当前位置： SCI文献检索 > CLINICAL AND EXPERIMENTAL MEDICINE期刊下所有文献 > The effect of rhBMP-2 on pulmonary arterioles remodeling in endotoxin-induced acute lung injury in rats.

The effect of rhBMP-2 on pulmonary arterioles remodeling in endotoxin-induced acute lung injury in rats.

Abstract：

:Endotoxin is known to cause acute lung injury (ALI). Here, we investigated the effects and mechanisms of recombinant human bone morphogenetic protein-2 (rhBMP-2) on pulmonary arteriole remodeling in endotoxin-induced ALI in rats. Sixty Wistar rats were randomly divided into 3 groups (n = 20). Control group was infused with normal saline. Lipopolysaccharides (LPS) alone group was infused with LPS. LPS plus rhBMP2 group was infused with rhBMP-2 and LPS. Lung tissue was harvested. The tunica media of the pulmonary arterioles was measured. The expression levels of survivin, p21, cyclin D1, and activated caspase-3 were examined. The proliferation and apoptosis of pulmonary artery smooth muscle cells were evaluated. The tunica media of pulmonary arterioles in LPS alone group was significantly thicker than both that in control and that in LPS plus rhBMP2 groups (P < 0.01). The multiplication rate in LPS alone group was also significantly higher than both that in control and that in LPS plus rhBMP2 groups (P < 0.01). The apoptotic rate in LPS alone group was lower than that in LPS plus rhBMP2 group (P < 0.01). Compared with the control and LPS plus rhBMP2 groups, the expression levels of mRNA and proteins of survivin and cyclin D1 were increased in LPS alone group (P < 0.01), while the expression levels of p21 and activated caspase-3 were decreased (P < 0.01). RhBMP-2 inhibits the remodeling of pulmonary arterioles in endotoxin-induced ALI, which is achieved by enhancing apoptosis and inhibiting proliferation of pulmonary artery smooth muscle cells.

journal_name

Clin Exp Med

journal_title

Clinical and experimental medicine

authors

Wang K,Gong J,Pei L,Shan S,Tan W

doi

10.1007/s10238-012-0197-2

subject

Has Abstract

pub_date

2013-08-01 00:00:00

pages

187-92

issue

3

eissn

1591-8890

issn

1591-9528

journal_volume

13

pub_type

杂志文章

相关文献

CLINICAL AND EXPERIMENTAL MEDICINE文献大全
  • Upregulation of ROCK2 in gastric cancer cell promotes tumor cell proliferation, metastasis and invasion.

    abstract：:Rho-associated coiled-coil-containing protein kinase 2 (ROCK2) has been known as an effector for the small GTPase Rho and plays an important role in tumor progression and metastasis. However, the effect of ROCK2 in gastric cancer (GC) has not been identified. This study showed that ROCK2 expression significantly incre...

    journal_title：Clinical and experimental medicine

    pub_type： 杂志文章

    doi：10.1007/s10238-016-0444-z

    authors： Li M,Ke J,Wang Q,Qian H,Yang L,Zhang X,Xiao J,Ding H,Shan X,Liu Q,Xiao Y,Bao B,Huang H

    更新日期：2017-11-01 00:00:00

  • Role of mesenchymal stem cells in leukaemia: Dr. Jekyll or Mr. Hyde?

    abstract：:Mesenchymal stem cells (MSCs) have captured the attention of researchers today due to their multipotent differentiation capacity. Also, they have been successfully applied clinically, in the treatment of various diseases of the heart and musculoskeletal systems, with encouraging results. Their supportive role in haema...

    journal_title：Clinical and experimental medicine

    pub_type： 杂志文章,评审

    doi：10.1007/s10238-013-0247-4

    authors： Wong RS,Cheong SK

    更新日期：2014-08-01 00:00:00

  • Oxidative stress and protein glycation in primary hypothyroidism. Male/female difference.

    abstract：:Oxidative stress (OS) has recently been documented in hypothyroidism, a disease more prevalent in women. In general, OS is reported to be more prevalent in males. However, the effect of gender on OS and protein glycation in hypothyroidism has not been addressed. Blood samples from 37 recently diagnosed primary hypothy...

    journal_title：Clinical and experimental medicine

    pub_type： 杂志文章

    doi：10.1007/s10238-008-0164-0

    authors： Nanda N,Bobby Z,Hamide A

    更新日期：2008-06-01 00:00:00

  • A simple new method to calculate small intestine absorptive surface in the rat.

    abstract：:The rat is an established model for studying intestinal adaptations following abdominal surgery. In the study of functional and morphological adaptations of the small intestine, it is helpful to estimate the mucosal surface area. In order to simplify measurements and calculation we developed a new mathematical model f...

    journal_title：Clinical and experimental medicine

    pub_type： 杂志文章

    doi：10.1007/s102380200018

    authors： Kisielinski K,Willis S,Prescher A,Klosterhalfen B,Schumpelick V

    更新日期：2002-11-01 00:00:00

  • Influence of IL17A polymorphisms (rs2275913 and rs3748067) on the susceptibility to ulcerative colitis.

    abstract：:Interleukin-17A plays a role in tissue inflammation by inducing release of proinflammatory and neutrophil-mobilizing cytokines. We investigated the association between ulcerative colitis (UC) and polymorphisms of IL17A, rs2275913 (-197 G > A), and rs3748067 (*1249 C > T). The study was performed in 475 healthy subject...

    journal_title：Clinical and experimental medicine

    pub_type： 杂志文章

    doi：10.1007/s10238-012-0206-5

    authors： Hayashi R,Tahara T,Shiroeda H,Saito T,Nakamura M,Tsutsumi M,Shibata T,Arisawa T

    更新日期：2013-11-01 00:00:00

  • Effects of vascular endothelial growth factor expression on pathological characteristics and prognosis of osteosarcoma.

    abstract：:Vascular endothelial growth factor (VEGF) has been linked with tumor invasion and metastasis. However, the role of VEGF expression in osteosarcoma remains controversial. By searching the PubMed, Embase, and Google Scholar databases, we conducted a meta-analysis to evaluate the pathological and prognostic significance ...

    journal_title：Clinical and experimental medicine

    pub_type： 杂志文章,meta分析

    doi：10.1007/s10238-015-0382-1

    authors： Han G,Wang Y,Bi W,Jia J,Wang W,Xu M

    更新日期：2016-11-01 00:00:00

  • Effect of allogeneic bone marrow-derived mesenchymal stem cells transplantation in a polyI:C-induced primary biliary cirrhosis mouse model.

    abstract：:Primary biliary cirrhosis (PBC) is a slowly progressive autoimmune disease of unknown mechanism. We established a PBC animal model by injecting C57BL/6 mice with polyinosinic-polycytidylic acid sodium (polyI:C) to investigate the therapeutic effect of bone marrow-derived mesenchymal stem cells (BM-MSC) on this model. ...

    journal_title：Clinical and experimental medicine

    pub_type： 杂志文章

    doi：10.1007/s10238-010-0105-6

    authors： Wang D,Zhang H,Liang J,Gu Z,Ma X,Huang J,Lin J,Hou Y,Lu L,Sun L

    更新日期：2011-03-01 00:00:00

  • Leukocytes apoptosis and adipocytokines in children with beta thalassemia major.

    abstract：:β-Thalassemia is a significant public health problem in Egypt. Infectious complications represent the second most common cause of mortality and the major cause of morbidity in β-thalassemia major (BTM). The increased susceptibility of these patients to infectious diseases has been attributed to the abnormalities of th...

    journal_title：Clinical and experimental medicine

    pub_type： 杂志文章

    doi：10.1007/s10238-015-0361-6

    authors： Elsayh KI,Mohammed WS,Zahran AM,Saad K

    更新日期：2016-08-01 00:00:00

  • Single oligoarray-based detection of specific M918T mutation in RET oncogene in multiple endocrine neoplasia type 2B.

    abstract：:The most important mutation associated with Multiple Endocrine Neoplasia type 2B (MEN 2B) is the change of thymine to cytosine in codon 918 of exon 16 in the RET oncogene (ATG → ACG). The aim of this work was to develop a single oligoarray by using tandem hybridization to detect the T918C/RET mutation for MEN 2B patie...

    journal_title：Clinical and experimental medicine

    pub_type： 杂志文章

    doi：10.1007/s10238-010-0128-z

    authors： Pacheco-Rivera RA,Hernández-Zamora E,González-Yebra B,Beattie K,Maldonado-Rodríguez R,Santiago-Hernández JC,Medrano-Ortiz de Zárate ME,Salcedo M

    更新日期：2011-12-01 00:00:00

  • Nitric oxide production by Leishmania-infected macrophages and modulation by prostaglandin E2.

    abstract：:Nitric oxide (NO), produced by the nitric oxide synthase (iNOS) enzyme, is the most-important molecule responsible for the killing of Leishmania parasites by macrophages. In previous work we have demonstrated that, after activation with recombinant human interferon-gamma and/or bacterial lipopolysaccharide, human macr...

    journal_title：Clinical and experimental medicine

    pub_type： 杂志文章

    doi：10.1007/s10238-001-8025-0

    authors： Panaro MA,Brandonisio O,Sisto M,Acquafredda A,Leogrande D,Fumarola L,Mitolo V

    更新日期：2001-09-01 00:00:00

  • Injection of basic fibroblast growth factor together with adipose-derived stem cell transplantation: improved cardiac remodeling and function in myocardial infarction.

    abstract：:Recent findings suggest that cell and gene transplantation in the infarcted myocardium may improve heart function. The aim of the study was to investigate the mechanism involved in improving heart function following the co-injection of adipose-derived stem cells (ADSCs) and basic fibroblast growth factor (bFGF) in a r...

    journal_title：Clinical and experimental medicine

    pub_type： 杂志文章

    doi：10.1007/s10238-015-0383-0

    authors： Wang B,Ma X,Zhao L,Zhou X,Ma Y,Sun H,Yang Y,Chen B

    更新日期：2016-11-01 00:00:00

  • Establishing serological classification tree model in rheumatoid arthritis using combination of MALDI-TOF-MS and magnetic beads.

    abstract：:To establish a serological classification tree model for rheumatoid arthritis (RA), protein/peptide profiles of serum were detected by matrix-assisted laser desorption-ionization time-of-flight mass spectrometry (MALDI-TOF-MS) combined with weak cationic exchange (WCX) from Cohort 1, including 65 patients with RA and ...

    journal_title：Clinical and experimental medicine

    pub_type： 杂志文章

    doi：10.1007/s10238-013-0265-2

    authors： Yan Z,Chaojun H,Chuiwen D,Xiaomei L,Xin Z,Yongzhe L,Fengchun Z

    更新日期：2015-02-01 00:00:00

  • Prognostic significance of serum progranulin level in de novo adult acute lymphoblastic leukemia patients.

    abstract：:Increased expression of progranulin (PGRN) has been reported in some hematological cancers, but limited information regarding its significance in acute lymphoblastic leukemia (ALL) is available. This study involved 60 subjects (40 de novo adult ALL patients and 20 controls). Serum PGRN level was measured by enzyme-lin...

    journal_title：Clinical and experimental medicine

    pub_type： 杂志文章

    doi：10.1007/s10238-020-00610-x

    authors： El-Ghammaz AMS,Azzazi MO,Mostafa N,Hegab HM,Mahmoud AA

    更新日期：2020-05-01 00:00:00

  • Antioxidant potential, paraoxonase 1, ceruloplasmin activity and C-reactive protein concentration in diabetic retinopathy.

    abstract：:The aim of this study was to evaluate the ferric-reducing ability of serum (FRAS), paraoxonase 1 (PON1), ceruloplasmin serum oxidase activity and hsCRP level in patients with type1 diabetes mellitus without and with diabetic retinopathy. The study was performed in 76 patients with type 1 diabetes mellitus, 35 without ...

    journal_title：Clinical and experimental medicine

    pub_type： 杂志文章

    doi：10.1007/s10238-009-0084-7

    authors： Nowak M,Wielkoszyński T,Marek B,Kos-Kudła B,Swietochowska E,Siemińska L,Karpe J,Kajdaniuk D,Głogowska-Szelag J,Nowak K

    更新日期：2010-09-01 00:00:00

  • High mobility group box 1 induces synoviocyte proliferation in rheumatoid arthritis by activating the signal transducer and activator transcription signal pathway.

    abstract：:Recently, it was discovered that high mobility group box chromosomal protein 1 (HMGB1) acts as a potent pro-inflammatory cytokine that is released into the extracellular milieu. Signal transducer and activator of transcription (STAT) proteins play an important role in cytokine signaling. Some investigators have report...

    journal_title：Clinical and experimental medicine

    pub_type： 杂志文章

    doi：10.1007/s10238-010-0116-3

    authors： Guo HF,Liu SX,Zhang YJ,Liu QJ,Hao J,Gao LX

    更新日期：2011-06-01 00:00:00

  • CCR2-V64I genetic polymorphism: a possible involvement in HER2+ breast cancer.

    abstract：:Many tumor cells express chemokines and chemokine receptors, and these molecules can affect both tumor progression and anti-tumor immune response. Genetic polymorphisms of some chemokine receptors were found to be closely related to malignant tumors, especially in metastasis process, including breast cancer (BC). Cons...

    journal_title：Clinical and experimental medicine

    pub_type： 杂志文章,评审

    doi：10.1007/s10238-015-0342-9

    authors： Banin-Hirata BK,Losi-Guembarovski R,Oda JM,de Oliveira CE,Campos CZ,Mazzuco TL,Borelli SD,Ceribelli JR,Watanabe MA

    更新日期：2016-05-01 00:00:00

  • Inhibitory effects of simvastatin on staphylococcus aureus lipoteichoic acid-induced inflammation in human alveolar macrophages.

    abstract：:Staphylococcus aureus (S. aureus) is the most common bacterium in sepsis and pneumonia involving gram-positive bacteria. Lipoteichoic acid (LTA) is a cell wall component of gram-positive bacteria. It is a potent inducer of inflammatory mediators in human dendritic cells, human pulmonary epithelial cells, and murine ma...

    journal_title：Clinical and experimental medicine

    pub_type： 杂志文章

    doi：10.1007/s10238-013-0231-z

    authors： Wu BQ,Luo JM,Wang YH,Shi YF,Liu H,Ba JH,Zhang TT

    更新日期：2014-05-01 00:00:00

  • TNM staging for GIT cancers is correlated with the level of MMPs and TGF-β1.

    abstract：:Gastrointestinal (GIT) cancers represent the third common cancers worldwide, characterized by rapid progression and higher mortality rate. Matrix metalloproteinases (MMPs) play an important role in cancer metastases. The present study was conducted to estimate and evaluate the role of MMP-7, -9, -10 and -12 and TGF β1...

    journal_title：Clinical and experimental medicine

    pub_type： 杂志文章

    doi：10.1007/s10238-020-00651-2

    authors： El-Ashmawy NE,Khedr NF,Mansour MG,Al-Ashmawy GM

    更新日期：2020-11-01 00:00:00

  • Immunophenotypic, cytogenetic and clinical features of 192 AML patients in China.

    abstract：:Immunophenotypic characterization of the leukemic cells has been widely used as a tool for diagnosis, classification and prognosis of leukaemia. A total of 192 Chinese patients with acute myeloid leukemia (AML) were immunophenotyped by flow cytometry using a panel of monoclonal antibodies. Among the 192 patients enrol...

    journal_title：Clinical and experimental medicine

    pub_type： 杂志文章

    doi：10.1007/s10238-009-0030-8

    authors： Tong H,Lu C,Zhang J,Liu Z,Ma Y

    更新日期：2009-06-01 00:00:00

  • Association of genetic polymorphisms in MIF with breast cancer risk in Chinese women.

    abstract：:Macrophage migration inhibitory factor (MIF) has been reported to associate with increased cancer risk in several cancers. However, the role of MIF in breast cancer (BC) susceptibility remains unknown. For the first time, we conducted a case-control study to assess the potential association of three common MIF gene va...

    journal_title：Clinical and experimental medicine

    pub_type： 杂志文章

    doi：10.1007/s10238-016-0439-9

    authors： Lin S,Wang M,Liu X,Zhu W,Guo Y,Dai Z,Yang P,Tian T,Dai C,Zheng Y,Hu C,Wei L,Dai Z

    更新日期：2017-08-01 00:00:00

  • Telomere length in non-neoplastic colonic mucosa in ulcerative colitis (UC) and its relationship to the severe clinical phenotypes.

    abstract：:Telomere shortening occurs with human aging in many organs and tissues and is accelerated by rapid cell turnover and oxidative injury. To clarify the clinical importance of telomere shortening in colonic mucosa in ulcerative colitis (UC), we measured average telomere length using quantitative real-time PCR in non-neop...

    journal_title：Clinical and experimental medicine

    pub_type： 杂志文章

    doi：10.1007/s10238-014-0295-4

    authors： Tahara T,Shibata T,Okubo M,Kawamura T,Sumi K,Ishizuka T,Nakamura M,Nagasaka M,Nakagawa Y,Ohmiya N,Arisawa T,Hirata I

    更新日期：2015-08-01 00:00:00

  • Increased B7H4 tissue expression correlates with high CA19.9 serum levels and a worse prognosis of pancreatic adenocarcinoma.

    abstract：:Pancreatic cancer (PC) is a leading cause of cancer death worldwide, especially in Western societies. Its aggressive nature and poor prognosis increase the need for identifying new and more accurate diagnostic and prognostic tools. We studied 41 patients who had undergone radical surgical resection for PC, investigate...

    journal_title：Clinical and experimental medicine

    pub_type： 杂志文章

    doi：10.1007/s10238-015-0352-7

    authors： Tsiaousidou A,Tsaroucha AK,Lambropoulou M,Pitiakoudis M,Polychronidis A,Chatzitheoklitos E,Romanidis K,Simopoulos C

    更新日期：2016-08-01 00:00:00

  • Recombinant human interferon gamma (Gamma Immunex) in treatment of atopic dermatitis.

    abstract：:Atopic dermatitis (AD) is a chronic, inflammatory skin disease which is characterized by severe pruritus and affects patients' quality of life. In recent years gamma interferon (IFN-gamma) has been accepted as a novel treatment for severe AD, however, its mechanism of action is not clearly identified. Present study ev...

    journal_title：Clinical and experimental medicine

    pub_type： 临床试验,杂志文章

    doi：10.1007/s10238-011-0164-3

    authors： Panahi Y,Davoudi SM,Madanchi N,Abolhasani E

    更新日期：2012-12-01 00:00:00

  • Thyroid autoimmunity and dysfunction associated with type I interferon therapy.

    abstract：:Type I interferons are currently used for the treatment of chronic viral hepatitis, multiple sclerosis and several hematological and solid tumors. Side effects are not uncommon, and include multiple alterations in thyroid function, some of which are unrelated to autoimmunity. Review of the literature revealed an overa...

    journal_title：Clinical and experimental medicine

    pub_type： 杂志文章,评审

    doi：10.1007/s10238-004-0026-3

    authors： Monzani F,Caraccio N,Dardano A,Ferrannini E

    更新日期：2004-04-01 00:00:00

  • A new measure for in vivo thrombin activity in comparison with in vitro thrombin generation potential in patients with hyper- and hypocoagulability.

    abstract：:The thrombin generation potential is an in vitro measure for the capacity of an individual to generate thrombin and recognized as a reflection of a hypo- or hypercoagulable status. Measurement of the in vivo thrombin activity, however, may be of clinical significance. We evaluated a new assay for in vivo thrombin acti...

    journal_title：Clinical and experimental medicine

    pub_type： 杂志文章

    doi：10.1007/s10238-016-0417-2

    authors： Königsbrügge O,Koder S,Riedl J,Panzer S,Pabinger I,Ay C

    更新日期：2017-05-01 00:00:00

  • Metabolic syndrome and chronic arthritis: effects of anti-TNF-α therapy.

    abstract：:TNF-α plays a key role in the inflammatory cytokine cascade involved in the pathogenesis of chronic arthritis, including rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis. Systemic inflammation and the increased production of pro-inflammatory cytokines in these patients may favor the onset of metab...

    journal_title：Clinical and experimental medicine

    pub_type： 杂志文章,评审

    doi：10.1007/s10238-014-0323-4

    authors： Maruotti N,d'Onofrio F,Cantatore FP

    更新日期：2015-11-01 00:00:00

  • BAL biomarkers' panel for differential diagnosis of interstitial lung diseases.

    abstract：:Bronchoalveolar lavage (BAL) is a useful procedure for differential diagnosis of interstitial lung diseases (ILDs) and for identification of granulomatous lung diseases. We investigated a panel of biomarkers from BAL fluid of ILD patients to evaluate their utility in differentiating ILDs. Bronchoscopy with BAL was per...

    journal_title：Clinical and experimental medicine

    pub_type： 杂志文章

    doi：10.1007/s10238-020-00608-5

    authors： d'Alessandro M,Carleo A,Cameli P,Bergantini L,Perrone A,Vietri L,Lanzarone N,Vagaggini C,Sestini P,Bargagli E

    更新日期：2020-05-01 00:00:00

  • Detection of promoter methylation status of suppressor of cytokine signaling 3 (SOCS3) in tissue and plasma from Chinese patients with different hepatic diseases.

    abstract：:SOCS3 as an important negative regulator of IL6/JAK/STAT3 signaling pathway may be early critical determinants of carcinogenesis. This study aimed to explore the aberrant promoter methylation of SOCS3 gene in circulating DNA as a noninvasive biomarker for screening hepatocellular carcinoma (HCC) high-risk individuals ...

    journal_title：Clinical and experimental medicine

    pub_type： 杂志文章

    doi：10.1007/s10238-017-0473-2

    authors： Wei L,Huang Y,Zhao R,Zhang J,Liu Q,Liang W,Ding X,Gao B,Li B,Sun C,He J,Yu X,Liu Z,Sun A,Qin Y

    更新日期：2018-02-01 00:00:00

  • The diagnostic and prognostic value of exosome-derived long non-coding RNAs in cancer patients: a meta-analysis.

    abstract：PURPOSE:Exosome-derived long non-coding RNAs (lncRNAs) as novel biomarkers are widely investigated in various cancers, yet results remain controversial. The aim of this meta-analysis was to clarify the diagnostic and prognostic value of exosome-derived lncRNAs in cancer. METHODS:PubMed, Web of Science, EMBASE, CNKI, a...

    journal_title：Clinical and experimental medicine

    pub_type： 杂志文章,评审

    doi：10.1007/s10238-020-00638-z

    authors： Mu H,Zhang S,Yao Z,Liu Y,Lin K,Zhao Z,Zhu Y

    更新日期：2020-08-01 00:00:00

  • Behcet's disease.

    abstract：:Behcet's disease is a recurrent multisystem vasculitis that can affect any organ or system, but was originally described as orogenital ulcerations and uveitis. Specific criteria have been proposed for diagnosis and identification of affected organs by different national authorities. Behcet's disease is proposed to be ...

    journal_title：Clinical and experimental medicine

    pub_type： 杂志文章,评审

    doi：10.1007/s10238-004-0045-0

    authors： Al-Mutawa SA,Hegab SM

    更新日期：2004-12-01 00:00:00