Abstract:
:Familial hypercholesterolaemia is a genetic disorder characterised by high low-density lipoprotein (LDL) cholesterol concentrations, which frequently gives rise to premature coronary artery disease (CAD). The clinical expression of familial hypercholesterolaemia is highly variable even in patients carrying the same LDL receptor gene mutation. This variability may be due to environmental and other genetic factors. Apolipoprotein E (Apo-E) has been extensively studied for its effects on the phenotype of familial hypercholesterolaemia. In this study we examined the influence of Apo-E genotype on lipid parameters and the incidence of CAD in 93 Greek patients with familial hypercholesterolaemia. Apo-E E2, E3 and E4 allele frequencies were 0.06, 0.86 and 0.09 respectively. The levels of total cholesterol, LDL cholesterol, HDL cholesterol, triglycerides, apolipoproteins A and B and lipoprotein alpha did not differ significantly among carriers and non-carriers of the E4 allele. The prevalence of CAD and hypertension did not differ either. Our results suggest that the E4 allele is not associated with lipid levels or with the prevalence of CAD among familial hypercholesterolaemia patients of the Greek population.
journal_name
Clin Exp Medjournal_title
Clinical and experimental medicineauthors
Pitsavos C,Choumerianou DM,Skoumas J,Maumus S,Stefanadis C,Dedoussis GV,Visvikis-Siest Sdoi
10.1007/s10238-005-0086-zsubject
Has Abstractpub_date
2005-12-01 00:00:00pages
196-201issue
4eissn
1591-8890issn
1591-9528journal_volume
5pub_type
杂志文章abstract::Many tumor cells express chemokines and chemokine receptors, and these molecules can affect both tumor progression and anti-tumor immune response. Genetic polymorphisms of some chemokine receptors were found to be closely related to malignant tumors, especially in metastasis process, including breast cancer (BC). Cons...
journal_title:Clinical and experimental medicine
pub_type: 杂志文章,评审
doi:10.1007/s10238-015-0342-9
更新日期:2016-05-01 00:00:00
abstract::Interleukin (IL)-27 is an IL-12 family cytokine and exerts a critical role in immune regulation in the context of infection, autoimmunity, and angiogenesis. In this study, we aimed to investigate the possible pathophysiological role of IL-27 and vascular endothelial growth factor (VEGF) in ankylosing spondylitis (AS)....
journal_title:Clinical and experimental medicine
pub_type: 杂志文章
doi:10.1007/s10238-014-0281-x
更新日期:2015-05-01 00:00:00
abstract::Slit2 glycoprotein has been described to regulate the inflammatory response and be involved in autoimmune diseases. Here, we investigated the expression of Slit2 and its potential significance in systemic lupus erythematosus (SLE). A total of 103 patients with SLE participated in our study. The levels of serum Slit2 w...
journal_title:Clinical and experimental medicine
pub_type: 杂志文章
doi:10.1007/s10238-020-00664-x
更新日期:2020-10-20 00:00:00
abstract::Alpha1-adrenoceptor antagonists (alpha1-blockers) are currently used as first-line drugs for the treatment of benign prostatic hyperplasia (BPH). However, cases of BPH are often encountered in which the efficacy of alpha1-blockers decreases and switching to surgical treatment is required. One factor responsible for th...
journal_title:Clinical and experimental medicine
pub_type: 杂志文章
doi:10.1007/s10238-009-0073-x
更新日期:2010-06-01 00:00:00
abstract::Mixed-phenotype acute leukemia (MPAL) is the infrequent type of acute leukemia characterized by immunophenotypic and/or cytochemical features of both lineages, but the diagnosis of this disease still is a challenge. In this study, we analyzed immunophenotyping, cytochemistry and frequency of MPAL patients to better di...
journal_title:Clinical and experimental medicine
pub_type: 杂志文章
doi:10.1007/s10238-018-0520-7
更新日期:2018-11-01 00:00:00
abstract::SOCS3 as an important negative regulator of IL6/JAK/STAT3 signaling pathway may be early critical determinants of carcinogenesis. This study aimed to explore the aberrant promoter methylation of SOCS3 gene in circulating DNA as a noninvasive biomarker for screening hepatocellular carcinoma (HCC) high-risk individuals ...
journal_title:Clinical and experimental medicine
pub_type: 杂志文章
doi:10.1007/s10238-017-0473-2
更新日期:2018-02-01 00:00:00
abstract::Nasopharyngeal carcinoma (NPC) is a very common head and neck cancer in southern china. Despite advances in surgical and chemotherapeutic approaches, its prognosis is still not promising. Hedgehog signaling pathway was reported to be involved in a number of cancers including head and neck. However, it remains unclear ...
journal_title:Clinical and experimental medicine
pub_type: 杂志文章
doi:10.1007/s10238-012-0198-1
更新日期:2013-11-01 00:00:00
abstract::Systemic lupus erythematosus (SLE) is the prototype autoimmune rheumatic disease. The etiology of this disease is incompletely understood; however, environmental factors and genetic predisposition are involved. Cytokine-mediated immunity plays a crucial role in the pathogenesis of SLE. We investigate the association o...
journal_title:Clinical and experimental medicine
pub_type: 杂志文章
doi:10.1007/s10238-014-0315-4
更新日期:2015-11-01 00:00:00
abstract::The present study was initiated to examine whether the concentration of CO in the breath is elevated in patients with inflammatory bowel disease (IBD). Twenty-three clinically stable patients with IBD in the outpatient clinic (11 with Crohn's disease, 12 with ulcerative colitis), who are non-smokers and non-passive sm...
journal_title:Clinical and experimental medicine
pub_type: 杂志文章
doi:10.1007/s10238-007-0129-8
更新日期:2007-06-01 00:00:00
abstract::We have recently found that pigment epithelium-derived factor (PEDF), a glycoprotein with potent neuronal differentiating activity, not only inhibits endothelial cell damage, smooth muscle cell proliferation and platelet aggregation in vitro, but also suppresses occlusive thrombus formation in rats. These observations...
journal_title:Clinical and experimental medicine
pub_type: 杂志文章
doi:10.1007/s10238-008-0010-4
更新日期:2009-03-01 00:00:00
abstract::Pancreatic cancer (PC) is a leading cause of cancer death worldwide, especially in Western societies. Its aggressive nature and poor prognosis increase the need for identifying new and more accurate diagnostic and prognostic tools. We studied 41 patients who had undergone radical surgical resection for PC, investigate...
journal_title:Clinical and experimental medicine
pub_type: 杂志文章
doi:10.1007/s10238-015-0352-7
更新日期:2016-08-01 00:00:00
abstract::Rho-associated coiled-coil-containing protein kinase 2 (ROCK2) has been known as an effector for the small GTPase Rho and plays an important role in tumor progression and metastasis. However, the effect of ROCK2 in gastric cancer (GC) has not been identified. This study showed that ROCK2 expression significantly incre...
journal_title:Clinical and experimental medicine
pub_type: 杂志文章
doi:10.1007/s10238-016-0444-z
更新日期:2017-11-01 00:00:00
abstract::Hyperhomocysteinemia is an independent risk factor for vascular disease, frequently observed in patients with severe renal impairment. Hyperhomocysteinemia has never been considered as a possible risk factor in renal artery stenosis. We investigated plasma folate and vitamin B12, methylenetetrahydrofolate reductase (M...
journal_title:Clinical and experimental medicine
pub_type: 杂志文章
doi:10.1007/s102380100005
更新日期:2001-12-01 00:00:00
abstract::The sensitivity of the alkaline comet assay for the evaluation of baseline and treatment-induced DNA damage in white blood cells of breast cancer patients receiving adjuvant chemotherapy according to three conventional anthracycline- and cyclophosphamide-containing protocols was investigated. Additionally, baseline DN...
journal_title:Clinical and experimental medicine
pub_type: 杂志文章
doi:10.1007/s10238-006-0113-8
更新日期:2006-12-01 00:00:00
abstract::Recently, Th17 cell-associated responses have received growing attention; however, the role of IL-22 (a cytokines also produced by Th17 cells) in the pathogenesis of systemic lupus erythematosus (SLE) has not been widely explored. In this study, we analyze the frequencies of IL-22-positive CD4+/CD8+ T cells in periphe...
journal_title:Clinical and experimental medicine
pub_type: 杂志文章
doi:10.1007/s10238-011-0134-9
更新日期:2011-12-01 00:00:00
abstract::The objective of this study was to compare between the effects of mesenchymal stem cell (MSC) and betamethasone in the treatment of rheumatoid arthritis. Sixty male albino mice were divided equally into 2 models. They are MSC model, group 1: saline control group, group 2: collagen-induced arthritis (CIA), group 3: ind...
journal_title:Clinical and experimental medicine
pub_type: 杂志文章
doi:10.1007/s10238-013-0248-3
更新日期:2014-08-01 00:00:00
abstract::The most important mutation associated with Multiple Endocrine Neoplasia type 2B (MEN 2B) is the change of thymine to cytosine in codon 918 of exon 16 in the RET oncogene (ATG → ACG). The aim of this work was to develop a single oligoarray by using tandem hybridization to detect the T918C/RET mutation for MEN 2B patie...
journal_title:Clinical and experimental medicine
pub_type: 杂志文章
doi:10.1007/s10238-010-0128-z
更新日期:2011-12-01 00:00:00
abstract::Type I interferons are currently used for the treatment of chronic viral hepatitis, multiple sclerosis and several hematological and solid tumors. Side effects are not uncommon, and include multiple alterations in thyroid function, some of which are unrelated to autoimmunity. Review of the literature revealed an overa...
journal_title:Clinical and experimental medicine
pub_type: 杂志文章,评审
doi:10.1007/s10238-004-0026-3
更新日期:2004-04-01 00:00:00
abstract::Apoptosis of the acinar and ductal epithelial cells of the salivary glands has been proposed as a mechanism possibly responsible for the impairment of the secretory function in Sjögren's syndrome, an organ-specific autoimmune disorder characterized by destruction of these glandular structures. The presence of serum au...
journal_title:Clinical and experimental medicine
pub_type: 杂志文章
doi:10.1007/s10238-009-0087-4
更新日期:2010-09-01 00:00:00
abstract::Primary biliary cirrhosis (PBC) is a slowly progressive autoimmune disease of unknown mechanism. We established a PBC animal model by injecting C57BL/6 mice with polyinosinic-polycytidylic acid sodium (polyI:C) to investigate the therapeutic effect of bone marrow-derived mesenchymal stem cells (BM-MSC) on this model. ...
journal_title:Clinical and experimental medicine
pub_type: 杂志文章
doi:10.1007/s10238-010-0105-6
更新日期:2011-03-01 00:00:00
abstract::Catastrophic antiphospholipid syndrome (CAPS) is a rare disorder, characterized by the development of multiple vascular thrombosis over a short period of time, in patients with persistently detectable antiphospholipid antibodies (aPLs). The vascular occlusions predominantly affect small vessels. The overall mortality ...
journal_title:Clinical and experimental medicine
pub_type: 杂志文章
doi:10.1007/s10238-019-00565-8
更新日期:2019-08-01 00:00:00
abstract::Diabetes is one of the most common and challenging health problems. Studies in several nations show that polymorphisms within the transcription factor 7-like 2 genes could be associated with type 2 diabetes (T2D). Therefore, a case-control study was conducted to find the association between SNP rs7903146 and T2D in ou...
journal_title:Clinical and experimental medicine
pub_type: 杂志文章
doi:10.1007/s10238-011-0144-7
更新日期:2012-06-01 00:00:00
abstract::Bronchoalveolar lavage (BAL) is a useful procedure for differential diagnosis of interstitial lung diseases (ILDs) and for identification of granulomatous lung diseases. We investigated a panel of biomarkers from BAL fluid of ILD patients to evaluate their utility in differentiating ILDs. Bronchoscopy with BAL was per...
journal_title:Clinical and experimental medicine
pub_type: 杂志文章
doi:10.1007/s10238-020-00608-5
更新日期:2020-05-01 00:00:00
abstract::B-cell chronic lymphocytic leukemia (B-CLL) is one of the most common leukemias among the elderly and, despite many efforts, still stays incurable. Recent studies point to the microenvironment as the critical factor providing leukemic lymphocytes with pro-survival signals. Thus, the neighboring cells appear to be a pe...
journal_title:Clinical and experimental medicine
pub_type: 杂志文章
doi:10.1007/s10238-013-0268-z
更新日期:2015-02-01 00:00:00
abstract::The aim of this work was to investigate the presence of the RHD gene in fetal cells obtained from amniotic fluid. We studied 65 samples of amniotic fluid, 11 from RhD-negative mothers sensitized with anti-D alloantibodies. The fetal origin of the DNA was confirmed with the analysis of 1 VNTR locus and 3 STR loci in DN...
journal_title:Clinical and experimental medicine
pub_type: 杂志文章
doi:10.1007/s102380200010
更新日期:2002-07-01 00:00:00
abstract::Chronic infection with hepatitis C virus (HCV) is a leading cause of liver-related morbidity and mortality throughout the world. Although reliable figures regarding the global prevalence of HCV infection are wanting, it is likely that HCV prevalence will continue to increase. Injection drug use is the most important s...
journal_title:Clinical and experimental medicine
pub_type: 杂志文章,评审
doi:10.1007/s10238-006-0089-4
更新日期:2006-03-01 00:00:00
abstract::STAT6 transcription factor, which has been implicated in commitment to Th2, is known to be activated by IL-4 and IL-13. Accordingly, STAT6 is primarily responsible for the transcriptional effects of IL-4 and IL-13. STAT6-deficient mice are known to have defective IL-4-mediated functions, such as B cell proliferation, ...
journal_title:Clinical and experimental medicine
pub_type: 杂志文章
doi:10.1007/s10238-009-0083-8
更新日期:2010-09-01 00:00:00
abstract::Previous studies have implicated protective effects of vitamin D on insulin secretion and pancreas beta cell function. The goal of the present study is to determine if a combination therapy of 25-hydroxyvitamin D3 and insulin had any advantage over insulin therapy alone on lipid peroxidation and antioxidant activity i...
journal_title:Clinical and experimental medicine
pub_type: 杂志文章
doi:10.1007/s10238-005-0061-8
更新日期:2005-05-01 00:00:00
abstract::The aim of this study was to discover potential biomarkers for rheumatoid arthritis (RA) using Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry combined with magnetic beads. Proteomic fingerprint technology combining magnetic beads with MALDI-TOF-MS was used to profile and compare the prote...
journal_title:Clinical and experimental medicine
pub_type: 杂志文章
doi:10.1007/s10238-011-0154-5
更新日期:2012-09-01 00:00:00
abstract::The cross-sectional study was conducted to examine hepatic function via liver enzymes/proteins assessments, along with the estimation of an inflammatory response from C-reactive protein (CRP)-which is a liver-synthesized protein. The liver function tests with aspartate aminotransferase (AST), alanine aminotransferase ...
journal_title:Clinical and experimental medicine
pub_type: 杂志文章
doi:10.1007/s10238-017-0462-5
更新日期:2018-02-01 00:00:00