Glycosylation of mucins present in gastric juice: the effect of helicobacter pylori eradication treatment.

abstract：:Anti-tumour necrosis factor-α (TNF-α) therapy brought new hopes for treating rheumatic diseases but also increased the risk of infection, including mycobacterium tuberculosis (MTb). Conventional screening tools, such as tuberculin skin test (TST), lack sensitivity or specificity. Recently, T-SPOT.TB has been introduce...

journal_title：Clinical and experimental medicine

authors： Xie X,Chen JW,Li F,Tian J,Gao JS,Zhang D

更新日期：2011-09-01 00:00:00

abstract：:The background of this article is as follows: Few data are available about the persistence of serum-specific IgG antibodies to L. infantum after acute VL. The objective of this article is to evaluate the persistence of antibodies against L. infantum in patients healed from acute VL, and the kinetic of the same antibod...

journal_title：Clinical and experimental medicine

authors： Mansueto P,Pepe I,Seidita A,Scozzari F,Vitale G,Arcoleo F,Elvira I,Cillari E,Rini GB,Napoli N,Di Rosa S,Mansueto S,Di Fede G

更新日期：2012-06-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) has been linked with tumor invasion and metastasis. However, the role of VEGF expression in osteosarcoma remains controversial. By searching the PubMed, Embase, and Google Scholar databases, we conducted a meta-analysis to evaluate the pathological and prognostic significance ...

journal_title：Clinical and experimental medicine

authors： Han G,Wang Y,Bi W,Jia J,Wang W,Xu M

更新日期：2016-11-01 00:00:00

abstract：:The melphalan-prednisone regimen has been considered as standard therapy for patients with multiple myeloma (MM) for many years. Recently, high-dose chemotherapy with stem-cell support has extended progression-free survival and increased overall survival, and it is now considered conventional therapy in younger patien...

journal_title：Clinical and experimental medicine

authors： Merchionne F,Perosa F,Dammacco F

更新日期：2007-09-01 00:00:00

abstract：:Pancreatic cancer (PC) is a leading cause of cancer death worldwide, especially in Western societies. Its aggressive nature and poor prognosis increase the need for identifying new and more accurate diagnostic and prognostic tools. We studied 41 patients who had undergone radical surgical resection for PC, investigate...

journal_title：Clinical and experimental medicine

authors： Tsiaousidou A,Tsaroucha AK,Lambropoulou M,Pitiakoudis M,Polychronidis A,Chatzitheoklitos E,Romanidis K,Simopoulos C

更新日期：2016-08-01 00:00:00

abstract：:The aim of this study was to discover potential biomarkers for rheumatoid arthritis (RA) using Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry combined with magnetic beads. Proteomic fingerprint technology combining magnetic beads with MALDI-TOF-MS was used to profile and compare the prote...

journal_title：Clinical and experimental medicine

authors： Zhang X,Yuan Z,Shen B,Zhu M,Liu C,Xu W

更新日期：2012-09-01 00:00:00

abstract：:Although the role of cholesterol absorption by the gallbladder epithelium in gallstone formation is well established, the exact process is poorly understood. Potential candidates for regulation of transepithelial cholesterol transport are suggested to be two large membrane multiple ligand receptors, megalin and cubili...

journal_title：Clinical and experimental medicine

authors： Tsaroucha AK,Chatzaki E,Lambropoulou M,Despoudi K,Laftsidis P,Charsou C,Polychronidis A,Papadopoulos N,Simopoulos CE

更新日期：2008-09-01 00:00:00

abstract：:Interleukin-17A plays a role in tissue inflammation by inducing release of proinflammatory and neutrophil-mobilizing cytokines. We investigated the association between ulcerative colitis (UC) and polymorphisms of IL17A, rs2275913 (-197 G > A), and rs3748067 (*1249 C > T). The study was performed in 475 healthy subject...

journal_title：Clinical and experimental medicine

authors： Hayashi R,Tahara T,Shiroeda H,Saito T,Nakamura M,Tsutsumi M,Shibata T,Arisawa T

更新日期：2013-11-01 00:00:00

abstract：:Accurate prediction of the outcome of molecular target-based treatment in advanced renal cell carcinoma (RCC) is an important clinical problem. Positron emission tomography/computed tomography using [18F]-2-fluoro-2-deoxyglucose (FDG PET/CT) is a noninvasive tool for the assessment of glucose accumulation which can be...

journal_title：Clinical and experimental medicine

authors： Pankowska V,Malkowski B,Wedrowski M,Wedrowska E,Roszkowski K

更新日期：2019-02-01 00:00:00

abstract：:Atopic dermatitis (AD) is a chronic, inflammatory skin disease which is characterized by severe pruritus and affects patients' quality of life. In recent years gamma interferon (IFN-gamma) has been accepted as a novel treatment for severe AD, however, its mechanism of action is not clearly identified. Present study ev...

journal_title：Clinical and experimental medicine

authors： Panahi Y,Davoudi SM,Madanchi N,Abolhasani E

更新日期：2012-12-01 00:00:00

abstract：:Breast cancer is the most common cause of malignancy and mortality in women worldwide. This study aimed at localising homologous recombination repair (HR) genes and their chromosomal loci and correlating their nucleotide variants with susceptibility to breast cancer. In this study, authors analysed the association bet...

journal_title：Clinical and experimental medicine

authors： Romanowicz H,Strapagiel D,Słomka M,Sobalska-Kwapis M,Kępka E,Siewierska-Górska A,Zadrożny M,Bieńkiewicz J,Smolarz B

更新日期：2017-11-01 00:00:00

abstract：PURPOSE:Exosome-derived long non-coding RNAs (lncRNAs) as novel biomarkers are widely investigated in various cancers, yet results remain controversial. The aim of this meta-analysis was to clarify the diagnostic and prognostic value of exosome-derived lncRNAs in cancer. METHODS:PubMed, Web of Science, EMBASE, CNKI, a...

journal_title：Clinical and experimental medicine

authors： Mu H,Zhang S,Yao Z,Liu Y,Lin K,Zhao Z,Zhu Y

更新日期：2020-08-01 00:00:00

abstract：:Slit2 glycoprotein has been described to regulate the inflammatory response and be involved in autoimmune diseases. Here, we investigated the expression of Slit2 and its potential significance in systemic lupus erythematosus (SLE). A total of 103 patients with SLE participated in our study. The levels of serum Slit2 w...

journal_title：Clinical and experimental medicine

authors： Zhang Y,Hu L,Li X,Chen L,Yang X

更新日期：2020-10-20 00:00:00

abstract：:The aim of this study was to evaluate the ferric-reducing ability of serum (FRAS), paraoxonase 1 (PON1), ceruloplasmin serum oxidase activity and hsCRP level in patients with type1 diabetes mellitus without and with diabetic retinopathy. The study was performed in 76 patients with type 1 diabetes mellitus, 35 without ...

journal_title：Clinical and experimental medicine

authors： Nowak M,Wielkoszyński T,Marek B,Kos-Kudła B,Swietochowska E,Siemińska L,Karpe J,Kajdaniuk D,Głogowska-Szelag J,Nowak K

更新日期：2010-09-01 00:00:00

abstract：:Previous studies have implicated protective effects of vitamin D on insulin secretion and pancreas beta cell function. The goal of the present study is to determine if a combination therapy of 25-hydroxyvitamin D3 and insulin had any advantage over insulin therapy alone on lipid peroxidation and antioxidant activity i...

journal_title：Clinical and experimental medicine

authors： Noyan T,Balaharoğlu R,Kömüroğlu U

更新日期：2005-05-01 00:00:00

abstract：:The sensitivity of the alkaline comet assay for the evaluation of baseline and treatment-induced DNA damage in white blood cells of breast cancer patients receiving adjuvant chemotherapy according to three conventional anthracycline- and cyclophosphamide-containing protocols was investigated. Additionally, baseline DN...

journal_title：Clinical and experimental medicine

authors： Kopjar N,Milas I,Garaj-Vrhovac V,Gamulin M

更新日期：2006-12-01 00:00:00

abstract：:Takayasu arteritis (TAK) is a rare granulomatous vasculitis of unknown etiology that mainly affects the aorta and its major branches. The aim is to describe the clinical features, diagnostic procedures, pathogenesis, and management of TAK in a longitudinal cohort of patients recruited within a single region of souther...

journal_title：Clinical and experimental medicine

authors： Dammacco F,Cirulli A,Simeone A,Leone P,Pulli R,Angiletta D,Rubini G,Di Palo A,Vacca A,Dammacco R

更新日期：2020-10-07 00:00:00

abstract：:TNF-α plays a key role in the inflammatory cytokine cascade involved in the pathogenesis of chronic arthritis, including rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis. Systemic inflammation and the increased production of pro-inflammatory cytokines in these patients may favor the onset of metab...

journal_title：Clinical and experimental medicine

authors： Maruotti N,d'Onofrio F,Cantatore FP

更新日期：2015-11-01 00:00:00

abstract：:Nitric oxide (NO), produced by the nitric oxide synthase (iNOS) enzyme, is the most-important molecule responsible for the killing of Leishmania parasites by macrophages. In previous work we have demonstrated that, after activation with recombinant human interferon-gamma and/or bacterial lipopolysaccharide, human macr...

journal_title：Clinical and experimental medicine

authors： Panaro MA,Brandonisio O,Sisto M,Acquafredda A,Leogrande D,Fumarola L,Mitolo V

更新日期：2001-09-01 00:00:00

abstract：:High glucose plays an important role in the pathogenesis of atherosclerosis. In this study, we assessed the effects of high glucose on human umbilical vein endothelial cell (HUVEC) apoptosis. Additionally, we investigated whether alpha-lipoic acid, an antioxidant, prevents high glucose-induced apoptosis of HUVECs. HUV...

journal_title：Clinical and experimental medicine

authors： Meng X,Li ZM,Zhou YJ,Cao YL,Zhang J

更新日期：2008-03-01 00:00:00

abstract：:The development of new therapies based on tumor biology is one of the main topics in cancer treatment. In this regard, investigating the microenvironment and cellular composition of the tumor is of particular interest. Mesenchymal stem cells (MSCs) are a major group of cells in the tumor tissue and play a critical rol...

journal_title：Clinical and experimental medicine

authors： Arab S,Alizadeh A,Asgharzade S

更新日期：2021-01-23 00:00:00

abstract：:The aim of this work was to investigate the presence of the RHD gene in fetal cells obtained from amniotic fluid. We studied 65 samples of amniotic fluid, 11 from RhD-negative mothers sensitized with anti-D alloantibodies. The fetal origin of the DNA was confirmed with the analysis of 1 VNTR locus and 3 STR loci in DN...

journal_title：Clinical and experimental medicine

authors： Cotorruelo C,Biondi C,García Borrás S,Di Mónaco R,Racca A

更新日期：2002-07-01 00:00:00

abstract：:Bronchoalveolar lavage (BAL) is a useful procedure for differential diagnosis of interstitial lung diseases (ILDs) and for identification of granulomatous lung diseases. We investigated a panel of biomarkers from BAL fluid of ILD patients to evaluate their utility in differentiating ILDs. Bronchoscopy with BAL was per...

journal_title：Clinical and experimental medicine

authors： d'Alessandro M,Carleo A,Cameli P,Bergantini L,Perrone A,Vietri L,Lanzarone N,Vagaggini C,Sestini P,Bargagli E

更新日期：2020-05-01 00:00:00

abstract：:Twist1 is a key transcription factor, which confers tumor cells with cancer stem cell (CSC)-like characteristics and enhances epithelial-mesenchymal transition in pathological conditions including tumor malignancy and metastasis. This study aimed to evaluate the expression patterns and clinical significance of Twist1 ...

journal_title：Clinical and experimental medicine

authors： Rasti A,Madjd Z,Abolhasani M,Mehrazma M,Janani L,Saeednejad Zanjani L,Asgari M

更新日期：2018-05-01 00:00:00

abstract：:Glioblastoma multiforme (GBM) is the most common malignancy in central nervous system. A small subpopulation of GBM cells known as GBM stem-like cells (GSLCs) were supposed to be the most malignant cells among GBM cells as they are resistant to multiple therapies including radiotherapy. In this study, we set up two GS...

journal_title：Clinical and experimental medicine

authors： Liu J,Gao Q,Xie T,Liu Y,Luo L,Xu C,Shen L,Wan F,Lei T,Ye F

更新日期：2018-08-01 00:00:00

abstract：:Current hepatitis C virus (HCV) genotyping techniques are often highly technical, costly, or need improvements in sensitivity and specificity. These limitations indicate the need of novel methods for HCV genotyping. The present study aimed to develop a novel genotyping method combining high-resolution melting (HRM) an...

journal_title：Clinical and experimental medicine

authors： Wu D,Fu X,Wen Y,Liu B,Deng Z,Dai L,Tan D

更新日期：2017-08-01 00:00:00

abstract：:Recently, it was discovered that high mobility group box chromosomal protein 1 (HMGB1) acts as a potent pro-inflammatory cytokine that is released into the extracellular milieu. Signal transducer and activator of transcription (STAT) proteins play an important role in cytokine signaling. Some investigators have report...

journal_title：Clinical and experimental medicine

authors： Guo HF,Liu SX,Zhang YJ,Liu QJ,Hao J,Gao LX

更新日期：2011-06-01 00:00:00

abstract：:Apoptosis of the acinar and ductal epithelial cells of the salivary glands has been proposed as a mechanism possibly responsible for the impairment of the secretory function in Sjögren's syndrome, an organ-specific autoimmune disorder characterized by destruction of these glandular structures. The presence of serum au...

journal_title：Clinical and experimental medicine

authors： Lisi S,Sisto M,Lofrumento D,Frassanito MA,Caprio S,Romano ML,Mitolo V,D'Amore M

更新日期：2010-09-01 00:00:00

abstract：:We retrospectively analyzed the medical history of 19 elderly myeloma patients treated with the "novel subcutaneous formulation of bortezomib." In our experience, two patients (10 %) discontinued treatment for paralytic ileus. The exact pathogenetic mechanisms of toxic megacolon and paralytic ileus due to "novel subcu...

journal_title：Clinical and experimental medicine

authors： Mele G,Coppi MR,Melpignano A,Quarta G

更新日期：2016-02-01 00:00:00

abstract：:The thrombin generation potential is an in vitro measure for the capacity of an individual to generate thrombin and recognized as a reflection of a hypo- or hypercoagulable status. Measurement of the in vivo thrombin activity, however, may be of clinical significance. We evaluated a new assay for in vivo thrombin acti...

journal_title：Clinical and experimental medicine

authors： Königsbrügge O,Koder S,Riedl J,Panzer S,Pabinger I,Ay C

更新日期：2017-05-01 00:00:00