Erythromycin derivative improves gastric emptying and insulin requirement in diabetic patients with gastroparesis.

Abstract:

OBJECTIVE:To evaluate the effect of the erythromycin derivative EM523L on gastric emptying and postprandial insulin requirement in insulin-dependent diabetic patients with severe gastroparesis. RESEARCH DESIGN AND METHODS:In six IDDM patients with severe gastroparesis (two men and four women, mean age 44.5 years [range 36-53]), the insulin infusion pattern during feedback control with an artificial endocrine pancreas device (Biostator) after intake of a test meal, the retention rate of residual isotope ([99m]Tc-labelled Sn-colloid) in the stomach, and the time-concentration curve of plasma acetaminophen as the marker for liquid emptying were studied with EM523L or a control placebo RESULTS:Time courses of insulin infusion rates peaked within 120 min after intake of the test meal in the EM523L phase, whereas no apparent peak rates were observed in the control phase. The total amount of insulin required in the first 90 min postprandial was significantly greater in the EM523L phase than in the control phase. EM523L significantly decreased the residual isotope ratio in the stomach at > or =50 min postprandial and increased the plasma acetaminophen concentrations at 30-120 min postprandial, compared with respective values in the control phase. CONCLUSIONS:Preliminary results obtained from a small number of patients suggest that EM523L or erythromycin analogs, which have agonistic activity to motilin receptors as well as no antibacterial effect, may be useful to accelerate gastric emptying and improve insulin requirement patterns, thereby establishing more stable glycemic control.

journal_name

Diabetes Care

journal_title

Diabetes care

authors

Ishii M,Nakamura T,Kasai F,Baba T,Takebe K

doi

10.2337/diacare.20.7.1134

subject

Has Abstract

pub_date

1997-07-01 00:00:00

pages

1134-7

issue

7

eissn

0149-5992

issn

1935-5548

journal_volume

20

pub_type

临床试验,杂志文章
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    authors: Hyppönen E,Power C

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    更新日期:2013-07-01 00:00:00

  • Lifestyle Counseling and Long-term Clinical Outcomes in Patients With Diabetes.

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    pub_type: 杂志文章

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    pub_type: 杂志文章,随机对照试验

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    pub_type: 杂志文章

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    pub_type: 杂志文章

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    authors: Stefan N,Stumvoll M,Vozarova B,Weyer C,Funahashi T,Matsuzawa Y,Bogardus C,Tataranni PA

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  • Effect of temperament on metabolic control in children with diabetes mellitus.

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    更新日期:1988-01-01 00:00:00

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    pub_type: 杂志文章

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    journal_title:Diabetes care

    pub_type: 杂志文章

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    pub_type: 杂志文章

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    pub_type: 临床试验,杂志文章,随机对照试验

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    pub_type: 杂志文章

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    pub_type: 杂志文章,多中心研究

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    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc06-1085

    authors: Kovatchev BP,Otto E,Cox D,Gonder-Frederick L,Clarke W

    更新日期:2006-11-01 00:00:00

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    pub_type: 杂志文章

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