Postprandial exercise in type I diabetic patients on multiple daily insulin injection regimen.

Abstract:

:This study shows the influence on plasma glucose concentrations of 45 min of mild exercise (48 +/- 4% of maximum aerobic capacity) performed 180 min after breakfast and 195 min after a subcutaneous injection of regular insulin by six type I (insulin-dependent) diabetic patients on a three-daily insulin injection regimen (regular insulin before breakfast and lunch, regular + intermediate insulin before supper). It has been observed that such exercise does not induce a large plasma glucose decrease. Actually, plasma glucose concentrations were 99 +/- 18 mg/dl before exercise, reached a nadir of 78 +/- 17 mg/dl at 35 min, and were 81 +/- 15 mg/dl at the end of exercise. During the control study at rest, in the same 45-min time interval, plasma glucose decreased from 146 +/- 31 to 128 +/- 31 mg/dl. In the exercise study, one patient began exercising while hypoglycemic, and another patient developed asymptomatic hypoglycemia during exercise. In the control study at rest, one patient showed hypoglycemic glucose concentrations. Throughout the exercise study, plasma free-insulin concentrations decreased (from 32 +/- 5 to 20 +/- 4 microU/ml) as a result of the pharmacokinetics of subcutaneously injected insulin.

journal_name

Diabetes Care

journal_title

Diabetes care

authors

Trovati M,Anfossi G,Vitali S,Mularoni E,Massucco P,De Facis R,Carta Q,Lucchina PG,Emanuelli G

doi

10.2337/diacare.11.2.107

subject

Has Abstract

pub_date

1988-02-01 00:00:00

pages

107-10

issue

2

eissn

0149-5992

issn

1935-5548

journal_volume

11

pub_type

杂志文章
  • Impact of diabetes among revascularized patients in Japan and the U.S.

    abstract:OBJECTIVE:Approximately 25% of patients who undergo percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG) have diabetes, and the diagnosis of diabetes roughly doubles the mortality risk associated with coronary artery disease. However, the impact of diabetes may differ according to ethnicit...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc11-1547

    authors: Kohsaka S,Goto M,Nagai T,Lee VV,Elayda M,Furukawa Y,Fukushima M,Komeda M,Sakata R,Ohsugi M,Fukuda K,Wilson JM,Kita T,Kimura T

    更新日期:2012-03-01 00:00:00

  • Hemoglobin A1c versus oral glucose tolerance test in postpartum diabetes screening.

    abstract:OBJECTIVE:To determine the usefulness of measuring hemoglobin A(1c) (A1C), alone or combined with the fasting glucose test, compared with the oral glucose tolerance test (OGTT) for the reassessment of the carbohydrate metabolism status in postpartum women with a history of gestational diabetes mellitus (GDM). RESEARCH...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc11-2111

    authors: Picón MJ,Murri M,Muñoz A,Fernández-García JC,Gomez-Huelgas R,Tinahones FJ

    更新日期:2012-08-01 00:00:00

  • The Impact of Glycated Hemoglobin (HbA1c) on Cardiovascular Disease Risk: A Mendelian Randomization Study Using UK Biobank.

    abstract:OBJECTIVE:Glycated hemoglobin (HbA1c) is positively associated with cardiovascular disease (CVD), although evidence is primarily observational. Mendelian randomization studies have only examined its relation with subtypes of CVD. We examined the relation of HbA1c with CVD and its subtypes in the UK Biobank using Mendel...

    journal_title:Diabetes care

    pub_type: 杂志文章,meta分析

    doi:10.2337/dc18-0289

    authors: Au Yeung SL,Luo S,Schooling CM

    更新日期:2018-09-01 00:00:00

  • Intranasal glucagon as remedy for hypoglycemia. Studies in healthy subjects and type I diabetic patients.

    abstract::Intranasal glucagon can raise blood glucose levels in healthy subjects. The aims of this study were to 1) compare the hyperglycemic effect of intranasal and intramuscular glucagon in healthy subjects and type I (insulin-dependent) diabetes patients during euglycemic conditions and 2) test the efficacy of intranasal an...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章

    doi:10.2337/diacare.12.9.604

    authors: Pontiroli AE,Calderara A,Pajetta E,Alberetto M,Pozza G

    更新日期:1989-10-01 00:00:00

  • Oral disposition index predicts the development of future diabetes above and beyond fasting and 2-h glucose levels.

    abstract:OBJECTIVE:We sought to determine whether an oral disposition index (DI(O)) predicts the development of diabetes over a 10-year period. First, we assessed the validity of the DI(O) by demonstrating that a hyperbolic relationship exists between oral indexes of insulin sensitivity and beta-cell function. RESEARCH DESIGN ...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc08-1478

    authors: Utzschneider KM,Prigeon RL,Faulenbach MV,Tong J,Carr DB,Boyko EJ,Leonetti DL,McNeely MJ,Fujimoto WY,Kahn SE

    更新日期:2009-02-01 00:00:00

  • Long-term metabolic and immunological follow-up of nonimmunosuppressed patients with type 1 diabetes treated with microencapsulated islet allografts: four cases.

    abstract:OBJECTIVE:To assess long-term metabolic and immunological follow-up of microencapsulated human islet allografts in nonimmunosuppressed patients with type 1 diabetes (T1DM). RESEARCH DESIGN AND METHODS:Four nonimmunosuppressed patients, with long-standing T1DM, received intraperitoneal transplant (TX) of microencapsula...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc11-0731

    authors: Basta G,Montanucci P,Luca G,Boselli C,Noya G,Barbaro B,Qi M,Kinzer KP,Oberholzer J,Calafiore R

    更新日期:2011-11-01 00:00:00

  • Insufficient control of blood pressure and incident diabetes.

    abstract:OBJECTIVE:Incidence of type 2 diabetes might be associated with preexisting hypertension. There is no information on whether incident diabetes is predicted by blood pressure control. We evaluated the hazard of diabetes in relation to blood pressure control in treated hypertensive patients. RESEARCH DESIGN AND METHODS:...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc08-1881

    authors: Izzo R,de Simone G,Chinali M,Iaccarino G,Trimarco V,Rozza F,Giudice R,Trimarco B,De Luca N

    更新日期:2009-05-01 00:00:00

  • Twenty-Year Progression Rate to Clinical Onset According to Autoantibody Profile, Age, and HLA-DQ Genotype in a Registry-Based Group of Children and Adults With a First-Degree Relative With Type 1 Diabetes.

    abstract:OBJECTIVE:We investigated whether islet autoantibody profile, HLA-DQ genotype, and age influenced a 20-year progression to diabetes from first autoantibody positivity (autoAb+) in first-degree relatives of patients with type 1 diabetes. RESEARCH DESIGN AND METHODS:Persistently islet autoAb+ siblings and offspring (n =...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc16-2228

    authors: Gorus FK,Balti EV,Messaaoui A,Demeester S,Van Dalem A,Costa O,Dorchy H,Mathieu C,Van Gaal L,Keymeulen B,Pipeleers DG,Weets I,Belgian Diabetes Registry.

    更新日期:2017-08-01 00:00:00

  • Sodium-Glucose Cotransporter Inhibitors: Effects on Renal and Intestinal Glucose Transport: From Bench to Bedside.

    abstract::Type 2 diabetes is a chronic disease with disabling micro- and macrovascular complications that lead to excessive morbidity and premature mortality. It affects hundreds of millions of people and imposes an undue economic burden on populations across the world. Although insulin resistance and insulin secretory defects ...

    journal_title:Diabetes care

    pub_type: 杂志文章,评审

    doi:10.2337/dc15-0642

    authors: Mudaliar S,Polidori D,Zambrowicz B,Henry RR

    更新日期:2015-12-01 00:00:00

  • Reciprocal association of plasma IGF-1 and interleukin-6 levels with cardiometabolic risk factors in nondiabetic subjects.

    abstract:OBJECTIVE:To examine the relationship between plasma IGF-1 and interleukin-6 (IL-6) levels in Caucasian nondiabetic subjects and evaluate the association of IGF-1 and IL-6 with the cardiometabolic risk factors characterizing metabolic syndrome (MetS). RESEARCH DESIGN AND METHODS:The study group consisted of 186 Caucas...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc08-0553

    authors: Succurro E,Andreozzi F,Sciacqua A,Hribal ML,Perticone F,Sesti G

    更新日期:2008-09-01 00:00:00

  • Reduction in carotid intima-media thickness after pancreatic islet transplantation in patients with type 1 diabetes.

    abstract:OBJECTIVE:Determine the impact of islet transplantation on carotid intima-media thickness (CIMT), a marker for atherosclerosis, in type 1 diabetes without kidney disease. RESEARCH DESIGN AND METHODS:Consecutive case series of 15 adults (mean age [SD], 49 years [10 years]; 87% female) with type 1 diabetes for ≥5 years ...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc12-0679

    authors: Danielson KK,Hatipoglu B,Kinzer K,Kaplan B,Martellotto J,Qi M,Mele A,Benedetti E,Oberholzer J

    更新日期:2013-02-01 00:00:00

  • Heterogeneity of patients with latent autoimmune diabetes in adults: linkage to autoimmunity is apparent only in those with perceived need for insulin treatment: results from the Nord-Trøndelag Health (HUNT) study.

    abstract:OBJECTIVE:Subjects with the diagnosis of latent autoimmune diabetes in adults (LADA) are more prone to need insulin treatment than those with type 2 diabetes. However, not all patients with LADA develop the need for insulin treatment, indicating the heterogeneity of LADA. We investigated this heterogeneity by comparing...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc08-1468

    authors: Radtke MA,Midthjell K,Nilsen TI,Grill V

    更新日期:2009-02-01 00:00:00

  • Can new-onset diabetes after kidney transplant be prevented?

    abstract::Because the negative consequences of new-onset diabetes mellitus after transplantation (NODAT) diminish the significant gains of kidney transplantation, it is imperative to develop clinical interventions to reduce the incidence of NODAT. In this review, we discuss whether intensive lifestyle interventions that delay o...

    journal_title:Diabetes care

    pub_type: 杂志文章,评审

    doi:10.2337/dc12-2067

    authors: Chakkera HA,Weil EJ,Pham PT,Pomeroy J,Knowler WC

    更新日期:2013-05-01 00:00:00

  • Circulating visfatin is associated with parameters of iron metabolism in subjects with altered glucose tolerance.

    abstract:OBJECTIVE:Visfatin is a novel adipokine that is predominantly secreted by visceral adipose tissue. Accumulation of visceral adipose tissue is also associated with iron metabolism. Despite the coincidence of visfatin expression in iron-rich tissues, no study has investigated the possible interaction of visfatin with par...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc06-1581

    authors: Fernández-Real JM,Moreno JM,Chico B,López-Bermejo A,Ricart W

    更新日期:2007-03-01 00:00:00

  • Apolipoprotein E polymorphism as a risk factor for vascular disease in diabetic patients.

    abstract:OBJECTIVE:To examine the prevalence of cardiovascular disease in diabetic patients as a function of apolipoprotein (apo) E polymorphism. RESEARCH DESIGN AND METHODS:The apo E phenotypes and plasma lipid, lipoprotein, and apo levels were determined for 517 Italian diabetic patients. The prevalence of cardiovascular dis...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.18.4.504

    authors: Boemi M,Sirolla C,Amadio L,Fumelli P,Pometta D,James RW

    更新日期:1995-04-01 00:00:00

  • Is pancreatic diabetes (type 3c diabetes) underdiagnosed and misdiagnosed?

    abstract::Exocrine pancreatic insufficiency is frequently associated with diabetes, with high prevalence in both insulin-dependent or insulin-independent patients. Exocrine pancreatic failure has often been perceived as a complication of diabetes. In contrast, recent clinical observations lead to the notion that nonendocrine pa...

    journal_title:Diabetes care

    pub_type: 杂志文章,评审

    doi:10.2337/dc08-s244

    authors: Hardt PD,Brendel MD,Kloer HU,Bretzel RG

    更新日期:2008-02-01 00:00:00

  • Improving the comparability of diabetes mortality statistics in the U.S. and Mexico.

    abstract:OBJECTIVE:The aim of this study was to increase the cross-state comparability of diabetes mortality statistics related in the U.S. and Mexico. RESEARCH DESIGN AND METHODS:We used multinomial logistic regression to estimate the effects of individual and community factors on a death for which diabetes was recorded as on...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc07-1370

    authors: Murray CJ,Dias RH,Kulkarni SC,Lozano R,Stevens GA,Ezzati M

    更新日期:2008-03-01 00:00:00

  • Predictors of glycemic control in insulin-using adults with type 2 diabetes.

    abstract:OBJECTIVE:To determine the characteristics that influence glycemic control among insulin-using adults with type 2 diabetes. RESEARCH DESIGN AND METHODS:We studied all 1,333 eligible members of a large not-for-profit health maintenance organization who responded to a 1997 survey. We tested associations among demographi...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.23.3.273

    authors: Nichols GA,Hillier TA,Javor K,Brown JB

    更新日期:2000-03-01 00:00:00

  • Impaired fasting plasma glucose and type 2 diabetes are related to the risk of out-of-hospital sudden cardiac death and all-cause mortality.

    abstract:OBJECTIVE:The aim of the study was to determine whether impaired fasting plasma glucose (FPG) and type 2 diabetes may be risk factors for sudden cardiac death (SCD). RESEARCH DESIGN AND METHODS:This prospective study was based on 2,641 middle-aged men 42-60 years of age at baseline. Impaired FPG level (≥5.6 mmol/L) am...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc12-0110

    authors: Laukkanen JA,Mäkikallio TH,Ronkainen K,Karppi J,Kurl S

    更新日期:2013-05-01 00:00:00

  • Cost-effectiveness of surgically induced weight loss for the management of type 2 diabetes: modeled lifetime analysis.

    abstract:OBJECTIVE:To estimate the cost-effectiveness of surgically induced weight loss relative to conventional therapy for the management of recently diagnosed type 2 diabetes in class I/II obese patients. RESEARCH DESIGN AND METHODS:This study builds on a within-trial cost-efficacy analysis. The analysis compares the lifeti...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc08-1749

    authors: Keating CL,Dixon JB,Moodie ML,Peeters A,Bulfone L,Maglianno DJ,O'Brien PE

    更新日期:2009-04-01 00:00:00

  • Ginseng therapy in non-insulin-dependent diabetic patients.

    abstract:OBJECTIVE:To investigate the effect of ginseng on newly diagnosed non-insulin-dependent diabetes mellitus (NIDDM) patients. RESEARCH DESIGN AND METHODS:In this double-blind placebo-controlled study, 36 NIDDM patients were treated for 8 weeks with ginseng (100 or 200 mg) or placebo. Efficacy was evaluated with psychoph...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.2337/diacare.18.10.1373

    authors: Sotaniemi EA,Haapakoski E,Rautio A

    更新日期:1995-10-01 00:00:00

  • Atherosclerotic vascular disease and its risk factors in non-insulin-dependent diabetic and nondiabetic subjects in Finland.

    abstract::A cross-sectional study on the prevalence of atherosclerotic vascular disease (ASVD) and its risk factors in non-insulin-dependent diabetic and nondiabetic subjects was carried out from 1982 to 1984 in East Finland (Kuopio) and West Finland (Turku), two areas known to differ markedly in prevalence of ASVD in the nondi...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.11.6.449

    authors: Laakso M,Rönnemaa T,Pyörälä K,Kallio V,Puukka P,Penttilä I

    更新日期:1988-06-01 00:00:00

  • Can self-rated health scores be used for risk prediction in patients with type 2 diabetes?

    abstract:OBJECTIVE:To investigate whether self-rated health profiles compiled using the EuroQol group's visual analog scale (EQ VAS) are independent predictors of vascular events and major complications in people with type 2 diabetes after controlling for standard clinical risk factors. RESEARCH DESIGN AND METHODS:The study is...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc07-1391

    authors: Hayes AJ,Clarke PM,Glasziou PG,Simes RJ,Drury PL,Keech AC

    更新日期:2008-04-01 00:00:00

  • HOMA-estimated insulin resistance is an independent predictor of cardiovascular disease in type 2 diabetic subjects: prospective data from the Verona Diabetes Complications Study.

    abstract:OBJECTIVE:To evaluate whether homeostasis model assessment-estimated insulin resistance (HOMA-IR) is an independent predictor of cardiovascular disease (CVD) in type 2 diabetes. RESEARCH DESIGN AND METHODS:Conventional CVD risk factors (sex, age, smoking, plasma lipids, blood pressure, and metabolic control) and insul...

    journal_title:Diabetes care

    pub_type: 杂志文章,多中心研究

    doi:10.2337/diacare.25.7.1135

    authors: Bonora E,Formentini G,Calcaterra F,Lombardi S,Marini F,Zenari L,Saggiani F,Poli M,Perbellini S,Raffaelli A,Cacciatori V,Santi L,Targher G,Bonadonna R,Muggeo M

    更新日期:2002-07-01 00:00:00

  • Why do low-fat high-carbohydrate diets accentuate postprandial lipemia in patients with NIDDM?

    abstract:OBJECTIVE:To understand why low-fat high-carbohydrate (CHO) diets lead to higher fasting and postprandial concentrations of triglyceride (TG)-rich lipoproteins in patients with non-insulin-dependent diabetes mellitus (NIDDM). RESEARCH DESIGN AND METHODS:Patients with NIDDM were placed randomly on diets containing eith...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.2337/diacare.18.1.10

    authors: Chen YD,Coulston AM,Zhou MY,Hollenbeck CB,Reaven GM

    更新日期:1995-01-01 00:00:00

  • Temporal validation of the UKPDS outcomes model using 10-year posttrial monitoring data.

    abstract:OBJECTIVE:To evaluate the accuracy of the UK Prospective Diabetes Study Outcomes Model (UKPDS-OM) in predicting clinical outcomes during the UKPDS posttrial monitoring (PTM) period. RESEARCH DESIGN AND METHODS:At trial end in 1997, the 4,031 surviving UKPDS patients, of the 5,102 originally enrolled in the study, retu...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc12-1120

    authors: Leal J,Hayes AJ,Gray AM,Holman RR,Clarke PM

    更新日期:2013-06-01 00:00:00

  • Collaborative care management of major depression among low-income, predominantly Hispanic subjects with diabetes: a randomized controlled trial.

    abstract:OBJECTIVE:To determine whether evidence-based socioculturally adapted collaborative depression care improves receipt of depression care and depression and diabetes outcomes in low-income Hispanic subjects. RESEARCH DESIGN AND METHODS:This was a randomized controlled trial of 387 diabetic patients (96.5% Hispanic) with...

    journal_title:Diabetes care

    pub_type: 杂志文章,随机对照试验

    doi:10.2337/dc09-1711

    authors: Ell K,Katon W,Xie B,Lee PJ,Kapetanovic S,Guterman J,Chou CP

    更新日期:2010-04-01 00:00:00

  • Effects of BAYm 1099, new alpha-glucosidase inhibitor, on acute metabolic responses and metabolic control in NIDDM over 1 mo.

    abstract::To examine the clinical role of BAYm 1099, 15 diet-treated non-insulin-dependent diabetic (NIDDM) subjects were randomized to start drug (50 mg 3 times/day) or placebo after a 4-wk run-in period in a double-blind crossover study. Treatment periods (4 wk) were separated by a 2-wk washout period. During the last week of...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.2337/diacare.11.4.337

    authors: Samad AH,Ty Willing TS,Alberti KG,Taylor R

    更新日期:1988-04-01 00:00:00

  • Role of liver in pathophysiology of NIDDM.

    abstract::Glucose homeostasis is physiologically maintained by the balance between glucose production by the liver and glucose utilization by the peripheral tissues. Insulin controls hepatic glucose production and promotes glucose utilization by the skeletal muscle. In non-insulin-dependent diabetes mellitus (NIDDM), postabsorp...

    journal_title:Diabetes care

    pub_type: 杂志文章,评审

    doi:10.2337/diacare.15.3.430

    authors: Consoli A

    更新日期:1992-03-01 00:00:00

  • Changes in inflammatory cytokines are related to impaired glucose tolerance in offspring of type 2 diabetic subjects.

    abstract:OBJECTIVE:We sought to determine whether levels of inflammatory markers and different cytokines are abnormal in nondiabetic offspring of type 2 diabetic subjects. RESEARCH DESIGN AND METHODS:Cytokine levels were measured in 19 healthy control subjects and 129 offspring of patients with type 2 diabetes (109 with normal...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc06-0147

    authors: Ruotsalainen E,Salmenniemi U,Vauhkonen I,Pihlajamäki J,Punnonen K,Kainulainen S,Laakso M

    更新日期:2006-12-01 00:00:00