Lenalidomide potentiates CD4+CD25+Treg-related suppression of lymphoma B-cell proliferation.

abstract：:The rat is an established model for studying intestinal adaptations following abdominal surgery. In the study of functional and morphological adaptations of the small intestine, it is helpful to estimate the mucosal surface area. In order to simplify measurements and calculation we developed a new mathematical model f...

journal_title：Clinical and experimental medicine

authors： Kisielinski K,Willis S,Prescher A,Klosterhalfen B,Schumpelick V

更新日期：2002-11-01 00:00:00

abstract：:Staphylococcus aureus (S. aureus) is the most common bacterium in sepsis and pneumonia involving gram-positive bacteria. Lipoteichoic acid (LTA) is a cell wall component of gram-positive bacteria. It is a potent inducer of inflammatory mediators in human dendritic cells, human pulmonary epithelial cells, and murine ma...

journal_title：Clinical and experimental medicine

authors： Wu BQ,Luo JM,Wang YH,Shi YF,Liu H,Ba JH,Zhang TT

更新日期：2014-05-01 00:00:00

abstract：:Behcet's disease is a recurrent multisystem vasculitis that can affect any organ or system, but was originally described as orogenital ulcerations and uveitis. Specific criteria have been proposed for diagnosis and identification of affected organs by different national authorities. Behcet's disease is proposed to be ...

journal_title：Clinical and experimental medicine

authors： Al-Mutawa SA,Hegab SM

更新日期：2004-12-01 00:00:00

abstract：:Catastrophic antiphospholipid syndrome (CAPS) is a rare disorder, characterized by the development of multiple vascular thrombosis over a short period of time, in patients with persistently detectable antiphospholipid antibodies (aPLs). The vascular occlusions predominantly affect small vessels. The overall mortality ...

journal_title：Clinical and experimental medicine

authors： Tinti MG,Carnevale V,Inglese M,Molinaro F,Bernal M,Migliore A,De Cata A

更新日期：2019-08-01 00:00:00

abstract：:SOCS3 as an important negative regulator of IL6/JAK/STAT3 signaling pathway may be early critical determinants of carcinogenesis. This study aimed to explore the aberrant promoter methylation of SOCS3 gene in circulating DNA as a noninvasive biomarker for screening hepatocellular carcinoma (HCC) high-risk individuals ...

journal_title：Clinical and experimental medicine

authors： Wei L,Huang Y,Zhao R,Zhang J,Liu Q,Liang W,Ding X,Gao B,Li B,Sun C,He J,Yu X,Liu Z,Sun A,Qin Y

更新日期：2018-02-01 00:00:00

abstract：:Experimental, epidemiologic, and clinical trial data indicate the antineoplastic effects of calcium and vitamin D in large-bowel neoplasia. The aim of this study was to determine serum levels of vitamin D metabolites and parathormone (PTH) in patients with colorectal cancer (CRC) and to extract conclusions comparing t...

journal_title：Clinical and experimental medicine

authors： Charalampopoulos A,Charalabopoulos A,Batistatou A,Golias C,Anogeianaki A,Peschos D,Iliadis I,Macheras A,Charalabopoulos K

更新日期：2010-03-01 00:00:00

abstract：:The main aim of this study was to investigate the genotoxic effect of combined pharmacotherapy applied in post-operative treatment of cervical cerclage in pregnant women over six days. This study included 19 phenotypically healthy pregnant women in mid-trimester with a diagnosis of cervical insufficiency, mean age 28+...

journal_title：Clinical and experimental medicine

authors： Grujicić D,Milosević Djordjević O,Arsenijević S,Marinković D

更新日期：2007-03-01 00:00:00

abstract：:Endotoxin is known to cause acute lung injury (ALI). Here, we investigated the effects and mechanisms of recombinant human bone morphogenetic protein-2 (rhBMP-2) on pulmonary arteriole remodeling in endotoxin-induced ALI in rats. Sixty Wistar rats were randomly divided into 3 groups (n = 20). Control group was infused...

journal_title：Clinical and experimental medicine

authors： Wang K,Gong J,Pei L,Shan S,Tan W

更新日期：2013-08-01 00:00:00

abstract：:Oxidative stress (OS) has recently been documented in hypothyroidism, a disease more prevalent in women. In general, OS is reported to be more prevalent in males. However, the effect of gender on OS and protein glycation in hypothyroidism has not been addressed. Blood samples from 37 recently diagnosed primary hypothy...

journal_title：Clinical and experimental medicine

authors： Nanda N,Bobby Z,Hamide A

更新日期：2008-06-01 00:00:00

abstract：:To investigate lncRNAs acting as competing endogenous RNAs (ceRNAs) involved in oncogenesis and progression of HCC. Different expressed lncRNAs, microRNAs, and mRNAs (DElncRNAs, DEmiRNAs, DEmRNAs), downloaded from The Cancer Genome Atlas (TCGA) database, were identified by edgeR package. CeRNA network was constructed ...

journal_title：Clinical and experimental medicine

authors： Qu L,Cai X,Xu J,Wei X,Qu X,Sun L,Gong L,Su C,Zhu Y

更新日期：2020-08-01 00:00:00

abstract：:Alpha1-adrenoceptor antagonists (alpha1-blockers) are currently used as first-line drugs for the treatment of benign prostatic hyperplasia (BPH). However, cases of BPH are often encountered in which the efficacy of alpha1-blockers decreases and switching to surgical treatment is required. One factor responsible for th...

journal_title：Clinical and experimental medicine

authors： Imamura T,Ishii K,Kanda H,Arase S,Yoshio Y,Hori Y,Soga N,Kise H,Arima K,Sugimura Y

更新日期：2010-06-01 00:00:00

abstract：PURPOSE:Exosome-derived long non-coding RNAs (lncRNAs) as novel biomarkers are widely investigated in various cancers, yet results remain controversial. The aim of this meta-analysis was to clarify the diagnostic and prognostic value of exosome-derived lncRNAs in cancer. METHODS:PubMed, Web of Science, EMBASE, CNKI, a...

journal_title：Clinical and experimental medicine

authors： Mu H,Zhang S,Yao Z,Liu Y,Lin K,Zhao Z,Zhu Y

更新日期：2020-08-01 00:00:00

abstract：:Telomere shortening occurs with human aging in many organs and tissues and is accelerated by rapid cell turnover and oxidative injury. To clarify the clinical importance of telomere shortening in colonic mucosa in ulcerative colitis (UC), we measured average telomere length using quantitative real-time PCR in non-neop...

journal_title：Clinical and experimental medicine

authors： Tahara T,Shibata T,Okubo M,Kawamura T,Sumi K,Ishizuka T,Nakamura M,Nagasaka M,Nakagawa Y,Ohmiya N,Arisawa T,Hirata I

更新日期：2015-08-01 00:00:00

abstract：:The effect of preimmunisation with cancer procoagulant (CP) on the growth of Walker 256 carcinosarcoma cells in Wistar Lew/Han/IMP rats in vivo has been analysed. One group of rats was immunised with CP purified from human amnion-chorion membranes. The rest of the animals (control groups) were injected with 0.9% NaCl ...

journal_title：Clinical and experimental medicine

authors： Kamocka M,Kaplinska K,Mielicki WP

更新日期：2006-10-01 00:00:00

abstract：:Although the role of cholesterol absorption by the gallbladder epithelium in gallstone formation is well established, the exact process is poorly understood. Potential candidates for regulation of transepithelial cholesterol transport are suggested to be two large membrane multiple ligand receptors, megalin and cubili...

journal_title：Clinical and experimental medicine

authors： Tsaroucha AK,Chatzaki E,Lambropoulou M,Despoudi K,Laftsidis P,Charsou C,Polychronidis A,Papadopoulos N,Simopoulos CE

更新日期：2008-09-01 00:00:00

abstract：:Atopic dermatitis (AD) is a chronic, inflammatory skin disease which is characterized by severe pruritus and affects patients' quality of life. In recent years gamma interferon (IFN-gamma) has been accepted as a novel treatment for severe AD, however, its mechanism of action is not clearly identified. Present study ev...

journal_title：Clinical and experimental medicine

authors： Panahi Y,Davoudi SM,Madanchi N,Abolhasani E

更新日期：2012-12-01 00:00:00

abstract：:Interleukin (IL)-27 is an IL-12 family cytokine and exerts a critical role in immune regulation in the context of infection, autoimmunity, and angiogenesis. In this study, we aimed to investigate the possible pathophysiological role of IL-27 and vascular endothelial growth factor (VEGF) in ankylosing spondylitis (AS)....

journal_title：Clinical and experimental medicine

authors： Lin TT,Lu J,Qi CY,Yuan L,Li XL,Xia LP,Shen H

更新日期：2015-05-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) has been linked with tumor invasion and metastasis. However, the role of VEGF expression in osteosarcoma remains controversial. By searching the PubMed, Embase, and Google Scholar databases, we conducted a meta-analysis to evaluate the pathological and prognostic significance ...

journal_title：Clinical and experimental medicine

authors： Han G,Wang Y,Bi W,Jia J,Wang W,Xu M

更新日期：2016-11-01 00:00:00

abstract：:Immunophenotypic characterization of the leukemic cells has been widely used as a tool for diagnosis, classification and prognosis of leukaemia. A total of 192 Chinese patients with acute myeloid leukemia (AML) were immunophenotyped by flow cytometry using a panel of monoclonal antibodies. Among the 192 patients enrol...

journal_title：Clinical and experimental medicine

authors： Tong H,Lu C,Zhang J,Liu Z,Ma Y

更新日期：2009-06-01 00:00:00

abstract：:Breast cancer is the most common cause of malignancy and mortality in women worldwide. This study aimed at localising homologous recombination repair (HR) genes and their chromosomal loci and correlating their nucleotide variants with susceptibility to breast cancer. In this study, authors analysed the association bet...

journal_title：Clinical and experimental medicine

authors： Romanowicz H,Strapagiel D,Słomka M,Sobalska-Kwapis M,Kępka E,Siewierska-Górska A,Zadrożny M,Bieńkiewicz J,Smolarz B

更新日期：2017-11-01 00:00:00

abstract：:Rho-associated coiled-coil-containing protein kinase 2 (ROCK2) has been known as an effector for the small GTPase Rho and plays an important role in tumor progression and metastasis. However, the effect of ROCK2 in gastric cancer (GC) has not been identified. This study showed that ROCK2 expression significantly incre...

journal_title：Clinical and experimental medicine

authors： Li M,Ke J,Wang Q,Qian H,Yang L,Zhang X,Xiao J,Ding H,Shan X,Liu Q,Xiao Y,Bao B,Huang H

更新日期：2017-11-01 00:00:00

abstract：:Apoptosis of the acinar and ductal epithelial cells of the salivary glands has been proposed as a mechanism possibly responsible for the impairment of the secretory function in Sjögren's syndrome, an organ-specific autoimmune disorder characterized by destruction of these glandular structures. The presence of serum au...

journal_title：Clinical and experimental medicine

authors： Lisi S,Sisto M,Lofrumento D,Frassanito MA,Caprio S,Romano ML,Mitolo V,D'Amore M

更新日期：2010-09-01 00:00:00

abstract：:Recently, Th17 cell-associated responses have received growing attention; however, the role of IL-22 (a cytokines also produced by Th17 cells) in the pathogenesis of systemic lupus erythematosus (SLE) has not been widely explored. In this study, we analyze the frequencies of IL-22-positive CD4+/CD8+ T cells in periphe...

journal_title：Clinical and experimental medicine

authors： Qin WZ,Chen LL,Pan HF,Leng RX,Zhai ZM,Wang C,Li RJ,Wang S,Wang HP,Ye DQ

更新日期：2011-12-01 00:00:00

abstract：:Familial hypercholesterolaemia is a genetic disorder characterised by high low-density lipoprotein (LDL) cholesterol concentrations, which frequently gives rise to premature coronary artery disease (CAD). The clinical expression of familial hypercholesterolaemia is highly variable even in patients carrying the same LD...

journal_title：Clinical and experimental medicine

authors： Pitsavos C,Choumerianou DM,Skoumas J,Maumus S,Stefanadis C,Dedoussis GV,Visvikis-Siest S

更新日期：2005-12-01 00:00:00

abstract：:To establish a serological classification tree model for rheumatoid arthritis (RA), protein/peptide profiles of serum were detected by matrix-assisted laser desorption-ionization time-of-flight mass spectrometry (MALDI-TOF-MS) combined with weak cationic exchange (WCX) from Cohort 1, including 65 patients with RA and ...

journal_title：Clinical and experimental medicine

authors： Yan Z,Chaojun H,Chuiwen D,Xiaomei L,Xin Z,Yongzhe L,Fengchun Z

更新日期：2015-02-01 00:00:00

abstract：:Pancreatic cancer (PC) is a leading cause of cancer death worldwide, especially in Western societies. Its aggressive nature and poor prognosis increase the need for identifying new and more accurate diagnostic and prognostic tools. We studied 41 patients who had undergone radical surgical resection for PC, investigate...

journal_title：Clinical and experimental medicine

authors： Tsiaousidou A,Tsaroucha AK,Lambropoulou M,Pitiakoudis M,Polychronidis A,Chatzitheoklitos E,Romanidis K,Simopoulos C

更新日期：2016-08-01 00:00:00

abstract：:Nasopharyngeal carcinoma (NPC) is a very common head and neck cancer in southern china. Despite advances in surgical and chemotherapeutic approaches, its prognosis is still not promising. Hedgehog signaling pathway was reported to be involved in a number of cancers including head and neck. However, it remains unclear ...

journal_title：Clinical and experimental medicine

authors： Yue Y,Zhong W,Pei G,Xiao B,Zhang G,Jiang F,Zhang J,Chen C,Yang P,Dang H,Chang H

更新日期：2013-11-01 00:00:00

abstract：:Slit2 glycoprotein has been described to regulate the inflammatory response and be involved in autoimmune diseases. Here, we investigated the expression of Slit2 and its potential significance in systemic lupus erythematosus (SLE). A total of 103 patients with SLE participated in our study. The levels of serum Slit2 w...

journal_title：Clinical and experimental medicine

authors： Zhang Y,Hu L,Li X,Chen L,Yang X

更新日期：2020-10-20 00:00:00

abstract：:Glioblastoma multiforme (GBM) is the most common malignancy in central nervous system. A small subpopulation of GBM cells known as GBM stem-like cells (GSLCs) were supposed to be the most malignant cells among GBM cells as they are resistant to multiple therapies including radiotherapy. In this study, we set up two GS...

journal_title：Clinical and experimental medicine

authors： Liu J,Gao Q,Xie T,Liu Y,Luo L,Xu C,Shen L,Wan F,Lei T,Ye F

更新日期：2018-08-01 00:00:00

abstract：:Accurate prediction of the outcome of molecular target-based treatment in advanced renal cell carcinoma (RCC) is an important clinical problem. Positron emission tomography/computed tomography using [18F]-2-fluoro-2-deoxyglucose (FDG PET/CT) is a noninvasive tool for the assessment of glucose accumulation which can be...

journal_title：Clinical and experimental medicine

authors： Pankowska V,Malkowski B,Wedrowski M,Wedrowska E,Roszkowski K

更新日期：2019-02-01 00:00:00