Abstract：
:Interleukin-17A plays a role in tissue inflammation by inducing release of proinflammatory and neutrophil-mobilizing cytokines. We investigated the association between ulcerative colitis (UC) and polymorphisms of IL17A, rs2275913 (-197 G > A), and rs3748067 (*1249 C > T). The study was performed in 475 healthy subjects (controls) and 202 with UC (UC cases), including 113 controls and 64 UC cases from previous study. We employed the multiplex PCR-SSCP method to detect gene polymorphisms. The minor allele frequency of rs2275913 was significantly higher but that of rs3748067 was significantly lower in UC cases than controls. The rs2275913 minor homozygote (AA) had an increased risk of the development of UC, whereas rs3748067 minor carrier (CT + TT) had decreased risks for the development of UC. When compared with LR group (rs2275913 GG + GA with rs3748067 CT + TT), HR group (rs2275913 AA with rs3748067 CC) had a more increased risk of the development of UC (OR, 3.38; p = 0.0007). The polymorphisms of IL17A were associated with the noncontinuous and pancolitis phenotypes of UC. Our results suggest that IL17A polymorphisms (both rs2275913 and rs3748067) influence the susceptibility to and pathophysiological features of UC, coordinately.
journal_name
Clin Exp Medjournal_title
Clinical and experimental medicineauthors
Hayashi R,Tahara T,Shiroeda H,Saito T,Nakamura M,Tsutsumi M,Shibata T,Arisawa Tdoi
10.1007/s10238-012-0206-5subject
Has Abstractpub_date
2013-11-01 00:00:00pages
239-44issue
4eissn
1591-8890issn
1591-9528journal_volume
13pub_type
杂志文章abstract：:To establish a serological classification tree model for rheumatoid arthritis (RA), protein/peptide profiles of serum were detected by matrix-assisted laser desorption-ionization time-of-flight mass spectrometry (MALDI-TOF-MS) combined with weak cationic exchange (WCX) from Cohort 1, including 65 patients with RA and ...
journal_title：Clinical and experimental medicine
pub_type： 杂志文章
doi：10.1007/s10238-013-0265-2
更新日期：2015-02-01 00:00:00
abstract：:Pancreatic cancer (PC) is a leading cause of cancer death worldwide, especially in Western societies. Its aggressive nature and poor prognosis increase the need for identifying new and more accurate diagnostic and prognostic tools. We studied 41 patients who had undergone radical surgical resection for PC, investigate...
journal_title：Clinical and experimental medicine
pub_type： 杂志文章
doi：10.1007/s10238-015-0352-7
更新日期：2016-08-01 00:00:00
abstract：:The sensitivity of the alkaline comet assay for the evaluation of baseline and treatment-induced DNA damage in white blood cells of breast cancer patients receiving adjuvant chemotherapy according to three conventional anthracycline- and cyclophosphamide-containing protocols was investigated. Additionally, baseline DN...
journal_title：Clinical and experimental medicine
pub_type： 杂志文章
doi：10.1007/s10238-006-0113-8
更新日期：2006-12-01 00:00:00
abstract：:To investigate the expression of cyclin G1, cyclin G2 in nasopharyngeal carcinoma (NPC) cell lines and its significance. The protein expression of cyclin G1, cyclin G2 in NPC cell lines of different differentiation degree (HNE2, CNE1) was detected by indirect immunofluorescence. The mRNA expression of cyclin G1, cycli...
journal_title：Clinical and experimental medicine
pub_type： 杂志文章
doi：10.1007/s10238-011-0142-9
更新日期：2012-03-01 00:00:00
abstract：:Longitudinal studies have improved current diagnostics and management of metabolic associated fatty liver disease (MAFLD) patients by liver biopsy and therapeutic intervention, yet the deficiency of biomarker spectrum for dissecting subtypes largely hinders the symptomatic treatment. We originally enriched serum from ...
journal_title：Clinical and experimental medicine
pub_type： 杂志文章
doi：10.1007/s10238-020-00636-1
更新日期：2020-11-01 00:00:00
abstract：:Mixed-phenotype acute leukemia (MPAL) is the infrequent type of acute leukemia characterized by immunophenotypic and/or cytochemical features of both lineages, but the diagnosis of this disease still is a challenge. In this study, we analyzed immunophenotyping, cytochemistry and frequency of MPAL patients to better di...
journal_title：Clinical and experimental medicine
pub_type： 杂志文章
doi：10.1007/s10238-018-0520-7
更新日期：2018-11-01 00:00:00
abstract：:We retrospectively analyzed the medical history of 19 elderly myeloma patients treated with the "novel subcutaneous formulation of bortezomib." In our experience, two patients (10 %) discontinued treatment for paralytic ileus. The exact pathogenetic mechanisms of toxic megacolon and paralytic ileus due to "novel subcu...
journal_title：Clinical and experimental medicine
pub_type： 杂志文章
doi：10.1007/s10238-015-0337-6
更新日期：2016-02-01 00:00:00
abstract：:The purpose of this study was to reveal the clinical diagnostic and prognostic value of miR-768-3p in HBV-related HCC and to investigate its effect on the biological function of HCC. Quantitative real-time polymerase chain reaction was used to detect the expression level of miR-768-3p in subjects' serum. The receiver ...
journal_title：Clinical and experimental medicine
pub_type： 杂志文章
doi：10.1007/s10238-020-00646-z
更新日期：2020-11-01 00:00:00
abstract：:Behcet's disease is a recurrent multisystem vasculitis that can affect any organ or system, but was originally described as orogenital ulcerations and uveitis. Specific criteria have been proposed for diagnosis and identification of affected organs by different national authorities. Behcet's disease is proposed to be ...
journal_title：Clinical and experimental medicine
pub_type： 杂志文章,评审
doi：10.1007/s10238-004-0045-0
更新日期：2004-12-01 00:00:00
abstract：:This paper describes the clinical significance of antibodies to the ribosomal P proteins in systemic lupus erythematosus. It appears that liver disease due to the lupus process and not attributable to viral infection, alcohol or drugs is associated with anti-ribosomal P. In addition, there is a strong relationship to ...
journal_title：Clinical and experimental medicine
pub_type： 杂志文章,评审
doi：10.1007/s10238-006-0094-7
更新日期：2006-06-01 00:00:00
abstract：:Although the role of cholesterol absorption by the gallbladder epithelium in gallstone formation is well established, the exact process is poorly understood. Potential candidates for regulation of transepithelial cholesterol transport are suggested to be two large membrane multiple ligand receptors, megalin and cubili...
journal_title：Clinical and experimental medicine
pub_type： 杂志文章
doi：10.1007/s10238-008-0174-y
更新日期：2008-09-01 00:00:00
abstract：:The melphalan-prednisone regimen has been considered as standard therapy for patients with multiple myeloma (MM) for many years. Recently, high-dose chemotherapy with stem-cell support has extended progression-free survival and increased overall survival, and it is now considered conventional therapy in younger patien...
journal_title：Clinical and experimental medicine
pub_type： 杂志文章,评审
doi：10.1007/s10238-007-0134-y
更新日期：2007-09-01 00:00:00
abstract：:The objective of this study was to compare between the effects of mesenchymal stem cell (MSC) and betamethasone in the treatment of rheumatoid arthritis. Sixty male albino mice were divided equally into 2 models. They are MSC model, group 1: saline control group, group 2: collagen-induced arthritis (CIA), group 3: ind...
journal_title：Clinical and experimental medicine
pub_type： 杂志文章
doi：10.1007/s10238-013-0248-3
更新日期：2014-08-01 00:00:00
abstract：:Nasopharyngeal carcinoma (NPC) is a very common head and neck cancer in southern china. Despite advances in surgical and chemotherapeutic approaches, its prognosis is still not promising. Hedgehog signaling pathway was reported to be involved in a number of cancers including head and neck. However, it remains unclear ...
journal_title：Clinical and experimental medicine
pub_type： 杂志文章
doi：10.1007/s10238-012-0198-1
更新日期：2013-11-01 00:00:00
abstract：:SOCS3 as an important negative regulator of IL6/JAK/STAT3 signaling pathway may be early critical determinants of carcinogenesis. This study aimed to explore the aberrant promoter methylation of SOCS3 gene in circulating DNA as a noninvasive biomarker for screening hepatocellular carcinoma (HCC) high-risk individuals ...
journal_title：Clinical and experimental medicine
pub_type： 杂志文章
doi：10.1007/s10238-017-0473-2
更新日期：2018-02-01 00:00:00
abstract：:The effect of preimmunisation with cancer procoagulant (CP) on the growth of Walker 256 carcinosarcoma cells in Wistar Lew/Han/IMP rats in vivo has been analysed. One group of rats was immunised with CP purified from human amnion-chorion membranes. The rest of the animals (control groups) were injected with 0.9% NaCl ...
journal_title：Clinical and experimental medicine
pub_type： 杂志文章
doi：10.1007/s10238-006-0106-7
更新日期：2006-10-01 00:00:00
abstract：:An in vitro skin explant model was originally developed to predict the occurrence and severity of acute graft-versus-host disease in allogeneic hematopoietic stem cell transplants. In previous studies we reported that peripheral blood mononuclear cells of patients with rheumatoid arthritis were able to induce graft-ve...
journal_title：Clinical and experimental medicine
pub_type： 杂志文章
doi：10.1007/s10238-001-8014-3
更新日期：2001-06-01 00:00:00
abstract：:The predominance of the effector mechanisms by CD4 + T cells is a characteristic of inflammatory autoimmune diseases such as rheumatoid arthritis (RA). The CD40/CD40L costimulatory pathway contributes to these pathogenic mechanisms by promoting autoantibody production and inflammation. Aberrant expression of CD40 and ...
journal_title：Clinical and experimental medicine
pub_type： 杂志文章
doi：10.1007/s10238-019-00568-5
更新日期：2019-11-01 00:00:00
abstract：:Tumor markers were used for disease monitoring in small-cell lung cancer patients. The aim of this study was to improve diagnostic efficiency in the detection of tumor progression in small-cell lung cancer patients by using fuzzy logic modeling in combination with a tumor marker panel (NSE, ProGRP, Tumor M2-PK, CYFRA ...
journal_title：Clinical and experimental medicine
pub_type： 杂志文章
doi：10.1007/s102380300005
更新日期：2003-02-01 00:00:00
abstract：:Recent findings suggest that cell and gene transplantation in the infarcted myocardium may improve heart function. The aim of the study was to investigate the mechanism involved in improving heart function following the co-injection of adipose-derived stem cells (ADSCs) and basic fibroblast growth factor (bFGF) in a r...
journal_title：Clinical and experimental medicine
pub_type： 杂志文章
doi：10.1007/s10238-015-0383-0
更新日期：2016-11-01 00:00:00
abstract：:We have previously found that ex vivo expanded human CD4+CD25+Treg cells suppress proliferation of lymphoma B-cell lines. Here we demonstrate that the immunomodulatory drug lenalidomide potentiates suppression of lymphoma B-cell proliferation by freshly isolated CD4+CD25+Tregs, as well as suppression by Tregs expanded...
journal_title：Clinical and experimental medicine
pub_type： 杂志文章
doi：10.1007/s10238-016-0411-8
更新日期：2017-05-01 00:00:00
abstract：:Macrophage migration inhibitory factor (MIF) has been reported to associate with increased cancer risk in several cancers. However, the role of MIF in breast cancer (BC) susceptibility remains unknown. For the first time, we conducted a case-control study to assess the potential association of three common MIF gene va...
journal_title：Clinical and experimental medicine
pub_type： 杂志文章
doi：10.1007/s10238-016-0439-9
更新日期：2017-08-01 00:00:00
abstract：:Nitric oxide (NO), produced by the nitric oxide synthase (iNOS) enzyme, is the most-important molecule responsible for the killing of Leishmania parasites by macrophages. In previous work we have demonstrated that, after activation with recombinant human interferon-gamma and/or bacterial lipopolysaccharide, human macr...
journal_title：Clinical and experimental medicine
pub_type： 杂志文章
doi：10.1007/s10238-001-8025-0
更新日期：2001-09-01 00:00:00
abstract：:The aim of this study was to evaluate the ferric-reducing ability of serum (FRAS), paraoxonase 1 (PON1), ceruloplasmin serum oxidase activity and hsCRP level in patients with type1 diabetes mellitus without and with diabetic retinopathy. The study was performed in 76 patients with type 1 diabetes mellitus, 35 without ...
journal_title：Clinical and experimental medicine
pub_type： 杂志文章
doi：10.1007/s10238-009-0084-7
更新日期：2010-09-01 00:00:00
abstract：:Twist1 is a key transcription factor, which confers tumor cells with cancer stem cell (CSC)-like characteristics and enhances epithelial-mesenchymal transition in pathological conditions including tumor malignancy and metastasis. This study aimed to evaluate the expression patterns and clinical significance of Twist1 ...
journal_title：Clinical and experimental medicine
pub_type： 杂志文章
doi：10.1007/s10238-017-0481-2
更新日期：2018-05-01 00:00:00
abstract：:The aim of this study was to discover potential biomarkers for rheumatoid arthritis (RA) using Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry combined with magnetic beads. Proteomic fingerprint technology combining magnetic beads with MALDI-TOF-MS was used to profile and compare the prote...
journal_title：Clinical and experimental medicine
pub_type： 杂志文章
doi：10.1007/s10238-011-0154-5
更新日期：2012-09-01 00:00:00
abstract：:Studies have demonstrated cytomegalovirus (CMV) DNA particles in restenotic lesions in atherosclerotic coronary arteries. We have shown that high (>1:800) anti-CMV IgG antibody titers in the serum are associated with active coronary disease and with post coronary angioplasty restenosis. In this study we assessed the a...
journal_title：Clinical and experimental medicine
pub_type： 杂志文章
doi：10.1007/s10238-003-0019-7
更新日期：2003-11-01 00:00:00
abstract：:The cross-sectional study was conducted to examine hepatic function via liver enzymes/proteins assessments, along with the estimation of an inflammatory response from C-reactive protein (CRP)-which is a liver-synthesized protein. The liver function tests with aspartate aminotransferase (AST), alanine aminotransferase ...
journal_title：Clinical and experimental medicine
pub_type： 杂志文章
doi：10.1007/s10238-017-0462-5
更新日期：2018-02-01 00:00:00
abstract：:B-cell chronic lymphocytic leukemia (B-CLL) is one of the most common leukemias among the elderly and, despite many efforts, still stays incurable. Recent studies point to the microenvironment as the critical factor providing leukemic lymphocytes with pro-survival signals. Thus, the neighboring cells appear to be a pe...
journal_title：Clinical and experimental medicine
pub_type： 杂志文章
doi：10.1007/s10238-013-0268-z
更新日期：2015-02-01 00:00:00
abstract：:Alpha1-adrenoceptor antagonists (alpha1-blockers) are currently used as first-line drugs for the treatment of benign prostatic hyperplasia (BPH). However, cases of BPH are often encountered in which the efficacy of alpha1-blockers decreases and switching to surgical treatment is required. One factor responsible for th...
journal_title：Clinical and experimental medicine
pub_type： 杂志文章
doi：10.1007/s10238-009-0073-x
更新日期：2010-06-01 00:00:00
