Abstract:
OBJECTIVE:In older women, higher levels of estrogen may exacerbate the increased risk for cognitive impairment conveyed by diabetes. We examined whether the effect of postmenopausal hormone therapy (HT) on cognitive impairment incidence differs depending on type 2 diabetes. RESEARCH DESIGN AND METHODS:The Women's Health Initiative (WHI) randomized clinical trials assigned women to HT (0.625 mg/day conjugated equine estrogens with or without [i.e., unopposed] 2.5 mg/day medroxyprogesterone acetate) or matching placebo for an average of 4.7-5.9 years. A total of 7,233 women, aged 65-80 years, were classified according to type 2 diabetes status and followed for probable dementia and cognitive impairment (mild cognitive impairment or dementia). RESULTS:Through a maximum of 18 years of follow-up, women with diabetes had increased risk of probable dementia (hazard ratio [HR] 1.54 [95% CI 1.16-2.06]) and cognitive impairment (HR 1.83 [1.50-2.23]). The combination of diabetes and random assignment to HT increased their risk of dementia (HR 2.12 [1.47-3.06]) and cognitive impairment (HR 2.20 [1.70-2.87]) compared with women without these conditions, interaction P = 0.09 and P = 0.08. These interactions appeared to be limited to women assigned to unopposed conjugated equine estrogens. CONCLUSIONS:These analyses provide additional support to a prior report that higher levels of estrogen may exacerbate risks that type 2 diabetes poses for cognitive function in older women. The role estrogen plays in suppressing non-glucose-based energy sources in the brain may explain this interaction.
journal_name
Diabetes Carejournal_title
Diabetes careauthors
Espeland MA,Brinton RD,Hugenschmidt C,Manson JE,Craft S,Yaffe K,Weitlauf J,Vaughan L,Johnson KC,Padula CB,Jackson RD,Resnick SM,WHIMS Study Group.doi
10.2337/dc15-1385subject
Has Abstractpub_date
2015-12-01 00:00:00pages
2316-24issue
12eissn
0149-5992issn
1935-5548pii
dc15-1385journal_volume
38pub_type
杂志文章,随机对照试验相关文献
DIABETES CARE文献大全abstract:OBJECTIVE:Individuals with impaired glucose tolerance (IGT) are at high risk for developing type 2 diabetes mellitus (T2DM). We examined which characteristics at baseline predicted the development of T2DM versus maintenance of IGT or conversion to normal glucose tolerance. RESEARCH DESIGN AND METHODS:We studied 228 su...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc13-0520
更新日期:2013-11-01 00:00:00
abstract:OBJECTIVE:Adverse microbial exposures might contribute to diabetogenesis. We hypothesized that clinical periodontal disease (a manifestation of microbial exposures in dysbiotic biofilms) would be related to insulin resistance among diabetes-free participants. The roles of inflammatory mediation and effect modification ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc12-0072
更新日期:2012-11-01 00:00:00
abstract:OBJECTIVE:Diabetes surveillance often requires manual medical chart reviews to confirm status and type. This project aimed to create an electronic health record (EHR)-based procedure for improving surveillance efficiency through automation of case identification. RESEARCH DESIGN AND METHODS:Youth (<20 years old) with ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc20-0063
更新日期:2020-10-01 00:00:00
abstract:OBJECTIVE:Evidence that midregional fragment of pro-A-type natriuretic peptide (MR-proANP) is a marker of mortality in patients with type 2 diabetes is limited. Therefore, we aimed to investigate the capabilities of MR-proANP in predicting mortality. We also investigated whether MR-proANP influences the relationship be...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc12-0428
更新日期:2013-05-01 00:00:00
abstract:OBJECTIVE:We evaluated a program of performance measurement and monitoring by assessing care process, utilization of services, and outcomes. RESEARCH DESIGN AND METHODS:Information on 63,264 diabetic individuals who were continuously enrolled as members of Kaiser Permanente Southern California from 1 January 1994 to 3...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.23.2.192
更新日期:2000-02-01 00:00:00
abstract::Nine healthy volunteers with normal body weights were injected subcutaneously with 125I-labeled soluble human insulin (10 U) in one thigh and 133Xe in the contralateral thigh for the measurement of subcutaneous blood flow on 2 consecutive mornings. On one of the days, standardized massage of both injection sites was p...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.9.6.570
更新日期:1986-11-01 00:00:00
abstract:OBJECTIVE:Sustained excess BMI increases the risk of type 1 diabetes (T1D) in autoantibody-positive relatives without diabetes of patients. We tested whether elevated BMI also accelerates the progression of islet autoimmunity before T1D diagnosis. RESEARCH DESIGN AND METHODS:We studied 706 single autoantibody-positive...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc19-1167
更新日期:2020-03-01 00:00:00
abstract:OBJECTIVE:This study aimed to assess the efficacy and safety of our newly developed nasal glucagon-like peptide-1 (GLP-1) compound and injector. RESEARCH DESIGN AND METHODS:Twenty-six patients with type 2 diabetes were enrolled in this double-blind placebo-controlled study. The nasal compound containing 1.2 mg of huma...
journal_title:Diabetes care
pub_type: 杂志文章,随机对照试验
doi:10.2337/dc13-0690
更新日期:2014-07-01 00:00:00
abstract:OBJECTIVE:The goal of this study was to determine whether the haptoglobin (Hp) genotype was predictive of restenosis and major adverse cardiac events (MACEs) after percutaneous transluminal coronary angioplasty (PTCA) in individuals with diabetes. RESEARCH DESIGN AND METHODS:A consecutive series of 935 diabetic patien...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.26.9.2628
更新日期:2003-09-01 00:00:00
abstract:OBJECTIVE:To investigate the possibility that leptin levels may be predictive of the risk of ischemic heart disease (IHD) through the relationship of leptin to body fat. RESEARCH DESIGN AND METHODS:The Quebec Cardiovascular Study cohort consisted of 2,103 French-Canadian men without IHD in 1985 who were followed until...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.21.5.782
更新日期:1998-05-01 00:00:00
abstract::A representative sample of 817 American women aged 20-44 yr who were not pregnant and had no medical history of diabetes were given 75-g 2-h oral glucose tolerance tests (OGTTs). Although these conditions are somewhat different from those recommended for pregnant women (100 g glucose, 3-h OGTT), 3.8% of the women migh...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.11.5.402
更新日期:1988-05-01 00:00:00
abstract:OBJECTIVE:To determine the incidence of retinopathy and the relative importance of its risk factors in type 1 diabetes. RESEARCH DESIGN AND METHODS:This is a 7.3-year follow-up of 764 of 1,215 (63%) people with type 1 diabetes across Europe, aged 15-60 years at baseline with no retinopathy (the EURODIAB Prospective Co...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.24.2.284
更新日期:2001-02-01 00:00:00
abstract:OBJECTIVE:The main purpose of this work was to study the possible differences in insulin secretion in a large group of type 2 diabetic patients in relation to diabetes duration, obesity, and the presence of secondary failure after treatment with oral hypoglycemic agents. RESEARCH DESIGN AND METHODS:There were 147 nono...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.21.10.1680
更新日期:1998-10-01 00:00:00
abstract:OBJECTIVE:To assess the efficacy and safety of switching from sitagliptin to liraglutide in metformin-treated adults with type 2 diabetes. RESEARCH DESIGN AND METHODS:In an open-label trial, participants randomized to receive either liraglutide (1.2 or 1.8 mg/day) or sitagliptin (100 mg/day), each added to metformin, ...
journal_title:Diabetes care
pub_type: 杂志文章,随机对照试验
doi:10.2337/dc11-2113
更新日期:2012-10-01 00:00:00
abstract:OBJECTIVE:Inflammatory markers predict type 2 diabetes and relate to the metabolic syndrome. Gestational diabetes mellitus (GDM) predicts type 2 diabetes and may be part of this syndrome. To examine the association of inflammatory markers with GDM, we investigated total sialic acid (TSA) in women with and without previ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.25.8.1331
更新日期:2002-08-01 00:00:00
abstract:OBJECTIVE:This multicenter open-label clinical trial compared the efficacy and safety of repaglinide/troglitazone combination therapy, repaglinide monotherapy, and troglitazone monotherapy in type 2 diabetes that had been inadequately controlled by sulfonylureas, acarbose, or metformin alone. RESEARCH DESIGN AND METHO...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.2337/diacare.23.7.979
更新日期:2000-07-01 00:00:00
abstract:OBJECTIVE:To evaluate the relationship between renal function, ambulatory blood pressure (AMBP), and glycemic control in microalbuminuric IDDM patients compared with normoalbuminuric patients. RESEARCH DESIGN AND METHODS:Nineteen male patients (age 33 +/- 6 years) with slight microalbuminuria (UAE 20-70 micrograms/min...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.20.3.429
更新日期:1997-03-01 00:00:00
abstract:OBJECTIVE:The prevalence of systemic hypertension is increased in patients with diabetes. In this prospective, randomized, crossover clinical trial, we assessed antihypertensive effects of chronic intermittent intravenous insulin therapy (CIIIT) on insulin-dependent diabetes mellitus (IDDM) subjects with hypertension a...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.2337/diacare.18.9.1260
更新日期:1995-09-01 00:00:00
abstract:OBJECTIVE:To determine the prevalence of macroalbuminuria and to describe the clinical and renal pathological changes associated with macroalbuminuria in a population of Canadian First Nation children and adolescents with type 2 diabetes. RESEARCH DESIGN AND METHODS:We conducted a retrospective chart review at a singl...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc08-1828
更新日期:2009-05-01 00:00:00
abstract:OBJECTIVE:Type 2 diabetes is frequently complicated with atherogenic dyslipidemia. This study aimed to evaluate the efficacy and safety of pemafibrate (K-877) in patients with type 2 diabetes comorbid with hypertriglyceridemia. RESEARCH DESIGN AND METHODS:Patients were randomly assigned to three groups and received pl...
journal_title:Diabetes care
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.2337/dc17-1589
更新日期:2018-03-01 00:00:00
abstract:OBJECTIVE:Reductions in heart attack and stroke hospitalizations are well documented in the U.S. population with diabetes. We extended trend analyses to other cardiovascular disease (CVD) conditions, including stroke by type, and used four additional years of data. RESEARCH DESIGN AND METHODS:Using 1998-2014 National ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc17-1259
更新日期:2018-02-01 00:00:00
abstract:OBJECTIVE:To evaluate the incidence and relative risk of type 2 diabetes defined by the newly proposed HbA(1c) diagnostic criteria in groups categorized by different baseline HbA(1c) levels. RESEARCH DESIGN AND METHODS:Using data from the European Prospective Investigation of Cancer (EPIC)-Norfolk cohort with repeat H...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc09-2326
更新日期:2011-04-01 00:00:00
abstract:OBJECTIVE:To determine whether intensive treatment and education strategies for type 2 diabetic patients with high-risk diabetic foot disease helps in preventing foot amputations. RESEARCH DESIGN AND METHODS:Participants included 4,872 consecutive type 2 diabetic patients (male-to-female ratio 3,422:1,450, mean (+/-SD...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.28.5.1019
更新日期:2005-05-01 00:00:00
abstract:OBJECTIVE:There is suggestive evidence linking hypoglycemia with cardiovascular disease, but few data have been collected in a community-based setting. Information is lacking on individual cardiovascular outcomes and cause-specific mortality. RESEARCH DESIGN AND METHODS:We conducted a prospective cohort analysis of 1,...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc17-1669
更新日期:2018-01-01 00:00:00
abstract::The prevalence of obesity among Hispanic American populations is generally greater than among white populations in the United States. Among Mexican Americans, the prevalence of obesity was higher than among either Cuban Americans or Puerto Ricans. It is well known that the prevalence of diabetes increases with increas...
journal_title:Diabetes care
pub_type: 杂志文章,评审
doi:10.2337/diacare.14.7.691
更新日期:1991-07-01 00:00:00
abstract::OBJECTIVE To examine the efficacy and safety of rimonabant, a selective cannabinoid receptor type-1 antagonist, in patients with type 2 diabetes receiving insulin monotherapy. RESEARCH DESIGN AND METHODS Patients (n = 368; A1C > or =7%) were randomized to 20 mg/day rimonabant or placebo in this 48-week, double-blind, ...
journal_title:Diabetes care
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.2337/dc09-0455
更新日期:2010-03-01 00:00:00
abstract:OBJECTIVE:To analyze the relationship between maternal adiponectin (mAdiponectin) and cord blood adiponectin (cbAdiponectin) multimeric forms (high molecular weight [HMW], medium molecular weight [MMW], and low molecular weight [LMW]) in a cohort of gestational diabetes mellitus (GDM) and normal glucose-tolerant (NGT) ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc11-0788
更新日期:2011-11-01 00:00:00
abstract:OBJECTIVE:The relationship between coronary endothelial function and insulin resistance remains speculative. We sought to determine whether pioglitazone, an insulin-sensitizing peroxisome proliferator-activated receptor (PPAR)-gamma agonist, improves cardiac endothelial function in individuals with type 2 diabetes. RE...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.2337/diacare.28.5.1145
更新日期:2005-05-01 00:00:00
abstract:OBJECTIVE:To investigate factors related to glycemic management among members of a professional cycling team with type 1 diabetes over a 7-day Union Cycliste Internationale World Tour stage race. RESEARCH DESIGN AND METHODS:An observational evaluation of possible factors related to glycemic management and performance ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc19-2302
更新日期:2020-05-01 00:00:00
abstract:OBJECTIVE:The risk of myocardial infarction (MI) in patients with diabetes is greater than for patients without diabetes. Consequently, prophylactic treatment is recommended for patients with diabetes and risk factors for ischemic heart disease. We aimed to estimate the risk of adverse cardiac events in patients with a...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc16-2388
更新日期:2017-08-01 00:00:00