Abstract：
:Immunophenotypic characterization of the leukemic cells has been widely used as a tool for diagnosis, classification and prognosis of leukaemia. A total of 192 Chinese patients with acute myeloid leukemia (AML) were immunophenotyped by flow cytometry using a panel of monoclonal antibodies. Among the 192 patients enrolled in this study, 125 cases were also subjected to karyotype analysis by G-banding technology. We found that CD33, CD13, MPO and CD117 were the most commonly expressed antigens in AML. A combination of intensive autofluorescence, both CD34(-) and HLA-DR(-), and high expression of CD13, CD33 and MPO had significant value for M3 diagnosis. CD14 was expressed only in M4 and M5, and both intensive positivity of CD64 and CD15 with high expression of HLA-DR may suggest great possibility for diagnosis of M5. Lymphoid markers expression was documented in 47.9% of the 192 AML cases analyzed. CD56 (26.0%) and CD7 (20.8%) were the most commonly expressed lymphoid markers in AML patients. Abnormal karyotypes were detected in 76 out of 125 (60.8%). Higher CD34 positivity was found in LymAg(+) group (77.2%) than in LymAg(-) group (48.0%). Our results indicate that immunophenotype analysis was useful for AML diagnosis and classification and the immunophenotype did have relevance to the abnormal cytogenetic changes and clinical features in AML.
journal_name
Clin Exp Medjournal_title
Clinical and experimental medicineauthors
Tong H,Lu C,Zhang J,Liu Z,Ma Ydoi
10.1007/s10238-009-0030-8subject
Has Abstractpub_date
2009-06-01 00:00:00pages
149-55issue
2eissn
1591-8890issn
1591-9528journal_volume
9pub_type
杂志文章abstract：:Cancer stem cells (CSCs) are thought to be a major player in tumor initiation, progression, and metastasis. Targeting CSCs for elimination presents a promising therapeutic strategy; however, this approach will require a stronger understanding of CSC biology and identification of CSC-specific markers. The present study...
journal_title：Clinical and experimental medicine
pub_type： 杂志文章
doi：10.1007/s10238-020-00665-w
更新日期：2020-09-23 00:00:00
abstract：:Apoptosis of the acinar and ductal epithelial cells of the salivary glands has been proposed as a mechanism possibly responsible for the impairment of the secretory function in Sjögren's syndrome, an organ-specific autoimmune disorder characterized by destruction of these glandular structures. The presence of serum au...
journal_title：Clinical and experimental medicine
pub_type： 杂志文章
doi：10.1007/s10238-009-0087-4
更新日期：2010-09-01 00:00:00
abstract：:Familial hypercholesterolaemia is a genetic disorder characterised by high low-density lipoprotein (LDL) cholesterol concentrations, which frequently gives rise to premature coronary artery disease (CAD). The clinical expression of familial hypercholesterolaemia is highly variable even in patients carrying the same LD...
journal_title：Clinical and experimental medicine
pub_type： 杂志文章
doi：10.1007/s10238-005-0086-z
更新日期：2005-12-01 00:00:00
abstract：:SOCS3 as an important negative regulator of IL6/JAK/STAT3 signaling pathway may be early critical determinants of carcinogenesis. This study aimed to explore the aberrant promoter methylation of SOCS3 gene in circulating DNA as a noninvasive biomarker for screening hepatocellular carcinoma (HCC) high-risk individuals ...
journal_title：Clinical and experimental medicine
pub_type： 杂志文章
doi：10.1007/s10238-017-0473-2
更新日期：2018-02-01 00:00:00
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journal_title：Clinical and experimental medicine
pub_type： 杂志文章
doi：10.1007/s10238-008-0155-1
更新日期：2008-03-01 00:00:00
abstract：:Staphylococcus aureus (S. aureus) is the most common bacterium in sepsis and pneumonia involving gram-positive bacteria. Lipoteichoic acid (LTA) is a cell wall component of gram-positive bacteria. It is a potent inducer of inflammatory mediators in human dendritic cells, human pulmonary epithelial cells, and murine ma...
journal_title：Clinical and experimental medicine
pub_type： 杂志文章
doi：10.1007/s10238-013-0231-z
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abstract：:Bronchoalveolar lavage (BAL) is a useful procedure for differential diagnosis of interstitial lung diseases (ILDs) and for identification of granulomatous lung diseases. We investigated a panel of biomarkers from BAL fluid of ILD patients to evaluate their utility in differentiating ILDs. Bronchoscopy with BAL was per...
journal_title：Clinical and experimental medicine
pub_type： 杂志文章
doi：10.1007/s10238-020-00608-5
更新日期：2020-05-01 00:00:00
abstract：:The purpose of this study was to reveal the clinical diagnostic and prognostic value of miR-768-3p in HBV-related HCC and to investigate its effect on the biological function of HCC. Quantitative real-time polymerase chain reaction was used to detect the expression level of miR-768-3p in subjects' serum. The receiver ...
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pub_type： 杂志文章
doi：10.1007/s10238-020-00646-z
更新日期：2020-11-01 00:00:00
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journal_title：Clinical and experimental medicine
pub_type： 杂志文章
doi：10.1007/s10238-009-0084-7
更新日期：2010-09-01 00:00:00
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journal_title：Clinical and experimental medicine
pub_type： 杂志文章
doi：10.1007/s10238-019-00568-5
更新日期：2019-11-01 00:00:00
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journal_title：Clinical and experimental medicine
pub_type： 杂志文章,评审
doi：10.1007/s10238-007-0134-y
更新日期：2007-09-01 00:00:00
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journal_title：Clinical and experimental medicine
pub_type： 杂志文章,评审
doi：10.1007/s10238-004-0045-0
更新日期：2004-12-01 00:00:00
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journal_title：Clinical and experimental medicine
pub_type： 杂志文章
doi：10.1007/s10238-005-0061-8
更新日期：2005-05-01 00:00:00
abstract：:Severe combined immunodeficiencies (SCID) comprise a spectrum of genetic defects that involve both humoral and cellular immunities. Defects in recombinating activating gene 1 (RAG1), RAG2, Artemis, or LIG4 can disrupt V(D)J recombination. Defective V(D)J recombination of the T and B cell receptors is responsible for T...
journal_title：Clinical and experimental medicine
pub_type： 杂志文章
doi：10.1007/s10238-009-0053-1
更新日期：2009-12-01 00:00:00
abstract：:Oxidative stress (OS) has recently been documented in hypothyroidism, a disease more prevalent in women. In general, OS is reported to be more prevalent in males. However, the effect of gender on OS and protein glycation in hypothyroidism has not been addressed. Blood samples from 37 recently diagnosed primary hypothy...
journal_title：Clinical and experimental medicine
pub_type： 杂志文章
doi：10.1007/s10238-008-0164-0
更新日期：2008-06-01 00:00:00
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journal_title：Clinical and experimental medicine
pub_type： 杂志文章,meta分析
doi：10.1007/s10238-015-0382-1
更新日期：2016-11-01 00:00:00
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journal_title：Clinical and experimental medicine
pub_type： 杂志文章
doi：10.1007/s10238-009-0073-x
更新日期：2010-06-01 00:00:00
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journal_title：Clinical and experimental medicine
pub_type： 杂志文章,评审
doi：10.1007/s10238-004-0032-5
更新日期：2004-09-01 00:00:00
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journal_title：Clinical and experimental medicine
pub_type： 杂志文章
doi：10.1007/s10238-001-8014-3
更新日期：2001-06-01 00:00:00
abstract：:Arginase activity was measured in serum and biopsy from healthy individuals and colorectal cancer patients. Arginase activity in tumor samples (87 +/- 7.7 U/g tissue) was significantly higher than in controls (40.7 +/- 3.3 U/g tissue). However, serum arginase activity did not show any significant change in both groups...
journal_title：Clinical and experimental medicine
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journal_title：Clinical and experimental medicine
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doi：10.1007/s10238-020-00668-7
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doi：10.1007/s10238-020-00636-1
更新日期：2020-11-01 00:00:00
abstract：:Pancreatic cancer (PC) is a leading cause of cancer death worldwide, especially in Western societies. Its aggressive nature and poor prognosis increase the need for identifying new and more accurate diagnostic and prognostic tools. We studied 41 patients who had undergone radical surgical resection for PC, investigate...
journal_title：Clinical and experimental medicine
pub_type： 杂志文章
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更新日期：2016-08-01 00:00:00
abstract：:Accurate prediction of the outcome of molecular target-based treatment in advanced renal cell carcinoma (RCC) is an important clinical problem. Positron emission tomography/computed tomography using [18F]-2-fluoro-2-deoxyglucose (FDG PET/CT) is a noninvasive tool for the assessment of glucose accumulation which can be...
journal_title：Clinical and experimental medicine
pub_type： 杂志文章
doi：10.1007/s10238-018-0539-9
更新日期：2019-02-01 00:00:00
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journal_title：Clinical and experimental medicine
pub_type： 杂志文章
doi：10.1007/s10238-009-0049-x
更新日期：2009-12-01 00:00:00
abstract：:Breast cancer is the most common cause of malignancy and mortality in women worldwide. This study aimed at localising homologous recombination repair (HR) genes and their chromosomal loci and correlating their nucleotide variants with susceptibility to breast cancer. In this study, authors analysed the association bet...
journal_title：Clinical and experimental medicine
pub_type： 杂志文章
doi：10.1007/s10238-016-0441-2
更新日期：2017-11-01 00:00:00
abstract：:Hereditary periodic fever syndromes (HPF) are a group of diseases characterised by recurrences of fever and inflammation separated by symptom-free intervals. Familial Mediterranean fever (FMF) is the most frequent entity within this group of disorders which further consists of hyperimmunoglobulinaemia D and periodic f...
journal_title：Clinical and experimental medicine
pub_type： 杂志文章,评审
doi：10.1007/s10238-005-0071-6
更新日期：2005-10-01 00:00:00
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journal_title：Clinical and experimental medicine
pub_type： 杂志文章
doi：10.1007/s10238-016-0439-9
更新日期：2017-08-01 00:00:00
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journal_title：Clinical and experimental medicine
pub_type： 杂志文章
doi：10.1007/s10238-011-0142-9
更新日期：2012-03-01 00:00:00
abstract：:Primary biliary cirrhosis (PBC) is a progressive autoimmune liver disease in which monocytes/macrophages infiltration and skewed T helper type (Th) 1 and Th17 cell responses participate in the development of the disease. Human peripheral blood monocytes are heterogeneous and can be divided into classical CD14highCD16-...
journal_title：Clinical and experimental medicine
pub_type： 杂志文章
doi：10.1007/s10238-015-0381-2
更新日期：2016-11-01 00:00:00
