Abstract:
:Severe combined immunodeficiencies (SCID) comprise a spectrum of genetic defects that involve both humoral and cellular immunities. Defects in recombinating activating gene 1 (RAG1), RAG2, Artemis, or LIG4 can disrupt V(D)J recombination. Defective V(D)J recombination of the T and B cell receptors is responsible for T(-)B(-)NK(+)SCID. Amorphic mutations in RAG1 and RAG2 cause T(-)B(-)NK(+)SCID, whereas hypomorphic mutations cause an immunodeficency characterized by oligoclonal expansion of TCRgammadelta T cells, severe CMV infection and autoimmunity. First patient is a typical T(-)B(-)NK(+)SCID with clinical and immunologic findings while the second is atypical with normal immunoglobulin levels, CD4 lymphopenia, elevated TCRgammadelta T cells, persistent CMV infection, and autoimmune hemolytic anemia. These cases are presented to emphasize that mutations in RAG1 gene may lead to a diverse spectrum of clinical and immunologic findings while hypomorphic mutations may be related with autoimmunity and refractory CMV infection during infancy.
journal_name
Clin Exp Medjournal_title
Clinical and experimental medicineauthors
Karaca NE,Aksu G,Genel F,Gulez N,Can S,Aydinok Y,Aksoylar S,Karaca E,Altuglu I,Kutukculer Ndoi
10.1007/s10238-009-0053-1subject
Has Abstractpub_date
2009-12-01 00:00:00pages
339-42issue
4eissn
1591-8890issn
1591-9528journal_volume
9pub_type
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journal_title:Clinical and experimental medicine
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journal_title:Clinical and experimental medicine
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journal_title:Clinical and experimental medicine
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journal_title:Clinical and experimental medicine
pub_type: 杂志文章
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journal_title:Clinical and experimental medicine
pub_type: 杂志文章,评审
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journal_title:Clinical and experimental medicine
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更新日期:2007-06-01 00:00:00
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journal_title:Clinical and experimental medicine
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journal_title:Clinical and experimental medicine
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doi:10.1007/s10238-008-0010-4
更新日期:2009-03-01 00:00:00
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journal_title:Clinical and experimental medicine
pub_type: 杂志文章
doi:10.1007/s10238-014-0315-4
更新日期:2015-11-01 00:00:00
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journal_title:Clinical and experimental medicine
pub_type: 临床试验,杂志文章
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journal_title:Clinical and experimental medicine
pub_type: 杂志文章
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journal_title:Clinical and experimental medicine
pub_type: 杂志文章,meta分析
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journal_title:Clinical and experimental medicine
pub_type: 杂志文章
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