Abstract:
:Breast cancer is the most common cause of malignancy and mortality in women worldwide. This study aimed at localising homologous recombination repair (HR) genes and their chromosomal loci and correlating their nucleotide variants with susceptibility to breast cancer. In this study, authors analysed the association between single nucleotide polymorphisms (SNPs) in homologous recombination repair genes and the incidence of breast cancer in the population of Polish women. Blood samples from 94 breast cancer patients were analysed as test group. Individuals were recruited into the study at the Department of Oncological Surgery and Breast Diseases of the Institute of the Polish Mother's Memorial Hospital in Lodz, Poland. Healthy controls (n = 500) were obtained from the Biobank Laboratory, Department of Molecular Biophysics, University of Lodz. Then, DNA of breast cancer patients was compared with one of the disease-free women. The test was supported by microarray analysis. Statistically significant correlations were identified between breast cancer and 3 not described previously SNPs of homologous recombination repair genes BRCA1 and BRCA2: rs59004709, rs4986852 and rs1799950. Further studies on larger groups are warranted to support the hypothesis of correlation between the abovementioned genetic variants and breast cancer risk.
journal_name
Clin Exp Medjournal_title
Clinical and experimental medicineauthors
Romanowicz H,Strapagiel D,Słomka M,Sobalska-Kwapis M,Kępka E,Siewierska-Górska A,Zadrożny M,Bieńkiewicz J,Smolarz Bdoi
10.1007/s10238-016-0441-2subject
Has Abstractpub_date
2017-11-01 00:00:00pages
541-546issue
4eissn
1591-8890issn
1591-9528pii
10.1007/s10238-016-0441-2journal_volume
17pub_type
杂志文章abstract::Cancer stem cells (CSCs) are thought to be a major player in tumor initiation, progression, and metastasis. Targeting CSCs for elimination presents a promising therapeutic strategy; however, this approach will require a stronger understanding of CSC biology and identification of CSC-specific markers. The present study...
journal_title:Clinical and experimental medicine
pub_type: 杂志文章
doi:10.1007/s10238-020-00665-w
更新日期:2020-09-23 00:00:00
abstract::Pancreatic cancer (PC) is a leading cause of cancer death worldwide, especially in Western societies. Its aggressive nature and poor prognosis increase the need for identifying new and more accurate diagnostic and prognostic tools. We studied 41 patients who had undergone radical surgical resection for PC, investigate...
journal_title:Clinical and experimental medicine
pub_type: 杂志文章
doi:10.1007/s10238-015-0352-7
更新日期:2016-08-01 00:00:00
abstract::B-cell chronic lymphocytic leukemia (B-CLL) is one of the most common leukemias among the elderly and, despite many efforts, still stays incurable. Recent studies point to the microenvironment as the critical factor providing leukemic lymphocytes with pro-survival signals. Thus, the neighboring cells appear to be a pe...
journal_title:Clinical and experimental medicine
pub_type: 杂志文章
doi:10.1007/s10238-013-0268-z
更新日期:2015-02-01 00:00:00
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journal_title:Clinical and experimental medicine
pub_type: 杂志文章
doi:10.1007/s10238-007-0129-8
更新日期:2007-06-01 00:00:00
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journal_title:Clinical and experimental medicine
pub_type: 杂志文章
doi:10.1007/s10238-001-8008-1
更新日期:2001-03-01 00:00:00
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journal_title:Clinical and experimental medicine
pub_type: 杂志文章
doi:10.1007/s10238-001-8014-3
更新日期:2001-06-01 00:00:00
abstract:PURPOSE:Exosome-derived long non-coding RNAs (lncRNAs) as novel biomarkers are widely investigated in various cancers, yet results remain controversial. The aim of this meta-analysis was to clarify the diagnostic and prognostic value of exosome-derived lncRNAs in cancer. METHODS:PubMed, Web of Science, EMBASE, CNKI, a...
journal_title:Clinical and experimental medicine
pub_type: 杂志文章,评审
doi:10.1007/s10238-020-00638-z
更新日期:2020-08-01 00:00:00
abstract::The main aim of this study was to investigate the genotoxic effect of combined pharmacotherapy applied in post-operative treatment of cervical cerclage in pregnant women over six days. This study included 19 phenotypically healthy pregnant women in mid-trimester with a diagnosis of cervical insufficiency, mean age 28+...
journal_title:Clinical and experimental medicine
pub_type: 杂志文章
doi:10.1007/s10238-007-0120-4
更新日期:2007-03-01 00:00:00
abstract::T helper (Th) 17 cells have a critical role in the pathogenesis of chronic hepatitis B virus (HBV) infection, and basic leucine zipper transcription factor, ATF-like (BATF) is a newly identified transcriptional factor regulating the differentiation of Th17 cells. However, its precise role in patients with chronic hepa...
journal_title:Clinical and experimental medicine
pub_type: 杂志文章
doi:10.1007/s10238-017-0480-3
更新日期:2018-05-01 00:00:00
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journal_title:Clinical and experimental medicine
pub_type: 杂志文章
doi:10.1007/s10238-010-0113-6
更新日期:2011-06-01 00:00:00
abstract::The identification of chromosome 1 translocations and deletions is a rare and poorly investigated event in chronic lymphocytic leukemia (CLL). Nevertheless, the identification of novel additional molecular alterations is of great interest, opening to new prognostic and therapeutic strategies for such heterogeneous hem...
journal_title:Clinical and experimental medicine
pub_type: 杂志文章
doi:10.1007/s10238-019-00551-0
更新日期:2019-05-01 00:00:00
abstract::Bronchoalveolar lavage (BAL) is a useful procedure for differential diagnosis of interstitial lung diseases (ILDs) and for identification of granulomatous lung diseases. We investigated a panel of biomarkers from BAL fluid of ILD patients to evaluate their utility in differentiating ILDs. Bronchoscopy with BAL was per...
journal_title:Clinical and experimental medicine
pub_type: 杂志文章
doi:10.1007/s10238-020-00608-5
更新日期:2020-05-01 00:00:00
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journal_title:Clinical and experimental medicine
pub_type: 杂志文章
doi:10.1007/s10238-010-0123-4
更新日期:2011-09-01 00:00:00
abstract::Interleukin-17A plays a role in tissue inflammation by inducing release of proinflammatory and neutrophil-mobilizing cytokines. We investigated the association between ulcerative colitis (UC) and polymorphisms of IL17A, rs2275913 (-197 G > A), and rs3748067 (*1249 C > T). The study was performed in 475 healthy subject...
journal_title:Clinical and experimental medicine
pub_type: 杂志文章
doi:10.1007/s10238-012-0206-5
更新日期:2013-11-01 00:00:00
abstract::The purpose of this study was to reveal the clinical diagnostic and prognostic value of miR-768-3p in HBV-related HCC and to investigate its effect on the biological function of HCC. Quantitative real-time polymerase chain reaction was used to detect the expression level of miR-768-3p in subjects' serum. The receiver ...
journal_title:Clinical and experimental medicine
pub_type: 杂志文章
doi:10.1007/s10238-020-00646-z
更新日期:2020-11-01 00:00:00
abstract::Glioblastoma multiforme (GBM) is the most common malignancy in central nervous system. A small subpopulation of GBM cells known as GBM stem-like cells (GSLCs) were supposed to be the most malignant cells among GBM cells as they are resistant to multiple therapies including radiotherapy. In this study, we set up two GS...
journal_title:Clinical and experimental medicine
pub_type: 杂志文章
doi:10.1007/s10238-018-0504-7
更新日期:2018-08-01 00:00:00
abstract::Arginase activity was measured in serum and biopsy from healthy individuals and colorectal cancer patients. Arginase activity in tumor samples (87 +/- 7.7 U/g tissue) was significantly higher than in controls (40.7 +/- 3.3 U/g tissue). However, serum arginase activity did not show any significant change in both groups...
journal_title:Clinical and experimental medicine
pub_type: 杂志文章
doi:10.1007/s102380200007
更新日期:2002-05-01 00:00:00
abstract::Tumor markers were used for disease monitoring in small-cell lung cancer patients. The aim of this study was to improve diagnostic efficiency in the detection of tumor progression in small-cell lung cancer patients by using fuzzy logic modeling in combination with a tumor marker panel (NSE, ProGRP, Tumor M2-PK, CYFRA ...
journal_title:Clinical and experimental medicine
pub_type: 杂志文章
doi:10.1007/s102380300005
更新日期:2003-02-01 00:00:00
abstract::Experimental, epidemiologic, and clinical trial data indicate the antineoplastic effects of calcium and vitamin D in large-bowel neoplasia. The aim of this study was to determine serum levels of vitamin D metabolites and parathormone (PTH) in patients with colorectal cancer (CRC) and to extract conclusions comparing t...
journal_title:Clinical and experimental medicine
pub_type: 杂志文章
doi:10.1007/s10238-009-0069-6
更新日期:2010-03-01 00:00:00
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journal_title:Clinical and experimental medicine
pub_type: 杂志文章
doi:10.1007/s10238-009-0084-7
更新日期:2010-09-01 00:00:00
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journal_title:Clinical and experimental medicine
pub_type: 杂志文章
doi:10.1007/s10238-012-0197-2
更新日期:2013-08-01 00:00:00
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journal_title:Clinical and experimental medicine
pub_type: 杂志文章
doi:10.1007/s10238-016-0411-8
更新日期:2017-05-01 00:00:00
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journal_title:Clinical and experimental medicine
pub_type: 杂志文章
doi:10.1007/s10238-005-0086-z
更新日期:2005-12-01 00:00:00
abstract::Catastrophic antiphospholipid syndrome (CAPS) is a rare disorder, characterized by the development of multiple vascular thrombosis over a short period of time, in patients with persistently detectable antiphospholipid antibodies (aPLs). The vascular occlusions predominantly affect small vessels. The overall mortality ...
journal_title:Clinical and experimental medicine
pub_type: 杂志文章
doi:10.1007/s10238-019-00565-8
更新日期:2019-08-01 00:00:00
abstract::High glucose plays an important role in the pathogenesis of atherosclerosis. In this study, we assessed the effects of high glucose on human umbilical vein endothelial cell (HUVEC) apoptosis. Additionally, we investigated whether alpha-lipoic acid, an antioxidant, prevents high glucose-induced apoptosis of HUVECs. HUV...
journal_title:Clinical and experimental medicine
pub_type: 杂志文章
doi:10.1007/s10238-008-0155-1
更新日期:2008-03-01 00:00:00
abstract::Previous studies have implicated protective effects of vitamin D on insulin secretion and pancreas beta cell function. The goal of the present study is to determine if a combination therapy of 25-hydroxyvitamin D3 and insulin had any advantage over insulin therapy alone on lipid peroxidation and antioxidant activity i...
journal_title:Clinical and experimental medicine
pub_type: 杂志文章
doi:10.1007/s10238-005-0061-8
更新日期:2005-05-01 00:00:00
abstract::Chronic infection with hepatitis C virus (HCV) is a leading cause of liver-related morbidity and mortality throughout the world. Although reliable figures regarding the global prevalence of HCV infection are wanting, it is likely that HCV prevalence will continue to increase. Injection drug use is the most important s...
journal_title:Clinical and experimental medicine
pub_type: 杂志文章,评审
doi:10.1007/s10238-006-0089-4
更新日期:2006-03-01 00:00:00
abstract::The aim of this study was to discover potential biomarkers for rheumatoid arthritis (RA) using Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry combined with magnetic beads. Proteomic fingerprint technology combining magnetic beads with MALDI-TOF-MS was used to profile and compare the prote...
journal_title:Clinical and experimental medicine
pub_type: 杂志文章
doi:10.1007/s10238-011-0154-5
更新日期:2012-09-01 00:00:00
abstract::Common variable immunodeficiency (CVID) is a heterogeneous group of disorders, characterized by hypogammaglobulinemia and increased susceptibility to infections, autoimmunity and malignancies. This study was performed to analyze the Mannose-binding lectin (MBL) polymorphisms in Iranian patients with CVID. Thirty-five ...
journal_title:Clinical and experimental medicine
pub_type: 杂志文章
doi:10.1007/s10238-009-0049-x
更新日期:2009-12-01 00:00:00
abstract::Many tumor cells express chemokines and chemokine receptors, and these molecules can affect both tumor progression and anti-tumor immune response. Genetic polymorphisms of some chemokine receptors were found to be closely related to malignant tumors, especially in metastasis process, including breast cancer (BC). Cons...
journal_title:Clinical and experimental medicine
pub_type: 杂志文章,评审
doi:10.1007/s10238-015-0342-9
更新日期:2016-05-01 00:00:00