Significance of decreased serum interleukin-10 levels in the progression of cerebral infarction.

Abstract:

:Anti-inflammatory cytokine and its serological detection may have an important role in the process of cardiovascular and cerebrovascular diseases. We investigated whether serum interleukin-10 (IL-10) is associated with cerebral infarction or not in the general population. Identified comprehensive searching was performed covering PubMed, EMBASE, Web of Science, Cochrane Library, CISCOM, CINAHL, Google Scholar, China BioMedicine, and China National Knowledge Infrastructure databases. Two reviewers extracted data and assessed studies independently. Information was extracted separately and classed into Asians and Caucasians. Summary standardized mean differences (SMDs) with 95 % confidence intervals (CI) were used with the utilization of Z test. Nine studies ranged from 2003 to 2014 were collected for meta-analysis. Results identified a negative association between serum IL-10 levels and cerebral infarction (SMD = 1.80, 95 % CI 0.79-2.81, P < 0.001). Country-subgroup analysis showed that low IL-10 level may be the main risk factor for cerebral infarction in India (SMD = 1.44, 95 % CI 1.13-1.75, P < 0.001) and Croatia (SMD = 2.96, 95 % CI 2.48-3.44, P < 0.001). In the ethnicity-stratified subgroup analysis, serum IL-10 levels were negatively correlated with cerebral infarction in Asians (SMD = 2.52, 95 % CI 0.47-4.57, P = 0.016), while not in Caucasians (P > 0.05). The lower serum IL-10 concentration was significantly associated with an increased likelihood of cerebral infarction in this meta-analysis. More prospective studies should be conducted to provide stronger evidence justifying the use of IL-10 as new biomarker to identify a predisposition toward cerebral infarction.

journal_name

Clin Exp Med

authors

Diao ZY,Wang CL,Qi HS,Jia GY,Yan CZ

doi

10.1007/s10238-015-0346-5

subject

Has Abstract

pub_date

2016-05-01 00:00:00

pages

203-11

issue

2

eissn

1591-8890

issn

1591-9528

pii

10.1007/s10238-015-0346-5

journal_volume

16

pub_type

杂志文章,meta分析
  • Significance of persistence of antibodies against Leishmania infantum in Sicilian patients affected by acute visceral leishmaniasis.

    abstract::The background of this article is as follows: Few data are available about the persistence of serum-specific IgG antibodies to L. infantum after acute VL. The objective of this article is to evaluate the persistence of antibodies against L. infantum in patients healed from acute VL, and the kinetic of the same antibod...

    journal_title:Clinical and experimental medicine

    pub_type: 杂志文章

    doi:10.1007/s10238-011-0150-9

    authors: Mansueto P,Pepe I,Seidita A,Scozzari F,Vitale G,Arcoleo F,Elvira I,Cillari E,Rini GB,Napoli N,Di Rosa S,Mansueto S,Di Fede G

    更新日期:2012-06-01 00:00:00

  • Paralytic ileus following "subcutaneous bortezomib" therapy: focus on the clinical emergency-report of two cases.

    abstract::We retrospectively analyzed the medical history of 19 elderly myeloma patients treated with the "novel subcutaneous formulation of bortezomib." In our experience, two patients (10 %) discontinued treatment for paralytic ileus. The exact pathogenetic mechanisms of toxic megacolon and paralytic ileus due to "novel subcu...

    journal_title:Clinical and experimental medicine

    pub_type: 杂志文章

    doi:10.1007/s10238-015-0337-6

    authors: Mele G,Coppi MR,Melpignano A,Quarta G

    更新日期:2016-02-01 00:00:00

  • Elevated circulating CD14lowCD16+ monocyte subset in primary biliary cirrhosis correlates with liver injury and promotes Th1 polarization.

    abstract::Primary biliary cirrhosis (PBC) is a progressive autoimmune liver disease in which monocytes/macrophages infiltration and skewed T helper type (Th) 1 and Th17 cell responses participate in the development of the disease. Human peripheral blood monocytes are heterogeneous and can be divided into classical CD14highCD16-...

    journal_title:Clinical and experimental medicine

    pub_type: 杂志文章

    doi:10.1007/s10238-015-0381-2

    authors: Peng A,Ke P,Zhao R,Lu X,Zhang C,Huang X,Tian G,Huang J,Wang J,Invernizzi P,Chen Q,Zhuang J

    更新日期:2016-11-01 00:00:00

  • A T-cell-based enzyme-linked immunospot assay for tuberculosis screening in Chinese patients with rheumatic diseases receiving infliximab therapy.

    abstract::Anti-tumour necrosis factor-α (TNF-α) therapy brought new hopes for treating rheumatic diseases but also increased the risk of infection, including mycobacterium tuberculosis (MTb). Conventional screening tools, such as tuberculin skin test (TST), lack sensitivity or specificity. Recently, T-SPOT.TB has been introduce...

    journal_title:Clinical and experimental medicine

    pub_type: 杂志文章

    doi:10.1007/s10238-010-0123-4

    authors: Xie X,Chen JW,Li F,Tian J,Gao JS,Zhang D

    更新日期:2011-09-01 00:00:00

  • Nitric oxide production by Leishmania-infected macrophages and modulation by prostaglandin E2.

    abstract::Nitric oxide (NO), produced by the nitric oxide synthase (iNOS) enzyme, is the most-important molecule responsible for the killing of Leishmania parasites by macrophages. In previous work we have demonstrated that, after activation with recombinant human interferon-gamma and/or bacterial lipopolysaccharide, human macr...

    journal_title:Clinical and experimental medicine

    pub_type: 杂志文章

    doi:10.1007/s10238-001-8025-0

    authors: Panaro MA,Brandonisio O,Sisto M,Acquafredda A,Leogrande D,Fumarola L,Mitolo V

    更新日期:2001-09-01 00:00:00

  • Elevated serum level of IL-27 and VEGF in patients with ankylosing spondylitis and associate with disease activity.

    abstract::Interleukin (IL)-27 is an IL-12 family cytokine and exerts a critical role in immune regulation in the context of infection, autoimmunity, and angiogenesis. In this study, we aimed to investigate the possible pathophysiological role of IL-27 and vascular endothelial growth factor (VEGF) in ankylosing spondylitis (AS)....

    journal_title:Clinical and experimental medicine

    pub_type: 杂志文章

    doi:10.1007/s10238-014-0281-x

    authors: Lin TT,Lu J,Qi CY,Yuan L,Li XL,Xia LP,Shen H

    更新日期:2015-05-01 00:00:00

  • Exhaled carbon monoxide concentration is not elevated in patients with inflammatory bowel disease.

    abstract::The present study was initiated to examine whether the concentration of CO in the breath is elevated in patients with inflammatory bowel disease (IBD). Twenty-three clinically stable patients with IBD in the outpatient clinic (11 with Crohn's disease, 12 with ulcerative colitis), who are non-smokers and non-passive sm...

    journal_title:Clinical and experimental medicine

    pub_type: 杂志文章

    doi:10.1007/s10238-007-0129-8

    authors: Nitta H,Kinoyama M,Teramoto F,Watanabe A,Koga H,Haruma K,Akagi R,Ueda H

    更新日期:2007-06-01 00:00:00

  • Thyroid autoimmunity and dysfunction associated with type I interferon therapy.

    abstract::Type I interferons are currently used for the treatment of chronic viral hepatitis, multiple sclerosis and several hematological and solid tumors. Side effects are not uncommon, and include multiple alterations in thyroid function, some of which are unrelated to autoimmunity. Review of the literature revealed an overa...

    journal_title:Clinical and experimental medicine

    pub_type: 杂志文章,评审

    doi:10.1007/s10238-004-0026-3

    authors: Monzani F,Caraccio N,Dardano A,Ferrannini E

    更新日期:2004-04-01 00:00:00

  • Effect of immunisation with cancer procoagulant on the growth of Walker 256 carcinosarcoma cells in rats.

    abstract::The effect of preimmunisation with cancer procoagulant (CP) on the growth of Walker 256 carcinosarcoma cells in Wistar Lew/Han/IMP rats in vivo has been analysed. One group of rats was immunised with CP purified from human amnion-chorion membranes. The rest of the animals (control groups) were injected with 0.9% NaCl ...

    journal_title:Clinical and experimental medicine

    pub_type: 杂志文章

    doi:10.1007/s10238-006-0106-7

    authors: Kamocka M,Kaplinska K,Mielicki WP

    更新日期:2006-10-01 00:00:00

  • Slit2 is a potential biomarker for renal impairment in systemic lupus erythematosus.

    abstract::Slit2 glycoprotein has been described to regulate the inflammatory response and be involved in autoimmune diseases. Here, we investigated the expression of Slit2 and its potential significance in systemic lupus erythematosus (SLE). A total of 103 patients with SLE participated in our study. The levels of serum Slit2 w...

    journal_title:Clinical and experimental medicine

    pub_type: 杂志文章

    doi:10.1007/s10238-020-00664-x

    authors: Zhang Y,Hu L,Li X,Chen L,Yang X

    更新日期:2020-10-20 00:00:00

  • Metabolic syndrome and chronic arthritis: effects of anti-TNF-α therapy.

    abstract::TNF-α plays a key role in the inflammatory cytokine cascade involved in the pathogenesis of chronic arthritis, including rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis. Systemic inflammation and the increased production of pro-inflammatory cytokines in these patients may favor the onset of metab...

    journal_title:Clinical and experimental medicine

    pub_type: 杂志文章,评审

    doi:10.1007/s10238-014-0323-4

    authors: Maruotti N,d'Onofrio F,Cantatore FP

    更新日期:2015-11-01 00:00:00

  • Discovery of serum protein biomarkers in rheumatoid arthritis using MALDI-TOF-MS combined with magnetic beads.

    abstract::The aim of this study was to discover potential biomarkers for rheumatoid arthritis (RA) using Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry combined with magnetic beads. Proteomic fingerprint technology combining magnetic beads with MALDI-TOF-MS was used to profile and compare the prote...

    journal_title:Clinical and experimental medicine

    pub_type: 杂志文章

    doi:10.1007/s10238-011-0154-5

    authors: Zhang X,Yuan Z,Shen B,Zhu M,Liu C,Xu W

    更新日期:2012-09-01 00:00:00

  • Association of a common variant in TCF7L2 gene with type 2 diabetes mellitus in a Persian population.

    abstract::Diabetes is one of the most common and challenging health problems. Studies in several nations show that polymorphisms within the transcription factor 7-like 2 genes could be associated with type 2 diabetes (T2D). Therefore, a case-control study was conducted to find the association between SNP rs7903146 and T2D in ou...

    journal_title:Clinical and experimental medicine

    pub_type: 杂志文章

    doi:10.1007/s10238-011-0144-7

    authors: Palizban A,Nikpour M,Salehi R,Maracy MR

    更新日期:2012-06-01 00:00:00

  • Early detection of RhD status in pregnancies at risk of hemolytic disease of the newborn.

    abstract::The aim of this work was to investigate the presence of the RHD gene in fetal cells obtained from amniotic fluid. We studied 65 samples of amniotic fluid, 11 from RhD-negative mothers sensitized with anti-D alloantibodies. The fetal origin of the DNA was confirmed with the analysis of 1 VNTR locus and 3 STR loci in DN...

    journal_title:Clinical and experimental medicine

    pub_type: 杂志文章

    doi:10.1007/s102380200010

    authors: Cotorruelo C,Biondi C,García Borrás S,Di Mónaco R,Racca A

    更新日期:2002-07-01 00:00:00

  • Diagnostic performance of arginase activity in colorectal cancer.

    abstract::Arginase activity was measured in serum and biopsy from healthy individuals and colorectal cancer patients. Arginase activity in tumor samples (87 +/- 7.7 U/g tissue) was significantly higher than in controls (40.7 +/- 3.3 U/g tissue). However, serum arginase activity did not show any significant change in both groups...

    journal_title:Clinical and experimental medicine

    pub_type: 杂志文章

    doi:10.1007/s102380200007

    authors: del Ara RM,González-Polo RA,Caro A,del Amo E,Palomo L,Hernández E,Soler G,Fuentes JM

    更新日期:2002-05-01 00:00:00

  • DNA methylation and not allelic variation regulates STAT6 expression in human T cells.

    abstract::STAT6 transcription factor, which has been implicated in commitment to Th2, is known to be activated by IL-4 and IL-13. Accordingly, STAT6 is primarily responsible for the transcriptional effects of IL-4 and IL-13. STAT6-deficient mice are known to have defective IL-4-mediated functions, such as B cell proliferation, ...

    journal_title:Clinical and experimental medicine

    pub_type: 杂志文章

    doi:10.1007/s10238-009-0083-8

    authors: Kim EG,Shin HJ,Lee CG,Park HY,Kim YK,Park HW,Cho SH,Min KU,Cho ML,Park SH,Lee CW

    更新日期:2010-09-01 00:00:00

  • Apolipoprotein E polymorphism is not associated with lipid levels and coronary artery disease in Greek patients with familial hypercholesterolaemia.

    abstract::Familial hypercholesterolaemia is a genetic disorder characterised by high low-density lipoprotein (LDL) cholesterol concentrations, which frequently gives rise to premature coronary artery disease (CAD). The clinical expression of familial hypercholesterolaemia is highly variable even in patients carrying the same LD...

    journal_title:Clinical and experimental medicine

    pub_type: 杂志文章

    doi:10.1007/s10238-005-0086-z

    authors: Pitsavos C,Choumerianou DM,Skoumas J,Maumus S,Stefanadis C,Dedoussis GV,Visvikis-Siest S

    更新日期:2005-12-01 00:00:00

  • Mixed-phenotype acute leukemia characteristics: first report from Iran.

    abstract::Mixed-phenotype acute leukemia (MPAL) is the infrequent type of acute leukemia characterized by immunophenotypic and/or cytochemical features of both lineages, but the diagnosis of this disease still is a challenge. In this study, we analyzed immunophenotyping, cytochemistry and frequency of MPAL patients to better di...

    journal_title:Clinical and experimental medicine

    pub_type: 杂志文章

    doi:10.1007/s10238-018-0520-7

    authors: Poopak B,Khosravi A,Bahoush-Mehdiabadi G,Madani T,Khodadi E,Farahani Z,Vahedi AA,Khosravipour G,Poopak P,Poopak AH

    更新日期:2018-11-01 00:00:00

  • Autoantibodies to the ribosomal P proteins in systemic lupus erythematosus.

    abstract::This paper describes the clinical significance of antibodies to the ribosomal P proteins in systemic lupus erythematosus. It appears that liver disease due to the lupus process and not attributable to viral infection, alcohol or drugs is associated with anti-ribosomal P. In addition, there is a strong relationship to ...

    journal_title:Clinical and experimental medicine

    pub_type: 杂志文章,评审

    doi:10.1007/s10238-006-0094-7

    authors: Reichlin M

    更新日期:2006-06-01 00:00:00

  • LncPRYP4-3 serves as a novel diagnostic biomarker for dissecting subtypes of metabolic associated fatty liver disease by targeting RPS4Y2.

    abstract::Longitudinal studies have improved current diagnostics and management of metabolic associated fatty liver disease (MAFLD) patients by liver biopsy and therapeutic intervention, yet the deficiency of biomarker spectrum for dissecting subtypes largely hinders the symptomatic treatment. We originally enriched serum from ...

    journal_title:Clinical and experimental medicine

    pub_type: 杂志文章

    doi:10.1007/s10238-020-00636-1

    authors: Yang H,Li Q,Zhang L,Zhu M,Niu J,Xue F,Yang L,Qu Q,Lao Y,Ding Z,Xiao C,Wang K

    更新日期:2020-11-01 00:00:00

  • Recombinant human interferon gamma (Gamma Immunex) in treatment of atopic dermatitis.

    abstract::Atopic dermatitis (AD) is a chronic, inflammatory skin disease which is characterized by severe pruritus and affects patients' quality of life. In recent years gamma interferon (IFN-gamma) has been accepted as a novel treatment for severe AD, however, its mechanism of action is not clearly identified. Present study ev...

    journal_title:Clinical and experimental medicine

    pub_type: 临床试验,杂志文章

    doi:10.1007/s10238-011-0164-3

    authors: Panahi Y,Davoudi SM,Madanchi N,Abolhasani E

    更新日期:2012-12-01 00:00:00

  • The oxidant and antioxidant effects of 25-hydroxyvitamin D3 in liver, kidney and heart tissues of diabetic rats.

    abstract::Previous studies have implicated protective effects of vitamin D on insulin secretion and pancreas beta cell function. The goal of the present study is to determine if a combination therapy of 25-hydroxyvitamin D3 and insulin had any advantage over insulin therapy alone on lipid peroxidation and antioxidant activity i...

    journal_title:Clinical and experimental medicine

    pub_type: 杂志文章

    doi:10.1007/s10238-005-0061-8

    authors: Noyan T,Balaharoğlu R,Kömüroğlu U

    更新日期:2005-05-01 00:00:00

  • Synergistic effect of TRAIL and irradiation in elimination of glioblastoma stem-like cells.

    abstract::Glioblastoma multiforme (GBM) is the most common malignancy in central nervous system. A small subpopulation of GBM cells known as GBM stem-like cells (GSLCs) were supposed to be the most malignant cells among GBM cells as they are resistant to multiple therapies including radiotherapy. In this study, we set up two GS...

    journal_title:Clinical and experimental medicine

    pub_type: 杂志文章

    doi:10.1007/s10238-018-0504-7

    authors: Liu J,Gao Q,Xie T,Liu Y,Luo L,Xu C,Shen L,Wan F,Lei T,Ye F

    更新日期:2018-08-01 00:00:00

  • Inhibitory effects of simvastatin on staphylococcus aureus lipoteichoic acid-induced inflammation in human alveolar macrophages.

    abstract::Staphylococcus aureus (S. aureus) is the most common bacterium in sepsis and pneumonia involving gram-positive bacteria. Lipoteichoic acid (LTA) is a cell wall component of gram-positive bacteria. It is a potent inducer of inflammatory mediators in human dendritic cells, human pulmonary epithelial cells, and murine ma...

    journal_title:Clinical and experimental medicine

    pub_type: 杂志文章

    doi:10.1007/s10238-013-0231-z

    authors: Wu BQ,Luo JM,Wang YH,Shi YF,Liu H,Ba JH,Zhang TT

    更新日期:2014-05-01 00:00:00

  • Tumor-resident adenosine-producing mesenchymal stem cells as a potential target for cancer treatment.

    abstract::The development of new therapies based on tumor biology is one of the main topics in cancer treatment. In this regard, investigating the microenvironment and cellular composition of the tumor is of particular interest. Mesenchymal stem cells (MSCs) are a major group of cells in the tumor tissue and play a critical rol...

    journal_title:Clinical and experimental medicine

    pub_type: 杂志文章,评审

    doi:10.1007/s10238-020-00674-9

    authors: Arab S,Alizadeh A,Asgharzade S

    更新日期:2021-01-23 00:00:00

  • Mannose-binding lectin polymorphisms in common variable immunodeficiency.

    abstract::Common variable immunodeficiency (CVID) is a heterogeneous group of disorders, characterized by hypogammaglobulinemia and increased susceptibility to infections, autoimmunity and malignancies. This study was performed to analyze the Mannose-binding lectin (MBL) polymorphisms in Iranian patients with CVID. Thirty-five ...

    journal_title:Clinical and experimental medicine

    pub_type: 杂志文章

    doi:10.1007/s10238-009-0049-x

    authors: Aghamohammadi A,Foroughi F,Rezaei N,Dianat S,Solgi G,Amirzargar AA

    更新日期:2009-12-01 00:00:00

  • Upregulation of ROCK2 in gastric cancer cell promotes tumor cell proliferation, metastasis and invasion.

    abstract::Rho-associated coiled-coil-containing protein kinase 2 (ROCK2) has been known as an effector for the small GTPase Rho and plays an important role in tumor progression and metastasis. However, the effect of ROCK2 in gastric cancer (GC) has not been identified. This study showed that ROCK2 expression significantly incre...

    journal_title:Clinical and experimental medicine

    pub_type: 杂志文章

    doi:10.1007/s10238-016-0444-z

    authors: Li M,Ke J,Wang Q,Qian H,Yang L,Zhang X,Xiao J,Ding H,Shan X,Liu Q,Xiao Y,Bao B,Huang H

    更新日期:2017-11-01 00:00:00

  • Parathormone and 1,25(OH)2D3 but not 25(OH)D3 serum levels, in an inverse correlation, reveal an association with advanced stages of colorectal cancer.

    abstract::Experimental, epidemiologic, and clinical trial data indicate the antineoplastic effects of calcium and vitamin D in large-bowel neoplasia. The aim of this study was to determine serum levels of vitamin D metabolites and parathormone (PTH) in patients with colorectal cancer (CRC) and to extract conclusions comparing t...

    journal_title:Clinical and experimental medicine

    pub_type: 杂志文章

    doi:10.1007/s10238-009-0069-6

    authors: Charalampopoulos A,Charalabopoulos A,Batistatou A,Golias C,Anogeianaki A,Peschos D,Iliadis I,Macheras A,Charalabopoulos K

    更新日期:2010-03-01 00:00:00

  • Homocysteine and atheromatous renal artery stenosis.

    abstract::Hyperhomocysteinemia is an independent risk factor for vascular disease, frequently observed in patients with severe renal impairment. Hyperhomocysteinemia has never been considered as a possible risk factor in renal artery stenosis. We investigated plasma folate and vitamin B12, methylenetetrahydrofolate reductase (M...

    journal_title:Clinical and experimental medicine

    pub_type: 杂志文章

    doi:10.1007/s102380100005

    authors: Olivieri O,Friso S,Trabetti E,Girelli D,Pizzolo F,Faccini G,Stranieri C,Pignatti PF,Corrocher R

    更新日期:2001-12-01 00:00:00

  • Glycosylation of mucins present in gastric juice: the effect of helicobacter pylori eradication treatment.

    abstract::It is suggested that gastric mucins, and in particular some specific glycan structures that can act as carbohydrate receptors, are involved in the interactions with Helicobacter pylori adhesins. The main aim of our study was to evaluate glycosylation pattern of glycoproteins of gastric juice before and at the end of e...

    journal_title:Clinical and experimental medicine

    pub_type: 杂志文章

    doi:10.1007/s10238-010-0113-6

    authors: Radziejewska I,Borzym-Kluczyk M,Namiot Z,Stefańska E

    更新日期:2011-06-01 00:00:00