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Mucosal immunity: aliment and ailments.

Abstract：

:The development of the primitive gut in the multicellular aquatic eukaryote was driven by the insufficient absorption of nutrients from the oceanic soup. The anatomy of this evolving specialized system invited its colonization by environmental prokaryotes and resulted in the establishment of the intestinal microflora. Innate immunity had previously evolved in gutless organisms such as plants and was fully functional in the gut of invertebrates. On the other hand, adaptive immunity evolved in vertebrates, most probably because of some selective pressure such as the adaptation to a predatory lifestyle. Interestingly, this form of immunity was localized first in their primitive gut. Although the newly generated eukaryote-prokaryote relationship in the gut evolved under mutualistic principles, its symbiotic nature is easily interrupted by extrinsic factors such the composition of the consumed food. Thus, it is argued below that a state of disequilibrium with the microflora (dysbiosis) results in potentially serious immune-related disadvantages to the host.

journal_name

Mucosal Immunol

journal_title

Mucosal immunology

authors

Raz E

doi

10.1038/mi.2009.123

subject

Has Abstract

pub_date

2010-01-01 00:00:00

pages

4-7

issue

1

eissn

1933-0219

issn

1935-3456

pii

mi2009123

journal_volume

3

pub_type

杂志文章

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