ApoE epsilon2/epsilon3/epsilon4 polymorphism, ApoC-III/ApoE ratio and metabolic syndrome.


:Triglyceride-rich lipoproteins contain both apolipoproteins E (ApoE) and C-III (ApoC-III), which show opposite functional properties. The relationships between the ApoE (epsilon2/epsilon3/epsilon4) gene polymorphism and ApoC-III/ApoE ratio has never been investigated. A large population (n=552) of cardiovascular patients, without diabetes and/or lipid-lowering therapy, with or without metabolic syndrome (MetSyn), was genotyped for epsilon2/epsilon3/epsilon4 polymorphism and their ApoCIII/ApoE ratio was evaluated. A second group of patients (n=76) with peripheral artery disease was also genotyped and their ApoC-III/ApoE ratios were measured in HDL and non-HDL fractions. Subjects with E2 had higher and E4 carriers lower TG,ApoE and ApoC-III levels, respectively. The ApoCIII/ ApoE ratio showed an opposite trend, gradually increasing from E2/E2 to E4/E4 subjects. MetSyn patients also had an elevated ApoC-III/ApoE ratio and E4 carriers were more frequent in MetSyn patients (OR 2.08 with a 95%CI 1.22-3.5). The distribution of ApoC-III/ApoE ratio was confirmed also in the second group, with lower values in E2/E3 and higher in E3/E4 subjects. Similar results were obtained for the concentrations measured in non-HDL fractions, but not in the HDL fractions. ApoE epsilon2/epsilon3/epsilon4 gene polymorphism is a determinant of the relative proportion of apolipoprotein C-III to E. Carriers of the unfavourable E4 allele present the highest ApoCIII/ApoE ratio and are twofold more frequent among individuals affected by MetSyn.


Clin Exp Med


Olivieri O,Martinelli N,Bassi A,Trabetti E,Girelli D,Pizzolo F,Friso S,Pignatti PF,Corrocher R




Has Abstract


2007-12-01 00:00:00












  • Aberrant activation of hedgehog pathway in nasopharyngeal carcinoma.

    abstract::Nasopharyngeal carcinoma (NPC) is a very common head and neck cancer in southern china. Despite advances in surgical and chemotherapeutic approaches, its prognosis is still not promising. Hedgehog signaling pathway was reported to be involved in a number of cancers including head and neck. However, it remains unclear ...

    journal_title:Clinical and experimental medicine

    pub_type: 杂志文章


    authors: Yue Y,Zhong W,Pei G,Xiao B,Zhang G,Jiang F,Zhang J,Chen C,Yang P,Dang H,Chang H

    更新日期:2013-11-01 00:00:00

  • Clinical significance of serum miR-768-3p in HBV-related hepatocellular carcinoma and its potential mechanism.

    abstract::The purpose of this study was to reveal the clinical diagnostic and prognostic value of miR-768-3p in HBV-related HCC and to investigate its effect on the biological function of HCC. Quantitative real-time polymerase chain reaction was used to detect the expression level of miR-768-3p in subjects' serum. The receiver ...

    journal_title:Clinical and experimental medicine

    pub_type: 杂志文章


    authors: Cao C,Wang C

    更新日期:2020-11-01 00:00:00

  • Paralytic ileus following "subcutaneous bortezomib" therapy: focus on the clinical emergency-report of two cases.

    abstract::We retrospectively analyzed the medical history of 19 elderly myeloma patients treated with the "novel subcutaneous formulation of bortezomib." In our experience, two patients (10 %) discontinued treatment for paralytic ileus. The exact pathogenetic mechanisms of toxic megacolon and paralytic ileus due to "novel subcu...

    journal_title:Clinical and experimental medicine

    pub_type: 杂志文章


    authors: Mele G,Coppi MR,Melpignano A,Quarta G

    更新日期:2016-02-01 00:00:00

  • Alkaline comet assay study with breast cancer patients: evaluation of baseline and chemotherapy-induced DNA damage in non-target cells.

    abstract::The sensitivity of the alkaline comet assay for the evaluation of baseline and treatment-induced DNA damage in white blood cells of breast cancer patients receiving adjuvant chemotherapy according to three conventional anthracycline- and cyclophosphamide-containing protocols was investigated. Additionally, baseline DN...

    journal_title:Clinical and experimental medicine

    pub_type: 杂志文章


    authors: Kopjar N,Milas I,Garaj-Vrhovac V,Gamulin M

    更新日期:2006-12-01 00:00:00

  • The expression of cyclin G in nasopharyngeal carcinoma and its significance.

    abstract::To investigate the expression of cyclin G1, cyclin G2 in nasopharyngeal carcinoma (NPC) cell lines and its significance. The protein expression of cyclin G1, cyclin G2 in NPC cell lines of different differentiation degree (HNE2, CNE1) was detected by indirect immunofluorescence. The mRNA expression of cyclin G1, cycli...

    journal_title:Clinical and experimental medicine

    pub_type: 杂志文章


    authors: Ye XX,Liu CB,Chen JY,Tao BH,Zhi-Yi C

    更新日期:2012-03-01 00:00:00

  • Diverse phenotypic and genotypic presentation of RAG1 mutations in two cases with SCID.

    abstract::Severe combined immunodeficiencies (SCID) comprise a spectrum of genetic defects that involve both humoral and cellular immunities. Defects in recombinating activating gene 1 (RAG1), RAG2, Artemis, or LIG4 can disrupt V(D)J recombination. Defective V(D)J recombination of the T and B cell receptors is responsible for T...

    journal_title:Clinical and experimental medicine

    pub_type: 杂志文章


    authors: Karaca NE,Aksu G,Genel F,Gulez N,Can S,Aydinok Y,Aksoylar S,Karaca E,Altuglu I,Kutukculer N

    更新日期:2009-12-01 00:00:00

  • Inhibitory effects of simvastatin on staphylococcus aureus lipoteichoic acid-induced inflammation in human alveolar macrophages.

    abstract::Staphylococcus aureus (S. aureus) is the most common bacterium in sepsis and pneumonia involving gram-positive bacteria. Lipoteichoic acid (LTA) is a cell wall component of gram-positive bacteria. It is a potent inducer of inflammatory mediators in human dendritic cells, human pulmonary epithelial cells, and murine ma...

    journal_title:Clinical and experimental medicine

    pub_type: 杂志文章


    authors: Wu BQ,Luo JM,Wang YH,Shi YF,Liu H,Ba JH,Zhang TT

    更新日期:2014-05-01 00:00:00

  • Role of mesenchymal stem cells in leukaemia: Dr. Jekyll or Mr. Hyde?

    abstract::Mesenchymal stem cells (MSCs) have captured the attention of researchers today due to their multipotent differentiation capacity. Also, they have been successfully applied clinically, in the treatment of various diseases of the heart and musculoskeletal systems, with encouraging results. Their supportive role in haema...

    journal_title:Clinical and experimental medicine

    pub_type: 杂志文章,评审


    authors: Wong RS,Cheong SK

    更新日期:2014-08-01 00:00:00

  • New single nucleotide polymorphisms (SNPs) in homologous recombination repair genes detected by microarray analysis in Polish breast cancer patients.

    abstract::Breast cancer is the most common cause of malignancy and mortality in women worldwide. This study aimed at localising homologous recombination repair (HR) genes and their chromosomal loci and correlating their nucleotide variants with susceptibility to breast cancer. In this study, authors analysed the association bet...

    journal_title:Clinical and experimental medicine

    pub_type: 杂志文章


    authors: Romanowicz H,Strapagiel D,Słomka M,Sobalska-Kwapis M,Kępka E,Siewierska-Górska A,Zadrożny M,Bieńkiewicz J,Smolarz B

    更新日期:2017-11-01 00:00:00

  • Management of patients with chronic hepatitis C infection.

    abstract::Chronic infection with hepatitis C virus (HCV) is a leading cause of liver-related morbidity and mortality throughout the world. Although reliable figures regarding the global prevalence of HCV infection are wanting, it is likely that HCV prevalence will continue to increase. Injection drug use is the most important s...

    journal_title:Clinical and experimental medicine

    pub_type: 杂志文章,评审


    authors: Herrine SK,Rossi S,Navarro VJ

    更新日期:2006-03-01 00:00:00

  • DNA methylation and not allelic variation regulates STAT6 expression in human T cells.

    abstract::STAT6 transcription factor, which has been implicated in commitment to Th2, is known to be activated by IL-4 and IL-13. Accordingly, STAT6 is primarily responsible for the transcriptional effects of IL-4 and IL-13. STAT6-deficient mice are known to have defective IL-4-mediated functions, such as B cell proliferation, ...

    journal_title:Clinical and experimental medicine

    pub_type: 杂志文章


    authors: Kim EG,Shin HJ,Lee CG,Park HY,Kim YK,Park HW,Cho SH,Min KU,Cho ML,Park SH,Lee CW

    更新日期:2010-09-01 00:00:00

  • Effects of vascular endothelial growth factor expression on pathological characteristics and prognosis of osteosarcoma.

    abstract::Vascular endothelial growth factor (VEGF) has been linked with tumor invasion and metastasis. However, the role of VEGF expression in osteosarcoma remains controversial. By searching the PubMed, Embase, and Google Scholar databases, we conducted a meta-analysis to evaluate the pathological and prognostic significance ...

    journal_title:Clinical and experimental medicine

    pub_type: 杂志文章,meta分析


    authors: Han G,Wang Y,Bi W,Jia J,Wang W,Xu M

    更新日期:2016-11-01 00:00:00

  • Imatinib mesylate--gold standards and silver linings.

    abstract::Imatinib mesylate represents the first of a new generation of molecularly targeted therapies engineered to disrupt signal transduction pathways. It is a tyrosine kinase inhibitor with relatively selective activity against the Abelson (ABL) proto-oncogene, platelet-derived growth factor receptor, and c-KIT receptor. De...

    journal_title:Clinical and experimental medicine

    pub_type: 杂志文章,评审


    authors: Peggs K

    更新日期:2004-09-01 00:00:00

  • Mesenchymal stromal cells versus betamethasone can dampen disease activity in the collagen arthritis mouse model.

    abstract::The objective of this study was to compare between the effects of mesenchymal stem cell (MSC) and betamethasone in the treatment of rheumatoid arthritis. Sixty male albino mice were divided equally into 2 models. They are MSC model, group 1: saline control group, group 2: collagen-induced arthritis (CIA), group 3: ind...

    journal_title:Clinical and experimental medicine

    pub_type: 杂志文章


    authors: El-Denshary ES,Rashed LA,Elhussiny M

    更新日期:2014-08-01 00:00:00

  • Mannose-binding lectin polymorphisms in common variable immunodeficiency.

    abstract::Common variable immunodeficiency (CVID) is a heterogeneous group of disorders, characterized by hypogammaglobulinemia and increased susceptibility to infections, autoimmunity and malignancies. This study was performed to analyze the Mannose-binding lectin (MBL) polymorphisms in Iranian patients with CVID. Thirty-five ...

    journal_title:Clinical and experimental medicine

    pub_type: 杂志文章


    authors: Aghamohammadi A,Foroughi F,Rezaei N,Dianat S,Solgi G,Amirzargar AA

    更新日期:2009-12-01 00:00:00

  • Cytoplasmic expression of Twist1, an EMT-related transcription factor, is associated with higher grades renal cell carcinomas and worse progression-free survival in clear cell renal cell carcinoma.

    abstract::Twist1 is a key transcription factor, which confers tumor cells with cancer stem cell (CSC)-like characteristics and enhances epithelial-mesenchymal transition in pathological conditions including tumor malignancy and metastasis. This study aimed to evaluate the expression patterns and clinical significance of Twist1 ...

    journal_title:Clinical and experimental medicine

    pub_type: 杂志文章


    authors: Rasti A,Madjd Z,Abolhasani M,Mehrazma M,Janani L,Saeednejad Zanjani L,Asgari M

    更新日期:2018-05-01 00:00:00

  • Antioxidant potential, paraoxonase 1, ceruloplasmin activity and C-reactive protein concentration in diabetic retinopathy.

    abstract::The aim of this study was to evaluate the ferric-reducing ability of serum (FRAS), paraoxonase 1 (PON1), ceruloplasmin serum oxidase activity and hsCRP level in patients with type1 diabetes mellitus without and with diabetic retinopathy. The study was performed in 76 patients with type 1 diabetes mellitus, 35 without ...

    journal_title:Clinical and experimental medicine

    pub_type: 杂志文章


    authors: Nowak M,Wielkoszyński T,Marek B,Kos-Kudła B,Swietochowska E,Siemińska L,Karpe J,Kajdaniuk D,Głogowska-Szelag J,Nowak K

    更新日期:2010-09-01 00:00:00

  • Expressions of IL-22 in circulating CD4+/CD8+ T cells and their correlation with disease activity in SLE patients.

    abstract::Recently, Th17 cell-associated responses have received growing attention; however, the role of IL-22 (a cytokines also produced by Th17 cells) in the pathogenesis of systemic lupus erythematosus (SLE) has not been widely explored. In this study, we analyze the frequencies of IL-22-positive CD4+/CD8+ T cells in periphe...

    journal_title:Clinical and experimental medicine

    pub_type: 杂志文章


    authors: Qin WZ,Chen LL,Pan HF,Leng RX,Zhai ZM,Wang C,Li RJ,Wang S,Wang HP,Ye DQ

    更新日期:2011-12-01 00:00:00

  • BAL biomarkers' panel for differential diagnosis of interstitial lung diseases.

    abstract::Bronchoalveolar lavage (BAL) is a useful procedure for differential diagnosis of interstitial lung diseases (ILDs) and for identification of granulomatous lung diseases. We investigated a panel of biomarkers from BAL fluid of ILD patients to evaluate their utility in differentiating ILDs. Bronchoscopy with BAL was per...

    journal_title:Clinical and experimental medicine

    pub_type: 杂志文章


    authors: d'Alessandro M,Carleo A,Cameli P,Bergantini L,Perrone A,Vietri L,Lanzarone N,Vagaggini C,Sestini P,Bargagli E

    更新日期:2020-05-01 00:00:00

  • Diagnostic performance of arginase activity in colorectal cancer.

    abstract::Arginase activity was measured in serum and biopsy from healthy individuals and colorectal cancer patients. Arginase activity in tumor samples (87 +/- 7.7 U/g tissue) was significantly higher than in controls (40.7 +/- 3.3 U/g tissue). However, serum arginase activity did not show any significant change in both groups...

    journal_title:Clinical and experimental medicine

    pub_type: 杂志文章


    authors: del Ara RM,González-Polo RA,Caro A,del Amo E,Palomo L,Hernández E,Soler G,Fuentes JM

    更新日期:2002-05-01 00:00:00

  • Autoantibodies to the ribosomal P proteins in systemic lupus erythematosus.

    abstract::This paper describes the clinical significance of antibodies to the ribosomal P proteins in systemic lupus erythematosus. It appears that liver disease due to the lupus process and not attributable to viral infection, alcohol or drugs is associated with anti-ribosomal P. In addition, there is a strong relationship to ...

    journal_title:Clinical and experimental medicine

    pub_type: 杂志文章,评审


    authors: Reichlin M

    更新日期:2006-06-01 00:00:00

  • PDX-1 mRNA-induced reprogramming of mouse pancreas-derived mesenchymal stem cells into insulin-producing cells in vitro.

    abstract::Pancreatic islet transplantation has remained an effective therapy for type 1 diabetes since 2000. Its widespread use has been prohibited by the shortage of suitable donors. It is critical to explore an applicable alternative for β-cell replacement. This study was performed to generate insulin-producing cells (IPCs) f...

    journal_title:Clinical and experimental medicine

    pub_type: 杂志文章


    authors: Guo XR,Wang XL,Li MC,Yuan YH,Chen Y,Zou DD,Bian LJ,Li DS

    更新日期:2015-11-01 00:00:00

  • The oxidant and antioxidant effects of 25-hydroxyvitamin D3 in liver, kidney and heart tissues of diabetic rats.

    abstract::Previous studies have implicated protective effects of vitamin D on insulin secretion and pancreas beta cell function. The goal of the present study is to determine if a combination therapy of 25-hydroxyvitamin D3 and insulin had any advantage over insulin therapy alone on lipid peroxidation and antioxidant activity i...

    journal_title:Clinical and experimental medicine

    pub_type: 杂志文章


    authors: Noyan T,Balaharoğlu R,Kömüroğlu U

    更新日期:2005-05-01 00:00:00

  • Increased B7H4 tissue expression correlates with high CA19.9 serum levels and a worse prognosis of pancreatic adenocarcinoma.

    abstract::Pancreatic cancer (PC) is a leading cause of cancer death worldwide, especially in Western societies. Its aggressive nature and poor prognosis increase the need for identifying new and more accurate diagnostic and prognostic tools. We studied 41 patients who had undergone radical surgical resection for PC, investigate...

    journal_title:Clinical and experimental medicine

    pub_type: 杂志文章


    authors: Tsiaousidou A,Tsaroucha AK,Lambropoulou M,Pitiakoudis M,Polychronidis A,Chatzitheoklitos E,Romanidis K,Simopoulos C

    更新日期:2016-08-01 00:00:00

  • Fuzzy logic-based tumor marker profiles improved sensitivity of the detection of progression in small-cell lung cancer patients.

    abstract::Tumor markers were used for disease monitoring in small-cell lung cancer patients. The aim of this study was to improve diagnostic efficiency in the detection of tumor progression in small-cell lung cancer patients by using fuzzy logic modeling in combination with a tumor marker panel (NSE, ProGRP, Tumor M2-PK, CYFRA ...

    journal_title:Clinical and experimental medicine

    pub_type: 杂志文章


    authors: Schneider J,Peltri G,Bitterlich N,Philipp M,Velcovsky HG,Morr H,Katz N,Eigenbrodt E

    更新日期:2003-02-01 00:00:00

  • LncPRYP4-3 serves as a novel diagnostic biomarker for dissecting subtypes of metabolic associated fatty liver disease by targeting RPS4Y2.

    abstract::Longitudinal studies have improved current diagnostics and management of metabolic associated fatty liver disease (MAFLD) patients by liver biopsy and therapeutic intervention, yet the deficiency of biomarker spectrum for dissecting subtypes largely hinders the symptomatic treatment. We originally enriched serum from ...

    journal_title:Clinical and experimental medicine

    pub_type: 杂志文章


    authors: Yang H,Li Q,Zhang L,Zhu M,Niu J,Xue F,Yang L,Qu Q,Lao Y,Ding Z,Xiao C,Wang K

    更新日期:2020-11-01 00:00:00

  • Significance of decreased serum interleukin-10 levels in the progression of cerebral infarction.

    abstract::Anti-inflammatory cytokine and its serological detection may have an important role in the process of cardiovascular and cerebrovascular diseases. We investigated whether serum interleukin-10 (IL-10) is associated with cerebral infarction or not in the general population. Identified comprehensive searching was perform...

    journal_title:Clinical and experimental medicine

    pub_type: 杂志文章,meta分析


    authors: Diao ZY,Wang CL,Qi HS,Jia GY,Yan CZ

    更新日期:2016-05-01 00:00:00

  • New therapies in multiple myeloma.

    abstract::The melphalan-prednisone regimen has been considered as standard therapy for patients with multiple myeloma (MM) for many years. Recently, high-dose chemotherapy with stem-cell support has extended progression-free survival and increased overall survival, and it is now considered conventional therapy in younger patien...

    journal_title:Clinical and experimental medicine

    pub_type: 杂志文章,评审


    authors: Merchionne F,Perosa F,Dammacco F

    更新日期:2007-09-01 00:00:00

  • Regulation of mRNA caspase-8 levels by anti-nuclear autoantibodies.

    abstract::Apoptosis of the acinar and ductal epithelial cells of the salivary glands has been proposed as a mechanism possibly responsible for the impairment of the secretory function in Sjögren's syndrome, an organ-specific autoimmune disorder characterized by destruction of these glandular structures. The presence of serum au...

    journal_title:Clinical and experimental medicine

    pub_type: 杂志文章


    authors: Lisi S,Sisto M,Lofrumento D,Frassanito MA,Caprio S,Romano ML,Mitolo V,D'Amore M

    更新日期:2010-09-01 00:00:00

  • 1q23.1 homozygous deletion and downregulation of Fc receptor-like family genes confer poor prognosis in chronic lymphocytic leukemia.

    abstract::The identification of chromosome 1 translocations and deletions is a rare and poorly investigated event in chronic lymphocytic leukemia (CLL). Nevertheless, the identification of novel additional molecular alterations is of great interest, opening to new prognostic and therapeutic strategies for such heterogeneous hem...

    journal_title:Clinical and experimental medicine

    pub_type: 杂志文章


    authors: Daniele G,L'Abbate A,Turchiano A,Palumbo O,Carella M,Lo Cunsolo C,Iuzzolino P,Lonoce A,Hernández-Sánchez M,Minoia C,Leone P,Hernandez-Rivas JM,Storlazzi CT

    更新日期:2019-05-01 00:00:00