Abstract:
OBJECTIVE:Dietary recommendations are focused mainly on relative dietary fat and carbohydrate content in relation to diabetes risk. Meanwhile, high-protein diets may contribute to disturbance of glucose metabolism, but evidence from prospective studies is scarce. We examined the association among dietary total, vegetable, and animal protein intake and diabetes incidence and whether consuming 5 energy % from protein at the expense of 5 energy % from either carbohydrates or fat was associated with diabetes risk. RESEARCH DESIGN AND METHODS:A prospective cohort study was conducted among 38,094 participants of the European Prospective Investigation into Cancer and Nutrition (EPIC)-NL study. Dietary protein intake was measured with a validated food frequency questionnaire. Incident diabetes was verified against medical records. RESULTS:During 10 years of follow-up, 918 incident cases of diabetes were documented. Diabetes risk increased with higher total protein (hazard ratio 2.15 [95% CI 1.77-2.60] highest vs. lowest quartile) and animal protein (2.18 [1.80-2.63]) intake. Adjustment for confounders did not materially change these results. Further adjustment for adiposity measures attenuated the associations. Vegetable protein was not related to diabetes. Consuming 5 energy % from total or animal protein at the expense of 5 energy % from carbohydrates or fat increased diabetes risk. CONCLUSIONS:Diets high in animal protein are associated with an increased diabetes risk. Our findings also suggest a similar association for total protein itself instead of only animal sources. Consumption of energy from protein at the expense of energy from either carbohydrates or fat may similarly increase diabetes risk. This finding indicates that accounting for protein content in dietary recommendations for diabetes prevention may be useful.
journal_name
Diabetes Carejournal_title
Diabetes careauthors
Sluijs I,Beulens JW,van der A DL,Spijkerman AM,Grobbee DE,van der Schouw YTdoi
10.2337/dc09-1321subject
Has Abstractpub_date
2010-01-01 00:00:00pages
43-8issue
1eissn
0149-5992issn
1935-5548pii
dc09-1321journal_volume
33pub_type
杂志文章相关文献
DIABETES CARE文献大全abstract:OBJECTIVE:High triglyceride (TG) levels and low HDL cholesterol (HDL-C) levels are risk factors for cardiovascular disease. It is unclear whether this relationship depends on glycemic dysregulation, sex, or LDL cholesterol (LDL-C) level. RESEARCH DESIGN AND METHODS:We studied 3,216 participants (40% men, 41% with diab...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc16-1958
更新日期:2017-04-01 00:00:00
abstract:OBJECTIVE:Acarbose inhibits alpha-glucosidases of the small intestine and thus delays glucose release from complex carbohydrates. Therefore, its efficacy and acceptability as a first-line drug in non-insulin-dependent diabetes mellitus (NIDDM) insufficiently treated with diet alone was tested in a randomized double-bli...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.2337/diacare.14.8.732
更新日期:1991-08-01 00:00:00
abstract:OBJECTIVE:To determine whether adults diagnosed with type 2 diabetes from age 18 to 44 years more aggressively develop clinical complications after diagnosis than adults diagnosed at >or=45 years of age. RESEARCH DESIGN AND METHODS:We compared outcomes among 7844 adults in a health maintenance organization who were ne...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.26.11.2999
更新日期:2003-11-01 00:00:00
abstract::Core Outcome Sets (COS) contain an agreed minimum set of outcomes to be measured and reported in all studies in a specific area, with the objective of standardizing outcome reporting. COS may minimize research waste by identifying outcomes important to key stakeholders, allowing for improved evidence synthesis, and fa...
journal_title:Diabetes care
pub_type: 杂志文章,评审
doi:10.2337/dc20-1621
更新日期:2020-12-01 00:00:00
abstract::In seven type II (non-insulin-dependent) diabetic patients, given either 50 g glucose or a mixed meal potentially containing 61 g glucose as starch and sucrose, the postmeal plasma glucose area integrated over 4 h was less after the mixed meal. The insulin area was considerably greater (2.1-fold). The greater increase...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.11.1.72
更新日期:1988-01-01 00:00:00
abstract:OBJECTIVE:Differences in risk of erectile dysfunction (ED) by characteristics of diabetes among older men are not well understood. We examined the association of type and duration of diabetes with erectile function in men >50 years of age in a large prospective cohort study. RESEARCH DESIGN AND METHODS:Subjects includ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.25.8.1458
更新日期:2002-08-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to compare different outcome measures in the audit of management of diabetic foot ulcers RESEARCH DESIGN AND METHODS:Data collected prospectively in a consecutive cohort of patients referred to a specialist multidisciplinary foot care clinic between 1 January 2000 and 31 Decembe...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc06-0306
更新日期:2006-08-01 00:00:00
abstract:OBJECTIVE:Cardiomyopathy is noted in up to 40% of infants of diabetic mothers, and the exact mechanisms are unknown. The aim of this study was to determine whether fetal serum markers of cardiac function differ between normal and type 1 diabetic pregnancies and to examine the relationship between these markers and feta...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc09-0552
更新日期:2009-11-01 00:00:00
abstract:OBJECTIVE:To assess the mechanistic effects of the glucagon-like peptide 1 (GLP-1) receptor agonist liraglutide and the dipeptidyl peptidase 4 (DPP-4) inhibitor sitagliptin on (exocrine) pancreatic physiology and morphology. RESEARCH DESIGN AND METHODS:For this randomized, double-blind, parallel-group trial, 55 patien...
journal_title:Diabetes care
pub_type: 杂志文章,随机对照试验
doi:10.2337/dc16-0836
更新日期:2017-03-01 00:00:00
abstract:OBJECTIVE:Growth deferentiation factor-15 (GDF-15) is involved in inflammation and apoptosis. Expression is induced in the heart in response to ischemia and in atherosclerotic plaques. The aim of this study was to investigate GDF-15 levels in relation to all-cause mortality, cardiovascular mortality and morbidity, decl...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc09-2174
更新日期:2010-07-01 00:00:00
abstract:OBJECTIVE:In 2010, the American Diabetes Association (ADA) added hemoglobin A1c (A1C) to the guidelines for diagnosing type 2 diabetes. However, existing models for predicting diabetes risk were developed prior to the widespread adoption of A1C. Thus, it remains unknown how well existing diabetes risk prediction models...
journal_title:Diabetes care
pub_type: 杂志文章,多中心研究
doi:10.2337/dc15-0509
更新日期:2016-02-01 00:00:00
abstract:OBJECTIVE:To evaluate racial differences and factors associated with worse glycemic control in well-functioning older individuals with type 2 diabetes. Our hypothesis was that glycemic control would be worse among black than white diabetic individuals but that this association would be explained by differences in sever...
journal_title:Diabetes care
pub_type: 杂志文章,多中心研究
doi:10.2337/diacare.26.7.1986
更新日期:2003-07-01 00:00:00
abstract:OBJECTIVE:To determine the prevalence and clinical associations of impaired awareness of hypoglycemia in a population-based sample of children and adolescents with type 1 diabetes. RESEARCH DESIGN AND METHODS:A validated questionnaire was administered to 656 patients with type 1 diabetes over a 6-month period to deter...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc09-0541
更新日期:2009-10-01 00:00:00
abstract::Cyclosporin and other immunosuppressive agents have been proposed as a preventive treatment against the development of insulin-dependent diabetes mellitus (IDDM) in relatives at increased risk for the disease, based on the understanding that its etiology is an ongoing process of autoimmune beta-cell destruction. We us...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章,评审
doi:10.2337/diacare.13.7.776
更新日期:1990-07-01 00:00:00
abstract:OBJECTIVE:To compare the glucose variability associated with insulin glargine and NPH/Lente insulin used as the basal insulin component of a multiple daily injection (MDI) regimen in pediatric patients with type 1 diabetes. RESEARCH DESIGN AND METHODS:Continuous glucose monitoring data were collected from a subset of ...
journal_title:Diabetes care
pub_type: 杂志文章,随机对照试验
doi:10.2337/dc08-0800
更新日期:2009-03-01 00:00:00
abstract::Intensive insulin therapy is best defined as a comprehensive system of diabetes management with the patient and management team as partners. The system is directed at improvement of glycemia and patient well-being. Glycemic targets should be individually defined. Frequent self-monitoring of blood glucose, probably at ...
journal_title:Diabetes care
pub_type: 杂志文章,评审
doi:10.2337/diacare.13.12.1265
更新日期:1990-12-01 00:00:00
abstract:OBJECTIVE:To identify the clinical and genetic factors that explain why the rate of diabetes progression is highly variable between individuals following diagnosis of type 2 diabetes. RESEARCH DESIGN AND METHODS:We studied 5,250 patients with type 2 diabetes using comprehensive electronic medical records in Tayside, S...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc13-1995
更新日期:2014-01-01 00:00:00
abstract:OBJECTIVE:To determine whether macronutrient intake differs by awareness of glycemic status among people with diabetes and prediabetes. RESEARCH DESIGN AND METHODS:We used 24-h dietary recall and other data from 3,725 nonpregnant adults with diabetes or prediabetes aged ≥20 years from the morning fasting sample of the...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc14-1342
更新日期:2014-12-01 00:00:00
abstract:OBJECTIVE:To examine the magnitude and types of hospitalizations among persons with prediabetes, undiagnosed diabetes, and diagnosed diabetes. RESEARCH DESIGN AND METHODS:This study included 13,522 participants in the Atherosclerosis Risk in Communities (ARIC) study (mean age 57 years, 56% female, 24% black, 18% with ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc15-1335
更新日期:2016-05-01 00:00:00
abstract:OBJECTIVE:Thiazolidinediones (TZDs) and metformin are insulin-sensitizing antihyperglycemic agents with reported benefits on atherosclerosis. Despite extensive use in patients with diabetes and cardiovascular disease, there is a paucity of outcomes data with metformin and none yet with TZDs. We sought to determine the ...
journal_title:Diabetes care
pub_type: 杂志文章,多中心研究
doi:10.2337/diacare.28.7.1680
更新日期:2005-07-01 00:00:00
abstract::Heart rate variability (HRV) during deep breathing was studied with a neonatal heart monitor in 143 control subjects and 218 patients with diabetes (102 with IDDM and 116 with NIDDM). In the control group HRV decreased after age 20 by 4-5 beats per decade (from 29.7 +/- 5.8 beats at age 20-29 to 11.8 +/- 5.4 beats at ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.8.1.64
更新日期:1985-01-01 00:00:00
abstract:OBJECTIVE:To determine the association between triglyceride levels and lower-extremity amputation (LEA) risk in a large diabetic cohort. RESEARCH DESIGN AND METHODS:This is a 10-year survey follow-up study (from 1995-2006) of 28,701 diabetic patients with a baseline triglyceride measure. All patients were fully insure...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc10-0878
更新日期:2011-03-01 00:00:00
abstract:OBJECTIVE:Insulin pump therapy (continuous subcutaneous insulin infusion [CSII]) and multiple daily injections (MDIs) with insulin glargine as basal insulin and mealtime insulin lispro have not been prospectively compared in people naïve to either regimen in a multicenter study. We aimed to help close that deficiency. ...
journal_title:Diabetes care
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.2337/dc08-1874
更新日期:2009-07-01 00:00:00
abstract::Many of the family psychosocial variables significantly related to child abuse are also significantly related to insulin-dependent diabetes mellitus (IDDM) control. These variables are reviewed, and an increased child abuse risk factor for children with IDDM is discussed. Behavioral indicators of families experiencing...
journal_title:Diabetes care
pub_type: 杂志文章,评审
doi:10.2337/diacare.9.3.302
更新日期:1986-05-01 00:00:00
abstract:OBJECTIVE:To determine whether food insecurity--the inability to reliably afford safe and nutritious food--is associated with poor glycemic control and whether this association is mediated by difficulty following a healthy diet, diabetes self-efficacy, or emotional distress related to diabetes. RESEARCH DESIGN AND MET...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc11-1627
更新日期:2012-02-01 00:00:00
abstract:OBJECTIVE:To improve prognosis, it is important to predict the incidence of renal failure and cardiovascular disease in type 2 diabetic patients before the progression to advanced nephropathy. We investigated the predictive effects of urinary liver-type fatty acid-binding protein (L-FABP), which is associated with rena...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc12-1298
更新日期:2013-05-01 00:00:00
abstract:OBJECTIVE:In adults with diabetes, in vivo platelet activation is a marker for atherosclerosis and cardiovascular disease (CVD). This pilot study investigated whether adolescents with diabetes had evidence of increased in vivo platelet activation. RESEARCH DESIGN AND METHODS:In vivo platelet activation was compared in...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc13-2718
更新日期:2014-08-01 00:00:00
abstract:OBJECTIVE:This study assessed the ability to distinguish between type 1 diabetes-affected individuals and their unaffected relatives using HLA and single nucleotide polymorphism (SNP) genotypes. RESEARCH DESIGN AND METHODS:Eight models, ranging from only the high-risk DR3/DR4 genotype to all significantly associated H...
journal_title:Diabetes care
pub_type: 杂志文章,随机对照试验
doi:10.2337/dc12-2284
更新日期:2013-09-01 00:00:00
abstract:OBJECTIVE:Because the bovine serum albumin residues 126-144 (ABBOS) have been reported to be responsible for the autoimmune reaction directed against pancreatic islet cells, it was our aim to study the potential survival of the ABBOS epitope during digestion in the gastrointestinal tract. RESEARCH DESIGN AND METHODS:E...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.20.5.875
更新日期:1997-05-01 00:00:00
abstract:OBJECTIVE:Recent studies have drawn attention to the adverse effects of ambient air pollutants such as particulate matter 2.5 (PM2.5) on human health. We evaluated the association between PM2.5 exposure and diabetes prevalence in the U.S. and explored factors that may influence this relationship. RESEARCH DESIGN AND M...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc10-0698
更新日期:2010-10-01 00:00:00