Abstract：
:To investigate lncRNAs acting as competing endogenous RNAs (ceRNAs) involved in oncogenesis and progression of HCC. Different expressed lncRNAs, microRNAs, and mRNAs (DElncRNAs, DEmiRNAs, DEmRNAs), downloaded from The Cancer Genome Atlas (TCGA) database, were identified by edgeR package. CeRNA network was constructed based on miRcode, TargetScan, and miRTarBase. Target DEmRNAs were annotated by KEGG pathway and GO analysis. Negatively correlated lncRNA-miRNA pairs were analyzed by Pearson correlation coefficient, simultaneously, overall survival (OS) were evaluated. The expression of these lncRNAs were examined in HCC cell lines and tissues through qRT-PCR. 1070 DElncRNAs, 147 DEmiRNAs and 1993 DEmRNAs were acquired. CeRNA network was successfully established, including 27 lncRNAs, 5 miRNAs, and 30 mRNAs significantly correlated with OS. The DEmRNAs were significantly enriched in "Cell Cycle" and "pathways in cancer". Six lncRNAs and 2 miRNAs were negatively correlated. These lncRNAs were validated by qRT-PCR. These observations will provide a novel perspective to elucidate HCC pathogenesis.
journal_name
Clin Exp Medjournal_title
Clinical and experimental medicineauthors
Qu L,Cai X,Xu J,Wei X,Qu X,Sun L,Gong L,Su C,Zhu Ydoi
10.1007/s10238-020-00634-3subject
Has Abstractpub_date
2020-08-01 00:00:00pages
437-447issue
3eissn
1591-8890issn
1591-9528pii
10.1007/s10238-020-00634-3journal_volume
20pub_type
杂志文章abstract：:The cross-sectional study was conducted to examine hepatic function via liver enzymes/proteins assessments, along with the estimation of an inflammatory response from C-reactive protein (CRP)-which is a liver-synthesized protein. The liver function tests with aspartate aminotransferase (AST), alanine aminotransferase ...
journal_title：Clinical and experimental medicine
pub_type： 杂志文章
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更新日期：2018-02-01 00:00:00
abstract：:Breast cancer is the most common cause of malignancy and mortality in women worldwide. This study aimed at localising homologous recombination repair (HR) genes and their chromosomal loci and correlating their nucleotide variants with susceptibility to breast cancer. In this study, authors analysed the association bet...
journal_title：Clinical and experimental medicine
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journal_title：Clinical and experimental medicine
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更新日期：2018-05-01 00:00:00
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journal_title：Clinical and experimental medicine
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pub_type： 杂志文章,meta分析
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doi：10.1007/s10238-013-0231-z
更新日期：2014-05-01 00:00:00
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journal_title：Clinical and experimental medicine
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更新日期：2002-05-01 00:00:00
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pub_type： 杂志文章
doi：10.1007/s10238-015-0337-6
更新日期：2016-02-01 00:00:00
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journal_title：Clinical and experimental medicine
pub_type： 临床试验,杂志文章
doi：10.1007/s10238-011-0164-3
更新日期：2012-12-01 00:00:00
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journal_title：Clinical and experimental medicine
pub_type： 杂志文章
doi：10.1007/s10238-010-0113-6
更新日期：2011-06-01 00:00:00
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journal_title：Clinical and experimental medicine
pub_type： 杂志文章
doi：10.1007/s10238-008-0164-0
更新日期：2008-06-01 00:00:00
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journal_title：Clinical and experimental medicine
pub_type： 杂志文章
doi：10.1007/s10238-001-8025-0
更新日期：2001-09-01 00:00:00
abstract：:The rat is an established model for studying intestinal adaptations following abdominal surgery. In the study of functional and morphological adaptations of the small intestine, it is helpful to estimate the mucosal surface area. In order to simplify measurements and calculation we developed a new mathematical model f...
journal_title：Clinical and experimental medicine
pub_type： 杂志文章
doi：10.1007/s102380200018
更新日期：2002-11-01 00:00:00
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journal_title：Clinical and experimental medicine
pub_type： 杂志文章,评审
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journal_title：Clinical and experimental medicine
pub_type： 杂志文章,评审
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journal_title：Clinical and experimental medicine
pub_type： 杂志文章,评审
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journal_title：Clinical and experimental medicine
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abstract：:The effect of preimmunisation with cancer procoagulant (CP) on the growth of Walker 256 carcinosarcoma cells in Wistar Lew/Han/IMP rats in vivo has been analysed. One group of rats was immunised with CP purified from human amnion-chorion membranes. The rest of the animals (control groups) were injected with 0.9% NaCl ...
journal_title：Clinical and experimental medicine
pub_type： 杂志文章
doi：10.1007/s10238-006-0106-7
更新日期：2006-10-01 00:00:00
abstract：:Experimental, epidemiologic, and clinical trial data indicate the antineoplastic effects of calcium and vitamin D in large-bowel neoplasia. The aim of this study was to determine serum levels of vitamin D metabolites and parathormone (PTH) in patients with colorectal cancer (CRC) and to extract conclusions comparing t...
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