当前位置： SCI文献检索 > CLINICAL AND EXPERIMENTAL MEDICINE期刊下所有文献 > Association of genetic polymorphisms in MIF with breast cancer risk in Chinese women.

Association of genetic polymorphisms in MIF with breast cancer risk in Chinese women.

Abstract：

:Macrophage migration inhibitory factor (MIF) has been reported to associate with increased cancer risk in several cancers. However, the role of MIF in breast cancer (BC) susceptibility remains unknown. For the first time, we conducted a case-control study to assess the potential association of three common MIF gene variants (rs755622, rs1803976, rs11548059) with BC susceptibility in Chinese women. Total 560 breast cancer patients and 583 age- and sex-matched healthy individuals were recruited from Northwest China, and the DNA was genotyped by Sequenom MassARRAY. Odds ratios (OR) and 95% confidence intervals (95% CI) were computed to estimate the associations. We found that C/G, C/C, and C/G-C/C genotype carriers in MIF rs755622 have a significantly increased risk of BC (C/G vs. G/G: OR = 1.36, 95% CI = 1.07-1.75, P = 0.014; C/C vs. GG: OR = 2.01, 95% CI = 1.06-3.79, P = 0.029; C/G-C/C vs. G/G: OR = 1.42 95% CI = 1.11-1.80, P = 0.004). Further analyses indicate that the BC risk is associated with Ki-67 status, and the rs755622 polymorphism increases breast cancer risk among elder patients (≥49 years). There is no association between BC risk and other two polymorphisms (rs1803976 and rs11548059) by overall analysis and stratified analysis. In conclusion, MIF rs755622 polymorphism increases BC susceptibility in Chinese population, especially among elder patients.

journal_name

Clin Exp Med

journal_title

Clinical and experimental medicine

authors

Lin S,Wang M,Liu X,Zhu W,Guo Y,Dai Z,Yang P,Tian T,Dai C,Zheng Y,Hu C,Wei L,Dai Z

doi

10.1007/s10238-016-0439-9

subject

Has Abstract

pub_date

2017-08-01 00:00:00

pages

395-401

issue

3

eissn

1591-8890

issn

1591-9528

pii

10.1007/s10238-016-0439-9

journal_volume

17

pub_type

杂志文章

相关文献

CLINICAL AND EXPERIMENTAL MEDICINE文献大全
  • High mobility group box 1 induces synoviocyte proliferation in rheumatoid arthritis by activating the signal transducer and activator transcription signal pathway.

    abstract：:Recently, it was discovered that high mobility group box chromosomal protein 1 (HMGB1) acts as a potent pro-inflammatory cytokine that is released into the extracellular milieu. Signal transducer and activator of transcription (STAT) proteins play an important role in cytokine signaling. Some investigators have report...

    journal_title：Clinical and experimental medicine

    pub_type： 杂志文章

    doi：10.1007/s10238-010-0116-3

    authors： Guo HF,Liu SX,Zhang YJ,Liu QJ,Hao J,Gao LX

    更新日期：2011-06-01 00:00:00

  • Oxidative stress and protein glycation in primary hypothyroidism. Male/female difference.

    abstract：:Oxidative stress (OS) has recently been documented in hypothyroidism, a disease more prevalent in women. In general, OS is reported to be more prevalent in males. However, the effect of gender on OS and protein glycation in hypothyroidism has not been addressed. Blood samples from 37 recently diagnosed primary hypothy...

    journal_title：Clinical and experimental medicine

    pub_type： 杂志文章

    doi：10.1007/s10238-008-0164-0

    authors： Nanda N,Bobby Z,Hamide A

    更新日期：2008-06-01 00:00:00

  • The acute phase response following implantation of triclosan-bonded vascular prostheses.

    abstract：OBJECTIVE:Infection of prosthetic material is a major complication of vascular surgery. Therapy for it includes implantation of antimicrobial prostheses bonded with different antimicrobial agents. These agents may, however, induce an acute phase reaction following implantation in the host, thus compromising follow-up o...

    journal_title：Clinical and experimental medicine

    pub_type： 杂志文章

    doi：10.1007/s10238-001-8008-1

    authors： Hernandez-Richter TM,Wichmann MW,Schrödl W,Angele MK,Heinritzi K,Schildberg FW

    更新日期：2001-03-01 00:00:00

  • Regulation of mRNA caspase-8 levels by anti-nuclear autoantibodies.

    abstract：:Apoptosis of the acinar and ductal epithelial cells of the salivary glands has been proposed as a mechanism possibly responsible for the impairment of the secretory function in Sjögren's syndrome, an organ-specific autoimmune disorder characterized by destruction of these glandular structures. The presence of serum au...

    journal_title：Clinical and experimental medicine

    pub_type： 杂志文章

    doi：10.1007/s10238-009-0087-4

    authors： Lisi S,Sisto M,Lofrumento D,Frassanito MA,Caprio S,Romano ML,Mitolo V,D'Amore M

    更新日期：2010-09-01 00:00:00

  • Metabolic syndrome and chronic arthritis: effects of anti-TNF-α therapy.

    abstract：:TNF-α plays a key role in the inflammatory cytokine cascade involved in the pathogenesis of chronic arthritis, including rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis. Systemic inflammation and the increased production of pro-inflammatory cytokines in these patients may favor the onset of metab...

    journal_title：Clinical and experimental medicine

    pub_type： 杂志文章,评审

    doi：10.1007/s10238-014-0323-4

    authors： Maruotti N,d'Onofrio F,Cantatore FP

    更新日期：2015-11-01 00:00:00

  • High-resolution melting combines with Bayes discriminant analysis: a novel hepatitis C virus genotyping method.

    abstract：:Current hepatitis C virus (HCV) genotyping techniques are often highly technical, costly, or need improvements in sensitivity and specificity. These limitations indicate the need of novel methods for HCV genotyping. The present study aimed to develop a novel genotyping method combining high-resolution melting (HRM) an...

    journal_title：Clinical and experimental medicine

    pub_type： 杂志文章

    doi：10.1007/s10238-016-0424-3

    authors： Wu D,Fu X,Wen Y,Liu B,Deng Z,Dai L,Tan D

    更新日期：2017-08-01 00:00:00

  • A T-cell-based enzyme-linked immunospot assay for tuberculosis screening in Chinese patients with rheumatic diseases receiving infliximab therapy.

    abstract：:Anti-tumour necrosis factor-α (TNF-α) therapy brought new hopes for treating rheumatic diseases but also increased the risk of infection, including mycobacterium tuberculosis (MTb). Conventional screening tools, such as tuberculin skin test (TST), lack sensitivity or specificity. Recently, T-SPOT.TB has been introduce...

    journal_title：Clinical and experimental medicine

    pub_type： 杂志文章

    doi：10.1007/s10238-010-0123-4

    authors： Xie X,Chen JW,Li F,Tian J,Gao JS,Zhang D

    更新日期：2011-09-01 00:00:00

  • Telomere length in non-neoplastic colonic mucosa in ulcerative colitis (UC) and its relationship to the severe clinical phenotypes.

    abstract：:Telomere shortening occurs with human aging in many organs and tissues and is accelerated by rapid cell turnover and oxidative injury. To clarify the clinical importance of telomere shortening in colonic mucosa in ulcerative colitis (UC), we measured average telomere length using quantitative real-time PCR in non-neop...

    journal_title：Clinical and experimental medicine

    pub_type： 杂志文章

    doi：10.1007/s10238-014-0295-4

    authors： Tahara T,Shibata T,Okubo M,Kawamura T,Sumi K,Ishizuka T,Nakamura M,Nagasaka M,Nakagawa Y,Ohmiya N,Arisawa T,Hirata I

    更新日期：2015-08-01 00:00:00

  • Effect of allogeneic bone marrow-derived mesenchymal stem cells transplantation in a polyI:C-induced primary biliary cirrhosis mouse model.

    abstract：:Primary biliary cirrhosis (PBC) is a slowly progressive autoimmune disease of unknown mechanism. We established a PBC animal model by injecting C57BL/6 mice with polyinosinic-polycytidylic acid sodium (polyI:C) to investigate the therapeutic effect of bone marrow-derived mesenchymal stem cells (BM-MSC) on this model. ...

    journal_title：Clinical and experimental medicine

    pub_type： 杂志文章

    doi：10.1007/s10238-010-0105-6

    authors： Wang D,Zhang H,Liang J,Gu Z,Ma X,Huang J,Lin J,Hou Y,Lu L,Sun L

    更新日期：2011-03-01 00:00:00

  • Cytoplasmic expression of Twist1, an EMT-related transcription factor, is associated with higher grades renal cell carcinomas and worse progression-free survival in clear cell renal cell carcinoma.

    abstract：:Twist1 is a key transcription factor, which confers tumor cells with cancer stem cell (CSC)-like characteristics and enhances epithelial-mesenchymal transition in pathological conditions including tumor malignancy and metastasis. This study aimed to evaluate the expression patterns and clinical significance of Twist1 ...

    journal_title：Clinical and experimental medicine

    pub_type： 杂志文章

    doi：10.1007/s10238-017-0481-2

    authors： Rasti A,Madjd Z,Abolhasani M,Mehrazma M,Janani L,Saeednejad Zanjani L,Asgari M

    更新日期：2018-05-01 00:00:00

  • The expression of cyclin G in nasopharyngeal carcinoma and its significance.

    abstract：:To investigate the expression of cyclin G1, cyclin G2 in nasopharyngeal carcinoma (NPC) cell lines and its significance. The protein expression of cyclin G1, cyclin G2 in NPC cell lines of different differentiation degree (HNE2, CNE1) was detected by indirect immunofluorescence. The mRNA expression of cyclin G1, cycli...

    journal_title：Clinical and experimental medicine

    pub_type： 杂志文章

    doi：10.1007/s10238-011-0142-9

    authors： Ye XX,Liu CB,Chen JY,Tao BH,Zhi-Yi C

    更新日期：2012-03-01 00:00:00

  • Single oligoarray-based detection of specific M918T mutation in RET oncogene in multiple endocrine neoplasia type 2B.

    abstract：:The most important mutation associated with Multiple Endocrine Neoplasia type 2B (MEN 2B) is the change of thymine to cytosine in codon 918 of exon 16 in the RET oncogene (ATG → ACG). The aim of this work was to develop a single oligoarray by using tandem hybridization to detect the T918C/RET mutation for MEN 2B patie...

    journal_title：Clinical and experimental medicine

    pub_type： 杂志文章

    doi：10.1007/s10238-010-0128-z

    authors： Pacheco-Rivera RA,Hernández-Zamora E,González-Yebra B,Beattie K,Maldonado-Rodríguez R,Santiago-Hernández JC,Medrano-Ortiz de Zárate ME,Salcedo M

    更新日期：2011-12-01 00:00:00

  • Synergistic effect of TRAIL and irradiation in elimination of glioblastoma stem-like cells.

    abstract：:Glioblastoma multiforme (GBM) is the most common malignancy in central nervous system. A small subpopulation of GBM cells known as GBM stem-like cells (GSLCs) were supposed to be the most malignant cells among GBM cells as they are resistant to multiple therapies including radiotherapy. In this study, we set up two GS...

    journal_title：Clinical and experimental medicine

    pub_type： 杂志文章

    doi：10.1007/s10238-018-0504-7

    authors： Liu J,Gao Q,Xie T,Liu Y,Luo L,Xu C,Shen L,Wan F,Lei T,Ye F

    更新日期：2018-08-01 00:00:00

  • Early detection of RhD status in pregnancies at risk of hemolytic disease of the newborn.

    abstract：:The aim of this work was to investigate the presence of the RHD gene in fetal cells obtained from amniotic fluid. We studied 65 samples of amniotic fluid, 11 from RhD-negative mothers sensitized with anti-D alloantibodies. The fetal origin of the DNA was confirmed with the analysis of 1 VNTR locus and 3 STR loci in DN...

    journal_title：Clinical and experimental medicine

    pub_type： 杂志文章

    doi：10.1007/s102380200010

    authors： Cotorruelo C,Biondi C,García Borrás S,Di Mónaco R,Racca A

    更新日期：2002-07-01 00:00:00

  • Increased BATF expression is associated with the severity of liver damage in patients with chronic hepatitis B.

    abstract：:T helper (Th) 17 cells have a critical role in the pathogenesis of chronic hepatitis B virus (HBV) infection, and basic leucine zipper transcription factor, ATF-like (BATF) is a newly identified transcriptional factor regulating the differentiation of Th17 cells. However, its precise role in patients with chronic hepa...

    journal_title：Clinical and experimental medicine

    pub_type： 杂志文章

    doi：10.1007/s10238-017-0480-3

    authors： Wang LY,Fan YC,Zhao J,Ji XF,Wang K

    更新日期：2018-05-01 00:00:00

  • Clinical significance of serum miR-768-3p in HBV-related hepatocellular carcinoma and its potential mechanism.

    abstract：:The purpose of this study was to reveal the clinical diagnostic and prognostic value of miR-768-3p in HBV-related HCC and to investigate its effect on the biological function of HCC. Quantitative real-time polymerase chain reaction was used to detect the expression level of miR-768-3p in subjects' serum. The receiver ...

    journal_title：Clinical and experimental medicine

    pub_type： 杂志文章

    doi：10.1007/s10238-020-00646-z

    authors： Cao C,Wang C

    更新日期：2020-11-01 00:00:00

  • Mesenchymal stromal cells versus betamethasone can dampen disease activity in the collagen arthritis mouse model.

    abstract：:The objective of this study was to compare between the effects of mesenchymal stem cell (MSC) and betamethasone in the treatment of rheumatoid arthritis. Sixty male albino mice were divided equally into 2 models. They are MSC model, group 1: saline control group, group 2: collagen-induced arthritis (CIA), group 3: ind...

    journal_title：Clinical and experimental medicine

    pub_type： 杂志文章

    doi：10.1007/s10238-013-0248-3

    authors： El-Denshary ES,Rashed LA,Elhussiny M

    更新日期：2014-08-01 00:00:00

  • Expressions of IL-22 in circulating CD4+/CD8+ T cells and their correlation with disease activity in SLE patients.

    abstract：:Recently, Th17 cell-associated responses have received growing attention; however, the role of IL-22 (a cytokines also produced by Th17 cells) in the pathogenesis of systemic lupus erythematosus (SLE) has not been widely explored. In this study, we analyze the frequencies of IL-22-positive CD4+/CD8+ T cells in periphe...

    journal_title：Clinical and experimental medicine

    pub_type： 杂志文章

    doi：10.1007/s10238-011-0134-9

    authors： Qin WZ,Chen LL,Pan HF,Leng RX,Zhai ZM,Wang C,Li RJ,Wang S,Wang HP,Ye DQ

    更新日期：2011-12-01 00:00:00

  • Association of interleukin-10 promoter haplotypes with disease susceptibility and IL-10 levels in Mexican patients with systemic lupus erythematosus.

    abstract：:Systemic lupus erythematosus (SLE) is the prototype autoimmune rheumatic disease. The etiology of this disease is incompletely understood; however, environmental factors and genetic predisposition are involved. Cytokine-mediated immunity plays a crucial role in the pathogenesis of SLE. We investigate the association o...

    journal_title：Clinical and experimental medicine

    pub_type： 杂志文章

    doi：10.1007/s10238-014-0315-4

    authors： Palafox-Sánchez CA,Oregon-Romero E,Salazar-Camarena DC,Valle YM,Machado-Contreras JR,Cruz A,Orozco-López M,Orozco-Barocio G,Vázquez-Del Mercado M,Muñoz-Valle JF

    更新日期：2015-11-01 00:00:00

  • Imatinib mesylate--gold standards and silver linings.

    abstract：:Imatinib mesylate represents the first of a new generation of molecularly targeted therapies engineered to disrupt signal transduction pathways. It is a tyrosine kinase inhibitor with relatively selective activity against the Abelson (ABL) proto-oncogene, platelet-derived growth factor receptor, and c-KIT receptor. De...

    journal_title：Clinical and experimental medicine

    pub_type： 杂志文章,评审

    doi：10.1007/s10238-004-0032-5

    authors： Peggs K

    更新日期：2004-09-01 00:00:00

  • The effect of combined therapy with ritodrine, erythromycin and verapamil on the frequency of micronuclei in peripheral blood lymphocytes of pregnant women.

    abstract：:The main aim of this study was to investigate the genotoxic effect of combined pharmacotherapy applied in post-operative treatment of cervical cerclage in pregnant women over six days. This study included 19 phenotypically healthy pregnant women in mid-trimester with a diagnosis of cervical insufficiency, mean age 28+...

    journal_title：Clinical and experimental medicine

    pub_type： 杂志文章

    doi：10.1007/s10238-007-0120-4

    authors： Grujicić D,Milosević Djordjević O,Arsenijević S,Marinković D

    更新日期：2007-03-01 00:00:00

  • Administration of pigment epithelium-derived factor prolongs bleeding time by suppressing plasminogen activator inhibitor-1 activity and platelet aggregation in rats.

    abstract：:We have recently found that pigment epithelium-derived factor (PEDF), a glycoprotein with potent neuronal differentiating activity, not only inhibits endothelial cell damage, smooth muscle cell proliferation and platelet aggregation in vitro, but also suppresses occlusive thrombus formation in rats. These observations...

    journal_title：Clinical and experimental medicine

    pub_type： 杂志文章

    doi：10.1007/s10238-008-0010-4

    authors： Yamagishi S,Matsui T,Nakamura K,Takenaka K

    更新日期：2009-03-01 00:00:00

  • New single nucleotide polymorphisms (SNPs) in homologous recombination repair genes detected by microarray analysis in Polish breast cancer patients.

    abstract：:Breast cancer is the most common cause of malignancy and mortality in women worldwide. This study aimed at localising homologous recombination repair (HR) genes and their chromosomal loci and correlating their nucleotide variants with susceptibility to breast cancer. In this study, authors analysed the association bet...

    journal_title：Clinical and experimental medicine

    pub_type： 杂志文章

    doi：10.1007/s10238-016-0441-2

    authors： Romanowicz H,Strapagiel D,Słomka M,Sobalska-Kwapis M,Kępka E,Siewierska-Górska A,Zadrożny M,Bieńkiewicz J,Smolarz B

    更新日期：2017-11-01 00:00:00

  • PDX-1 mRNA-induced reprogramming of mouse pancreas-derived mesenchymal stem cells into insulin-producing cells in vitro.

    abstract：:Pancreatic islet transplantation has remained an effective therapy for type 1 diabetes since 2000. Its widespread use has been prohibited by the shortage of suitable donors. It is critical to explore an applicable alternative for β-cell replacement. This study was performed to generate insulin-producing cells (IPCs) f...

    journal_title：Clinical and experimental medicine

    pub_type： 杂志文章

    doi：10.1007/s10238-014-0319-0

    authors： Guo XR,Wang XL,Li MC,Yuan YH,Chen Y,Zou DD,Bian LJ,Li DS

    更新日期：2015-11-01 00:00:00

  • Upregulation of ROCK2 in gastric cancer cell promotes tumor cell proliferation, metastasis and invasion.

    abstract：:Rho-associated coiled-coil-containing protein kinase 2 (ROCK2) has been known as an effector for the small GTPase Rho and plays an important role in tumor progression and metastasis. However, the effect of ROCK2 in gastric cancer (GC) has not been identified. This study showed that ROCK2 expression significantly incre...

    journal_title：Clinical and experimental medicine

    pub_type： 杂志文章

    doi：10.1007/s10238-016-0444-z

    authors： Li M,Ke J,Wang Q,Qian H,Yang L,Zhang X,Xiao J,Ding H,Shan X,Liu Q,Xiao Y,Bao B,Huang H

    更新日期：2017-11-01 00:00:00

  • Anti-cytomegalovirus (CMV) IgG antibody titer in patients with risk factors to atherosclerosis.

    abstract：:Studies have demonstrated cytomegalovirus (CMV) DNA particles in restenotic lesions in atherosclerotic coronary arteries. We have shown that high (>1:800) anti-CMV IgG antibody titers in the serum are associated with active coronary disease and with post coronary angioplasty restenosis. In this study we assessed the a...

    journal_title：Clinical and experimental medicine

    pub_type： 杂志文章

    doi：10.1007/s10238-003-0019-7

    authors： Blum A,Peleg A,Weinberg M

    更新日期：2003-11-01 00:00:00

  • In vitro autoreactivity against skin in rheumatoid arthritis: are peripheral blood mononuclear cells of patients with rheumatoid arthritis able to lyze autologous keratinocytes?

    abstract：:An in vitro skin explant model was originally developed to predict the occurrence and severity of acute graft-versus-host disease in allogeneic hematopoietic stem cell transplants. In previous studies we reported that peripheral blood mononuclear cells of patients with rheumatoid arthritis were able to induce graft-ve...

    journal_title：Clinical and experimental medicine

    pub_type： 杂志文章

    doi：10.1007/s10238-001-8014-3

    authors： Stechová K,Vavrincová P,Reitzová H,Chudoba D,Zimák J,Hromadníková I

    更新日期：2001-06-01 00:00:00

  • Elevated circulating CD14lowCD16+ monocyte subset in primary biliary cirrhosis correlates with liver injury and promotes Th1 polarization.

    abstract：:Primary biliary cirrhosis (PBC) is a progressive autoimmune liver disease in which monocytes/macrophages infiltration and skewed T helper type (Th) 1 and Th17 cell responses participate in the development of the disease. Human peripheral blood monocytes are heterogeneous and can be divided into classical CD14highCD16-...

    journal_title：Clinical and experimental medicine

    pub_type： 杂志文章

    doi：10.1007/s10238-015-0381-2

    authors： Peng A,Ke P,Zhao R,Lu X,Zhang C,Huang X,Tian G,Huang J,Wang J,Invernizzi P,Chen Q,Zhuang J

    更新日期：2016-11-01 00:00:00

  • The oxidant and antioxidant effects of 25-hydroxyvitamin D3 in liver, kidney and heart tissues of diabetic rats.

    abstract：:Previous studies have implicated protective effects of vitamin D on insulin secretion and pancreas beta cell function. The goal of the present study is to determine if a combination therapy of 25-hydroxyvitamin D3 and insulin had any advantage over insulin therapy alone on lipid peroxidation and antioxidant activity i...

    journal_title：Clinical and experimental medicine

    pub_type： 杂志文章

    doi：10.1007/s10238-005-0061-8

    authors： Noyan T,Balaharoğlu R,Kömüroğlu U

    更新日期：2005-05-01 00:00:00

  • Tumor-resident adenosine-producing mesenchymal stem cells as a potential target for cancer treatment.

    abstract：:The development of new therapies based on tumor biology is one of the main topics in cancer treatment. In this regard, investigating the microenvironment and cellular composition of the tumor is of particular interest. Mesenchymal stem cells (MSCs) are a major group of cells in the tumor tissue and play a critical rol...

    journal_title：Clinical and experimental medicine

    pub_type： 杂志文章,评审

    doi：10.1007/s10238-020-00674-9

    authors： Arab S,Alizadeh A,Asgharzade S

    更新日期：2021-01-23 00:00:00