Abstract:
:Chronic infection with hepatitis C virus (HCV) is a leading cause of liver-related morbidity and mortality throughout the world. Although reliable figures regarding the global prevalence of HCV infection are wanting, it is likely that HCV prevalence will continue to increase. Injection drug use is the most important source of HCV transmission in the developed world, while unsafe therapeutic injection is an important source of transmission in developing nations. The majority of exposed individuals become chronically infected, of whom 50% develop chronic liver injury. Cirrhosis and hepatocellular carcinoma can arise in those chronically infected over a mean of 20-30 years. Despite this high prevalence and morbidity, recommendations regarding who to screen by antibody testing remain disparate. Quantitative measurement of HCV RNA and HCV genotyping is useful in predicting response to antiviral therapy. Noninvasive methods of detecting liver injury, such as serologic batteries, have not been as informative or predictable as liver biopsy. The current pharmacologic standard of care for chronic HCV infection is the combination of subcutaneous peginterferon and oral ribavirin, which yields sustained virologic response in 54%-56%. Higher rates of SVR are seen in those patients who are infected with HCV genotypes 2 and 3. As intravenous drug use remains the most important source of HCV transmission in the US and Europe, education within this group is an important preventive tool.
journal_name
Clin Exp Medjournal_title
Clinical and experimental medicineauthors
Herrine SK,Rossi S,Navarro VJdoi
10.1007/s10238-006-0089-4subject
Has Abstractpub_date
2006-03-01 00:00:00pages
20-6issue
1eissn
1591-8890issn
1591-9528journal_volume
6pub_type
杂志文章,评审abstract::Endotoxin is known to cause acute lung injury (ALI). Here, we investigated the effects and mechanisms of recombinant human bone morphogenetic protein-2 (rhBMP-2) on pulmonary arteriole remodeling in endotoxin-induced ALI in rats. Sixty Wistar rats were randomly divided into 3 groups (n = 20). Control group was infused...
journal_title:Clinical and experimental medicine
pub_type: 杂志文章
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abstract::It is suggested that gastric mucins, and in particular some specific glycan structures that can act as carbohydrate receptors, are involved in the interactions with Helicobacter pylori adhesins. The main aim of our study was to evaluate glycosylation pattern of glycoproteins of gastric juice before and at the end of e...
journal_title:Clinical and experimental medicine
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doi:10.1007/s10238-010-0113-6
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abstract::Hyperhomocysteinemia is an independent risk factor for vascular disease, frequently observed in patients with severe renal impairment. Hyperhomocysteinemia has never been considered as a possible risk factor in renal artery stenosis. We investigated plasma folate and vitamin B12, methylenetetrahydrofolate reductase (M...
journal_title:Clinical and experimental medicine
pub_type: 杂志文章
doi:10.1007/s102380100005
更新日期:2001-12-01 00:00:00
abstract::Nitric oxide (NO), produced by the nitric oxide synthase (iNOS) enzyme, is the most-important molecule responsible for the killing of Leishmania parasites by macrophages. In previous work we have demonstrated that, after activation with recombinant human interferon-gamma and/or bacterial lipopolysaccharide, human macr...
journal_title:Clinical and experimental medicine
pub_type: 杂志文章
doi:10.1007/s10238-001-8025-0
更新日期:2001-09-01 00:00:00
abstract::Mixed-phenotype acute leukemia (MPAL) is the infrequent type of acute leukemia characterized by immunophenotypic and/or cytochemical features of both lineages, but the diagnosis of this disease still is a challenge. In this study, we analyzed immunophenotyping, cytochemistry and frequency of MPAL patients to better di...
journal_title:Clinical and experimental medicine
pub_type: 杂志文章
doi:10.1007/s10238-018-0520-7
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abstract::The main aim of this study was to investigate the genotoxic effect of combined pharmacotherapy applied in post-operative treatment of cervical cerclage in pregnant women over six days. This study included 19 phenotypically healthy pregnant women in mid-trimester with a diagnosis of cervical insufficiency, mean age 28+...
journal_title:Clinical and experimental medicine
pub_type: 杂志文章
doi:10.1007/s10238-007-0120-4
更新日期:2007-03-01 00:00:00
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journal_title:Clinical and experimental medicine
pub_type: 杂志文章
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更新日期:2020-08-01 00:00:00
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journal_title:Clinical and experimental medicine
pub_type: 杂志文章
doi:10.1007/s10238-001-8014-3
更新日期:2001-06-01 00:00:00
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journal_title:Clinical and experimental medicine
pub_type: 杂志文章
doi:10.1007/s10238-015-0361-6
更新日期:2016-08-01 00:00:00
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更新日期:2019-08-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s10238-008-0010-4
更新日期:2009-03-01 00:00:00
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journal_title:Clinical and experimental medicine
pub_type: 杂志文章
doi:10.1007/s10238-009-0087-4
更新日期:2010-09-01 00:00:00
abstract::Studies have demonstrated cytomegalovirus (CMV) DNA particles in restenotic lesions in atherosclerotic coronary arteries. We have shown that high (>1:800) anti-CMV IgG antibody titers in the serum are associated with active coronary disease and with post coronary angioplasty restenosis. In this study we assessed the a...
journal_title:Clinical and experimental medicine
pub_type: 杂志文章
doi:10.1007/s10238-003-0019-7
更新日期:2003-11-01 00:00:00
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journal_title:Clinical and experimental medicine
pub_type: 杂志文章
doi:10.1007/s10238-016-0444-z
更新日期:2017-11-01 00:00:00
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journal_title:Clinical and experimental medicine
pub_type: 杂志文章
doi:10.1007/s10238-010-0123-4
更新日期:2011-09-01 00:00:00
abstract::Oxidative stress (OS) has recently been documented in hypothyroidism, a disease more prevalent in women. In general, OS is reported to be more prevalent in males. However, the effect of gender on OS and protein glycation in hypothyroidism has not been addressed. Blood samples from 37 recently diagnosed primary hypothy...
journal_title:Clinical and experimental medicine
pub_type: 杂志文章
doi:10.1007/s10238-008-0164-0
更新日期:2008-06-01 00:00:00
abstract::Primary biliary cirrhosis (PBC) is a progressive autoimmune liver disease in which monocytes/macrophages infiltration and skewed T helper type (Th) 1 and Th17 cell responses participate in the development of the disease. Human peripheral blood monocytes are heterogeneous and can be divided into classical CD14highCD16-...
journal_title:Clinical and experimental medicine
pub_type: 杂志文章
doi:10.1007/s10238-015-0381-2
更新日期:2016-11-01 00:00:00
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journal_title:Clinical and experimental medicine
pub_type: 杂志文章
doi:10.1007/s10238-019-00568-5
更新日期:2019-11-01 00:00:00
abstract::TNF-α plays a key role in the inflammatory cytokine cascade involved in the pathogenesis of chronic arthritis, including rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis. Systemic inflammation and the increased production of pro-inflammatory cytokines in these patients may favor the onset of metab...
journal_title:Clinical and experimental medicine
pub_type: 杂志文章,评审
doi:10.1007/s10238-014-0323-4
更新日期:2015-11-01 00:00:00
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journal_title:Clinical and experimental medicine
pub_type: 杂志文章,评审
doi:10.1007/s10238-005-0071-6
更新日期:2005-10-01 00:00:00
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journal_title:Clinical and experimental medicine
pub_type: 杂志文章
doi:10.1007/s10238-015-0352-7
更新日期:2016-08-01 00:00:00
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journal_title:Clinical and experimental medicine
pub_type: 杂志文章
doi:10.1007/s10238-013-0268-z
更新日期:2015-02-01 00:00:00
abstract:OBJECTIVE:Infection of prosthetic material is a major complication of vascular surgery. Therapy for it includes implantation of antimicrobial prostheses bonded with different antimicrobial agents. These agents may, however, induce an acute phase reaction following implantation in the host, thus compromising follow-up o...
journal_title:Clinical and experimental medicine
pub_type: 杂志文章
doi:10.1007/s10238-001-8008-1
更新日期:2001-03-01 00:00:00
abstract::Primary biliary cirrhosis (PBC) is a slowly progressive autoimmune disease of unknown mechanism. We established a PBC animal model by injecting C57BL/6 mice with polyinosinic-polycytidylic acid sodium (polyI:C) to investigate the therapeutic effect of bone marrow-derived mesenchymal stem cells (BM-MSC) on this model. ...
journal_title:Clinical and experimental medicine
pub_type: 杂志文章
doi:10.1007/s10238-010-0105-6
更新日期:2011-03-01 00:00:00
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journal_title:Clinical and experimental medicine
pub_type: 杂志文章
doi:10.1007/s102380200010
更新日期:2002-07-01 00:00:00
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journal_title:Clinical and experimental medicine
pub_type: 杂志文章
doi:10.1007/s10238-010-0116-3
更新日期:2011-06-01 00:00:00
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journal_title:Clinical and experimental medicine
pub_type: 杂志文章
doi:10.1007/s10238-007-0129-8
更新日期:2007-06-01 00:00:00
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journal_title:Clinical and experimental medicine
pub_type: 杂志文章
doi:10.1007/s10238-014-0295-4
更新日期:2015-08-01 00:00:00
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journal_title:Clinical and experimental medicine
pub_type: 杂志文章
doi:10.1007/s10238-008-0174-y
更新日期:2008-09-01 00:00:00
abstract::Common variable immunodeficiency (CVID) is a heterogeneous group of disorders, characterized by hypogammaglobulinemia and increased susceptibility to infections, autoimmunity and malignancies. This study was performed to analyze the Mannose-binding lectin (MBL) polymorphisms in Iranian patients with CVID. Thirty-five ...
journal_title:Clinical and experimental medicine
pub_type: 杂志文章
doi:10.1007/s10238-009-0049-x
更新日期:2009-12-01 00:00:00