Abstract:
:TNF-α plays a key role in the inflammatory cytokine cascade involved in the pathogenesis of chronic arthritis, including rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis. Systemic inflammation and the increased production of pro-inflammatory cytokines in these patients may favor the onset of metabolic syndrome. In patients affected by chronic arthritis, TNF-α is considered as one of the factors responsible for favouring insulin resistance and dyslipidemia, which are important features of the metabolic syndrome. Even if TNF-α is a single player in the great molecular cauldron of inflammation, the use of TNF-α inhibitors may be an important approach for not only treating articular and cutaneous symptoms but also for ameliorating glucose and lipid metabolism. Nevertheless, further research and clinical trials are needed to better determine the effects of biologic therapies on metabolic components in chronic arthritis patients and to identify the most appropriate strategies on the basis of the comorbidities in these patients.
journal_name
Clin Exp Medjournal_title
Clinical and experimental medicineauthors
Maruotti N,d'Onofrio F,Cantatore FPdoi
10.1007/s10238-014-0323-4subject
Has Abstractpub_date
2015-11-01 00:00:00pages
433-8issue
4eissn
1591-8890issn
1591-9528pii
10.1007/s10238-014-0323-4journal_volume
15pub_type
杂志文章,评审abstract::Mixed-phenotype acute leukemia (MPAL) is the infrequent type of acute leukemia characterized by immunophenotypic and/or cytochemical features of both lineages, but the diagnosis of this disease still is a challenge. In this study, we analyzed immunophenotyping, cytochemistry and frequency of MPAL patients to better di...
journal_title:Clinical and experimental medicine
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journal_title:Clinical and experimental medicine
pub_type: 杂志文章
doi:10.1007/s10238-007-0142-y
更新日期:2007-12-01 00:00:00
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journal_title:Clinical and experimental medicine
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journal_title:Clinical and experimental medicine
pub_type: 杂志文章,评审
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更新日期:2006-03-01 00:00:00
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journal_title:Clinical and experimental medicine
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pub_type: 杂志文章,meta分析
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更新日期:2020-08-31 00:00:00
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journal_title:Clinical and experimental medicine
pub_type: 杂志文章,评审
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更新日期:2007-09-01 00:00:00
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更新日期:2002-11-01 00:00:00
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doi:10.1007/s10238-008-0010-4
更新日期:2009-03-01 00:00:00
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doi:10.1007/s10238-020-00651-2
更新日期:2020-11-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s10238-011-0134-9
更新日期:2011-12-01 00:00:00
abstract::To investigate lncRNAs acting as competing endogenous RNAs (ceRNAs) involved in oncogenesis and progression of HCC. Different expressed lncRNAs, microRNAs, and mRNAs (DElncRNAs, DEmiRNAs, DEmRNAs), downloaded from The Cancer Genome Atlas (TCGA) database, were identified by edgeR package. CeRNA network was constructed ...
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doi:10.1007/s10238-020-00634-3
更新日期:2020-08-01 00:00:00
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更新日期:2018-05-01 00:00:00
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更新日期:2009-12-01 00:00:00
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更新日期:2010-09-01 00:00:00
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更新日期:2020-10-07 00:00:00