当前位置： SCI文献检索 > CLINICAL AND EXPERIMENTAL MEDICINE期刊下所有文献 > Increased B7H4 tissue expression correlates with high CA19.9 serum levels and a worse prognosis of pancreatic adenocarcinoma.

Increased B7H4 tissue expression correlates with high CA19.9 serum levels and a worse prognosis of pancreatic adenocarcinoma.

Abstract：

:Pancreatic cancer (PC) is a leading cause of cancer death worldwide, especially in Western societies. Its aggressive nature and poor prognosis increase the need for identifying new and more accurate diagnostic and prognostic tools. We studied 41 patients who had undergone radical surgical resection for PC, investigated B7H4 protein expression in the PC tissue specimens of these patients by immunohistochemistry and analyzed several clinical and pathological features. The positive expression of the B7H4 antigen was associated with a negative impact of chemotherapy with gemcitabine on patient survival and also correlated with high CA19.9 serum levels and poorly differentiated tumors. Moreover, patients that overexpressed B7H4 antigen had worse prognosis compared to the ones that did not overexpress B7H4. B7H4 antigen is a negative prognostic marker for PC patients and also seems to express resistance of PC patients to chemotherapy with gemcitabine.

journal_name

Clin Exp Med

journal_title

Clinical and experimental medicine

authors

Tsiaousidou A,Tsaroucha AK,Lambropoulou M,Pitiakoudis M,Polychronidis A,Chatzitheoklitos E,Romanidis K,Simopoulos C

doi

10.1007/s10238-015-0352-7

subject

Has Abstract

pub_date

2016-08-01 00:00:00

pages

351-6

issue

3

eissn

1591-8890

issn

1591-9528

pii

10.1007/s10238-015-0352-7

journal_volume

16

pub_type

杂志文章

相关文献

CLINICAL AND EXPERIMENTAL MEDICINE文献大全
  • Regulation of mRNA caspase-8 levels by anti-nuclear autoantibodies.

    abstract：:Apoptosis of the acinar and ductal epithelial cells of the salivary glands has been proposed as a mechanism possibly responsible for the impairment of the secretory function in Sjögren's syndrome, an organ-specific autoimmune disorder characterized by destruction of these glandular structures. The presence of serum au...

    journal_title：Clinical and experimental medicine

    pub_type： 杂志文章

    doi：10.1007/s10238-009-0087-4

    authors： Lisi S,Sisto M,Lofrumento D,Frassanito MA,Caprio S,Romano ML,Mitolo V,D'Amore M

    更新日期：2010-09-01 00:00:00

  • Association of interleukin-10 promoter haplotypes with disease susceptibility and IL-10 levels in Mexican patients with systemic lupus erythematosus.

    abstract：:Systemic lupus erythematosus (SLE) is the prototype autoimmune rheumatic disease. The etiology of this disease is incompletely understood; however, environmental factors and genetic predisposition are involved. Cytokine-mediated immunity plays a crucial role in the pathogenesis of SLE. We investigate the association o...

    journal_title：Clinical and experimental medicine

    pub_type： 杂志文章

    doi：10.1007/s10238-014-0315-4

    authors： Palafox-Sánchez CA,Oregon-Romero E,Salazar-Camarena DC,Valle YM,Machado-Contreras JR,Cruz A,Orozco-López M,Orozco-Barocio G,Vázquez-Del Mercado M,Muñoz-Valle JF

    更新日期：2015-11-01 00:00:00

  • Structural changes in alpha1-adrenoceptor antagonist-treated human prostatic stroma.

    abstract：:Alpha1-adrenoceptor antagonists (alpha1-blockers) are currently used as first-line drugs for the treatment of benign prostatic hyperplasia (BPH). However, cases of BPH are often encountered in which the efficacy of alpha1-blockers decreases and switching to surgical treatment is required. One factor responsible for th...

    journal_title：Clinical and experimental medicine

    pub_type： 杂志文章

    doi：10.1007/s10238-009-0073-x

    authors： Imamura T,Ishii K,Kanda H,Arase S,Yoshio Y,Hori Y,Soga N,Kise H,Arima K,Sugimura Y

    更新日期：2010-06-01 00:00:00

  • Role of mesenchymal stem cells in leukaemia: Dr. Jekyll or Mr. Hyde?

    abstract：:Mesenchymal stem cells (MSCs) have captured the attention of researchers today due to their multipotent differentiation capacity. Also, they have been successfully applied clinically, in the treatment of various diseases of the heart and musculoskeletal systems, with encouraging results. Their supportive role in haema...

    journal_title：Clinical and experimental medicine

    pub_type： 杂志文章,评审

    doi：10.1007/s10238-013-0247-4

    authors： Wong RS,Cheong SK

    更新日期：2014-08-01 00:00:00

  • ApoE epsilon2/epsilon3/epsilon4 polymorphism, ApoC-III/ApoE ratio and metabolic syndrome.

    abstract：:Triglyceride-rich lipoproteins contain both apolipoproteins E (ApoE) and C-III (ApoC-III), which show opposite functional properties. The relationships between the ApoE (epsilon2/epsilon3/epsilon4) gene polymorphism and ApoC-III/ApoE ratio has never been investigated. A large population (n=552) of cardiovascular patie...

    journal_title：Clinical and experimental medicine

    pub_type： 杂志文章

    doi：10.1007/s10238-007-0142-y

    authors： Olivieri O,Martinelli N,Bassi A,Trabetti E,Girelli D,Pizzolo F,Friso S,Pignatti PF,Corrocher R

    更新日期：2007-12-01 00:00:00

  • Upregulation of ROCK2 in gastric cancer cell promotes tumor cell proliferation, metastasis and invasion.

    abstract：:Rho-associated coiled-coil-containing protein kinase 2 (ROCK2) has been known as an effector for the small GTPase Rho and plays an important role in tumor progression and metastasis. However, the effect of ROCK2 in gastric cancer (GC) has not been identified. This study showed that ROCK2 expression significantly incre...

    journal_title：Clinical and experimental medicine

    pub_type： 杂志文章

    doi：10.1007/s10238-016-0444-z

    authors： Li M,Ke J,Wang Q,Qian H,Yang L,Zhang X,Xiao J,Ding H,Shan X,Liu Q,Xiao Y,Bao B,Huang H

    更新日期：2017-11-01 00:00:00

  • Imatinib mesylate--gold standards and silver linings.

    abstract：:Imatinib mesylate represents the first of a new generation of molecularly targeted therapies engineered to disrupt signal transduction pathways. It is a tyrosine kinase inhibitor with relatively selective activity against the Abelson (ABL) proto-oncogene, platelet-derived growth factor receptor, and c-KIT receptor. De...

    journal_title：Clinical and experimental medicine

    pub_type： 杂志文章,评审

    doi：10.1007/s10238-004-0032-5

    authors： Peggs K

    更新日期：2004-09-01 00:00:00

  • Effect of allogeneic bone marrow-derived mesenchymal stem cells transplantation in a polyI:C-induced primary biliary cirrhosis mouse model.

    abstract：:Primary biliary cirrhosis (PBC) is a slowly progressive autoimmune disease of unknown mechanism. We established a PBC animal model by injecting C57BL/6 mice with polyinosinic-polycytidylic acid sodium (polyI:C) to investigate the therapeutic effect of bone marrow-derived mesenchymal stem cells (BM-MSC) on this model. ...

    journal_title：Clinical and experimental medicine

    pub_type： 杂志文章

    doi：10.1007/s10238-010-0105-6

    authors： Wang D,Zhang H,Liang J,Gu Z,Ma X,Huang J,Lin J,Hou Y,Lu L,Sun L

    更新日期：2011-03-01 00:00:00

  • Immunophenotypic, cytogenetic and clinical features of 192 AML patients in China.

    abstract：:Immunophenotypic characterization of the leukemic cells has been widely used as a tool for diagnosis, classification and prognosis of leukaemia. A total of 192 Chinese patients with acute myeloid leukemia (AML) were immunophenotyped by flow cytometry using a panel of monoclonal antibodies. Among the 192 patients enrol...

    journal_title：Clinical and experimental medicine

    pub_type： 杂志文章

    doi：10.1007/s10238-009-0030-8

    authors： Tong H,Lu C,Zhang J,Liu Z,Ma Y

    更新日期：2009-06-01 00:00:00

  • The diagnostic and prognostic value of exosome-derived long non-coding RNAs in cancer patients: a meta-analysis.

    abstract：PURPOSE:Exosome-derived long non-coding RNAs (lncRNAs) as novel biomarkers are widely investigated in various cancers, yet results remain controversial. The aim of this meta-analysis was to clarify the diagnostic and prognostic value of exosome-derived lncRNAs in cancer. METHODS:PubMed, Web of Science, EMBASE, CNKI, a...

    journal_title：Clinical and experimental medicine

    pub_type： 杂志文章,评审

    doi：10.1007/s10238-020-00638-z

    authors： Mu H,Zhang S,Yao Z,Liu Y,Lin K,Zhao Z,Zhu Y

    更新日期：2020-08-01 00:00:00

  • A prediction model of sepsis-associated acute kidney injury based on antithrombin III.

    abstract：:The incidence of sepsis-associated acute kidney injury (AKI) is on the rise. Recent studies have found a correlation between antithrombin III and AKI. We established a predictive model for sepsis-associated AKI based on plasma ATIII levels. A prospective study (March 2018-January 2020) was conducted in sepsis patients...

    journal_title：Clinical and experimental medicine

    pub_type： 杂志文章

    doi：10.1007/s10238-020-00656-x

    authors： Xie Y,Zhang Y,Tian R,Jin W,Du J,Zhou Z,Wang R

    更新日期：2020-08-31 00:00:00

  • The effect of combined therapy with ritodrine, erythromycin and verapamil on the frequency of micronuclei in peripheral blood lymphocytes of pregnant women.

    abstract：:The main aim of this study was to investigate the genotoxic effect of combined pharmacotherapy applied in post-operative treatment of cervical cerclage in pregnant women over six days. This study included 19 phenotypically healthy pregnant women in mid-trimester with a diagnosis of cervical insufficiency, mean age 28+...

    journal_title：Clinical and experimental medicine

    pub_type： 杂志文章

    doi：10.1007/s10238-007-0120-4

    authors： Grujicić D,Milosević Djordjević O,Arsenijević S,Marinković D

    更新日期：2007-03-01 00:00:00

  • High-resolution melting combines with Bayes discriminant analysis: a novel hepatitis C virus genotyping method.

    abstract：:Current hepatitis C virus (HCV) genotyping techniques are often highly technical, costly, or need improvements in sensitivity and specificity. These limitations indicate the need of novel methods for HCV genotyping. The present study aimed to develop a novel genotyping method combining high-resolution melting (HRM) an...

    journal_title：Clinical and experimental medicine

    pub_type： 杂志文章

    doi：10.1007/s10238-016-0424-3

    authors： Wu D,Fu X,Wen Y,Liu B,Deng Z,Dai L,Tan D

    更新日期：2017-08-01 00:00:00

  • Parathormone and 1,25(OH)2D3 but not 25(OH)D3 serum levels, in an inverse correlation, reveal an association with advanced stages of colorectal cancer.

    abstract：:Experimental, epidemiologic, and clinical trial data indicate the antineoplastic effects of calcium and vitamin D in large-bowel neoplasia. The aim of this study was to determine serum levels of vitamin D metabolites and parathormone (PTH) in patients with colorectal cancer (CRC) and to extract conclusions comparing t...

    journal_title：Clinical and experimental medicine

    pub_type： 杂志文章

    doi：10.1007/s10238-009-0069-6

    authors： Charalampopoulos A,Charalabopoulos A,Batistatou A,Golias C,Anogeianaki A,Peschos D,Iliadis I,Macheras A,Charalabopoulos K

    更新日期：2010-03-01 00:00:00

  • A new measure for in vivo thrombin activity in comparison with in vitro thrombin generation potential in patients with hyper- and hypocoagulability.

    abstract：:The thrombin generation potential is an in vitro measure for the capacity of an individual to generate thrombin and recognized as a reflection of a hypo- or hypercoagulable status. Measurement of the in vivo thrombin activity, however, may be of clinical significance. We evaluated a new assay for in vivo thrombin acti...

    journal_title：Clinical and experimental medicine

    pub_type： 杂志文章

    doi：10.1007/s10238-016-0417-2

    authors： Königsbrügge O,Koder S,Riedl J,Panzer S,Pabinger I,Ay C

    更新日期：2017-05-01 00:00:00

  • Effect of immunisation with cancer procoagulant on the growth of Walker 256 carcinosarcoma cells in rats.

    abstract：:The effect of preimmunisation with cancer procoagulant (CP) on the growth of Walker 256 carcinosarcoma cells in Wistar Lew/Han/IMP rats in vivo has been analysed. One group of rats was immunised with CP purified from human amnion-chorion membranes. The rest of the animals (control groups) were injected with 0.9% NaCl ...

    journal_title：Clinical and experimental medicine

    pub_type： 杂志文章

    doi：10.1007/s10238-006-0106-7

    authors： Kamocka M,Kaplinska K,Mielicki WP

    更新日期：2006-10-01 00:00:00

  • Injection of basic fibroblast growth factor together with adipose-derived stem cell transplantation: improved cardiac remodeling and function in myocardial infarction.

    abstract：:Recent findings suggest that cell and gene transplantation in the infarcted myocardium may improve heart function. The aim of the study was to investigate the mechanism involved in improving heart function following the co-injection of adipose-derived stem cells (ADSCs) and basic fibroblast growth factor (bFGF) in a r...

    journal_title：Clinical and experimental medicine

    pub_type： 杂志文章

    doi：10.1007/s10238-015-0383-0

    authors： Wang B,Ma X,Zhao L,Zhou X,Ma Y,Sun H,Yang Y,Chen B

    更新日期：2016-11-01 00:00:00

  • Establishing serological classification tree model in rheumatoid arthritis using combination of MALDI-TOF-MS and magnetic beads.

    abstract：:To establish a serological classification tree model for rheumatoid arthritis (RA), protein/peptide profiles of serum were detected by matrix-assisted laser desorption-ionization time-of-flight mass spectrometry (MALDI-TOF-MS) combined with weak cationic exchange (WCX) from Cohort 1, including 65 patients with RA and ...

    journal_title：Clinical and experimental medicine

    pub_type： 杂志文章

    doi：10.1007/s10238-013-0265-2

    authors： Yan Z,Chaojun H,Chuiwen D,Xiaomei L,Xin Z,Yongzhe L,Fengchun Z

    更新日期：2015-02-01 00:00:00

  • Autoantibodies to the ribosomal P proteins in systemic lupus erythematosus.

    abstract：:This paper describes the clinical significance of antibodies to the ribosomal P proteins in systemic lupus erythematosus. It appears that liver disease due to the lupus process and not attributable to viral infection, alcohol or drugs is associated with anti-ribosomal P. In addition, there is a strong relationship to ...

    journal_title：Clinical and experimental medicine

    pub_type： 杂志文章,评审

    doi：10.1007/s10238-006-0094-7

    authors： Reichlin M

    更新日期：2006-06-01 00:00:00

  • Tumor-resident adenosine-producing mesenchymal stem cells as a potential target for cancer treatment.

    abstract：:The development of new therapies based on tumor biology is one of the main topics in cancer treatment. In this regard, investigating the microenvironment and cellular composition of the tumor is of particular interest. Mesenchymal stem cells (MSCs) are a major group of cells in the tumor tissue and play a critical rol...

    journal_title：Clinical and experimental medicine

    pub_type： 杂志文章,评审

    doi：10.1007/s10238-020-00674-9

    authors： Arab S,Alizadeh A,Asgharzade S

    更新日期：2021-01-23 00:00:00

  • Effects of vascular endothelial growth factor expression on pathological characteristics and prognosis of osteosarcoma.

    abstract：:Vascular endothelial growth factor (VEGF) has been linked with tumor invasion and metastasis. However, the role of VEGF expression in osteosarcoma remains controversial. By searching the PubMed, Embase, and Google Scholar databases, we conducted a meta-analysis to evaluate the pathological and prognostic significance ...

    journal_title：Clinical and experimental medicine

    pub_type： 杂志文章,meta分析

    doi：10.1007/s10238-015-0382-1

    authors： Han G,Wang Y,Bi W,Jia J,Wang W,Xu M

    更新日期：2016-11-01 00:00:00

  • Exhaled carbon monoxide concentration is not elevated in patients with inflammatory bowel disease.

    abstract：:The present study was initiated to examine whether the concentration of CO in the breath is elevated in patients with inflammatory bowel disease (IBD). Twenty-three clinically stable patients with IBD in the outpatient clinic (11 with Crohn's disease, 12 with ulcerative colitis), who are non-smokers and non-passive sm...

    journal_title：Clinical and experimental medicine

    pub_type： 杂志文章

    doi：10.1007/s10238-007-0129-8

    authors： Nitta H,Kinoyama M,Teramoto F,Watanabe A,Koga H,Haruma K,Akagi R,Ueda H

    更新日期：2007-06-01 00:00:00

  • Discovery of serum protein biomarkers in rheumatoid arthritis using MALDI-TOF-MS combined with magnetic beads.

    abstract：:The aim of this study was to discover potential biomarkers for rheumatoid arthritis (RA) using Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry combined with magnetic beads. Proteomic fingerprint technology combining magnetic beads with MALDI-TOF-MS was used to profile and compare the prote...

    journal_title：Clinical and experimental medicine

    pub_type： 杂志文章

    doi：10.1007/s10238-011-0154-5

    authors： Zhang X,Yuan Z,Shen B,Zhu M,Liu C,Xu W

    更新日期：2012-09-01 00:00:00

  • LncPRYP4-3 serves as a novel diagnostic biomarker for dissecting subtypes of metabolic associated fatty liver disease by targeting RPS4Y2.

    abstract：:Longitudinal studies have improved current diagnostics and management of metabolic associated fatty liver disease (MAFLD) patients by liver biopsy and therapeutic intervention, yet the deficiency of biomarker spectrum for dissecting subtypes largely hinders the symptomatic treatment. We originally enriched serum from ...

    journal_title：Clinical and experimental medicine

    pub_type： 杂志文章

    doi：10.1007/s10238-020-00636-1

    authors： Yang H,Li Q,Zhang L,Zhu M,Niu J,Xue F,Yang L,Qu Q,Lao Y,Ding Z,Xiao C,Wang K

    更新日期：2020-11-01 00:00:00

  • Elevated circulating CD14lowCD16+ monocyte subset in primary biliary cirrhosis correlates with liver injury and promotes Th1 polarization.

    abstract：:Primary biliary cirrhosis (PBC) is a progressive autoimmune liver disease in which monocytes/macrophages infiltration and skewed T helper type (Th) 1 and Th17 cell responses participate in the development of the disease. Human peripheral blood monocytes are heterogeneous and can be divided into classical CD14highCD16-...

    journal_title：Clinical and experimental medicine

    pub_type： 杂志文章

    doi：10.1007/s10238-015-0381-2

    authors： Peng A,Ke P,Zhao R,Lu X,Zhang C,Huang X,Tian G,Huang J,Wang J,Invernizzi P,Chen Q,Zhuang J

    更新日期：2016-11-01 00:00:00

  • Cytoplasmic expression of Twist1, an EMT-related transcription factor, is associated with higher grades renal cell carcinomas and worse progression-free survival in clear cell renal cell carcinoma.

    abstract：:Twist1 is a key transcription factor, which confers tumor cells with cancer stem cell (CSC)-like characteristics and enhances epithelial-mesenchymal transition in pathological conditions including tumor malignancy and metastasis. This study aimed to evaluate the expression patterns and clinical significance of Twist1 ...

    journal_title：Clinical and experimental medicine

    pub_type： 杂志文章

    doi：10.1007/s10238-017-0481-2

    authors： Rasti A,Madjd Z,Abolhasani M,Mehrazma M,Janani L,Saeednejad Zanjani L,Asgari M

    更新日期：2018-05-01 00:00:00

  • DNA methylation and not allelic variation regulates STAT6 expression in human T cells.

    abstract：:STAT6 transcription factor, which has been implicated in commitment to Th2, is known to be activated by IL-4 and IL-13. Accordingly, STAT6 is primarily responsible for the transcriptional effects of IL-4 and IL-13. STAT6-deficient mice are known to have defective IL-4-mediated functions, such as B cell proliferation, ...

    journal_title：Clinical and experimental medicine

    pub_type： 杂志文章

    doi：10.1007/s10238-009-0083-8

    authors： Kim EG,Shin HJ,Lee CG,Park HY,Kim YK,Park HW,Cho SH,Min KU,Cho ML,Park SH,Lee CW

    更新日期：2010-09-01 00:00:00

  • Lenalidomide potentiates CD4+CD25+Treg-related suppression of lymphoma B-cell proliferation.

    abstract：:We have previously found that ex vivo expanded human CD4+CD25+Treg cells suppress proliferation of lymphoma B-cell lines. Here we demonstrate that the immunomodulatory drug lenalidomide potentiates suppression of lymphoma B-cell proliferation by freshly isolated CD4+CD25+Tregs, as well as suppression by Tregs expanded...

    journal_title：Clinical and experimental medicine

    pub_type： 杂志文章

    doi：10.1007/s10238-016-0411-8

    authors： Grygorowicz MA,Borycka IS,Nowak E,Paszkiewicz-Kozik E,Rymkiewicz G,Błachnio K,Biernacka M,Bujko M,Walewski J,Markowicz S

    更新日期：2017-05-01 00:00:00

  • Detection of promoter methylation status of suppressor of cytokine signaling 3 (SOCS3) in tissue and plasma from Chinese patients with different hepatic diseases.

    abstract：:SOCS3 as an important negative regulator of IL6/JAK/STAT3 signaling pathway may be early critical determinants of carcinogenesis. This study aimed to explore the aberrant promoter methylation of SOCS3 gene in circulating DNA as a noninvasive biomarker for screening hepatocellular carcinoma (HCC) high-risk individuals ...

    journal_title：Clinical and experimental medicine

    pub_type： 杂志文章

    doi：10.1007/s10238-017-0473-2

    authors： Wei L,Huang Y,Zhao R,Zhang J,Liu Q,Liang W,Ding X,Gao B,Li B,Sun C,He J,Yu X,Liu Z,Sun A,Qin Y

    更新日期：2018-02-01 00:00:00

  • A T-cell-based enzyme-linked immunospot assay for tuberculosis screening in Chinese patients with rheumatic diseases receiving infliximab therapy.

    abstract：:Anti-tumour necrosis factor-α (TNF-α) therapy brought new hopes for treating rheumatic diseases but also increased the risk of infection, including mycobacterium tuberculosis (MTb). Conventional screening tools, such as tuberculin skin test (TST), lack sensitivity or specificity. Recently, T-SPOT.TB has been introduce...

    journal_title：Clinical and experimental medicine

    pub_type： 杂志文章

    doi：10.1007/s10238-010-0123-4

    authors： Xie X,Chen JW,Li F,Tian J,Gao JS,Zhang D

    更新日期：2011-09-01 00:00:00