Dissociation and sorting out of Drosophila imaginal disc cells.

abstract：:Hedgehog (Hh) signaling is thought to occur in primary cilia, but the molecular basis of Gli2 and Gli3 activation by Hh signaling in cilia is unknown. Similarly, how ciliary gene mutations result in reduced Gli3 processing that generates a repressor is also not clear. Here we show that Hh signaling inhibits Gli2 and G...

journal_title：Developmental biology

authors： Li J,Wang C,Wu C,Cao T,Xu G,Meng Q,Wang B

更新日期：2017-09-01 00:00:00

abstract：:Integrin α5-null embryos die in mid-gestation from severe defects in cardiovascular morphogenesis, which stem from defective development of the neural crest, heart and vasculature. To investigate the role of integrin α5β1 in cardiovascular development, we used the Mesp1(Cre) knock-in strain of mice to ablate integrin ...

journal_title：Developmental biology

authors： Liang D,Wang X,Mittal A,Dhiman S,Hou SY,Degenhardt K,Astrof S

更新日期：2014-11-15 00:00:00

abstract：:Previous work in our laboratory has shown that a 62- to 64-kDa protein was a major component of the perinuclear ring of manchettes fractionated from rat spermatids. Mass spectrometry analysis of this protein indicated the presence of a glycine-rich domain homologous to human keratin 9 (K9). Several antibodies to K9, r...

journal_title：Developmental biology

authors： Mochida K,Rivkin E,Gil M,Kierszenbaum AL

更新日期：2000-11-15 00:00:00

abstract：:In this study, we present evidence that neurogenic cells inhibit the differentiation of cardiogenic cells. When cells of the entire area pellucida at stage 5 were dissociated and reaggregated, the aggregates differentiated into neural tissues and other structures of any germ layer origin, except for heart tissues, des...

journal_title：Developmental biology

authors： Climent S,Sarasa M,Villar JM,Murillo-Ferrol NL

更新日期：1995-09-01 00:00:00

abstract：:Extracellular modulators of cell-cell signaling control numerous aspects of organismal development. The Twisted gastrulation (Twsg1) gene product is a small, secreted cysteine-rich protein that has the unusual property of being able to either enhance or inhibit signaling by the bone morphogenetic protein (BMP) subfami...

journal_title：Developmental biology

authors： Petryk A,Anderson RM,Jarcho MP,Leaf I,Carlson CS,Klingensmith J,Shawlot W,O'Connor MB

更新日期：2004-03-15 00:00:00

abstract：:The protein content of various size follicles was measured in Fundulus heteroclitus and indicated four phases of increase relative to follicle volume: Phases I (previtellogenic; estimated to be less than 0.01 mg/mm3), II (vitellogenic; 0.20 mg/mm3), III (early maturation; 0.03 mg/mm3), and IV (late maturation; 0 mg/mm...

journal_title：Developmental biology

authors： Wallace RA,Selman K

更新日期：1985-08-01 00:00:00

abstract：:A reexamination of the cDNA clones of the Strongylocentrotus purpuratus sea urchin egg receptor for sperm resulted in several important changes to the sequence. By using both rapid amplification of cDNA ends (RACE) and Northern blot analysis for confirmation, the corrected deduced amino acid sequence was shown to lack...

journal_title：Developmental biology

authors： Just ML,Lennarz WJ

更新日期：1997-04-01 00:00:00

abstract：:BMPRIA is a receptor for bone morphogenetic proteins with high affinity for BMP2 and BMP4. Mouse embryos lacking Bmpr1a fail to gastrulate, complicating studies on the requirements for BMP signaling in germ layer development. Recent work shows that BMP4 produced in extraembryonic tissues initiates gastrulation. Here w...

journal_title：Developmental biology

authors： Davis S,Miura S,Hill C,Mishina Y,Klingensmith J

更新日期：2004-06-01 00:00:00

abstract：:In order to further our understanding of the biological role of desmin, the muscle-specific intermediate filament protein, a null mutation in the desmin gene was introduced into the germ line of mice. Despite the complete lack of desmin, these mice developed and reproduced. Since we show that skeletal, cardiac, and sm...

journal_title：Developmental biology

authors： Li Z,Colucci-Guyon E,Pinçon-Raymond M,Mericskay M,Pournin S,Paulin D,Babinet C

更新日期：1996-05-01 00:00:00

abstract：:Stem cells play an essential role in cellular specialization and pattern formation during embryogenesis and in tissue regeneration in adults. This is mainly due to a stem cell's ability to replenish itself (self-renewal) and, at the same time, produce differentiated progeny. Realization of these special stem cell feat...

journal_title：Developmental biology

authors： Zhang J,Li L

更新日期：2005-08-01 00:00:00

abstract：:The distribution of microtubules and microtubule organizing centers in the events leading up to the establishment of the first asymmetric cleavage furrow in nematode embryos was followed using indirect immunofluorescence of antibodies to tubulin. Oocytes arrest in meiotic prophase then undergo two meiotic reduction di...

journal_title：Developmental biology

authors： Albertson DG

更新日期：1984-01-01 00:00:00

abstract：:A mouse mammary epithelial cell line with morphogenetic properties in vivo, Comma-Dbeta, was used to isolate and to characterize mammary progenitor cells. We found that a homogeneous cell population expressing high surface levels of stem cell antigen 1 (Sca-1) was able to give rise in vivo to ductal and alveolar struc...

journal_title：Developmental biology

authors： Deugnier MA,Faraldo MM,Teulière J,Thiery JP,Medina D,Glukhova MA

更新日期：2006-05-15 00:00:00

abstract：:Growth factors and the extracellular matrix have been shown to fulfill vital developmental roles in many embryonic systems. Our hypothesis is that a developmental role played by the extracellular matrix in sea urchins may be the binding of a PDGF-like growth factor to promote signaling activity. We report here that an...

journal_title：Developmental biology

authors： Govindarajan V,Ramachandran RK,George JM,Shakes DC,Tomlinson CR

更新日期：1995-12-01 00:00:00

abstract：:Branching morphogenesis, the process by which cells or tissues generate tree-like networks that function to increase surface area or in contacting multiple targets, is a common developmental motif in multicellular organisms. We use Drosophila tracheal terminal cells, a component of the insect respiratory system, to in...

journal_title：Developmental biology

authors： Jones TA,Nikolova LS,Schjelderup A,Metzstein MM

更新日期：2014-06-01 00:00:00

abstract：:To examine whether the 200-kDa neurofilament protein (200K NFP) is involved in mechanically stabilizing axons, we studied the developmental appearance of immunoreactivity to nonphosphorylated and phosphorylated 200K NFP at the neuromuscular junction. Polyinnervated rat muscle fibers become singly innervated during the...

journal_title：Developmental biology

authors： Donahue SP,Wood JG,English AW

更新日期：1988-11-01 00:00:00

abstract：:Endogenous patterns of retinoic acid (RA) signaling in avian cardiac morphogenesis were characterized by localized expression of a key RA-synthetic enzyme, RALDH2, which displayed a biphasic pattern during heart development. RALDH2 immunoreactivity was initially apparent posterior to Hensen's node of stage 5-6 embryos...

journal_title：Developmental biology

authors： Xavier-Neto J,Shapiro MD,Houghton L,Rosenthal N

更新日期：2000-03-01 00:00:00

abstract：:The development of intrinsic ganglia, comprised of neurons and glia cells that innervate airway smooth muscle, is a recognized component of the growing lung. However, the embryological origin of these neurons and glia is unclear. The lung buds develop as an outgrowth of the foregut, which contains migrating neural cre...

journal_title：Developmental biology

authors： Burns AJ,Delalande JM

更新日期：2005-01-01 00:00:00

abstract：:We have used a subtractive method to clone novel messages enriched in the heart. Here we show that one such message, bves (blood vessel/epicardial substance) is a novel protein that is highly conserved between chicken and mouse. The bves message is detected at high levels in early chick hearts. Using anti-Bves antibod...

journal_title：Developmental biology

authors： Reese DE,Zavaljevski M,Streiff NL,Bader D

更新日期：1999-05-01 00:00:00

abstract：:The origin of the avian cardiovascular system from the primitive streak has been mapped by the construction of quail/chick transplantation chimeras, the use of QH-1 (an antiquail endothelial/endocardial cell marker), and injections of a vital fluorescent dye (DiI) into the primitive streak. Our studies reveal that the...

journal_title：Developmental biology

authors： Garcia-Martinez V,Schoenwolf GC

更新日期：1993-10-01 00:00:00

abstract：:Tube formation is a widespread process during organogenesis. Specific cellular behaviors participate in the invagination of epithelial monolayers that form tubes. However, little is known about the evolutionary mechanisms of cell assembly into tubes during development. In Caenorhabditis elegans, the detailed step-to-s...

journal_title：Developmental biology

authors： Kolotuev I,Podbilewicz B

更新日期：2004-02-15 00:00:00

abstract：:We defined the cellular mechanisms for genesis, migration, and differentiation of the initial population of olfactory bulb (OB) interneurons. This cohort of early generated cells, many of which become postmitotic on embryonic day (E) 14.5, differentiates into a wide range of mature OB interneurons by postnatal day (P)...

journal_title：Developmental biology

authors： Tucker ES,Polleux F,LaMantia AS

更新日期：2006-09-15 00:00:00

abstract：:There is a natural curiosity about how organisms give rise to offspring like themselves through a series of reproducible developmental events and how, once mature, these offspring mate and continue the process giving rise the next generation. In the mid-1800s investigators started using gametes and embryos to explore ...

journal_title：Developmental biology

authors： Ernst SG

更新日期：2011-10-15 00:00:00

abstract：:Tbx18 has been shown to be essential for ureteral development. However, it remains unclear whether it plays a direct role in kidney development. Here we addressed this by focusing on examining the pattern and contribution of Tbx18+ cells in the kidney and its role in kidney vascular development. Expression studies and...

journal_title：Developmental biology

authors： Xu J,Nie X,Cai X,Cai CL,Xu PX

更新日期：2014-07-01 00:00:00

abstract：:In warm-blooded vertebrates it is generally accepted that after early stages of development new neurons are not added to the retina. Contrary to this belief, we show here that hatched chickens have a zone of proliferating cells at the peripheral margin of the retina, similar to that of fish and amphibians. We found th...

journal_title：Developmental biology

authors： Fischer AJ,Reh TA

更新日期：2000-04-15 00:00:00

abstract：:Hes3 belongs to the Hes basic helix-loop-helix family of transcriptional repressors that play central roles in maintaining progenitor cells and regulating binary cell fate decisions in the embryo. During Xenopus laevis development, hes3 is expressed in the embryonic ectoderm in a horseshoe shape domain at the edge of ...

journal_title：Developmental biology

authors： Hong CS,Saint-Jeannet JP

更新日期：2018-10-01 00:00:00

abstract：:Immunocytochemical studies were performed to determine if denervated rodent iris produces nerve growth factor (NGF) in a form chemically similar to that of the 7S NGF complex in mouse submandibular glands. Antisera to the alpha, beta, and gamma subunits of 7S NGF were raised in rabbits and characterized on immunoblots...

journal_title：Developmental biology

authors： Murphy RA,Landis SC,Bernanke J,Siminoski K

更新日期：1986-04-01 00:00:00

abstract：:Early embryonic cells are capable of acquiring numerous developmental fates until they become irreversibly committed to specific lineages depending on intrinsic determinants and/or regional interactions. From fertilization to gastrulation, such pluripotent cells first increase in number and then turn to undergoing dif...

journal_title：Developmental biology

authors： Nakanoh S,Agata K

更新日期：2019-08-15 00:00:00

abstract：:A fundamental feature of cartilage differentiation in the developing limb is the formation of a prechondrogenic cell condensation. An apparently similar process of prechondrogenic cell aggregation occurs in micromass cultures of limb bud mesenchyme with the formation of cellular aggregates which often differentiate in...

journal_title：Developmental biology

authors： Cottrill CP,Archer CW,Wolpert L

更新日期：1987-08-01 00:00:00

abstract：:The murine allantois will become the umbilical artery and vein of the chorioallantoic placenta. In previous studies, growth and differentiation of the allantois had been elucidated in whole embryos. In this study, the extent to which explanted allantoises grow and differentiate outside of the conceptus was investigate...

journal_title：Developmental biology

authors： Downs KM,Temkin R,Gifford S,McHugh J

更新日期：2001-05-15 00:00:00

abstract：:We describe mesendoderm morphogenesis during gastrulation in the frog Xenopus laevis and investigate the mechanics of these movements with tissue explants. When a dorsal marginal zone explant is plated onto fibronectin, the mesendoderm moves away from the dorsal axial tissues as an intact sheet. Mesendodermal cells wi...

journal_title：Developmental biology

authors： Davidson LA,Hoffstrom BG,Keller R,DeSimone DW

更新日期：2002-02-15 00:00:00