New single nucleotide polymorphisms (SNPs) in homologous recombination repair genes detected by microarray analysis in Polish breast cancer patients.

abstract：:B-cell chronic lymphocytic leukemia (B-CLL) is one of the most common leukemias among the elderly and, despite many efforts, still stays incurable. Recent studies point to the microenvironment as the critical factor providing leukemic lymphocytes with pro-survival signals. Thus, the neighboring cells appear to be a pe...

journal_title：Clinical and experimental medicine

authors： Filip AA,Ciseł B,Wąsik-Szczepanek E

更新日期：2015-02-01 00:00:00

abstract：:SOCS3 as an important negative regulator of IL6/JAK/STAT3 signaling pathway may be early critical determinants of carcinogenesis. This study aimed to explore the aberrant promoter methylation of SOCS3 gene in circulating DNA as a noninvasive biomarker for screening hepatocellular carcinoma (HCC) high-risk individuals ...

journal_title：Clinical and experimental medicine

authors： Wei L,Huang Y,Zhao R,Zhang J,Liu Q,Liang W,Ding X,Gao B,Li B,Sun C,He J,Yu X,Liu Z,Sun A,Qin Y

更新日期：2018-02-01 00:00:00

abstract：:Recent findings suggest that cell and gene transplantation in the infarcted myocardium may improve heart function. The aim of the study was to investigate the mechanism involved in improving heart function following the co-injection of adipose-derived stem cells (ADSCs) and basic fibroblast growth factor (bFGF) in a r...

journal_title：Clinical and experimental medicine

authors： Wang B,Ma X,Zhao L,Zhou X,Ma Y,Sun H,Yang Y,Chen B

更新日期：2016-11-01 00:00:00

abstract：:High glucose plays an important role in the pathogenesis of atherosclerosis. In this study, we assessed the effects of high glucose on human umbilical vein endothelial cell (HUVEC) apoptosis. Additionally, we investigated whether alpha-lipoic acid, an antioxidant, prevents high glucose-induced apoptosis of HUVECs. HUV...

journal_title：Clinical and experimental medicine

authors： Meng X,Li ZM,Zhou YJ,Cao YL,Zhang J

更新日期：2008-03-01 00:00:00

abstract：:The melphalan-prednisone regimen has been considered as standard therapy for patients with multiple myeloma (MM) for many years. Recently, high-dose chemotherapy with stem-cell support has extended progression-free survival and increased overall survival, and it is now considered conventional therapy in younger patien...

journal_title：Clinical and experimental medicine

authors： Merchionne F,Perosa F,Dammacco F

更新日期：2007-09-01 00:00:00

abstract：:Nasopharyngeal carcinoma (NPC) is a very common head and neck cancer in southern china. Despite advances in surgical and chemotherapeutic approaches, its prognosis is still not promising. Hedgehog signaling pathway was reported to be involved in a number of cancers including head and neck. However, it remains unclear ...

journal_title：Clinical and experimental medicine

authors： Yue Y,Zhong W,Pei G,Xiao B,Zhang G,Jiang F,Zhang J,Chen C,Yang P,Dang H,Chang H

更新日期：2013-11-01 00:00:00

abstract：:Longitudinal studies have improved current diagnostics and management of metabolic associated fatty liver disease (MAFLD) patients by liver biopsy and therapeutic intervention, yet the deficiency of biomarker spectrum for dissecting subtypes largely hinders the symptomatic treatment. We originally enriched serum from ...

journal_title：Clinical and experimental medicine

authors： Yang H,Li Q,Zhang L,Zhu M,Niu J,Xue F,Yang L,Qu Q,Lao Y,Ding Z,Xiao C,Wang K

更新日期：2020-11-01 00:00:00

abstract：:Cancer stem cells (CSCs) are thought to be a major player in tumor initiation, progression, and metastasis. Targeting CSCs for elimination presents a promising therapeutic strategy; however, this approach will require a stronger understanding of CSC biology and identification of CSC-specific markers. The present study...

journal_title：Clinical and experimental medicine

authors： Razi S,Sadeghi A,Asadi-Lari Z,Tam KJ,Kalantari E,Madjd Z

更新日期：2020-09-23 00:00:00

abstract：:Pancreatic islet transplantation has remained an effective therapy for type 1 diabetes since 2000. Its widespread use has been prohibited by the shortage of suitable donors. It is critical to explore an applicable alternative for β-cell replacement. This study was performed to generate insulin-producing cells (IPCs) f...

journal_title：Clinical and experimental medicine

authors： Guo XR,Wang XL,Li MC,Yuan YH,Chen Y,Zou DD,Bian LJ,Li DS

更新日期：2015-11-01 00:00:00

abstract：:The effect of preimmunisation with cancer procoagulant (CP) on the growth of Walker 256 carcinosarcoma cells in Wistar Lew/Han/IMP rats in vivo has been analysed. One group of rats was immunised with CP purified from human amnion-chorion membranes. The rest of the animals (control groups) were injected with 0.9% NaCl ...

journal_title：Clinical and experimental medicine

authors： Kamocka M,Kaplinska K,Mielicki WP

更新日期：2006-10-01 00:00:00

abstract：:Macrophage migration inhibitory factor (MIF) has been reported to associate with increased cancer risk in several cancers. However, the role of MIF in breast cancer (BC) susceptibility remains unknown. For the first time, we conducted a case-control study to assess the potential association of three common MIF gene va...

journal_title：Clinical and experimental medicine

authors： Lin S,Wang M,Liu X,Zhu W,Guo Y,Dai Z,Yang P,Tian T,Dai C,Zheng Y,Hu C,Wei L,Dai Z

更新日期：2017-08-01 00:00:00

abstract：:Many tumor cells express chemokines and chemokine receptors, and these molecules can affect both tumor progression and anti-tumor immune response. Genetic polymorphisms of some chemokine receptors were found to be closely related to malignant tumors, especially in metastasis process, including breast cancer (BC). Cons...

journal_title：Clinical and experimental medicine

authors： Banin-Hirata BK,Losi-Guembarovski R,Oda JM,de Oliveira CE,Campos CZ,Mazzuco TL,Borelli SD,Ceribelli JR,Watanabe MA

更新日期：2016-05-01 00:00:00

abstract：:To evaluate potency and safety of 14-day bismuth-furazolidone quadruple regimens and to compare efficacies of five proton pump inhibitors (PPIs) for the initial eradication of Helicobacter pylori (H. pylori), 175 eligible patients were enrolled and randomly assigned to 14-day quadruple regimens consisting of bismuth (...

journal_title：Clinical and experimental medicine

authors： Chen L,He J,Wang L,Ge Q,Chu H,Chen Y,Chen X,Long Y,Deng Y,He H,Li A,Chen S

更新日期：2018-11-01 00:00:00

abstract：:We retrospectively analyzed the medical history of 19 elderly myeloma patients treated with the "novel subcutaneous formulation of bortezomib." In our experience, two patients (10 %) discontinued treatment for paralytic ileus. The exact pathogenetic mechanisms of toxic megacolon and paralytic ileus due to "novel subcu...

journal_title：Clinical and experimental medicine

authors： Mele G,Coppi MR,Melpignano A,Quarta G

更新日期：2016-02-01 00:00:00

abstract：:Staphylococcus aureus (S. aureus) is the most common bacterium in sepsis and pneumonia involving gram-positive bacteria. Lipoteichoic acid (LTA) is a cell wall component of gram-positive bacteria. It is a potent inducer of inflammatory mediators in human dendritic cells, human pulmonary epithelial cells, and murine ma...

journal_title：Clinical and experimental medicine

authors： Wu BQ,Luo JM,Wang YH,Shi YF,Liu H,Ba JH,Zhang TT

更新日期：2014-05-01 00:00:00

abstract：:The aim of this work was to investigate the presence of the RHD gene in fetal cells obtained from amniotic fluid. We studied 65 samples of amniotic fluid, 11 from RhD-negative mothers sensitized with anti-D alloantibodies. The fetal origin of the DNA was confirmed with the analysis of 1 VNTR locus and 3 STR loci in DN...

journal_title：Clinical and experimental medicine

authors： Cotorruelo C,Biondi C,García Borrás S,Di Mónaco R,Racca A

更新日期：2002-07-01 00:00:00

abstract：:Anti-inflammatory cytokine and its serological detection may have an important role in the process of cardiovascular and cerebrovascular diseases. We investigated whether serum interleukin-10 (IL-10) is associated with cerebral infarction or not in the general population. Identified comprehensive searching was perform...

journal_title：Clinical and experimental medicine

authors： Diao ZY,Wang CL,Qi HS,Jia GY,Yan CZ

更新日期：2016-05-01 00:00:00

abstract：:Apoptosis of the acinar and ductal epithelial cells of the salivary glands has been proposed as a mechanism possibly responsible for the impairment of the secretory function in Sjögren's syndrome, an organ-specific autoimmune disorder characterized by destruction of these glandular structures. The presence of serum au...

journal_title：Clinical and experimental medicine

authors： Lisi S,Sisto M,Lofrumento D,Frassanito MA,Caprio S,Romano ML,Mitolo V,D'Amore M

更新日期：2010-09-01 00:00:00

abstract：:The purpose of this study was to reveal the clinical diagnostic and prognostic value of miR-768-3p in HBV-related HCC and to investigate its effect on the biological function of HCC. Quantitative real-time polymerase chain reaction was used to detect the expression level of miR-768-3p in subjects' serum. The receiver ...

journal_title：Clinical and experimental medicine

authors： Cao C,Wang C

更新日期：2020-11-01 00:00:00

abstract：:To investigate lncRNAs acting as competing endogenous RNAs (ceRNAs) involved in oncogenesis and progression of HCC. Different expressed lncRNAs, microRNAs, and mRNAs (DElncRNAs, DEmiRNAs, DEmRNAs), downloaded from The Cancer Genome Atlas (TCGA) database, were identified by edgeR package. CeRNA network was constructed ...

journal_title：Clinical and experimental medicine

authors： Qu L,Cai X,Xu J,Wei X,Qu X,Sun L,Gong L,Su C,Zhu Y

更新日期：2020-08-01 00:00:00

abstract：:Accurate prediction of the outcome of molecular target-based treatment in advanced renal cell carcinoma (RCC) is an important clinical problem. Positron emission tomography/computed tomography using [18F]-2-fluoro-2-deoxyglucose (FDG PET/CT) is a noninvasive tool for the assessment of glucose accumulation which can be...

journal_title：Clinical and experimental medicine

authors： Pankowska V,Malkowski B,Wedrowski M,Wedrowska E,Roszkowski K

更新日期：2019-02-01 00:00:00

abstract：:Endotoxin is known to cause acute lung injury (ALI). Here, we investigated the effects and mechanisms of recombinant human bone morphogenetic protein-2 (rhBMP-2) on pulmonary arteriole remodeling in endotoxin-induced ALI in rats. Sixty Wistar rats were randomly divided into 3 groups (n = 20). Control group was infused...

journal_title：Clinical and experimental medicine

authors： Wang K,Gong J,Pei L,Shan S,Tan W

更新日期：2013-08-01 00:00:00

abstract：:The cross-sectional study was conducted to examine hepatic function via liver enzymes/proteins assessments, along with the estimation of an inflammatory response from C-reactive protein (CRP)-which is a liver-synthesized protein. The liver function tests with aspartate aminotransferase (AST), alanine aminotransferase ...

journal_title：Clinical and experimental medicine

authors： Shahid S,Masood K

更新日期：2018-02-01 00:00:00

abstract：:Gastrointestinal (GIT) cancers represent the third common cancers worldwide, characterized by rapid progression and higher mortality rate. Matrix metalloproteinases (MMPs) play an important role in cancer metastases. The present study was conducted to estimate and evaluate the role of MMP-7, -9, -10 and -12 and TGF β1...

journal_title：Clinical and experimental medicine

authors： El-Ashmawy NE,Khedr NF,Mansour MG,Al-Ashmawy GM

更新日期：2020-11-01 00:00:00

abstract：:Arginase activity was measured in serum and biopsy from healthy individuals and colorectal cancer patients. Arginase activity in tumor samples (87 +/- 7.7 U/g tissue) was significantly higher than in controls (40.7 +/- 3.3 U/g tissue). However, serum arginase activity did not show any significant change in both groups...

journal_title：Clinical and experimental medicine

authors： del Ara RM,González-Polo RA,Caro A,del Amo E,Palomo L,Hernández E,Soler G,Fuentes JM

更新日期：2002-05-01 00:00:00

abstract：:Triglyceride-rich lipoproteins contain both apolipoproteins E (ApoE) and C-III (ApoC-III), which show opposite functional properties. The relationships between the ApoE (epsilon2/epsilon3/epsilon4) gene polymorphism and ApoC-III/ApoE ratio has never been investigated. A large population (n=552) of cardiovascular patie...

journal_title：Clinical and experimental medicine

authors： Olivieri O,Martinelli N,Bassi A,Trabetti E,Girelli D,Pizzolo F,Friso S,Pignatti PF,Corrocher R

更新日期：2007-12-01 00:00:00

abstract：:Atopic dermatitis (AD) is a chronic, inflammatory skin disease which is characterized by severe pruritus and affects patients' quality of life. In recent years gamma interferon (IFN-gamma) has been accepted as a novel treatment for severe AD, however, its mechanism of action is not clearly identified. Present study ev...

journal_title：Clinical and experimental medicine

authors： Panahi Y,Davoudi SM,Madanchi N,Abolhasani E

更新日期：2012-12-01 00:00:00

abstract：:The predominance of the effector mechanisms by CD4 + T cells is a characteristic of inflammatory autoimmune diseases such as rheumatoid arthritis (RA). The CD40/CD40L costimulatory pathway contributes to these pathogenic mechanisms by promoting autoantibody production and inflammation. Aberrant expression of CD40 and ...

journal_title：Clinical and experimental medicine

authors： Román-Fernández IV,García-Chagollán M,Cerpa-Cruz S,Jave-Suárez LF,Palafox-Sánchez CA,García-Arellano S,Sánchez-Zuno GA,Muñoz-Valle JF

更新日期：2019-11-01 00:00:00

abstract：:The incidence of sepsis-associated acute kidney injury (AKI) is on the rise. Recent studies have found a correlation between antithrombin III and AKI. We established a predictive model for sepsis-associated AKI based on plasma ATIII levels. A prospective study (March 2018-January 2020) was conducted in sepsis patients...

journal_title：Clinical and experimental medicine

authors： Xie Y,Zhang Y,Tian R,Jin W,Du J,Zhou Z,Wang R

更新日期：2020-08-31 00:00:00

abstract：:TNF-α plays a key role in the inflammatory cytokine cascade involved in the pathogenesis of chronic arthritis, including rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis. Systemic inflammation and the increased production of pro-inflammatory cytokines in these patients may favor the onset of metab...

journal_title：Clinical and experimental medicine

authors： Maruotti N,d'Onofrio F,Cantatore FP

更新日期：2015-11-01 00:00:00