Lipoprotein(a) in android obesity and NIDDM.

abstract：:NIDDM in Pima Indians is characterized by obesity, abnormal insulin secretion, insulin resistance, and excess hepatic glucose output. Cross-sectional studies, and, as yet incomplete longitudinal studies of nondiabetic and diabetic Pima Indians suggest that the natural history of the disease begins with insulin resista...

journal_title：Diabetes care

authors： Bogardus C

更新日期：1993-01-01 00:00:00

abstract：:This review focuses on recent advances in molecular biology as they pertain to the insulin gene and diabetes mellitus. The structure of the human insulin gene is examined, and factors related to its normal functioning in the beta cells of the pancreas are explored. DNA polymorphisms near the insulin locus and their re...

journal_title：Diabetes care

authors： Permutt MA,Chirgwin J,Rotwein P,Giddings S

更新日期：1984-07-01 00:00:00

abstract：OBJECTIVE:We sought to examine the mechanisms by which the addition of glargine insulin or rosiglitazone improves glycemic control in type 2 diabetic subjects poorly controlled on maximally effective doses of metformin plus sulfonylurea. RESEARCH DESIGN AND METHODS:Subjects (aged 47 +/- 11 years, BMI 31 +/- 5 kg/m(2),...

journal_title：Diabetes care

authors： Triplitt C,Glass L,Miyazaki Y,Wajcberg E,Gastaldelli A,De Filippis E,Cersosimo E,DeFronzo RA

更新日期：2006-11-01 00:00:00

abstract：OBJECTIVE:To examine the contribution of nerve-axon reflex-related vasodilation to total acetylcholine-induced vasodilation in the skin of normal and diabetic subjects. RESEARCH DESIGN AND METHODS:The skin microcirculation was evaluated at the forearm level in 69 healthy subjects and 42 nonneuropathic diabetic patient...

journal_title：Diabetes care

authors： Hamdy O,Abou-Elenin K,LoGerfo FW,Horton ES,Veves A

更新日期：2001-02-01 00:00:00

abstract：OBJECTIVE:In older women, higher levels of estrogen may exacerbate the increased risk for cognitive impairment conveyed by diabetes. We examined whether the effect of postmenopausal hormone therapy (HT) on cognitive impairment incidence differs depending on type 2 diabetes. RESEARCH DESIGN AND METHODS:The Women's Heal...

journal_title：Diabetes care

authors： Espeland MA,Brinton RD,Hugenschmidt C,Manson JE,Craft S,Yaffe K,Weitlauf J,Vaughan L,Johnson KC,Padula CB,Jackson RD,Resnick SM,WHIMS Study Group.

更新日期：2015-12-01 00:00:00

abstract：:Increasingly more tests are being used to detect and characterize diabetic polyneuropathy, but their value in setting minimal criteria for the diagnosis of neuropathy and for staging severity remains inadequately studied. In 180 diabetics, we compared the percentage of patients with test abnormalities and associations...

journal_title：Diabetes care

authors： Dyck PJ,Bushek W,Spring EM,Karnes JL,Litchy WJ,O'Brien PC,Service FJ

更新日期：1987-07-01 00:00:00

abstract：OBJECTIVE:To evaluate the prevalence of NIDDM and IGT in the urban and rural areas in southern India. RESEARCH DESIGN AND METHODS:Two populations of the same ethnic background, but different socioeconomic background were chosen for this study. Nine-hundred urban people and 1038 rural subjects were studied. Fasting and...

journal_title：Diabetes care

authors： Ramachandran A,Snehalatha C,Dharmaraj D,Viswanathan M

更新日期：1992-10-01 00:00:00

abstract：OBJECTIVE:The role of fibrosis in early progressive renal decline in type 2 diabetes is unknown. Circulating WFDC2 (WAP four-disulfide core domain protein 2) and matrix metalloproteinase 7 (MMP-7; Matrilysin) are postulated to be biomarkers of renal fibrosis. This study examined an association of circulating levels of ...

journal_title：Diabetes care

authors： Ihara K,Skupien J,Kobayashi H,Md Dom ZI,Wilson JM,O'Neil K,Badger HS,Bowsman LM,Satake E,Breyer MD,Duffin KL,Krolewski AS

更新日期：2020-11-01 00:00:00

abstract：OBJECTIVE:A combined analysis of whether islet cell autoantibodies (ICAs) are cross-reactive with mouse pancreas, with glutamate decarboxylase (GAD) antibodies, and with 64K antibodies was performed in a large sample of recently diagnosed type I diabetic patients. The disappearance rates of these different autoantibodi...

journal_title：Diabetes care

authors： Chaillous L,Delamaire M,Martignat L,Maugendre D,Marre M,Mathieu E,Limal JM,Charbonnel B,Allannic H,Saï P

更新日期：1994-10-01 00:00:00

abstract：OBJECTIVE:To determine the best autoantibody-based testing strategy for recruiting relatives for future intervention trials and to establish the role of islet cell antibodies (ICAs) within this strategy. RESEARCH DESIGN AND METHODS:ICAs, insulin autoantibodies (IAAs), GAD antibodies, and IA-2 antibodies were determine...

journal_title：Diabetes care

authors： Bingley PJ,Williams AJ,Gale EA

更新日期：1999-11-01 00:00:00

abstract：OBJECTIVE:Given the transient nature of exercise-induced improvements in insulin sensitivity, it has been speculated that daily exercise is preferred to maximize the benefits of exercise for glycemic control. The current study investigates the impact of daily exercise versus exercise performed every other day on glycem...

journal_title：Diabetes care

authors： van Dijk JW,Tummers K,Stehouwer CD,Hartgens F,van Loon LJ

更新日期：2012-05-01 00:00:00

abstract：OBJECTIVE:The monosaccharides resulting from the digestion of ingested carbohydrates are glucose, fructose, and galactose. Of these three monosaccharides, only ingested glucose resulted in a large increase in the plasma glucose concentration. Fructose (Metabolism 41:510-517, 1992) and galactose (Metabolism 42:1560-1567...

journal_title：Diabetes care

authors： Gannon MC,Nuttall FQ,Westphal SA,Fang S,Ercan-Fang N

更新日期：1998-10-01 00:00:00

abstract：OBJECTIVE:To determine whether the use of glyburide is associated with an increased risk of cancer compared with the use of other second-generation sulfonylureas among patients with type 2 diabetes. RESEARCH DESIGN AND METHODS:The U.K. Clinical Practice Research Datalink was used to conduct a cohort study among 52,600...

journal_title：Diabetes care

authors： Tuccori M,Wu JW,Yin H,Majdan A,Azoulay L

更新日期：2015-11-01 00:00:00

abstract：OBJECTIVE:Many non-European ethnic groups have an increased risk for diabetes; however, the published literature demonstrates considerable uncertainty about the rates of diabetes complications among minority populations. The objective of this study was to determine the risks of cardiovascular complications and of morta...

journal_title：Diabetes care

authors： Shah BR,Victor JC,Chiu M,Tu JV,Anand SS,Austin PC,Manuel DG,Hux JE

更新日期：2013-09-01 00:00:00

abstract：OBJECTIVE:We sought to test the hypothesis that a fixed-dose combination of trandolapril/verapamil-SR (T/V) is superior to a fixed-dose combination of losartan/hydrochlorothiazide (L/H) on glucose tolerance in hypertensive patients with impaired glucose tolerance (IGT). RESEARCH DESIGN AND METHODS:A prospective, rando...

journal_title：Diabetes care

authors： Bakris G,Molitch M,Hewkin A,Kipnes M,Sarafidis P,Fakouhi K,Bacher P,Sowers J,STAR Investigators.

更新日期：2006-12-01 00:00:00

abstract：OBJECTIVE:To compare the influence on blood pressure, glucose, and lipid levels of a diet rich in monounsaturated fatty acids with an isocaloric, high-carbohydrate diet in 15 NIDDM subjects. RESEARCH DESIGN AND METHODS:A crossover design with diet interventions and wash-out periods of 3 wk was applied. The patients we...

journal_title：Diabetes care

authors： Rasmussen OW,Thomsen C,Hansen KW,Vesterlund M,Winther E,Hermansen K

更新日期：1993-12-01 00:00:00

abstract：OBJECTIVE:The objectives of this study were to compare early predictive marker of the metabolic syndrome with proopiomelanocortin (POMC) methylation status and to determine the association among birth weight, ponderal index, and cord blood methylation status. RESEARCH DESIGN AND METHODS:We collected pregnancy outcome ...

journal_title：Diabetes care

authors： Yoo JY,Lee S,Lee HA,Park H,Park YJ,Ha EH,Kim YJ

更新日期：2014-01-01 00:00:00

abstract：OBJECTIVE:A large proportion of vulvovaginal candidiasis (VVC) in diabetes is due to non-albicans Candida species such as C. glabrata and C. tropicalis. Observational studies indicate that diabetic patients with C. glabrata VVC respond poorly to azole drugs. We evaluated the response to oral fluconazole and boric acid ...

journal_title：Diabetes care

authors： Ray D,Goswami R,Banerjee U,Dadhwal V,Goswami D,Mandal P,Sreenivas V,Kochupillai N

更新日期：2007-02-01 00:00:00

abstract：OBJECTIVE:To study the association between microalbuminuria and development of preeclampsia and preterm delivery in pregnant women with type 1 diabetes. RESEARCH DESIGN AND METHODS:This was a population-based prospective study in 846 normoalbuminuric or microalbuminuric women with type 1 diabetes without antihypertens...

journal_title：Diabetes care

authors： Jensen DM,Damm P,Ovesen P,Mølsted-Pedersen L,Beck-Nielsen H,Westergaard JG,Moeller M,Mathiesen ER

更新日期：2010-01-01 00:00:00

abstract：OBJECTIVE:To investigate the metabolic effects of metformin, as compared with placebo, in type 2 diabetic patients intensively treated with insulin. RESEARCH DESIGN AND METHODS:Metformin improves glycemic control in poorly controlled type 2 diabetic patients. Its effect in type 2 diabetic patients who are intensively ...

journal_title：Diabetes care

authors： Wulffelé MG,Kooy A,Lehert P,Bets D,Ogterop JC,Borger van der Burg B,Donker AJ,Stehouwer CD

更新日期：2002-12-01 00:00:00

abstract：OBJECTIVE:Long-term implications of childhood obesity and BMI change over the life course for risk of type 2 diabetes remain uncertain. The objective was to establish whether there are effects on adult glucose metabolism of 1) sensitive periods of BMI gain or 2) long duration of overweight and obesity. RESEARCH DESIGN...

journal_title：Diabetes care

authors： Power C,Thomas C

更新日期：2011-09-01 00:00:00

abstract：OBJECTIVE:Depression is common in patients with diabetes and is associated with worse treatment outcomes. Its relationship to treatment adherence, however, has not been systematically reviewed. We used meta-analysis to examine the relationship between depression and treatment nonadherence in patients with type 1 and ty...

journal_title：Diabetes care

authors： Gonzalez JS,Peyrot M,McCarl LA,Collins EM,Serpa L,Mimiaga MJ,Safren SA

更新日期：2008-12-01 00:00:00

abstract：OBJECTIVE:The purpose of this study was to examine the association of physical activity and cardiovascular fitness (CVF) with insulin sensitivity in a nationally representative sample of U.S. youth. RESEARCH DESIGN AND METHODS:The study included 1,783 U.S. adolescents (11% Mexican American, 14% non-Hispanic black, 63%...

journal_title：Diabetes care

authors： Imperatore G,Cheng YJ,Williams DE,Fulton J,Gregg EW

更新日期：2006-07-01 00:00:00

abstract：OBJECTIVE:Short-term weight loss improves cardiovascular disease (CVD) risk factors. We sought to determine the longer-term effects of maintaining weight loss or, conversely, regaining weight. RESEARCH DESIGN AND METHODS:We used data from Action for Health in Diabetes (Look AHEAD), a randomized trial of intensive life...

journal_title：Diabetes care

authors： Wing RR,Espeland MA,Clark JM,Hazuda HP,Knowler WC,Pownall HJ,Unick J,Wadden T,Wagenknecht L,Action for Health in Diabetes (Look AHEAD) Study Group.

更新日期：2016-08-01 00:00:00

abstract：OBJECTIVE:In a previous study, we found observational evidence of improvement in beta-cell function when rosiglitazone was added to a failing oral antihyperglycemic regimen consisting of sulfonylureas and metformin. To confirm our previous observations, we designed and performed a prospective, randomized, and controlle...

journal_title：Diabetes care

authors： Ovalle F,Bell DS

更新日期：2004-11-01 00:00:00

abstract：OBJECTIVE:Observational studies have yielded inconsistent findings regarding the association of hemoglobin A(1c) (HbA(1c)) with survival in diabetic patients on dialysis. The association between pretransplant glycemic control and short- and long-term posttransplant outcomes in kidney transplant recipients is not clear....

journal_title：Diabetes care

authors： Molnar MZ,Huang E,Hoshino J,Krishnan M,Nissenson AR,Kovesdy CP,Kalantar-Zadeh K

更新日期：2011-12-01 00:00:00

abstract：OBJECTIVE:The mechanisms by which diabetes leads to rapidly progressive atherosclerosis are not fully understood. Adherence of monocytes to the arterial wall is an early event in the development of atherosclerotic lesions. RESEARCH DESIGN AND METHODS:The binding of freshly isolated monocytes from patients with NIDDM, ...

journal_title：Diabetes care

authors： Hoogerbrugge N,Verkerk A,Jacobs ML,Postema PT,Jongkind JF

更新日期：1996-10-01 00:00:00

abstract：OBJECTIVE:To evaluate the time course of leptin, adiponectin, and resting energy expenditure (REE) responses in overweight elderly males after acute resistance exercise protocols of various intensity configurations. RESEARCH DESIGN AND METHODS:Forty inactive men (65-82 years) were randomly assigned to one of four grou...

journal_title：Diabetes care

authors： Fatouros IG,Chatzinikolaou A,Tournis S,Nikolaidis MG,Jamurtas AZ,Douroudos II,Papassotiriou I,Thomakos PM,Taxildaris K,Mastorakos G,Mitrakou A

更新日期：2009-12-01 00:00:00

abstract：OBJECTIVE:Wound healing is known to require a well-organized balance of numerous factors, e.g., cytokines, matrix metalloproteinases (MMPs), and their inhibitors, as well as direct cell-cell communication (connexins). Disruption of this balance may lead to the formation of chronic wounds such as diabetic foot ulcers. T...

journal_title：Diabetes care

authors： Brandner JM,Zacheja S,Houdek P,Moll I,Lobmann R

更新日期：2008-01-01 00:00:00

abstract：OBJECTIVE:High-deductible health plans (HDHPs) are now the predominant commercial health insurance benefit in the U.S. We sought to determine the effects of HDHPs on emergency department and hospital care, adverse outcomes, and total health care expenditures among patients with diabetes. RESEARCH DESIGN AND METHODS:We...

journal_title：Diabetes care

authors： Wharam JF,Zhang F,Eggleston EM,Lu CY,Soumerai SB,Ross-Degnan D

更新日期：2018-05-01 00:00:00