Changes in BMI, duration of overweight and obesity, and glucose metabolism: 45 years of follow-up of a birth cohort.

Abstract:

OBJECTIVE:Long-term implications of childhood obesity and BMI change over the life course for risk of type 2 diabetes remain uncertain. The objective was to establish whether there are effects on adult glucose metabolism of 1) sensitive periods of BMI gain or 2) long duration of overweight and obesity. RESEARCH DESIGN AND METHODS:Participants in the 1958 British birth cohort with child to adult BMI and glycosylated hemoglobin (HbA(1c)) at 45 years (n = 7,855). RESULTS:Prevalence of type 2 diabetes or HbA(1c) ≥7 was 2%. BMI gains in child- and adulthood were associated with higher HbA(1c): for every SD of 5-year BMI increase from 0 to 7 years, there was a 75% (95% CI 1.42-2.16) increased risk of HbA(1c) ≥7, increasing to a 4.7-fold (3.12-7.00) risk for the interval 23-33 years. Associations for BMI gain in adulthood were related to attained BMI but were independent for the longer period birth (or 7 years) to 45 years. Duration of obesity was also associated with HbA(1c); compared with the never obese, those with childhood onset had a 23.9-fold risk (13.5-42.1) of HbA(1c) ≥7%; odds ratios were 16.0 (10.6-24.2) and 2.99 (1.77-5.03), respectively, for young and midadulthood onset. Similar trends by onset age were found in mean HbA(1c) levels and for onset of overweight. Those with the earliest age of onset had higher BMI and waist circumference at 45 years, which markedly explained the associations for onset age and HbA(1c). CONCLUSIONS:Excessive BMI gain across the life span and earlier onset of overweight/obesity are associated with impaired glucose metabolism, in part through attained adult BMI.

journal_name

Diabetes Care

journal_title

Diabetes care

authors

Power C,Thomas C

doi

10.2337/dc10-1482

subject

Has Abstract

pub_date

2011-09-01 00:00:00

pages

1986-91

issue

9

eissn

0149-5992

issn

1935-5548

pii

dc10-1482

journal_volume

34

pub_type

杂志文章
  • Comparison of A1C and fasting glucose criteria to diagnose diabetes among U.S. adults.

    abstract:OBJECTIVE:To compare A1C and fasting glucose for the diagnosis of diabetes among U.S. adults. RESEARCH DESIGN AND METHODS:This study included 6,890 adults (> or =20 years of age) from the 1999-2006 National Health and Nutrition Examination Survey without a self-reported history of diabetes who had fasted > or =9 h. A1...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc09-1227

    authors: Carson AP,Reynolds K,Fonseca VA,Muntner P

    更新日期:2010-01-01 00:00:00

  • Measurement of health status in diabetic patients. Diabetes impact measurement scales.

    abstract:OBJECTIVE:To develop an instrument to measure health status in adult insulin-dependent (type I) and non-insulin-dependent (type II) diabetic patients. RESEARCH DESIGN AND METHODS:Correlative study to examine psychometric properties of the questionnaire. Test-retest reliability, item-scale correlations, principal-compo...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.15.4.469

    authors: Hammond GS,Aoki TT

    更新日期:1992-04-01 00:00:00

  • Nonselective loss of contrast sensitivity in visual system testing in early type I diabetes.

    abstract:OBJECTIVE:Psychophysical methods in patients with diabetes mellitus reveal deficits of central or foveal vision. Our aim was to evaluate the contrast-sensitivity thresholds in 24 insulin-dependent (type I) diabetic patients with a short disease duration and without retinopathy, taking into account metabolic control. R...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.15.5.620

    authors: Di Leo MA,Caputo S,Falsini B,Porciatti V,Minnella A,Greco AV,Ghirlanda G

    更新日期:1992-05-01 00:00:00

  • Adolescent Type 1 Diabetes Cardio-Renal Intervention Trial (AdDIT): urinary screening and baseline biochemical and cardiovascular assessments.

    abstract:OBJECTIVE:We assessed the association between early increases in albumin excretion and cardiovascular (CV) and renal markers in a large cohort of young people with type 1 diabetes. RESEARCH DESIGN AND METHODS:As part of preliminary screening for a multicenter, randomized controlled trial of statins/ACE inhibitors, we ...

    journal_title:Diabetes care

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.2337/dc13-1634

    authors: Marcovecchio ML,Woodside J,Jones T,Daneman D,Neil A,Prevost T,Dalton RN,Deanfield J,Dunger DB,AdDIT Investigators.

    更新日期:2014-01-01 00:00:00

  • Current Challenges and Opportunities in the Prevention and Management of Diabetic Foot Ulcers.

    abstract::Diabetic foot ulcers remain a major health care problem. They are common, result in considerable suffering, frequently recur, and are associated with high mortality, as well as considerable health care costs. While national and international guidance exists, the evidence base for much of routine clinical care is thin....

    journal_title:Diabetes care

    pub_type: 杂志文章,评审

    doi:10.2337/dc17-1836

    authors: Jeffcoate WJ,Vileikyte L,Boyko EJ,Armstrong DG,Boulton AJM

    更新日期:2018-04-01 00:00:00

  • Predicting future cardiovascular disease: do we need the oral glucose tolerance test?

    abstract:OBJECTIVE:Our objective was to compare the performance of oral glucose tolerance tests (OGTTs) and multivariate models incorporating commonly available clinical variables in their ability to predict future cardiovascular disease (CVD). RESEARCH DESIGN AND METHODS:We randomly selected 2,662 Mexican-Americans and 1,595 ...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.25.10.1851

    authors: Stern MP,Fatehi P,Williams K,Haffner SM

    更新日期:2002-10-01 00:00:00

  • Implementation of treatment protocols in the Diabetes Control and Complications Trial.

    abstract:OBJECTIVE:To describe the methods used to implement intensive and conventional therapies in the Diabetes Control and Complications Trial (DCCT) and the metabolic results that occurred with the different treatment regimens. RESEARCH DESIGN AND METHODS:The DCCT was a controlled clinical trial that demonstrated the benef...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.2337/diacare.18.3.361

    authors:

    更新日期:1995-03-01 00:00:00

  • Insulin and glucose excursion following premeal insulin lispro or repaglinide in cystic fibrosis-related diabetes.

    abstract:OBJECTIVE:Insulin and glucose levels in response to premeal insulin lispro or repaglinide were evaluated in adult patients with cystic fibrosis-related diabetes (CFRD) without fasting hyperglycemia. RESEARCH DESIGN AND METHODS:Seven patients with CFRD were fed 1,000-kcal liquid mixed meals. Three study conditions were...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.24.10.1706

    authors: Moran A,Phillips J,Milla C

    更新日期:2001-10-01 00:00:00

  • Circulating and urinary transforming growth factor beta1, Amadori albumin, and complications of type 1 diabetes: the EURODIAB prospective complications study.

    abstract:OBJECTIVE:Transforming growth factor (TGF)-beta1 is overexpressed in diabetes as a consequence of hyperglycemia and the creation of early glycated end products and may be responsible for the characteristic structural renal changes associated with diabetes. We sought to examine the role of both urinary and circulating T...

    journal_title:Diabetes care

    pub_type: 杂志文章,多中心研究

    doi:10.2337/diacare.25.12.2320

    authors: Chaturvedi N,Schalkwijk CG,Abrahamian H,Fuller JH,Stehouwer CD,EURODIAB Prospective Complications Study Group.

    更新日期:2002-12-01 00:00:00

  • Sodium-Glucose Cotransporter Inhibitors: Effects on Renal and Intestinal Glucose Transport: From Bench to Bedside.

    abstract::Type 2 diabetes is a chronic disease with disabling micro- and macrovascular complications that lead to excessive morbidity and premature mortality. It affects hundreds of millions of people and imposes an undue economic burden on populations across the world. Although insulin resistance and insulin secretory defects ...

    journal_title:Diabetes care

    pub_type: 杂志文章,评审

    doi:10.2337/dc15-0642

    authors: Mudaliar S,Polidori D,Zambrowicz B,Henry RR

    更新日期:2015-12-01 00:00:00

  • Treatment of osteomyelitis in the diabetic foot. Contribution of conservative surgery.

    abstract:OBJECTIVE:To compare the duration of healing of foot ulcers with osteomyelitis in diabetic patients treated by medical treatment versus medical treatment associated with conservative orthopedic surgery. RESEARCH DESIGN AND METHODS:We entered into the study 67 diabetic patients who had a foot ulcer with osteomyelitis w...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章

    doi:10.2337/diacare.19.11.1257

    authors: Ha Van G,Siney H,Danan JP,Sachon C,Grimaldi A

    更新日期:1996-11-01 00:00:00

  • Novel use and utility of integrated electronic health records to assess rates of prediabetes recognition and treatment: brief report from an integrated electronic health records pilot study.

    abstract:OBJECTIVE:This study uses novel methods to examine the frequency of diagnosis and treatment of prediabetes in real-world clinical settings using electronic health record (EHR) data. RESEARCH DESIGN AND METHODS:We identified a cohort of 358,120 adults with incident prediabetes (fasting plasma glucose [FPG] 100-125 mg/d...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc13-1223

    authors: Schmittdiel JA,Adams SR,Segal J,Griffin MR,Roumie CL,Ohnsorg K,Grant RW,O'Connor PJ

    更新日期:2014-02-01 00:00:00

  • Effects of a home-based walking intervention on mobility and quality of life in people with diabetes and peripheral arterial disease: a randomized controlled trial.

    abstract:OBJECTIVE:Determine the efficacy of a home-based walking intervention to improve walking ability and quality of life in people with diabetes and peripheral arterial disease (PAD). RESEARCH DESIGN AND METHODS:We conducted a randomized, controlled, single-blind trial within university-affiliated clinics in our local com...

    journal_title:Diabetes care

    pub_type: 杂志文章,随机对照试验

    doi:10.2337/dc10-2399

    authors: Collins TC,Lunos S,Carlson T,Henderson K,Lightbourne M,Nelson B,Hodges JS

    更新日期:2011-10-01 00:00:00

  • Non-insulin-dependent diabetes: 10-year outcome in relation to initial response to diet and subsequent sulfonylurea therapy.

    abstract::Thirty-eight non-insulin-dependent diabetic patients within 130% of desirable body weight were given a 100-g oral glucose tolerance test (OGTT) at diagnosis and after at least 1 mo of dietary treatment with energy and carbohydrate restriction. Thirteen "responders" showed an improvement in fasting blood glucose, gluco...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章

    doi:

    authors: Sönksen PH,Lowy C,Perkins JR,Lim HS

    更新日期:1984-05-01 00:00:00

  • Efficacy of insulin analogs in achieving the hemoglobin A1c target of

    abstract:OBJECTIVE:Insulin analogs are increasingly used in patients with type 2 diabetes. We compared the effect of basal, biphasic, prandial, and basal-bolus insulin regimens with insulin analogs to reach the hemoglobin A(1c) (HbA(1c)) target of <7% in people with type 2 diabetes. RESEARCH DESIGN AND METHODS:We conducted an ...

    journal_title:Diabetes care

    pub_type: 杂志文章,meta分析

    doi:10.2337/dc10-1710

    authors: Giugliano D,Maiorino MI,Bellastella G,Chiodini P,Ceriello A,Esposito K

    更新日期:2011-02-01 00:00:00

  • The effects of aerobic exercise on glucose and counterregulatory hormone concentrations in children with type 1 diabetes.

    abstract:OBJECTIVE:To examine the acute glucose-lowering effects of aerobic exercise in children and adolescents with type 1 diabetes. RESEARCH DESIGN AND METHODS:Fifty children and adolescents with type 1 diabetes (ages 10 to <18 years) were studied during exercise. The 75-min exercise session consisted of four 15-min periods...

    journal_title:Diabetes care

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.2337/diacare.29.1.20

    authors: Tansey MJ,Tsalikian E,Beck RW,Mauras N,Buckingham BA,Weinzimer SA,Janz KF,Kollman C,Xing D,Ruedy KJ,Steffes MW,Borland TM,Singh RJ,Tamborlane WV,Diabetes Research in Children Network (DirecNet) Study Group.

    更新日期:2006-01-01 00:00:00

  • Diabetes mellitus and its vascular complications in Japanese migrants on the Island of Hawaii.

    abstract::Japanese migrants and their offspring on the island of Hawaii and Japanese living in Hiroshima were examined for diabetes mellitus and its vascular complications. the same methods and investigators were used in both locations. Death certificates of Japanese and Caucasians dying on the island during the past 26 yr were...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.2.2.161

    authors: Kawate R,Yamakido M,Nishimoto Y,Bennett PH,Hamman RF,Knowler WC

    更新日期:1979-03-01 00:00:00

  • Effects of energy-restricted diets containing increased protein on weight loss, resting energy expenditure, and the thermic effect of feeding in type 2 diabetes.

    abstract:OBJECTIVE:To determine the effect of a high-protein (HP) diet compared with a low-protein (LP) diet on weight loss, resting energy expenditure (REE), and the thermic effect of food (TEF) in subjects with type 2 diabetes during moderate energy restriction. RESEARCH DESIGN AND METHODS:In this study, 26 obese subjects wi...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章

    doi:10.2337/diacare.25.4.652

    authors: Luscombe ND,Clifton PM,Noakes M,Parker B,Wittert G

    更新日期:2002-04-01 00:00:00

  • Circulating and dietary trans fatty acids and incident type 2 diabetes in older adults: the Cardiovascular Health Study.

    abstract:OBJECTIVE:To investigate the effects of trans fatty acids (TFAs) on type 2 diabetes mellitus (DM) by specific TFA subtype or method of assessment. RESEARCH DESIGN AND METHODS:In the Cardiovascular Health Study, plasma phospholipid trans (t)-16:1n9, t-18:1, and cis (c)/t-, t/c-, and t/t-18:2 were measured in blood draw...

    journal_title:Diabetes care

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.2337/dc14-2101

    authors: Wang Q,Imamura F,Ma W,Wang M,Lemaitre RN,King IB,Song X,Biggs ML,Delaney JA,Mukamal KJ,Djousse L,Siscovick DS,Mozaffarian D

    更新日期:2015-06-01 00:00:00

  • Prospective evaluation of HDL cholesterol changes after diet and physical conditioning programs for patients with type II diabetes mellitus.

    abstract::High-density lipoprotein (HDL) cholesterol is known to be low in patients with diabetes mellitus. Low HDL levels are correlated with premature cardiovascular mortality in several major epidemiologic studies and many investigators believe increases in HDL cholesterol may reduce the risk of coronary heart disease. We ev...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.2337/diacare.8.4.343

    authors: Kaplan RM,Wilson DK,Hartwell SL,Merino KL,Wallace JP

    更新日期:1985-07-01 00:00:00

  • Racial disparities in quality-adjusted life-years associated with diabetes and visual impairment.

    abstract:OBJECTIVE:Compare differences in health-related quality of life among blacks and whites to examine if race, diabetes, and visual impairment (VI) present a triple disadvantage in terms of quality-adjusted life expectancy. RESEARCH DESIGN AND METHODS:Data were analyzed from the 2000-2003 Medical Expenditure Panel Survey...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc11-2433

    authors: McCollister KE,Zheng DD,Fernandez CA,Lee DJ,Lam BL,Arheart KL,Galor A,Ocasio M,Muennig P

    更新日期:2012-08-01 00:00:00

  • Maternal and cord blood adiponectin multimeric forms in gestational diabetes mellitus: a prospective analysis.

    abstract:OBJECTIVE:To analyze the relationship between maternal adiponectin (mAdiponectin) and cord blood adiponectin (cbAdiponectin) multimeric forms (high molecular weight [HMW], medium molecular weight [MMW], and low molecular weight [LMW]) in a cohort of gestational diabetes mellitus (GDM) and normal glucose-tolerant (NGT) ...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc11-0788

    authors: Ballesteros M,Simón I,Vendrell J,Ceperuelo-Mallafré V,Miralles RM,Albaiges G,Tinahones F,Megia A

    更新日期:2011-11-01 00:00:00

  • The association between cardiovascular autonomic neuropathy and mortality in individuals with diabetes: a meta-analysis.

    abstract:OBJECTIVE:To examine by meta-analysis the relationship between cardiovascular autonomic neuropathy (CAN) and risk of mortality in individuals with diabetes. RESEARCH DESIGN AND METHODS:We searched Medline for English-language articles published from 1966 to 2001. Fifteen studies having a baseline assessment of cardiov...

    journal_title:Diabetes care

    pub_type: 杂志文章,meta分析

    doi:10.2337/diacare.26.6.1895

    authors: Maser RE,Mitchell BD,Vinik AI,Freeman R

    更新日期:2003-06-01 00:00:00

  • C-Peptide Decline in Type 1 Diabetes Has Two Phases: An Initial Exponential Fall and a Subsequent Stable Phase.

    abstract:OBJECTIVE:The decline in C-peptide in the 5 years after diagnosis of type 1 diabetes has been well studied, but little is known about the longer-term trajectory. We aimed to examine the association between log-transformed C-peptide levels and the duration of diabetes up to 40 years after diagnosis. RESEARCH DESIGN AND...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc18-0465

    authors: Shields BM,McDonald TJ,Oram R,Hill A,Hudson M,Leete P,Pearson ER,Richardson SJ,Morgan NG,Hattersley AT,TIGI Consortium.

    更新日期:2018-07-01 00:00:00

  • Should Restrictions Be Relaxed for Metformin Use in Chronic Kidney Disease? Yes, They Should Be Relaxed! What's the Fuss?

    abstract::Metformin is and has been considered as first-line therapy for type 2 diabetes for over a quarter of a century. Like other biguanides, metformin can cause a lactic acidosis that is exceptionally rare but fatal. The likelihood of metformin-associated lactic acidosis is substantially higher in patients with kidney impai...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc15-2534

    authors: Bakris GL,Molitch ME

    更新日期:2016-07-01 00:00:00

  • Prediction of diabetes based on baseline metabolic characteristics in individuals at high risk.

    abstract:OBJECTIVE:Individuals with impaired glucose tolerance (IGT) are at high risk for developing type 2 diabetes mellitus (T2DM). We examined which characteristics at baseline predicted the development of T2DM versus maintenance of IGT or conversion to normal glucose tolerance. RESEARCH DESIGN AND METHODS:We studied 228 su...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc13-0520

    authors: Defronzo RA,Tripathy D,Schwenke DC,Banerji M,Bray GA,Buchanan TA,Clement SC,Henry RR,Kitabchi AE,Mudaliar S,Ratner RE,Stentz FB,Musi N,Reaven PD,Gastaldelli A,ACT NOW Study.

    更新日期:2013-11-01 00:00:00

  • Diabetes in a northern Minnesota Chippewa Tribe. Prevalence and incidence of diabetes and incidence of major complications, 1986-1988.

    abstract:OBJECTIVE:To determine the prevalence and incidence of diabetes, and the incidence of major diabetic complications, in a Chippewa Indian population. RESEARCH DESIGN AND METHODS:The format was a longitudinal population study that used active community and health center-based surveillance. The setting was a North Americ...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.16.1.266

    authors: Rith-Najarian SJ,Valway SE,Gohdes DM

    更新日期:1993-01-01 00:00:00

  • Role of hemochromatosis C282Y and H63D mutations in HFE gene in development of type 2 diabetes and diabetic nephropathy.

    abstract:OBJECTIVE:In patients with clinical hemochromatosis, the frequency of diabetes ranges from 20 to 50%, and the heterozygosity for the C282Y mutation in the HFE gene might be associated with an increased risk for diabetes. There are also some reports that suggest that iron overload might cause diabetic nephropathy. RESE...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.24.7.1187

    authors: Moczulski DK,Grzeszczak W,Gawlik B

    更新日期:2001-07-01 00:00:00

  • Receptor binding and effect of biosynthetic human insulin on 2-deoxyglucose transport.

    abstract::Biosynthetic human insulin (BHI) and purified pork insulin (PPI) were compared for binding properties and stimulatory effect on 2-deoxyglucose transport in isolated rat fat cells. No difference between these types of insulin could be demonstrated. ...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.4.2.254

    authors: Wieringa T,van Putten JP,Van Dijk-Besling M,Krans HM

    更新日期:1981-03-01 00:00:00

  • Relationship between prevalence of impaired glucose tolerance and NIDDM in a population.

    abstract:OBJECTIVE:To study the relationship between the prevalence of impaired glucose tolerance (IGT) and non-insulin-dependent diabetes mellitus (NIDDM) across populations of the Pacific Ocean region to assess whether variability in those two proportions followed some predictable pattern related to modernization of life-styl...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.14.11.968

    authors: Dowse GK,Zimmet PZ,King H

    更新日期:1991-11-01 00:00:00