Intranasal glucagon as remedy for hypoglycemia. Studies in healthy subjects and type I diabetic patients.

abstract：OBJECTIVE:We sought to ascertain quality-of-life measures and utility values associated with visual acuity in type 2 diabetes. RESEARCH DESIGN AND METHODS:The Medical Outcome Study Short Form with 36 items (SF-36) was administered to 4,051 individuals with type 2 diabetes who were enrolled in the Lipids in Diabetes St...

journal_title：Diabetes care

authors： Clarke PM,Simon J,Cull CA,Holman RR

更新日期：2006-07-01 00:00:00

abstract：:To assess the possible value of the use of high-purity pork insulin (HPPI) in the United States, the serum insulin (I), pancreatic polypeptide (PP), glucagon (G), and somatostatin (SRIF) antibody binding characteristics have been determined in 90 conventional insulin-treated diabetic subjects and related to their degr...

journal_title：Diabetes care

authors： Asplin CM,Hollander P,Pecoraro RE,Brodsky J,Palmer JP

更新日期：1981-05-01 00:00:00

abstract：OBJECTIVE:To longitudinally characterize changes in insulin sensitivity in obese women during and after pregnancy. RESEARCH DESIGN AND METHODS:Six glucose-tolerant obese women underwent a 4-h euglycemic-hyperinsulinemic (500-600 pmol/l) clamping during the second (22.5 +/- 2 weeks [mean +/- SD]) and third trimester (3...

journal_title：Diabetes care

authors： Sivan E,Chen X,Homko CJ,Reece EA,Boden G

更新日期：1997-09-01 00:00:00

abstract：OBJECTIVE:To understand why low-fat high-carbohydrate (CHO) diets lead to higher fasting and postprandial concentrations of triglyceride (TG)-rich lipoproteins in patients with non-insulin-dependent diabetes mellitus (NIDDM). RESEARCH DESIGN AND METHODS:Patients with NIDDM were placed randomly on diets containing eith...

journal_title：Diabetes care

authors： Chen YD,Coulston AM,Zhou MY,Hollenbeck CB,Reaven GM

更新日期：1995-01-01 00:00:00

abstract：OBJECTIVE:The decline in C-peptide in the 5 years after diagnosis of type 1 diabetes has been well studied, but little is known about the longer-term trajectory. We aimed to examine the association between log-transformed C-peptide levels and the duration of diabetes up to 40 years after diagnosis. RESEARCH DESIGN AND...

journal_title：Diabetes care

authors： Shields BM,McDonald TJ,Oram R,Hill A,Hudson M,Leete P,Pearson ER,Richardson SJ,Morgan NG,Hattersley AT,TIGI Consortium.

更新日期：2018-07-01 00:00:00

abstract：:The purpose of the study was to assess the value of 24-h urinary estriols in the management of diabetic pregnancies. Twenty-seven pregnant diabetic patients (White's class B through R) received insulin dosages twice daily as a combination of NPH and regular insulin. Laboratory and home monitored blood glucose was main...

journal_title：Diabetes care

authors： Fern PE,Grunert GM,Lewis SB

更新日期：1982-05-01 00:00:00

abstract：OBJECTIVE:To understand the interrelationship of coronary artery disease (CAD) risk factors including hyperlipidemia, hypertension, and glucose intolerance to prevent and better manage this disease. RESEARCH DESIGN AND METHODS:We performed a 100-g oral glucose tolerance test in 2,113 subjects, and we evaluated their p...

journal_title：Diabetes care

authors： Yamada N,Yoshinaga H,Sakurai N,Shimano H,Gotoda T,Ohashi Y,Yazaki Y,Kosaka K

更新日期：1994-02-01 00:00:00

abstract：OBJECTIVE:To evaluate the hospital care rendered to hyperglycemic individuals who did not have a diagnosis of diabetes before admission. RESEARCH DESIGN AND METHODS:A total of 1,034 consecutively hospitalized adult patients at a 750-bed inner-city teaching hospital were evaluated. Patients with one or more plasma gluc...

journal_title：Diabetes care

authors： Levetan CS,Passaro M,Jablonski K,Kass M,Ratner RE

更新日期：1998-02-01 00:00:00

abstract：OBJECTIVE:This multicenter open-label clinical trial compared the efficacy and safety of repaglinide/troglitazone combination therapy, repaglinide monotherapy, and troglitazone monotherapy in type 2 diabetes that had been inadequately controlled by sulfonylureas, acarbose, or metformin alone. RESEARCH DESIGN AND METHO...

journal_title：Diabetes care

authors： Raskin P,Jovanovic L,Berger S,Schwartz S,Woo V,Ratner R

更新日期：2000-07-01 00:00:00

abstract：OBJECTIVE:Independent association of chronic kidney disease (CKD) and proliferative diabetic retinopathy (PDR) with cardiovascular disease (CVD) has not been established. In the Joslin 50-Year Medalist study, characterizing individuals with type 1 diabetes for 50 years or more, we examined the associations of CKD and P...

journal_title：Diabetes care

authors： Gordin D,Harjutsalo V,Tinsley L,Fickweiler W,Sun JK,Forsblom C,Amenta PS,Pober D,D'Eon S,Khatri M,Stillman IE,Groop PH,Keenan HA,King GL

更新日期：2018-04-01 00:00:00

abstract：OBJECTIVE:To investigate the relationships of serum adipocyte fatty acid-binding protein (A-FABP) and epidermal fatty acid-binding protein (E-FABP) with renal dysfunction and macrovascular complications in type 2 diabetic patients. RESEARCH DESIGN AND METHODS:The associations of serum A-FABP and E-FABP with markers of...

journal_title：Diabetes care

authors： Yeung DC,Xu A,Tso AW,Chow WS,Wat NM,Fong CH,Tam S,Sham PC,Lam KS

更新日期：2009-01-01 00:00:00

abstract：OBJECTIVE:The purpose of the 1992 Singapore National Health Survey was to determine the current distribution of major noncommunicable diseases and their risk factors, including the prevalence of diabetes and dyslipidemia, in Singapore. RESEARCH DESIGN AND METHODS:A combination of disproportionate stratified sampling a...

journal_title：Diabetes care

authors： Tan CE,Emmanuel SC,Tan BY,Jacob E

更新日期：1999-02-01 00:00:00

abstract：:A major problem in replacing insulin in type I diabetes mellitus is that currently no depot preparation exists that is capable of mimicking the background insulin secretion of the healthy pancreas. Because all of the currently available intermediate- or long-acting insulin preparations have a peaked-action profile, ex...

journal_title：Diabetes care

authors： Bolli GB,Perriello G,Fanelli CG,De Feo P

更新日期：1993-12-01 00:00:00

abstract：:A state diabetes commission and university diabetes program in Kentucky jointly studied the social and economic impact of diabetes mellitus and its complications on the Commonwealth. This investigation revealed that diabetes was a more serious public health problem than previously supposed. Active, diagnosed diabetes ...

journal_title：Diabetes care

authors： Leichter SB,Hernandez C,Fisher A,Collins P,Courtney A

更新日期：1982-03-01 00:00:00

abstract：OBJECTIVE:Observational studies have associated metformin use with a decreased risk of lung cancer incidence in patients with type 2 diabetes, but the studies had important methodological shortcomings. The objective of this study was to determine whether metformin use is associated with a decreased risk of lung cancer ...

journal_title：Diabetes care

authors： Smiechowski BB,Azoulay L,Yin H,Pollak MN,Suissa S

更新日期：2013-01-01 00:00:00

abstract：:The availability of insulin analogs has offered insulin replacement strategies that are proposed to more closely mimic normal human physiology. Specifically, there are a considerable number of reports demonstrating that prandial insulin analogs (lispro, aspart, glulisine) have pharmacokinetic and pharmacodynamic profi...

journal_title：Diabetes care

authors： Davidson MB

更新日期：2014-06-01 00:00:00

abstract：OBJECTIVE:To investigate the influence of the insertion/deletion polymorphism of the ACE gene on the progression of early diabetic glomerulopathy in patients with and without antihypertensive treatment (AHT). RESEARCH DESIGN AND METHODS:There were 30 microalbuminuric patients with >5 years of type 1 diabetes who had r...

journal_title：Diabetes care

authors： Rudberg S,Rasmussen LM,Bangstad HJ,Osterby R

更新日期：2000-04-01 00:00:00

abstract：OBJECTIVE:Diabetes is the leading cause of nontraumatic lower-limb amputations in the U.S., but no research has prospectively examined associations between limb-specific measurements and amputation risk among patients without foot ulcer. We investigated amputation risk by limb in relation to the same limb- and person-l...

journal_title：Diabetes care

authors： Boyko EJ,Seelig AD,Ahroni JH

更新日期：2018-04-01 00:00:00

abstract：OBJECTIVE:Acarbose inhibits alpha-glucosidases of the small intestine and thus delays glucose release from complex carbohydrates. Therefore, its efficacy and acceptability as a first-line drug in non-insulin-dependent diabetes mellitus (NIDDM) insufficiently treated with diet alone was tested in a randomized double-bli...

journal_title：Diabetes care

authors： Hanefeld M,Fischer S,Schulze J,Spengler M,Wargenau M,Schollberg K,Fücker K

更新日期：1991-08-01 00:00:00

abstract：:This paper describes systematic studies on the absorption kinetics of exogenous insulin from its subcutaneous tissue depot in 52 male nonobese volunteers (age 20-30 yr). Five experimental protocols were used: effect of changing injection site, effect of temperature change and local massage, effect of aprotinin and hum...

journal_title：Diabetes care

authors： Berger M,Cüppers HJ,Hegner H,Jörgens V,Berchtold P

更新日期：1982-03-01 00:00:00

abstract：OBJECTIVE:Dietary recommendations are focused mainly on relative dietary fat and carbohydrate content in relation to diabetes risk. Meanwhile, high-protein diets may contribute to disturbance of glucose metabolism, but evidence from prospective studies is scarce. We examined the association among dietary total, vegetab...

journal_title：Diabetes care

authors： Sluijs I,Beulens JW,van der A DL,Spijkerman AM,Grobbee DE,van der Schouw YT

更新日期：2010-01-01 00:00:00

abstract：OBJECTIVE:To evaluate the effect of the erythromycin derivative EM523L on gastric emptying and postprandial insulin requirement in insulin-dependent diabetic patients with severe gastroparesis. RESEARCH DESIGN AND METHODS:In six IDDM patients with severe gastroparesis (two men and four women, mean age 44.5 years [rang...

journal_title：Diabetes care

authors： Ishii M,Nakamura T,Kasai F,Baba T,Takebe K

更新日期：1997-07-01 00:00:00

abstract：OBJECTIVE:To pilot, among women with gestational diabetes mellitus (GDM), the feasibility of a prenatal/postpartum intervention to modify diet and physical activity similar to the Diabetes Prevention Program. The intervention was delivered by telephone, and support for breastfeeding was addressed. RESEARCH DESIGN AND ...

journal_title：Diabetes care

authors： Ferrara A,Hedderson MM,Albright CL,Ehrlich SF,Quesenberry CP Jr,Peng T,Feng J,Ching J,Crites Y

更新日期：2011-07-01 00:00:00

abstract：OBJECTIVE:To determine the rheological properties of polymorphonuclear leukocytes (PMN) from non-insulin-dependent diabetes mellitus (NIDDM) patients. RESEARCH DESIGN AND METHODS:The deformability of PMN from 33 NIDDM subjects, 13 with impaired glucose tolerance (IGT), and 22 with normal glucose tolerance (NGT) was st...

journal_title：Diabetes care

authors： Pécsvarády Z,Fisher TC,Darwin CH,Fabók A,Maqueda TS,Saad MF,Meiselman HJ

更新日期：1994-01-01 00:00:00

abstract：OBJECTIVE:To investigate the effect of normal aging on the protective responses against hypoglycemia, in view of the fact that type II diabetes is primarily a disease of aging, and its treatment is associated with risk of hypoglycemia with cognitive impairment. RESEARCH DESIGN AND METHODS:Plasma glucose was lowered st...

journal_title：Diabetes care

authors： Matyka K,Evans M,Lomas J,Cranston I,Macdonald I,Amiel SA

更新日期：1997-02-01 00:00:00

abstract：OBJECTIVE:To examine the magnitude and types of hospitalizations among persons with prediabetes, undiagnosed diabetes, and diagnosed diabetes. RESEARCH DESIGN AND METHODS:This study included 13,522 participants in the Atherosclerosis Risk in Communities (ARIC) study (mean age 57 years, 56% female, 24% black, 18% with ...

journal_title：Diabetes care

authors： Schneider AL,Kalyani RR,Golden S,Stearns SC,Wruck L,Yeh HC,Coresh J,Selvin E

更新日期：2016-05-01 00:00:00

abstract：OBJECTIVE:We previously showed that in patients with diabetes mellitus, glycated hemoglobin (HbA1c) monitoring outside international guidance on testing frequency is widespread. Here we examined the relationship between testing frequency and diabetes control to test the hypothesis that retest interval is linked to chan...

journal_title：Diabetes care

authors： Driskell OJ,Holland D,Waldron JL,Ford C,Scargill JJ,Heald A,Tran M,Hanna FW,Jones PW,Pemberton RJ,Fryer AA

更新日期：2014-10-01 00:00:00

abstract：OBJECTIVE:To assess the level of serum lipoprotein(a) [Lp(a)] in nonobese and obese NIDDM subjects with android body distribution. RESEARCH DESIGN AND METHODS:Serum Lp(a) levels were measured in 30 long-standing NIDDM patients (duration of diabetes 12.5 +/- 3 years, mean +/- SD), with 15 of the patients being obese of...

journal_title：Diabetes care

authors： Wassef N,Sidhom G,Zakareya el-K,Mohamed el-K

更新日期：1997-11-01 00:00:00

abstract：OBJECTIVE:Gestational diabetes mellitus has been associated with offspring cardiac congenital malformations, ventricular hypertrophy, and diastolic dysfunction in large observational cohort studies and experimental animal models. We assessed the associations of maternal random glucose concentrations across the full ran...

journal_title：Diabetes care

authors： Wahab RJ,Jaddoe VWV,Roest AAW,Toemen L,Gaillard R

更新日期：2020-09-01 00:00:00

abstract：OBJECTIVE:To describe the extent to which hyperglycemia, hypertension, and dyslipidemia are currently detected, treated, and controlled in U.S. veterans with diabetes with and without ischemic heart disease (IHD). RESEARCH DESIGN AND METHODS:A cohort of 3,769 veterans who self-reported diabetes and who received all he...

journal_title：Diabetes care

authors： Smith NL,Chen L,Au DH,McDonell M,Fihn SD

更新日期：2004-05-01 00:00:00