Optimized autoantibody-based risk assessment in family members. Implications for future intervention trials.

Abstract:

OBJECTIVE:To determine the best autoantibody-based testing strategy for recruiting relatives for future intervention trials and to establish the role of islet cell antibodies (ICAs) within this strategy. RESEARCH DESIGN AND METHODS:ICAs, insulin autoantibodies (IAAs), GAD antibodies, and IA-2 antibodies were determined in serum samples at study entry of 3,655 non-diabetic first-degree relatives of patients with type 1 diabetes who were followed for a median of 5.5 years. The cumulative risk of diabetes associated with single and combined antibody marker levels of > or = 97.5th percentile in schoolchildren was calculated by using life-table analysis. RESULTS:Of the 26 relatives who developed insulin-requiring diabetes during follow-up, 16 were aged < 20 years and 7 were aged 20-39 years at study entry. Of the 23 cases aged < 40 years, 83% had IA-2 and/or GAD antibodies, and 87% had IAA and/or GAD antibodies > or = 97.5th percentile compared with 61% who had ICAs of > or = 5 Juvenile Diabetes Foundation units (JDF U). A two-step strategy with parallel testing for IA-2/GAD antibodies followed by IAA testing identified 50% of cases aged < 20 years and was associated with a 71% risk within 10 years. In subjects aged 20-39 years, this strategy conferred a 51% risk, whereas using ICAs as the second test gave 86% sensitivity and a 74% risk. Primary screening for IA-2 and/or GAD antibodies followed by testing for IAA and/or ICA antibodies achieved the highest sensitivity in both age-groups and conferred a 63% risk. In contrast, ICAs of > or = 20 JDF U (the inclusion criteria for the European Nicotinamide Diabetes Intervention Trial) gave 48% sensitivity and 35% risk. CONCLUSIONS:ICA testing can be replaced as a primary screening measure by IA-2/GAD or IAA/GAD antibody testing. The sensitivity of ICAs (used alone or in combination with IAAs) gives them a useful role in second-line testing. Combination testing could reduce the size of screening populations needed for recruitment in future intervention trials by approximately 50% compared with testing based on ICAs alone.

journal_name

Diabetes Care

journal_title

Diabetes care

authors

Bingley PJ,Williams AJ,Gale EA

doi

10.2337/diacare.22.11.1796

subject

Has Abstract

pub_date

1999-11-01 00:00:00

pages

1796-801

issue

11

eissn

0149-5992

issn

1935-5548

journal_volume

22

pub_type

杂志文章
  • Expression of matrix metalloproteinases, cytokines, and connexins in diabetic and nondiabetic human keratinocytes before and after transplantation into an ex vivo wound-healing model.

    abstract:OBJECTIVE:Wound healing is known to require a well-organized balance of numerous factors, e.g., cytokines, matrix metalloproteinases (MMPs), and their inhibitors, as well as direct cell-cell communication (connexins). Disruption of this balance may lead to the formation of chronic wounds such as diabetic foot ulcers. T...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc07-1304

    authors: Brandner JM,Zacheja S,Houdek P,Moll I,Lobmann R

    更新日期:2008-01-01 00:00:00

  • Linagliptin lowers albuminuria on top of recommended standard treatment in patients with type 2 diabetes and renal dysfunction.

    abstract:OBJECTIVE:Preclinical data suggest that linagliptin, a dipeptidyl peptidase-4 inhibitor, may lower urinary albumin excretion. The ability of linagliptin to lower albuminuria on top of renin-angiotensin-aldosterone system (RAAS) inhibition in humans was analyzed by pooling data from four similarly designed, 24-week, ran...

    journal_title:Diabetes care

    pub_type: 杂志文章,随机对照试验

    doi:10.2337/dc13-0323

    authors: Groop PH,Cooper ME,Perkovic V,Emser A,Woerle HJ,von Eynatten M

    更新日期:2013-11-01 00:00:00

  • Intra-individual variability of the metabolic effect of inhaled insulin together with an absorption enhancer.

    abstract:OBJECTIVE:To study the metabolic effect and the variability of the effect elicited by inhalation of 87.2 U insulin powder combined with an absorption enhancer. The metabolic effect was compared with that of 10.2 U regular insulin injected subcutaneously and of 5.5 U regular insulin given intravenously RESEARCH DESIGN ...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.2337/diacare.23.9.1343

    authors: Heinemann L,Klappoth W,Rave K,Hompesch B,Linkeschowa R,Heise T

    更新日期:2000-09-01 00:00:00

  • Normal glucose values are associated with a lower risk of mortality in hospitalized patients.

    abstract:OBJECTIVE:Hyperglycemia is a common condition in hospitalized patients. The aim of this study was to investigate the relationships between glycemia upon admission and mortality in a heterogeneous group of adult patients. RESEARCH DESIGN AND METHODS:The 3-year records released from a general hospital were associated wi...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc08-0672

    authors: Bruno A,Gregori D,Caropreso A,Lazzarato F,Petrinco M,Pagano E

    更新日期:2008-11-01 00:00:00

  • The Association of Severe Hypoglycemia With Incident Cardiovascular Events and Mortality in Adults With Type 2 Diabetes.

    abstract:OBJECTIVE:There is suggestive evidence linking hypoglycemia with cardiovascular disease, but few data have been collected in a community-based setting. Information is lacking on individual cardiovascular outcomes and cause-specific mortality. RESEARCH DESIGN AND METHODS:We conducted a prospective cohort analysis of 1,...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc17-1669

    authors: Lee AK,Warren B,Lee CJ,McEvoy JW,Matsushita K,Huang ES,Sharrett AR,Coresh J,Selvin E

    更新日期:2018-01-01 00:00:00

  • Reduced coronary artery and abdominal aortic calcification in Hispanics with type 2 diabetes.

    abstract:OBJECTIVE:To compare lifestyle factors, cardiovascular risk factors, and coronary artery calcium (CAC) and abdominal aortic calcium (AAC) levels in Hispanic and non-Hispanic white (NHW) individuals with type 2 diabetes. RESEARCH DESIGN AND METHODS:We recently demonstrated in a small group of nonreferred, healthy, nond...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.27.5.1115

    authors: Reaven PD,Sacks J,Investigators for the Veterans Affairs Cooperative Study of Glycemic Control and Complications in Diabetes Mellitus Type 2.

    更新日期:2004-05-01 00:00:00

  • Patients With Diabetes Without Significant Angiographic Coronary Artery Disease Have the Same Risk of Myocardial Infarction as Patients Without Diabetes in a Real-World Population Receiving Appropriate Prophylactic Treatment.

    abstract:OBJECTIVE:The risk of myocardial infarction (MI) in patients with diabetes is greater than for patients without diabetes. Consequently, prophylactic treatment is recommended for patients with diabetes and risk factors for ischemic heart disease. We aimed to estimate the risk of adverse cardiac events in patients with a...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc16-2388

    authors: Olesen KKW,Madsen M,Egholm G,Thim T,Jensen LO,Raungaard B,Bøtker HE,Sørensen HT,Maeng M

    更新日期:2017-08-01 00:00:00

  • The development and utility of a novel scale that quantifies the glycemic progression toward type 1 diabetes over 6 months.

    abstract:OBJECTIVE:We developed a scale to serve as a potential end point for 6-month glycemic progression (PS6M) toward type 1 diabetes (T1D) in autoantibody-positive relatives of individuals with T1D. RESEARCH DESIGN AND METHODS:The PS6M was developed from Diabetes Prevention Trial-Type 1 (DPT-1) data and tested in the Trial...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc14-2787

    authors: Sosenko JM,Skyler JS,Beam CA,Boulware D,Mahon JL,Krischer JP,Greenbaum CJ,Rafkin LE,Matheson D,Herold KC,Palmer JP,Type 1 Diabetes TrialNet and Diabetes Prevention Trial–Type 1 Study Groups.

    更新日期:2015-05-01 00:00:00

  • Challenges to healthy eating for people with diabetes in a low-income, minority neighborhood.

    abstract:OBJECTIVE:This study used qualitative interviews with black and Latino participants with diabetes to further understanding about types of foods eaten, food preparation, sources of foods and meals, communication with providers, and effects of race and ethnicity on eating in this population. RESEARCH DESIGN AND METHODS:...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc12-1632

    authors: Breland JY,McAndrew LM,Gross RL,Leventhal H,Horowitz CR

    更新日期:2013-10-01 00:00:00

  • Night Shift Work, Genetic Risk, and Type 2 Diabetes in the UK Biobank.

    abstract:OBJECTIVE:To examine the effects of past and current night shift work and genetic type 2 diabetes vulnerability on type 2 diabetes odds. RESEARCH DESIGN AND METHODS:In the UK Biobank, we examined associations of current (N = 272,214) and lifetime (N = 70,480) night shift work exposure with type 2 diabetes risk (6,770 ...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc17-1933

    authors: Vetter C,Dashti HS,Lane JM,Anderson SG,Schernhammer ES,Rutter MK,Saxena R,Scheer FAJL

    更新日期:2018-04-01 00:00:00

  • Using Indirect Measures to Identify Geographic Hot Spots of Poor Glycemic Control: Cross-sectional Comparisons With an A1C Registry.

    abstract:OBJECTIVE:Focusing health interventions in places with suboptimal glycemic control can help direct resources to neighborhoods with poor diabetes-related outcomes, but finding these areas can be difficult. Our objective was to use indirect measures versus a gold standard, population-based A1C registry to identify areas ...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc18-0181

    authors: Lee DC,Jiang Q,Tabaei BP,Elbel B,Koziatek CA,Konty KJ,Wu WY

    更新日期:2018-07-01 00:00:00

  • C-Peptide responses to glucose load in maturity-onset diabetes of the young (MODY).

    abstract::Pancreatic beta cell responses were measured in obese and nonobese maturity-onset diabetes of the young (MODY) patients by estimating serum immunoreactive insulin (IRI) and C-peptide (CP) during oral glucose tolerance testing (OGTT). The serum CP responses were generally low in MODY patients and more pronounced in obe...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.8.1.69

    authors: Mohan V,Snehalatha C,Ramachandran A,Jayashree R,Viswanathan M

    更新日期:1985-01-01 00:00:00

  • Trends in the prevalence of preexisting diabetes and gestational diabetes mellitus among a racially/ethnically diverse population of pregnant women, 1999-2005.

    abstract:OBJECTIVE:The purpose of this study was to assess changes in the prevalence of preexisting diabetes (diabetes antedating pregnancy) and gestational diabetes mellitus (GDM) from 1999 through 2005. RESEARCH DESIGN AND METHODS:In this retrospective study of 175,249 women aged 13-58 years with 209,287 singleton deliveries...

    journal_title:Diabetes care

    pub_type: 杂志文章,多中心研究

    doi:10.2337/dc07-2345

    authors: Lawrence JM,Contreras R,Chen W,Sacks DA

    更新日期:2008-05-01 00:00:00

  • Evaluation of capillary collection system for HbA1c specimens.

    abstract:OBJECTIVE:We evaluated the accuracy and stability of a capillary HbA1c collection system for use with a high-performance liquid chromatography analyzer. RESEARCH DESIGN AND METHODS:The collection system requires that 5 ul blood is drawn into a calibrated capillary tube, which is then placed into a vial of stabilizing ...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.15.5.700

    authors: Voss EM,Cembrowski GS,Clasen BL,Spencer ML,Ainslie MB,Haig B

    更新日期:1992-05-01 00:00:00

  • Effect of case-based training for medical residents on inpatient glycemia.

    abstract:OBJECTIVE:To determine whether an educational intervention for medical house staff improves blood glucose (BG) in hospitalized patients. RESEARCH DESIGN AND METHODS:All 116 medicine residents at an academic medical center were assigned to online or classroom training on inpatient dysglycemia in fall 2008. Both groups ...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc11-0517

    authors: Tamler R,Green DE,Skamagas M,Breen TL,Looker HC,Babyatsky M,Leroith D

    更新日期:2011-08-01 00:00:00

  • Patterns of metabolic progression to type 1 diabetes in the Diabetes Prevention Trial-Type 1.

    abstract:OBJECTIVE:There is little information regarding the pattern of metabolic deterioration before the onset of type 1 diabetes. The goal of this study was to utilize data from the Diabetes Prevention Trial-Type 1 (DPT-1) to obtain a picture of the metabolic progression to type 1 diabetes over a period of approximately 2.5 ...

    journal_title:Diabetes care

    pub_type: 杂志文章,随机对照试验

    doi:10.2337/diacare.29.03.06.dc05-1006

    authors: Sosenko JM,Palmer JP,Greenbaum CJ,Mahon J,Cowie C,Krischer JP,Chase HP,White NH,Buckingham B,Herold KC,Cuthbertson D,Skyler JS

    更新日期:2006-03-01 00:00:00

  • Evaluation of nonfasting tests to screen for childhood and adolescent dysglycemia.

    abstract:OBJECTIVE:To assess performance of nonfasting tests to screen children for dysglycemia (prediabetes or diabetes). RESEARCH DESIGN AND METHODS:This was a cross-sectional study of 254 overweight or obese (BMI ≥85th percentile) children aged 10-17 years. Subjects came for two visits to a clinical research unit. For visit...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc11-0827

    authors: Lee JM,Gebremariam A,Wu EL,LaRose J,Gurney JG

    更新日期:2011-12-01 00:00:00

  • Lifestyle intervention for prevention of type 2 diabetes in primary health care: one-year follow-up of the Finnish National Diabetes Prevention Program (FIN-D2D).

    abstract:OBJECTIVE:To investigate 1-year outcomes of a national diabetes prevention program in Finland. RESEARCH DESIGN AND METHODS:Altogether 10,149 individuals at high risk for diabetes were identified with the Finnish Diabetes Risk Score (FINDRISC; scoring ≥15 points), by a history of impaired fasting glucose (IFG) or impai...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc10-0410

    authors: Saaristo T,Moilanen L,Korpi-Hyövälti E,Vanhala M,Saltevo J,Niskanen L,Jokelainen J,Peltonen M,Oksa H,Tuomilehto J,Uusitupa M,Keinänen-Kiukaanniemi S

    更新日期:2010-10-01 00:00:00

  • Hypocalcemia, hypomagnesemia, and transient hypoparathyroidism during therapy with potassium phosphate in diabetic ketoacidosis.

    abstract::The effects of intravenous administration of potassium phosphate in the treatment of diabetic ketoacidosis were studied in nine children, ages 9 9/12 to 17 10/12 yr. During phosphate infusion (20--40 meq/L of fluid), all children maintained normal serum concentrations of phosphorus. Transient hypocalcemia occurred in ...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.2.3.265

    authors: Zipf WB,Bacon GE,Spencer ML,Kelch RP,Hopwood NJ,Hawker CD

    更新日期:1979-05-01 00:00:00

  • Is pregnancy in diabetic women associated with folate deficiency?

    abstract:OBJECTIVE:To determine whether folate metabolism in pregnant diabetic women is significantly different from that in pregnant nondiabetic women, thus predisposing them to having offspring with major congenital anomalies. RESEARCH DESIGN AND METHODS:A total of 31 pregnant diabetic women and 54 pregnant nondiabetic contr...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.22.7.1017

    authors: Kaplan JS,Iqbal S,England BG,Zawacki CM,Herman WH

    更新日期:1999-07-01 00:00:00

  • Central processing of gut pain in diabetic patients with gastrointestinal symptoms.

    abstract:OBJECTIVE:To evaluate the brain's responses to painful visceral and somatic stimuli in diabetic patients with gastrointestinal symptoms. RESEARCH DESIGN AND METHODS:The sensitivity to electrical esophageal and median nerve stimulations was assessed in 15 healthy volunteers and 14 type 1 diabetic patients with autonomi...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc09-0324

    authors: Frøkjaer JB,Søfteland E,Graversen C,Dimcevski G,Egsgaard LL,Arendt-Nielsen L,Drewes AM

    更新日期:2009-07-01 00:00:00

  • Hyperglycemia and Adverse Pregnancy Outcome Follow-up Study (HAPO FUS): Maternal Gestational Diabetes Mellitus and Childhood Glucose Metabolism.

    abstract:OBJECTIVE:Whether hyperglycemia in utero less than overt diabetes is associated with altered childhood glucose metabolism is unknown. We examined associations of gestational diabetes mellitus (GDM) not confounded by treatment with childhood glycemia in the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) cohort. RES...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc18-1646

    authors: Lowe WL Jr,Scholtens DM,Kuang A,Linder B,Lawrence JM,Lebenthal Y,McCance D,Hamilton J,Nodzenski M,Talbot O,Brickman WJ,Clayton P,Ma RC,Tam WH,Dyer AR,Catalano PM,Lowe LP,Metzger BE,HAPO Follow-up Study Cooperative Res

    更新日期:2019-03-01 00:00:00

  • Rarefaction of the peripheral nerve network in diabetic patients is associated with a pronounced reduction of terminal Schwann cells.

    abstract:OBJECTIVE:Peripheral neuropathy is the most frequent neurological complication in diabetic patients. The diagnosis is established by both clinical neurological examination and demonstration of reduced epidermal nerve fibers in skin biopsies (1). Whereas the decrease of free nerve endings has been extensively studied in...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc07-1832

    authors: Reinisch CM,Traxler H,Piringer S,Tangl S,Nader A,Tschachler E

    更新日期:2008-06-01 00:00:00

  • Transient neonatal diabetes, ZFP57, and hypomethylation of multiple imprinted loci: a detailed follow-up.

    abstract:OBJECTIVE:Transient neonatal diabetes mellitus 1 (TNDM1) is the most common cause of diabetes presenting at birth. Approximately 5% of the cases are due to recessive ZFP57 mutations, causing hypomethylation at the TNDM locus and other imprinted loci (HIL). This has consequences for patient care because it has impact on...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc12-0700

    authors: Boonen SE,Mackay DJ,Hahnemann JM,Docherty L,Grønskov K,Lehmann A,Larsen LG,Haemers AP,Kockaerts Y,Dooms L,Vu DC,Ngoc CT,Nguyen PB,Kordonouri O,Sundberg F,Dayanikli P,Puthi V,Acerini C,Massoud AF,Tümer Z,Temple IK

    更新日期:2013-03-01 00:00:00

  • Short stature and the risk of adiposity, insulin resistance, and type 2 diabetes in middle age: the Third National Health and Nutrition Examination Survey (NHANES III), 1988-1994.

    abstract:OBJECTIVE:To investigate the association between stature-related measurements (height, leg length, and leg length-to-height ratio) and adiposity, insulin resistance, and glucose intolerance. RESEARCH DESIGN AND METHODS:We conducted a cross-sectional analysis of a nationally representative sample of 7,424 adults aged 4...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc05-1997

    authors: Asao K,Kao WH,Baptiste-Roberts K,Bandeen-Roche K,Erlinger TP,Brancati FL

    更新日期:2006-07-01 00:00:00

  • Well-being and treatment satisfaction in older people with diabetes.

    abstract:OBJECTIVE:To measure well-being and treatment satisfaction and their correlates in older people with diabetes. RESEARCH DESIGN AND METHODS:A postal survey was conducted of 1,000 diabetic patients aged > or = 60 years, representing 56% of the resident older diabetic population in an inner-city health district with a la...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.21.6.930

    authors: Petterson T,Lee P,Hollis S,Young B,Newton P,Dornan T

    更新日期:1998-06-01 00:00:00

  • Determinants of racial/ethnic disparities in incidence of diabetes in postmenopausal women in the U.S.: The Women's Health Initiative 1993-2009.

    abstract:OBJECTIVE:To examine determinants of racial/ethnic differences in diabetes incidence among postmenopausal women participating in the Women's Health Initiative. RESEARCH DESIGN AND METHODS:Data on race/ethnicity, baseline diabetes prevalence, and incident diabetes were obtained from 158,833 women recruited from 1993-19...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc12-0412

    authors: Ma Y,Hébert JR,Manson JE,Balasubramanian R,Liu S,Lamonte MJ,Bird CE,Ockene JK,Qiao Y,Olendzki B,Schneider KL,Rosal MC,Sepavich DM,Wactawski-Wende J,Stefanick ML,Phillips LS,Ockene IS,Kaplan RC,Sarto GE,Garcia L,Ho

    更新日期:2012-11-01 00:00:00

  • Effects of metformin on insulin resistance, risk factors for cardiovascular disease, and plasminogen activator inhibitor in NIDDM subjects. A study of two ethnic groups.

    abstract:OBJECTIVE:To investigate the effects of metformin on glycemic control, insulin resistance, and risk factors for cardiovascular disease in NIDDM subjects from two ethnic groups (Caucasian and Asian) with different risks of cardiovascular disease. RESEARCH DESIGN AND METHODS:A total of 27 subjects with NIDDM (17 Caucasi...

    journal_title:Diabetes care

    pub_type: 临床试验,评论,杂志文章,随机对照试验

    doi:10.2337/diacare.16.4.621

    authors: Nagi DK,Yudkin JS

    更新日期:1993-04-01 00:00:00

  • Effect of intrauterine diabetes exposure on the incidence of end-stage renal disease in young adults with type 2 diabetes.

    abstract:OBJECTIVE:We examined the effect of intrauterine diabetes exposure (IDE) on the incidence of diabetic end-stage renal disease (ESRD) in Pima Indians with type 2 diabetes. RESEARCH DESIGN AND METHODS:Individuals were followed from their first diabetic examination until December 2006, death, ESRD, or age of 45 years. R...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc10-0811

    authors: Pavkov ME,Hanson RL,Knowler WC,Sievers ML,Bennett PH,Nelson RG

    更新日期:2010-11-01 00:00:00

  • Independent and combined association of muscle strength and cardiorespiratory fitness in youth with insulin resistance and β-cell function in young adulthood: the European Youth Heart Study.

    abstract:OBJECTIVE:To examine the independent and combined association of isometric muscle strength of the abdomen and back and cardiorespiratory fitness (CRF) in youth with indices of glucose metabolism in young adulthood among boys and girls from the European Youth Heart Study. RESEARCH DESIGN AND METHODS:We used data from a...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc12-2252

    authors: Grøntved A,Ried-Larsen M,Ekelund U,Froberg K,Brage S,Andersen LB

    更新日期:2013-09-01 00:00:00