Abstract:
:The purpose of this study was to reveal the clinical diagnostic and prognostic value of miR-768-3p in HBV-related HCC and to investigate its effect on the biological function of HCC. Quantitative real-time polymerase chain reaction was used to detect the expression level of miR-768-3p in subjects' serum. The receiver operating characteristics curve (ROC) evaluated the diagnostic value of miR-768-3p in patients. A Chi-square test was used to analyze the relationship between miR-768-3p and clinical data of patients. Kaplan-Meier survival and Cox regression analysis assessed the prognostic value of miR-768-3p in HCC. Finally, CCK-8 and Transwell assays were used to demonstrate the effect of miR-768-3p on HBV-related HCC function. Serum miR-768-3p was significantly lower in HCC patients than in healthy controls and chronic hepatitis B (CHB) patients. ROC curve suggested that serum miR-768-3p has an important diagnostic value for HBV-related HCC and can significantly differentiate HCC patients from healthy controls, and it can also diagnose HCC patients from CHB patients. Cox analysis confirmed that miR-768-3p was an independent risk factor. Low expression of miR-768-3p was associated with Tumor, Node, Metastasis stage, Barcelona Clinic Liver Cancer stage, and poor prognosis in HCC patients. Finally, cell function experiments confirmed that high expression of miR-768-3p could inhibit cell proliferation, migration, and invasion. All experiments confirmed that miR-768-3p can inhibit the proliferation, migration, and invasion of HBV-related HCC cells, and the low expression of miR-768-3p can be used as a potential diagnostic and prognostic biomarker for HBV-related HCC.
journal_name
Clin Exp Medjournal_title
Clinical and experimental medicineauthors
Cao C,Wang Cdoi
10.1007/s10238-020-00646-zsubject
Has Abstractpub_date
2020-11-01 00:00:00pages
569-576issue
4eissn
1591-8890issn
1591-9528pii
10.1007/s10238-020-00646-zjournal_volume
20pub_type
杂志文章abstract::Telomere shortening occurs with human aging in many organs and tissues and is accelerated by rapid cell turnover and oxidative injury. To clarify the clinical importance of telomere shortening in colonic mucosa in ulcerative colitis (UC), we measured average telomere length using quantitative real-time PCR in non-neop...
journal_title:Clinical and experimental medicine
pub_type: 杂志文章
doi:10.1007/s10238-014-0295-4
更新日期:2015-08-01 00:00:00
abstract::The predominance of the effector mechanisms by CD4 + T cells is a characteristic of inflammatory autoimmune diseases such as rheumatoid arthritis (RA). The CD40/CD40L costimulatory pathway contributes to these pathogenic mechanisms by promoting autoantibody production and inflammation. Aberrant expression of CD40 and ...
journal_title:Clinical and experimental medicine
pub_type: 杂志文章
doi:10.1007/s10238-019-00568-5
更新日期:2019-11-01 00:00:00
abstract::SOCS3 as an important negative regulator of IL6/JAK/STAT3 signaling pathway may be early critical determinants of carcinogenesis. This study aimed to explore the aberrant promoter methylation of SOCS3 gene in circulating DNA as a noninvasive biomarker for screening hepatocellular carcinoma (HCC) high-risk individuals ...
journal_title:Clinical and experimental medicine
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abstract::Macrophage migration inhibitory factor (MIF) has been reported to associate with increased cancer risk in several cancers. However, the role of MIF in breast cancer (BC) susceptibility remains unknown. For the first time, we conducted a case-control study to assess the potential association of three common MIF gene va...
journal_title:Clinical and experimental medicine
pub_type: 杂志文章
doi:10.1007/s10238-016-0439-9
更新日期:2017-08-01 00:00:00
abstract::Triglyceride-rich lipoproteins contain both apolipoproteins E (ApoE) and C-III (ApoC-III), which show opposite functional properties. The relationships between the ApoE (epsilon2/epsilon3/epsilon4) gene polymorphism and ApoC-III/ApoE ratio has never been investigated. A large population (n=552) of cardiovascular patie...
journal_title:Clinical and experimental medicine
pub_type: 杂志文章
doi:10.1007/s10238-007-0142-y
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abstract::Interleukin (IL)-27 is an IL-12 family cytokine and exerts a critical role in immune regulation in the context of infection, autoimmunity, and angiogenesis. In this study, we aimed to investigate the possible pathophysiological role of IL-27 and vascular endothelial growth factor (VEGF) in ankylosing spondylitis (AS)....
journal_title:Clinical and experimental medicine
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doi:10.1007/s10238-014-0281-x
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journal_title:Clinical and experimental medicine
pub_type: 杂志文章,评审
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更新日期:2006-06-01 00:00:00
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journal_title:Clinical and experimental medicine
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doi:10.1007/s10238-020-00656-x
更新日期:2020-08-31 00:00:00
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journal_title:Clinical and experimental medicine
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doi:10.1007/s10238-016-0411-8
更新日期:2017-05-01 00:00:00
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doi:10.1007/s10238-001-8008-1
更新日期:2001-03-01 00:00:00
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journal_title:Clinical and experimental medicine
pub_type: 杂志文章,随机对照试验
doi:10.1007/s10238-018-0510-9
更新日期:2018-11-01 00:00:00
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journal_title:Clinical and experimental medicine
pub_type: 杂志文章
doi:10.1007/s10238-017-0480-3
更新日期:2018-05-01 00:00:00
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journal_title:Clinical and experimental medicine
pub_type: 杂志文章
doi:10.1007/s10238-018-0539-9
更新日期:2019-02-01 00:00:00
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journal_title:Clinical and experimental medicine
pub_type: 杂志文章
doi:10.1007/s10238-010-0113-6
更新日期:2011-06-01 00:00:00
abstract::Familial hypercholesterolaemia is a genetic disorder characterised by high low-density lipoprotein (LDL) cholesterol concentrations, which frequently gives rise to premature coronary artery disease (CAD). The clinical expression of familial hypercholesterolaemia is highly variable even in patients carrying the same LD...
journal_title:Clinical and experimental medicine
pub_type: 杂志文章
doi:10.1007/s10238-005-0086-z
更新日期:2005-12-01 00:00:00
abstract::Tumor markers were used for disease monitoring in small-cell lung cancer patients. The aim of this study was to improve diagnostic efficiency in the detection of tumor progression in small-cell lung cancer patients by using fuzzy logic modeling in combination with a tumor marker panel (NSE, ProGRP, Tumor M2-PK, CYFRA ...
journal_title:Clinical and experimental medicine
pub_type: 杂志文章
doi:10.1007/s102380300005
更新日期:2003-02-01 00:00:00
abstract::Bronchoalveolar lavage (BAL) is a useful procedure for differential diagnosis of interstitial lung diseases (ILDs) and for identification of granulomatous lung diseases. We investigated a panel of biomarkers from BAL fluid of ILD patients to evaluate their utility in differentiating ILDs. Bronchoscopy with BAL was per...
journal_title:Clinical and experimental medicine
pub_type: 杂志文章
doi:10.1007/s10238-020-00608-5
更新日期:2020-05-01 00:00:00
abstract::To establish a serological classification tree model for rheumatoid arthritis (RA), protein/peptide profiles of serum were detected by matrix-assisted laser desorption-ionization time-of-flight mass spectrometry (MALDI-TOF-MS) combined with weak cationic exchange (WCX) from Cohort 1, including 65 patients with RA and ...
journal_title:Clinical and experimental medicine
pub_type: 杂志文章
doi:10.1007/s10238-013-0265-2
更新日期:2015-02-01 00:00:00
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journal_title:Clinical and experimental medicine
pub_type: 杂志文章
doi:10.1007/s10238-009-0030-8
更新日期:2009-06-01 00:00:00
abstract::Behcet's disease is a recurrent multisystem vasculitis that can affect any organ or system, but was originally described as orogenital ulcerations and uveitis. Specific criteria have been proposed for diagnosis and identification of affected organs by different national authorities. Behcet's disease is proposed to be ...
journal_title:Clinical and experimental medicine
pub_type: 杂志文章,评审
doi:10.1007/s10238-004-0045-0
更新日期:2004-12-01 00:00:00
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journal_title:Clinical and experimental medicine
pub_type: 杂志文章
doi:10.1007/s10238-014-0319-0
更新日期:2015-11-01 00:00:00
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journal_title:Clinical and experimental medicine
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doi:10.1007/s10238-019-00551-0
更新日期:2019-05-01 00:00:00
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journal_title:Clinical and experimental medicine
pub_type: 杂志文章,评审
doi:10.1007/s10238-013-0247-4
更新日期:2014-08-01 00:00:00
abstract::Primary biliary cirrhosis (PBC) is a slowly progressive autoimmune disease of unknown mechanism. We established a PBC animal model by injecting C57BL/6 mice with polyinosinic-polycytidylic acid sodium (polyI:C) to investigate the therapeutic effect of bone marrow-derived mesenchymal stem cells (BM-MSC) on this model. ...
journal_title:Clinical and experimental medicine
pub_type: 杂志文章
doi:10.1007/s10238-010-0105-6
更新日期:2011-03-01 00:00:00
abstract::High glucose plays an important role in the pathogenesis of atherosclerosis. In this study, we assessed the effects of high glucose on human umbilical vein endothelial cell (HUVEC) apoptosis. Additionally, we investigated whether alpha-lipoic acid, an antioxidant, prevents high glucose-induced apoptosis of HUVECs. HUV...
journal_title:Clinical and experimental medicine
pub_type: 杂志文章
doi:10.1007/s10238-008-0155-1
更新日期:2008-03-01 00:00:00
abstract::Although the role of cholesterol absorption by the gallbladder epithelium in gallstone formation is well established, the exact process is poorly understood. Potential candidates for regulation of transepithelial cholesterol transport are suggested to be two large membrane multiple ligand receptors, megalin and cubili...
journal_title:Clinical and experimental medicine
pub_type: 杂志文章
doi:10.1007/s10238-008-0174-y
更新日期:2008-09-01 00:00:00
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journal_title:Clinical and experimental medicine
pub_type: 杂志文章
doi:10.1007/s10238-007-0129-8
更新日期:2007-06-01 00:00:00
abstract::Chronic infection with hepatitis C virus (HCV) is a leading cause of liver-related morbidity and mortality throughout the world. Although reliable figures regarding the global prevalence of HCV infection are wanting, it is likely that HCV prevalence will continue to increase. Injection drug use is the most important s...
journal_title:Clinical and experimental medicine
pub_type: 杂志文章,评审
doi:10.1007/s10238-006-0089-4
更新日期:2006-03-01 00:00:00
abstract::B-cell chronic lymphocytic leukemia (B-CLL) is one of the most common leukemias among the elderly and, despite many efforts, still stays incurable. Recent studies point to the microenvironment as the critical factor providing leukemic lymphocytes with pro-survival signals. Thus, the neighboring cells appear to be a pe...
journal_title:Clinical and experimental medicine
pub_type: 杂志文章
doi:10.1007/s10238-013-0268-z
更新日期:2015-02-01 00:00:00
abstract::Arginase activity was measured in serum and biopsy from healthy individuals and colorectal cancer patients. Arginase activity in tumor samples (87 +/- 7.7 U/g tissue) was significantly higher than in controls (40.7 +/- 3.3 U/g tissue). However, serum arginase activity did not show any significant change in both groups...
journal_title:Clinical and experimental medicine
pub_type: 杂志文章
doi:10.1007/s102380200007
更新日期:2002-05-01 00:00:00