnostics and management of metabolic associated fatty liver disease (MAFLD) patients by liver biopsy and therapeutic intervention, yet the deficiency of biomarker spectrum for dissecting subtypes largely hinders the symptomatic treatment. We originally enriched serum from ...
journal_title：Clinical and experimental medicine
pub_type： 杂志文章
doi：10.1007/s10238-020-00636-1
更新日期：2020-11-01 00:00:00
abstract：:The main aim of this study was to investigate the genotoxic effect of combined pharmacotherapy applied in post-operative treatment of cervical cerclage in pregnant women over six days. This study included 19 phenotypically healthy pregnant women in mid-trimester with a diagnosis of cervical insufficiency, mean age 28+...
journal_title：Clinical and experimental medicine
pub_type： 杂志文章
doi：10.1007/s10238-007-0120-4
更新日期：2007-03-01 00:00:00
abstract：:The aim of this study was to discover potential biomarkers for rheumatoid arthritis (RA) using Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry combined with magnetic beads. Proteomic fingerprint technology combining magnetic beads with MALDI-TOF-MS was used to profile and compare the prote...
journal_title：Clinical and experimental medicine
pub_type： 杂志文章
doi：10.1007/s10238-011-0154-5
更新日期：2012-09-01 00:00:00
