当前位置： SCI文献检索 > CLINICAL AND EXPERIMENTAL MEDICINE期刊下所有文献 > The oxidant and antioxidant effects of 25-hydroxyvitamin D3 in liver, kidney and heart tissues of diabetic rats.

The oxidant and antioxidant effects of 25-hydroxyvitamin D3 in liver, kidney and heart tissues of diabetic rats.

Abstract：

:Previous studies have implicated protective effects of vitamin D on insulin secretion and pancreas beta cell function. The goal of the present study is to determine if a combination therapy of 25-hydroxyvitamin D3 and insulin had any advantage over insulin therapy alone on lipid peroxidation and antioxidant activity in the streptozotocin (STZ)-induced diabetic rat. The lipid peroxidation product, thiobarbituric acid-reacting substances (TBARS), was measured to assess free radical activity in the heart, kidney and liver tissues. The enzymatic activities of glutathione peroxidase (GSH-Px), superoxide dismutase (SOD) and catalase (CAT) were measured as indicators of antioxidation in these tissues. Sprague-Dawley rats were made diabetic with a single injection of STZ (75 mg/kg i.p.). Rats were separated into three groups, each containing 10 animals: Group 1, non-diabetic and no drug treatment was given; Group 2, diabetic rats were treated with 3 IU/day subcutaneous (s.c.) insulin; and Group 3, diabetic rats were treated with 3 IU/day (s.c.) insulin plus 1 mg/kg/day per oral (p.o.) 25-hydroxyvitamin D3 for a period of 4 weeks. At the end of the study, TBARS contents of the liver, kidney and heart tissues in Groups 2 and 3 were found to be significantly increased as compared to Group 1 (P<0.05) and kidney MDA levels in Group 3 were also significantly increased as compared to Group 2 (P<0.05). The SOD and CAT contents of the heart in Group 2 were significantly increased as compared to Groups 1 and 3 (P<0.05). GSH-Px activity was unaltered in all groups (P>0.05). We suggest that a combination of insulin with 25-hydroxyvitamin D3 treatment would not be more beneficial than the use of insulin alone in antioxidant defence of diabetic liver and kidney tissues.

journal_name

Clin Exp Med

journal_title

Clinical and experimental medicine

authors

Noyan T,Balaharoğlu R,Kömüroğlu U

doi

10.1007/s10238-005-0061-8

subject

Has Abstract

pub_date

2005-05-01 00:00:00

pages

31-6

issue

1

eissn

1591-8890

issn

1591-9528

journal_volume

5

pub_type

杂志文章

相关文献

CLINICAL AND EXPERIMENTAL MEDICINE文献大全
  • Slit2 is a potential biomarker for renal impairment in systemic lupus erythematosus.

    abstract：:Slit2 glycoprotein has been described to regulate the inflammatory response and be involved in autoimmune diseases. Here, we investigated the expression of Slit2 and its potential significance in systemic lupus erythematosus (SLE). A total of 103 patients with SLE participated in our study. The levels of serum Slit2 w...

    journal_title：Clinical and experimental medicine

    pub_type： 杂志文章

    doi：10.1007/s10238-020-00664-x

    authors： Zhang Y,Hu L,Li X,Chen L,Yang X

    更新日期：2020-10-20 00:00:00

  • Significance of persistence of antibodies against Leishmania infantum in Sicilian patients affected by acute visceral leishmaniasis.

    abstract：:The background of this article is as follows: Few data are available about the persistence of serum-specific IgG antibodies to L. infantum after acute VL. The objective of this article is to evaluate the persistence of antibodies against L. infantum in patients healed from acute VL, and the kinetic of the same antibod...

    journal_title：Clinical and experimental medicine

    pub_type： 杂志文章

    doi：10.1007/s10238-011-0150-9

    authors： Mansueto P,Pepe I,Seidita A,Scozzari F,Vitale G,Arcoleo F,Elvira I,Cillari E,Rini GB,Napoli N,Di Rosa S,Mansueto S,Di Fede G

    更新日期：2012-06-01 00:00:00

  • Cytoplasmic expression of Twist1, an EMT-related transcription factor, is associated with higher grades renal cell carcinomas and worse progression-free survival in clear cell renal cell carcinoma.

    abstract：:Twist1 is a key transcription factor, which confers tumor cells with cancer stem cell (CSC)-like characteristics and enhances epithelial-mesenchymal transition in pathological conditions including tumor malignancy and metastasis. This study aimed to evaluate the expression patterns and clinical significance of Twist1 ...

    journal_title：Clinical and experimental medicine

    pub_type： 杂志文章

    doi：10.1007/s10238-017-0481-2

    authors： Rasti A,Madjd Z,Abolhasani M,Mehrazma M,Janani L,Saeednejad Zanjani L,Asgari M

    更新日期：2018-05-01 00:00:00

  • Association of interleukin-10 promoter haplotypes with disease susceptibility and IL-10 levels in Mexican patients with systemic lupus erythematosus.

    abstract：:Systemic lupus erythematosus (SLE) is the prototype autoimmune rheumatic disease. The etiology of this disease is incompletely understood; however, environmental factors and genetic predisposition are involved. Cytokine-mediated immunity plays a crucial role in the pathogenesis of SLE. We investigate the association o...

    journal_title：Clinical and experimental medicine

    pub_type： 杂志文章

    doi：10.1007/s10238-014-0315-4

    authors： Palafox-Sánchez CA,Oregon-Romero E,Salazar-Camarena DC,Valle YM,Machado-Contreras JR,Cruz A,Orozco-López M,Orozco-Barocio G,Vázquez-Del Mercado M,Muñoz-Valle JF

    更新日期：2015-11-01 00:00:00

  • Immunophenotypic, cytogenetic and clinical features of 192 AML patients in China.

    abstract：:Immunophenotypic characterization of the leukemic cells has been widely used as a tool for diagnosis, classification and prognosis of leukaemia. A total of 192 Chinese patients with acute myeloid leukemia (AML) were immunophenotyped by flow cytometry using a panel of monoclonal antibodies. Among the 192 patients enrol...

    journal_title：Clinical and experimental medicine

    pub_type： 杂志文章

    doi：10.1007/s10238-009-0030-8

    authors： Tong H,Lu C,Zhang J,Liu Z,Ma Y

    更新日期：2009-06-01 00:00:00

  • A simple new method to calculate small intestine absorptive surface in the rat.

    abstract：:The rat is an established model for studying intestinal adaptations following abdominal surgery. In the study of functional and morphological adaptations of the small intestine, it is helpful to estimate the mucosal surface area. In order to simplify measurements and calculation we developed a new mathematical model f...

    journal_title：Clinical and experimental medicine

    pub_type： 杂志文章

    doi：10.1007/s102380200018

    authors： Kisielinski K,Willis S,Prescher A,Klosterhalfen B,Schumpelick V

    更新日期：2002-11-01 00:00:00

  • Nitric oxide production by Leishmania-infected macrophages and modulation by prostaglandin E2.

    abstract：:Nitric oxide (NO), produced by the nitric oxide synthase (iNOS) enzyme, is the most-important molecule responsible for the killing of Leishmania parasites by macrophages. In previous work we have demonstrated that, after activation with recombinant human interferon-gamma and/or bacterial lipopolysaccharide, human macr...

    journal_title：Clinical and experimental medicine

    pub_type： 杂志文章

    doi：10.1007/s10238-001-8025-0

    authors： Panaro MA,Brandonisio O,Sisto M,Acquafredda A,Leogrande D,Fumarola L,Mitolo V

    更新日期：2001-09-01 00:00:00

  • Management of patients with chronic hepatitis C infection.

    abstract：:Chronic infection with hepatitis C virus (HCV) is a leading cause of liver-related morbidity and mortality throughout the world. Although reliable figures regarding the global prevalence of HCV infection are wanting, it is likely that HCV prevalence will continue to increase. Injection drug use is the most important s...

    journal_title：Clinical and experimental medicine

    pub_type： 杂志文章,评审

    doi：10.1007/s10238-006-0089-4

    authors： Herrine SK,Rossi S,Navarro VJ

    更新日期：2006-03-01 00:00:00

  • New therapies in multiple myeloma.

    abstract：:The melphalan-prednisone regimen has been considered as standard therapy for patients with multiple myeloma (MM) for many years. Recently, high-dose chemotherapy with stem-cell support has extended progression-free survival and increased overall survival, and it is now considered conventional therapy in younger patien...

    journal_title：Clinical and experimental medicine

    pub_type： 杂志文章,评审

    doi：10.1007/s10238-007-0134-y

    authors： Merchionne F,Perosa F,Dammacco F

    更新日期：2007-09-01 00:00:00

  • Prognostic significance of serum progranulin level in de novo adult acute lymphoblastic leukemia patients.

    abstract：:Increased expression of progranulin (PGRN) has been reported in some hematological cancers, but limited information regarding its significance in acute lymphoblastic leukemia (ALL) is available. This study involved 60 subjects (40 de novo adult ALL patients and 20 controls). Serum PGRN level was measured by enzyme-lin...

    journal_title：Clinical and experimental medicine

    pub_type： 杂志文章

    doi：10.1007/s10238-020-00610-x

    authors： El-Ghammaz AMS,Azzazi MO,Mostafa N,Hegab HM,Mahmoud AA

    更新日期：2020-05-01 00:00:00

  • The acute phase response following implantation of triclosan-bonded vascular prostheses.

    abstract：OBJECTIVE:Infection of prosthetic material is a major complication of vascular surgery. Therapy for it includes implantation of antimicrobial prostheses bonded with different antimicrobial agents. These agents may, however, induce an acute phase reaction following implantation in the host, thus compromising follow-up o...

    journal_title：Clinical and experimental medicine

    pub_type： 杂志文章

    doi：10.1007/s10238-001-8008-1

    authors： Hernandez-Richter TM,Wichmann MW,Schrödl W,Angele MK,Heinritzi K,Schildberg FW

    更新日期：2001-03-01 00:00:00

  • Diverse phenotypic and genotypic presentation of RAG1 mutations in two cases with SCID.

    abstract：:Severe combined immunodeficiencies (SCID) comprise a spectrum of genetic defects that involve both humoral and cellular immunities. Defects in recombinating activating gene 1 (RAG1), RAG2, Artemis, or LIG4 can disrupt V(D)J recombination. Defective V(D)J recombination of the T and B cell receptors is responsible for T...

    journal_title：Clinical and experimental medicine

    pub_type： 杂志文章

    doi：10.1007/s10238-009-0053-1

    authors： Karaca NE,Aksu G,Genel F,Gulez N,Can S,Aydinok Y,Aksoylar S,Karaca E,Altuglu I,Kutukculer N

    更新日期：2009-12-01 00:00:00

  • Effect of immunisation with cancer procoagulant on the growth of Walker 256 carcinosarcoma cells in rats.

    abstract：:The effect of preimmunisation with cancer procoagulant (CP) on the growth of Walker 256 carcinosarcoma cells in Wistar Lew/Han/IMP rats in vivo has been analysed. One group of rats was immunised with CP purified from human amnion-chorion membranes. The rest of the animals (control groups) were injected with 0.9% NaCl ...

    journal_title：Clinical and experimental medicine

    pub_type： 杂志文章

    doi：10.1007/s10238-006-0106-7

    authors： Kamocka M,Kaplinska K,Mielicki WP

    更新日期：2006-10-01 00:00:00

  • Leukocytes apoptosis and adipocytokines in children with beta thalassemia major.

    abstract：:β-Thalassemia is a significant public health problem in Egypt. Infectious complications represent the second most common cause of mortality and the major cause of morbidity in β-thalassemia major (BTM). The increased susceptibility of these patients to infectious diseases has been attributed to the abnormalities of th...

    journal_title：Clinical and experimental medicine

    pub_type： 杂志文章

    doi：10.1007/s10238-015-0361-6

    authors： Elsayh KI,Mohammed WS,Zahran AM,Saad K

    更新日期：2016-08-01 00:00:00

  • Effect of the antioxidant alpha-lipoic acid on apoptosis in human umbilical vein endothelial cells induced by high glucose.

    abstract：:High glucose plays an important role in the pathogenesis of atherosclerosis. In this study, we assessed the effects of high glucose on human umbilical vein endothelial cell (HUVEC) apoptosis. Additionally, we investigated whether alpha-lipoic acid, an antioxidant, prevents high glucose-induced apoptosis of HUVECs. HUV...

    journal_title：Clinical and experimental medicine

    pub_type： 杂志文章

    doi：10.1007/s10238-008-0155-1

    authors： Meng X,Li ZM,Zhou YJ,Cao YL,Zhang J

    更新日期：2008-03-01 00:00:00

  • Antioxidant potential, paraoxonase 1, ceruloplasmin activity and C-reactive protein concentration in diabetic retinopathy.

    abstract：:The aim of this study was to evaluate the ferric-reducing ability of serum (FRAS), paraoxonase 1 (PON1), ceruloplasmin serum oxidase activity and hsCRP level in patients with type1 diabetes mellitus without and with diabetic retinopathy. The study was performed in 76 patients with type 1 diabetes mellitus, 35 without ...

    journal_title：Clinical and experimental medicine

    pub_type： 杂志文章

    doi：10.1007/s10238-009-0084-7

    authors： Nowak M,Wielkoszyński T,Marek B,Kos-Kudła B,Swietochowska E,Siemińska L,Karpe J,Kajdaniuk D,Głogowska-Szelag J,Nowak K

    更新日期：2010-09-01 00:00:00

  • Single oligoarray-based detection of specific M918T mutation in RET oncogene in multiple endocrine neoplasia type 2B.

    abstract：:The most important mutation associated with Multiple Endocrine Neoplasia type 2B (MEN 2B) is the change of thymine to cytosine in codon 918 of exon 16 in the RET oncogene (ATG → ACG). The aim of this work was to develop a single oligoarray by using tandem hybridization to detect the T918C/RET mutation for MEN 2B patie...

    journal_title：Clinical and experimental medicine

    pub_type： 杂志文章

    doi：10.1007/s10238-010-0128-z

    authors： Pacheco-Rivera RA,Hernández-Zamora E,González-Yebra B,Beattie K,Maldonado-Rodríguez R,Santiago-Hernández JC,Medrano-Ortiz de Zárate ME,Salcedo M

    更新日期：2011-12-01 00:00:00

  • Administration of pigment epithelium-derived factor prolongs bleeding time by suppressing plasminogen activator inhibitor-1 activity and platelet aggregation in rats.

    abstract：:We have recently found that pigment epithelium-derived factor (PEDF), a glycoprotein with potent neuronal differentiating activity, not only inhibits endothelial cell damage, smooth muscle cell proliferation and platelet aggregation in vitro, but also suppresses occlusive thrombus formation in rats. These observations...

    journal_title：Clinical and experimental medicine

    pub_type： 杂志文章

    doi：10.1007/s10238-008-0010-4

    authors： Yamagishi S,Matsui T,Nakamura K,Takenaka K

    更新日期：2009-03-01 00:00:00

  • Structural changes in alpha1-adrenoceptor antagonist-treated human prostatic stroma.

    abstract：:Alpha1-adrenoceptor antagonists (alpha1-blockers) are currently used as first-line drugs for the treatment of benign prostatic hyperplasia (BPH). However, cases of BPH are often encountered in which the efficacy of alpha1-blockers decreases and switching to surgical treatment is required. One factor responsible for th...

    journal_title：Clinical and experimental medicine

    pub_type： 杂志文章

    doi：10.1007/s10238-009-0073-x

    authors： Imamura T,Ishii K,Kanda H,Arase S,Yoshio Y,Hori Y,Soga N,Kise H,Arima K,Sugimura Y

    更新日期：2010-06-01 00:00:00

  • Homocysteine and atheromatous renal artery stenosis.

    abstract：:Hyperhomocysteinemia is an independent risk factor for vascular disease, frequently observed in patients with severe renal impairment. Hyperhomocysteinemia has never been considered as a possible risk factor in renal artery stenosis. We investigated plasma folate and vitamin B12, methylenetetrahydrofolate reductase (M...

    journal_title：Clinical and experimental medicine

    pub_type： 杂志文章

    doi：10.1007/s102380100005

    authors： Olivieri O,Friso S,Trabetti E,Girelli D,Pizzolo F,Faccini G,Stranieri C,Pignatti PF,Corrocher R

    更新日期：2001-12-01 00:00:00

  • 1q23.1 homozygous deletion and downregulation of Fc receptor-like family genes confer poor prognosis in chronic lymphocytic leukemia.

    abstract：:The identification of chromosome 1 translocations and deletions is a rare and poorly investigated event in chronic lymphocytic leukemia (CLL). Nevertheless, the identification of novel additional molecular alterations is of great interest, opening to new prognostic and therapeutic strategies for such heterogeneous hem...

    journal_title：Clinical and experimental medicine

    pub_type： 杂志文章

    doi：10.1007/s10238-019-00551-0

    authors： Daniele G,L'Abbate A,Turchiano A,Palumbo O,Carella M,Lo Cunsolo C,Iuzzolino P,Lonoce A,Hernández-Sánchez M,Minoia C,Leone P,Hernandez-Rivas JM,Storlazzi CT

    更新日期：2019-05-01 00:00:00

  • Increased BATF expression is associated with the severity of liver damage in patients with chronic hepatitis B.

    abstract：:T helper (Th) 17 cells have a critical role in the pathogenesis of chronic hepatitis B virus (HBV) infection, and basic leucine zipper transcription factor, ATF-like (BATF) is a newly identified transcriptional factor regulating the differentiation of Th17 cells. However, its precise role in patients with chronic hepa...

    journal_title：Clinical and experimental medicine

    pub_type： 杂志文章

    doi：10.1007/s10238-017-0480-3

    authors： Wang LY,Fan YC,Zhao J,Ji XF,Wang K

    更新日期：2018-05-01 00:00:00

  • TNM staging for GIT cancers is correlated with the level of MMPs and TGF-β1.

    abstract：:Gastrointestinal (GIT) cancers represent the third common cancers worldwide, characterized by rapid progression and higher mortality rate. Matrix metalloproteinases (MMPs) play an important role in cancer metastases. The present study was conducted to estimate and evaluate the role of MMP-7, -9, -10 and -12 and TGF β1...

    journal_title：Clinical and experimental medicine

    pub_type： 杂志文章

    doi：10.1007/s10238-020-00651-2

    authors： El-Ashmawy NE,Khedr NF,Mansour MG,Al-Ashmawy GM

    更新日期：2020-11-01 00:00:00

  • New single nucleotide polymorphisms (SNPs) in homologous recombination repair genes detected by microarray analysis in Polish breast cancer patients.

    abstract：:Breast cancer is the most common cause of malignancy and mortality in women worldwide. This study aimed at localising homologous recombination repair (HR) genes and their chromosomal loci and correlating their nucleotide variants with susceptibility to breast cancer. In this study, authors analysed the association bet...

    journal_title：Clinical and experimental medicine

    pub_type： 杂志文章

    doi：10.1007/s10238-016-0441-2

    authors： Romanowicz H,Strapagiel D,Słomka M,Sobalska-Kwapis M,Kępka E,Siewierska-Górska A,Zadrożny M,Bieńkiewicz J,Smolarz B

    更新日期：2017-11-01 00:00:00

  • Early detection of RhD status in pregnancies at risk of hemolytic disease of the newborn.

    abstract：:The aim of this work was to investigate the presence of the RHD gene in fetal cells obtained from amniotic fluid. We studied 65 samples of amniotic fluid, 11 from RhD-negative mothers sensitized with anti-D alloantibodies. The fetal origin of the DNA was confirmed with the analysis of 1 VNTR locus and 3 STR loci in DN...

    journal_title：Clinical and experimental medicine

    pub_type： 杂志文章

    doi：10.1007/s102380200010

    authors： Cotorruelo C,Biondi C,García Borrás S,Di Mónaco R,Racca A

    更新日期：2002-07-01 00:00:00

  • Discovery of serum protein biomarkers in rheumatoid arthritis using MALDI-TOF-MS combined with magnetic beads.

    abstract：:The aim of this study was to discover potential biomarkers for rheumatoid arthritis (RA) using Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry combined with magnetic beads. Proteomic fingerprint technology combining magnetic beads with MALDI-TOF-MS was used to profile and compare the prote...

    journal_title：Clinical and experimental medicine

    pub_type： 杂志文章

    doi：10.1007/s10238-011-0154-5

    authors： Zhang X,Yuan Z,Shen B,Zhu M,Liu C,Xu W

    更新日期：2012-09-01 00:00:00

  • The effect of rhBMP-2 on pulmonary arterioles remodeling in endotoxin-induced acute lung injury in rats.

    abstract：:Endotoxin is known to cause acute lung injury (ALI). Here, we investigated the effects and mechanisms of recombinant human bone morphogenetic protein-2 (rhBMP-2) on pulmonary arteriole remodeling in endotoxin-induced ALI in rats. Sixty Wistar rats were randomly divided into 3 groups (n = 20). Control group was infused...

    journal_title：Clinical and experimental medicine

    pub_type： 杂志文章

    doi：10.1007/s10238-012-0197-2

    authors： Wang K,Gong J,Pei L,Shan S,Tan W

    更新日期：2013-08-01 00:00:00

  • Eculizumab in refractory catastrophic antiphospholipid syndrome: a case report and systematic review of the literature.

    abstract：:Catastrophic antiphospholipid syndrome (CAPS) is a rare disorder, characterized by the development of multiple vascular thrombosis over a short period of time, in patients with persistently detectable antiphospholipid antibodies (aPLs). The vascular occlusions predominantly affect small vessels. The overall mortality ...

    journal_title：Clinical and experimental medicine

    pub_type： 杂志文章

    doi：10.1007/s10238-019-00565-8

    authors： Tinti MG,Carnevale V,Inglese M,Molinaro F,Bernal M,Migliore A,De Cata A

    更新日期：2019-08-01 00:00:00

  • CCR2-V64I genetic polymorphism: a possible involvement in HER2+ breast cancer.

    abstract：:Many tumor cells express chemokines and chemokine receptors, and these molecules can affect both tumor progression and anti-tumor immune response. Genetic polymorphisms of some chemokine receptors were found to be closely related to malignant tumors, especially in metastasis process, including breast cancer (BC). Cons...

    journal_title：Clinical and experimental medicine

    pub_type： 杂志文章,评审

    doi：10.1007/s10238-015-0342-9

    authors： Banin-Hirata BK,Losi-Guembarovski R,Oda JM,de Oliveira CE,Campos CZ,Mazzuco TL,Borelli SD,Ceribelli JR,Watanabe MA

    更新日期：2016-05-01 00:00:00

  • Association of genetic polymorphisms in MIF with breast cancer risk in Chinese women.

    abstract：:Macrophage migration inhibitory factor (MIF) has been reported to associate with increased cancer risk in several cancers. However, the role of MIF in breast cancer (BC) susceptibility remains unknown. For the first time, we conducted a case-control study to assess the potential association of three common MIF gene va...

    journal_title：Clinical and experimental medicine

    pub_type： 杂志文章

    doi：10.1007/s10238-016-0439-9

    authors： Lin S,Wang M,Liu X,Zhu W,Guo Y,Dai Z,Yang P,Tian T,Dai C,Zheng Y,Hu C,Wei L,Dai Z

    更新日期：2017-08-01 00:00:00