Insulin gene structure and function: a review of studies using recombinant DNA methodology.

abstract：:We measured hemoglobin A1 (HbA1) and performed clean-catch urine cultures in 752 patients (411 men and 341 women) with non-insulin-dependent diabetes mellitus (NIDDM) attending an outpatient diabetes clinic. Prevalence of bacteriuria was significantly greater in diabetic women than in controls (9.1 vs. 5.0%, P less th...

journal_title：Diabetes care

authors： Schmitt JK,Fawcett CJ,Gullickson G

更新日期：1986-09-01 00:00:00

abstract：OBJECTIVE:Youth with type 1 diabetes face long-term risks of health complications of the disease. Little is known about patients' and parents' knowledge, acquisition of information, and family communication regarding these complications. This paper reports qualitative analyses of parental focus-group discussions of thi...

journal_title：Diabetes care

authors： Buckloh LM,Lochrie AS,Antal H,Milkes A,Canas JA,Hutchinson S,Wysocki T

更新日期：2008-08-01 00:00:00

abstract：OBJECTIVE:To determine the pharmacokinetic (PK) and glucodynamic (GD) dose response of human insulin inhalation powder (HIIP) delivered via AIR particle technology and dose equivalence to subcutaneous (SC) insulin lispro. RESEARCH DESIGN AND METHODS:Twenty healthy, nonsmoking, male or female subjects (aged 29.6 +/- 6....

journal_title：Diabetes care

authors： Rave KM,Nosek L,de la Peña A,Seger M,Ernest CS 2nd,Heinemann L,Batycky RP,Muchmore DB

更新日期：2005-10-01 00:00:00

abstract：OBJECTIVE:To evaluate whether, in adolescents with type 1 diabetes, the addition of metformin to insulin and standard diabetes management results in 1) higher insulin sensitivity and 2) lower HbA1c, fasting glucose, insulin dosage (units per kilogram per day) and BMI. RESEARCH DESIGN AND METHODS:This was a randomized,...

journal_title：Diabetes care

authors： Hamilton J,Cummings E,Zdravkovic V,Finegood D,Daneman D

更新日期：2003-01-01 00:00:00

abstract：OBJECTIVE:To evaluate the incidence and relative risk of type 2 diabetes defined by the newly proposed HbA(1c) diagnostic criteria in groups categorized by different baseline HbA(1c) levels. RESEARCH DESIGN AND METHODS:Using data from the European Prospective Investigation of Cancer (EPIC)-Norfolk cohort with repeat H...

journal_title：Diabetes care

authors： Chamnan P,Simmons RK,Forouhi NG,Luben RN,Khaw KT,Wareham NJ,Griffin SJ

更新日期：2011-04-01 00:00:00

abstract：OBJECTIVE:Cost-effectiveness analyses have reported that intensive glucose control is not cost-effective in older patients with new-onset diabetes. However, these analyses have had limited data on patient preferences concerning diabetic health states. We examined how the cost- effectiveness of intensive glucose control...

journal_title：Diabetes care

authors： Huang ES,Shook M,Jin L,Chin MH,Meltzer DO

更新日期：2006-02-01 00:00:00

abstract：OBJECTIVE:To investigate neurophysiological alterations of higher brain function in patients with NIDDM. RESEARCH DESIGN AND METHODS:Auditory P300 event-related potentials were recorded in 60 NIDDM patients who had no evidence of stroke, dementia, or any other neurological illnesses. The P300 wave latencies in diabeti...

journal_title：Diabetes care

authors： Kurita A,Katayama K,Mochio S

更新日期：1996-04-01 00:00:00

abstract：:Glycosylated serum protein (GSP) and glycosylated hemoglobin (GHb) were measured in 263 insulin-dependent and 41 non-insulin-dependent diabetic subjects. Both indices provided useful information in type II diabetes, but were extremely poor in judging control in type I diabetes. In both groups, there was poor correlati...

journal_title：Diabetes care

authors： Mehl TD,Wenzel SE,Russell B,Gardner D,Merimee TJ

更新日期：1983-01-01 00:00:00

abstract：OBJECTIVES:To establish the statistical significance of observed variations over the last decade in the incidence of insulin-dependent diabetes mellitus (IDDM) in the 0- to 19-yr-old age-group and to determine whether incidence has increased in Canterbury, New Zealand. RESEARCH DESIGN AND METHODS:The Canterbury, New Z...

journal_title：Diabetes care

authors： Scott RS,Brown LJ,Darlow BA,Forbes LV,Moore MP

更新日期：1992-07-01 00:00:00

abstract：OBJECTIVE:To evaluate racial differences and factors associated with worse glycemic control in well-functioning older individuals with type 2 diabetes. Our hypothesis was that glycemic control would be worse among black than white diabetic individuals but that this association would be explained by differences in sever...

journal_title：Diabetes care

authors： de Rekeneire N,Rooks RN,Simonsick EM,Shorr RI,Kuller LH,Schwartz AV,Harris TB,Health, Aging and Body Composition Study.

更新日期：2003-07-01 00:00:00

abstract：OBJECTIVE:Available basal insulin formulations do not provide a constant and reliable 24-h insulin supply. We compared the efficacy and safety of glargine (a long-acting insulin analog) and NPH insulins in insulin-naive type 2 diabetic patients treated with oral antidiabetic agents. RESEARCH DESIGN AND METHODS:There w...

journal_title：Diabetes care

authors： Yki-Järvinen H,Dressler A,Ziemen M,HOE 901\/300s Study Group.

更新日期：2000-08-01 00:00:00

abstract：OBJECTIVE:Recent studies suggest that air pollution plays a role in type 2 diabetes (T2D) incidence and mortality. The underlying physiological mechanisms have yet to be established. We hypothesized that air pollution adversely affects insulin sensitivity and secretion and serum lipid levels. RESEARCH DESIGN AND METHO...

journal_title：Diabetes care

authors： Chen Z,Salam MT,Toledo-Corral C,Watanabe RM,Xiang AH,Buchanan TA,Habre R,Bastain TM,Lurmann F,Wilson JP,Trigo E,Gilliland FD

更新日期：2016-04-01 00:00:00

abstract：:In June 2012, 13 thought leaders convened in a Diabetes Care Editors' Expert Forum to discuss the concept of personalized medicine in the wake of a recently published American Diabetes Association/European Association for the Study of Diabetes position statement calling for a patient-centered approach to hyperglycemia...

journal_title：Diabetes care

authors： Raz I,Riddle MC,Rosenstock J,Buse JB,Inzucchi SE,Home PD,Del Prato S,Ferrannini E,Chan JC,Leiter LA,Leroith D,Defronzo R,Cefalu WT

更新日期：2013-06-01 00:00:00

abstract：OBJECTIVE:To determine the prevalence of macroalbuminuria and to describe the clinical and renal pathological changes associated with macroalbuminuria in a population of Canadian First Nation children and adolescents with type 2 diabetes. RESEARCH DESIGN AND METHODS:We conducted a retrospective chart review at a singl...

journal_title：Diabetes care

authors： Sellers EA,Blydt-Hansen TD,Dean HJ,Gibson IW,Birk PE,Ogborn M

更新日期：2009-05-01 00:00:00

abstract：OBJECTIVE:To assess associations between dietary intake and rates of change in insulin resistance and β-cell function in Hispanic women with prior gestational diabetes mellitus (GDM). RESEARCH DESIGN AND METHODS:Sixty-two nondiabetic Hispanic women with pregnancies complicated by GDM completed oral and intravenous glu...

journal_title：Diabetes care

authors： Chen Z,Watanabe RM,Stram DO,Buchanan TA,Xiang AH

更新日期：2014-12-01 00:00:00

abstract：OBJECTIVE:There is considerable interest in identifying biomarkers that predict high risk for the development of macrovascular complications in patients with diabetes. Therefore, the longitudinal association between subclinical atherosclerosis as measured by internal carotid artery intima-media thickness (IMT) and acut...

journal_title：Diabetes care

authors： Hunt KJ,Baker NL,Cleary PA,Klein R,Virella G,Lopes-Virella MF,DCCT\/EDIC Group of Investigators.

更新日期：2015-07-01 00:00:00

abstract：OBJECTIVE:Use of automated bolus advisors is associated with improved glycemic control in patients treated with insulin pump therapy. We conducted a study to assess the impact of using an insulin bolus advisor embedded in a blood glucose (BG) meter on glycemic control and treatment satisfaction in patients treated with...

journal_title：Diabetes care

authors： Ziegler R,Cavan DA,Cranston I,Barnard K,Ryder J,Vogel C,Parkin CG,Koehler W,Vesper I,Petersen B,Schweitzer MA,Wagner RS

更新日期：2013-11-01 00:00:00

abstract：OBJECTIVE:Early use of insulin after diagnosis of type 2 diabetes is met with resistance because of associated weight gain, hypoglycemia, and fear of decreased compliance and quality of life (QoL). RESEARCH DESIGN AND METHODS:In treatment-naive patients with newly diagnosed type 2 diabetes, insulin and metformin were ...

journal_title：Diabetes care

authors： Lingvay I,Legendre JL,Kaloyanova PF,Zhang S,Adams-Huet B,Raskin P

更新日期：2009-10-01 00:00:00

abstract：OBJECTIVE:To assess the impact of hyperglycemia in different age-groups of patients with acute myocardial infarction (AMI). RESEARCH DESIGN AND METHODS:A total of 2,027 patients with AMI were categorized into one of five age-groups: <50 years (n = 301), ≥50 and <60 (n = 477), ≥60 and <70 (n = 545), ≥70 and <80 (n = 49...

journal_title：Diabetes care

authors： Nicolau JC,Serrano CV Jr,Giraldez RR,Baracioli LM,Moreira HG,Lima F,Franken M,Kalil R,Ramires JA,Giugliano RP

更新日期：2012-01-01 00:00:00

abstract：OBJECTIVE:To test the hypothesis that hepatic steatosis is associated with risk factors for type 2 diabetes in overweight and obese youth, mediated by cardiorespiratory fitness. RESEARCH DESIGN AND METHODS:This was a cross-sectional study comparing insulin sensitivity between 30 overweight and obese adolescents with h...

journal_title：Diabetes care

authors： Wicklow BA,Wittmeier KD,MacIntosh AC,Sellers EA,Ryner L,Serrai H,Dean HJ,McGavock JM

更新日期：2012-04-01 00:00:00

abstract：:In search of possible interactions between plastic tubings used for insulin-pump treatment and commercial regular insulin preparations, various catheter sets made from polyvinyl chloride (PVC), polyethylene (PE), and nylon plastics were perfused at 30 degrees C in a laboratory setting for up to 72 h. The perfused insu...

journal_title：Diabetes care

authors： Chantelau E,Lange G,Gasthaus M,Boxberger M,Berger M

更新日期：1987-05-01 00:00:00

abstract：OBJECTIVE:Diabetes and hypertension often co-occur and share risk factors. Hypertension is known to predict diabetes. However, hyperglycemia also may be independently associated with future development of hypertension. We investigated glycated hemoglobin (HbA(1c)) as a predictor of incident hypertension. RESEARCH DESI...

journal_title：Diabetes care

authors： Bower JK,Appel LJ,Matsushita K,Young JH,Alonso A,Brancati FL,Selvin E

更新日期：2012-05-01 00:00:00

abstract：OBJECTIVE:To examine the independent and combined association of isometric muscle strength of the abdomen and back and cardiorespiratory fitness (CRF) in youth with indices of glucose metabolism in young adulthood among boys and girls from the European Youth Heart Study. RESEARCH DESIGN AND METHODS:We used data from a...

journal_title：Diabetes care

authors： Grøntved A,Ried-Larsen M,Ekelund U,Froberg K,Brage S,Andersen LB

更新日期：2013-09-01 00:00:00

abstract：OBJECTIVE:The relative roles of insulin resistance and beta-cell dysfunction in the pathogenesis of impaired glucose tolerance (IGT) and type 2 diabetes are debated. First-degree relatives of individuals with type 2 diabetes are at increased risk of developing hyperglycemia. RESEARCH DESIGN AND METHODS:We evaluated th...

journal_title：Diabetes care

authors： Cnop M,Vidal J,Hull RL,Utzschneider KM,Carr DB,Schraw T,Scherer PE,Boyko EJ,Fujimoto WY,Kahn SE

更新日期：2007-03-01 00:00:00

abstract：OBJECTIVE:To investigate whether insulin resistance and microalbuminuria are associated in non-insulin-dependent diabetes mellitus (NIDDM). RESEARCH DESIGN AND METHODS:Insulin sensitivity was assessed using a hyperinsulinemic euglycemic clamp in 11 normoalbuminuric and 9 microalbuminuric NIDDM patients matched for sex...

journal_title：Diabetes care

authors： Nielsen S,Schmitz O,Orskov H,Mogensen CE

更新日期：1995-06-01 00:00:00

abstract：OBJECTIVE:The purpose of this study was to determine the effect of 24 weeks of treatment with 45 mg/day pioglitazone on peripheral skin blood flow (SkBF) and skin nitric oxide (NO) production in vivo in patients with type 2 diabetes. RESEARCH DESIGN AND METHODS:This was a randomized, parallel, cross-over, double-blind...

journal_title：Diabetes care

authors： Vinik AI,Ullal J,Parson HK,Barlow PM,Casellini CM

更新日期：2006-04-01 00:00:00

abstract：OBJECTIVE:To develop an instrument to measure health status in adult insulin-dependent (type I) and non-insulin-dependent (type II) diabetic patients. RESEARCH DESIGN AND METHODS:Correlative study to examine psychometric properties of the questionnaire. Test-retest reliability, item-scale correlations, principal-compo...

journal_title：Diabetes care

authors： Hammond GS,Aoki TT

更新日期：1992-04-01 00:00:00

abstract：OBJECTIVE:To determine the frequency of IDDM risk-associated HLA-DQ beta alleles in New Zealanders with IDDM and nondiabetic control subjects, and to examine these as susceptibility markers in relation to IDDM incidence. RESEARCH DESIGN AND METHODS:HLA-DQ beta typing was conducted in 55 juvenile-onset IDDM subjects di...

journal_title：Diabetes care

authors： Forbes LV,Brown LJ,Scott RS

更新日期：1993-08-01 00:00:00

abstract：OBJECTIVE:To determine the safety and efficacy of the long-acting insulin analog, insulin glargine, as a component of basal bolus therapy in patients with type 1 diabetes. RESEARCH DESIGN AND METHODS:Patients with type 1 diabetes receiving basal-bolus insulin treatment with NPH human insulin and insulin lispro were ra...

journal_title：Diabetes care

authors： Raskin P,Klaff L,Bergenstal R,Hallé JP,Donley D,Mecca T

更新日期：2000-11-01 00:00:00

abstract：OBJECTIVE:To determine the role of height and glycosylated hemoglobin in abnormal nerve conduction in pediatric patients with insulin-dependent (type I) diabetes mellitus. RESEARCH DESIGN AND METHODS:Sixty-six pediatric patients (aged 6.3-18.2 yr) with a duration of diabetes from 4 to 8.5 yr but free of clinical neuro...

journal_title：Diabetes care

authors： Duck SC,Wei FF,Parke J,Swick HM

更新日期：1991-05-01 00:00:00