Progressive loss of beta-cell function leads to worsening glucose tolerance in first-degree relatives of subjects with type 2 diabetes.

abstract：OBJECTIVE:To investigate the association of carotid atherosclerosis and serum lipoprotein(a) [Lp(a)] concentrations in subjects with NIDDM. RESEARCH DESIGN AND METHODS:We measured carotid intima-media thickness (IMT) and Lp(a) concentrations in 117 NIDDM subjects. Subjects were divided into tertiles according to IMT v...

journal_title：Diabetes care

authors： Yamamoto M,Egusa G,Yamakido M

更新日期：1997-05-01 00:00:00

abstract：OBJECTIVE:We evaluated the prevalence of endothelial dysfunction as measured by flow-mediated dilatation (FMD) of the brachial artery and carotid intima-media thickness (c-IMT) in relationship to vascular inflammatory biomarkers in preadolescent children with type 1 diabetes. RESEARCH DESIGN AND METHODS:We studied 21 ...

journal_title：Diabetes care

authors： Babar GS,Zidan H,Widlansky ME,Das E,Hoffmann RG,Daoud M,Alemzadeh R

更新日期：2011-03-01 00:00:00

abstract：OBJECTIVE:To compare the glucose variability associated with insulin glargine and NPH/Lente insulin used as the basal insulin component of a multiple daily injection (MDI) regimen in pediatric patients with type 1 diabetes. RESEARCH DESIGN AND METHODS:Continuous glucose monitoring data were collected from a subset of ...

journal_title：Diabetes care

authors： White NH,Chase HP,Arslanian S,Tamborlane WV,4030 Study Group.

更新日期：2009-03-01 00:00:00

abstract：OBJECTIVE:To objectively evaluate adherence to timing and dosing of insulin by using Bluetooth pen caps and examine factors related to adherence. RESEARCH DESIGN AND METHODS:Bluetooth-enabled insulin pen caps were used in younger (ages 18-35 years) and older (ages ≥65 years) adults on two or more insulin injections pe...

journal_title：Diabetes care

authors： Munshi MN,Slyne C,Greenberg JM,Greaves T,Lee A,Carl S,Atakov-Castillo A,Toschi E

更新日期：2019-06-01 00:00:00

abstract：OBJECTIVE:The results differ concerning randomized controlled trials of the effects of metformin on blood glucose regulation and body weight. To get a systematic overview, a meta-analysis of the efficacy of metformin was performed by comparing metformin with placebo and sulfonylurea. RESEARCH DESIGN AND METHODS:All ra...

journal_title：Diabetes care

authors： Johansen K

更新日期：1999-01-01 00:00:00

abstract：OBJECTIVE:The risk of myocardial infarction (MI) in patients with diabetes is greater than for patients without diabetes. Consequently, prophylactic treatment is recommended for patients with diabetes and risk factors for ischemic heart disease. We aimed to estimate the risk of adverse cardiac events in patients with a...

journal_title：Diabetes care

authors： Olesen KKW,Madsen M,Egholm G,Thim T,Jensen LO,Raungaard B,Bøtker HE,Sørensen HT,Maeng M

更新日期：2017-08-01 00:00:00

abstract：OBJECTIVE:High birth weight is a risk factor for neonatal complications. It is not known if the risk differs with body proportionality. The primary aim of this study was to determine the risk of adverse pregnancy outcome in relation to body proportionality in large-for-gestational-age (LGA) infants stratified by matern...

journal_title：Diabetes care

authors： Persson M,Fadl H,Hanson U,Pasupathy D

更新日期：2013-11-01 00:00:00

abstract：OBJECTIVE:High levels of dietary fiber, especially soluble fiber, are recommended to lower serum cholesterol levels and improve glycemic control in patients with type 2 diabetes. It is not clear, however, how high levels of fiber affect mineral balance. RESEARCH DESIGN AND METHODS:In a randomized crossover study, 13 p...

journal_title：Diabetes care

authors： Shah M,Chandalia M,Adams-Huet B,Brinkley LJ,Sakhaee K,Grundy SM,Garg A

更新日期：2009-06-01 00:00:00

abstract：OBJECTIVE:To estimate the health-related quality of life (HRQOL) and treatment satisfaction for patients with type 2 diabetes in the Netherlands and to examine which patient characteristics are associated with quality of life and treatment satisfaction. RESEARCH DESIGN AND METHODS:For a sample of 1,348 type 2 diabetes...

journal_title：Diabetes care

authors： Redekop WK,Koopmanschap MA,Stolk RP,Rutten GE,Wolffenbuttel BH,Niessen LW

更新日期：2002-03-01 00:00:00

abstract：OBJECTIVE:The purpose of this study was to compare measurements of glucose obtained via iontophoretic extraction with the GlucoWatch automatic glucose biographer (Cygnus, Inc., Redwood City, CA) with capillary blood glucose values that were determined 1) in a controlled outpatient clinic setting and 2) in a home settin...

journal_title：Diabetes care

authors： Garg SK,Potts RO,Ackerman NR,Fermi SJ,Tamada JA,Chase HP

更新日期：1999-10-01 00:00:00

abstract：OBJECTIVE:To compare pharmacokinetics (PK) and pharmacodynamics (PD) of insulin glargine in type 2 diabetes mellitus (T2DM) after evening versus morning administration. RESEARCH DESIGN AND METHODS:Ten T2DM insulin-treated persons were studied during 24-h euglycemic glucose clamp, after glargine injection (0.4 units/kg...

journal_title：Diabetes care

authors： Porcellati F,Lucidi P,Cioli P,Candeloro P,Marinelli Andreoli A,Marzotti S,Ambrogi M,Bolli GB,Fanelli CG

更新日期：2015-03-01 00:00:00

abstract：OBJECTIVE:This study examined associations between BMI and mortality in individuals with normoglycemia, impaired fasting glucose (IFG), newly diagnosed diabetes, and prevalent diabetes and identified BMI ranges associated with the lowest mortality in each group. RESEARCH DESIGN AND METHODS:A total of 12,815,006 adults...

journal_title：Diabetes care

authors： Lee EY,Lee YH,Yi SW,Shin SA,Yi JJ

更新日期：2017-08-01 00:00:00

abstract：OBJECTIVE:To examine cross-sectional associations of serum vitamin D [25-hydroxyvitamin D, 25(OH)D] concentration with insulin resistance (IR) and beta-cell dysfunction in 712 subjects at risk for type 2 diabetes. RESEARCH DESIGN AND METHODS:Serum 25(OH)D was determined using a chemiluminescence immunoassay. Insulin s...

journal_title：Diabetes care

authors： Kayaniyil S,Vieth R,Retnakaran R,Knight JA,Qi Y,Gerstein HC,Perkins BA,Harris SB,Zinman B,Hanley AJ

更新日期：2010-06-01 00:00:00

abstract：OBJECTIVE:To investigate the effect of parenteral insulin therapy on endogenous insulin secretion in the Diabetes Prevention Trial-Type 1 (DPT-1). RESEARCH DESIGN AND METHODS:In the parenteral insulin arm of DPT-1, subjects without diabetes at high risk of future type 1 diabetes randomized to active treatment received...

journal_title：Diabetes care

authors： Hao W,Greenbaum CJ,Krischer JP,Cuthbertson D,Marks JB,Palmer JP

更新日期：2015-05-01 00:00:00

abstract：OBJECTIVE:A combined analysis of whether islet cell autoantibodies (ICAs) are cross-reactive with mouse pancreas, with glutamate decarboxylase (GAD) antibodies, and with 64K antibodies was performed in a large sample of recently diagnosed type I diabetic patients. The disappearance rates of these different autoantibodi...

journal_title：Diabetes care

authors： Chaillous L,Delamaire M,Martignat L,Maugendre D,Marre M,Mathieu E,Limal JM,Charbonnel B,Allannic H,Saï P

更新日期：1994-10-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to evaluate the frequency of sympathetic versus parasympathetic neuropathy among type 1 and type 2 diabetic patients. RESEARCH DESIGN AND METHODS:There were 43 patients with type 1 and 17 with type 2 diabetes who were investigated. Sympathetic nerve function was assessed by measurem...

journal_title：Diabetes care

authors： Freccero C,Svensson H,Bornmyr S,Wollmer P,Sundkvist G

更新日期：2004-12-01 00:00:00

abstract：OBJECTIVE:To assess the relevance of pulse pressure as a predictor of foot ulcers in type 2 diabetic subjects. RESEARCH DESIGN AND METHODS:A cohort study was performed on a consecutive series of 1,945 type 2 diabetic outpatients without a foot ulcer at baseline. Incident foot ulcers were identified through the regiona...

journal_title：Diabetes care

authors： Monami M,Vivarelli M,Desideri CM,Colombi C,Marchionni N,Mannucci E

更新日期：2009-05-01 00:00:00

abstract：OBJECTIVE:Treatment guidelines for diabetes have become increasingly stringent as most research shows that more aggressive intervention reduces the risks for complications. Community data on the effect of these interventions are lacking. RESEARCH DESIGN AND METHODS:Changes in the pharmacologic treatment of diabetes, b...

journal_title：Diabetes care

authors： Looker HC,Krakoff J,Andre V,Kobus K,Nelson RG,Knowler WC,Hanson RL

更新日期：2010-11-01 00:00:00

abstract：:This commentary/review briefly considers the diverse criteria recommended for classification of overweight infants. Macrosomia continues to be a vexing problem for both obstetricians and pediatricians. Among the various techniques possible for use in assessing body composition, none are more practical than body weight...

journal_title：Diabetes care

authors： Schwartz R,Teramo KA

更新日期：1999-07-01 00:00:00

abstract：OBJECTIVE:Continuous glucose monitoring (CGM) reduces HbA1c and time spent in hypoglycemia in people with type 1 diabetes (T1D) treated with multiple daily insulin injections (MDI) when evaluated over shorter time periods. It is unclear to what extent CGM improves and helps to maintain glucose control, treatment satisf...

journal_title：Diabetes care

authors： Lind M,Ólafsdóttir AF,Hirsch IB,Bolinder J,Dahlqvist S,Pivodic A,Hellman J,Wijkman M,Schwarcz E,Albrektsson H,Heise T,Polonsky W

更新日期：2021-01-01 00:00:00

abstract：OBJECTIVE:To examine if dual replacement with insulin and rhIGF-I, recombinant human insulin-like growth factor I (rhIGF-I) may be safe and result in improved metabolic control and reduced insulin usage. RESEARCH DESIGN AND METHODS:Forty-three patients with IDDM were randomized to receive a daily injection of rhIGF-I ...

journal_title：Diabetes care

authors： Quattrin T,Thrailkill K,Baker L,Litton J,Dwigun K,Rearson M,Poppenheimer M,Giltinan D,Gesundheit N,Martha P Jr

更新日期：1997-03-01 00:00:00

abstract：OBJECTIVE:To investigate the relation between total fish, type of fish (lean and fatty), and eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) intake and risk of type 2 diabetes in a population-based cohort. RESEARCH DESIGN AND METHODS:The analysis included 4,472 Dutch participants aged >or=55 years without d...

journal_title：Diabetes care

authors： van Woudenbergh GJ,van Ballegooijen AJ,Kuijsten A,Sijbrands EJ,van Rooij FJ,Geleijnse JM,Hofman A,Witteman JC,Feskens EJ

更新日期：2009-11-01 00:00:00

abstract：OBJECTIVE:To determine whether the severity of retinopathy is higher in a group of NIDDM patients with sBP greater than or equal to 140 mmHg compared with NIDDM patients with sBP less than 140 mmHg. RESEARCH DESIGN AND METHODS:Ophthalmoscopy and FAG were conducted among a group of NIDDM patients with either a sBP abov...

journal_title：Diabetes care

authors： Cignarelli M,De Cicco ML,Damato A,Paternostro A,Pagliarini S,Santoro S,Cardia L,De Pergola G,Giorgino R

更新日期：1992-08-01 00:00:00

abstract：OBJECTIVE:Dietary fiber has recently received recognition for reducing the risk of developing diabetes and heart disease. The implication is that it may have therapeutic benefit in prediabetic metabolic conditions. To test this hypothesis, we investigated the effect of supplementing a high-carbohydrate diet with fiber ...

journal_title：Diabetes care

authors： Vuksan V,Sievenpiper JL,Owen R,Swilley JA,Spadafora P,Jenkins DJ,Vidgen E,Brighenti F,Josse RG,Leiter LA,Xu Z,Novokmet R

更新日期：2000-01-01 00:00:00

abstract：OBJECTIVE:Numerous publications have already demonstrated that diabetes is a risk factor for the development of periodontal diseases and various inflammatory lesions in the oral mucosa. A possible correlation between diabetes and oral premalignancies and tumors was examined in this study, as no literature data are avai...

journal_title：Diabetes care

authors： Ujpál M,Matos O,Bíbok G,Somogyi A,Szabó G,Suba Z

更新日期：2004-03-01 00:00:00

abstract：OBJECTIVE:To investigate neurophysiological alterations of higher brain function in patients with NIDDM. RESEARCH DESIGN AND METHODS:Auditory P300 event-related potentials were recorded in 60 NIDDM patients who had no evidence of stroke, dementia, or any other neurological illnesses. The P300 wave latencies in diabeti...

journal_title：Diabetes care

authors： Kurita A,Katayama K,Mochio S

更新日期：1996-04-01 00:00:00

abstract：:Cyclosporin and other immunosuppressive agents have been proposed as a preventive treatment against the development of insulin-dependent diabetes mellitus (IDDM) in relatives at increased risk for the disease, based on the understanding that its etiology is an ongoing process of autoimmune beta-cell destruction. We us...

journal_title：Diabetes care

authors： Lipton R,LaPorte RE,Becker DJ,Dorman JS,Orchard TJ,Atchison J,Drash AL

更新日期：1990-07-01 00:00:00

abstract：OBJECTIVE:To investigate the effect of ginseng on newly diagnosed non-insulin-dependent diabetes mellitus (NIDDM) patients. RESEARCH DESIGN AND METHODS:In this double-blind placebo-controlled study, 36 NIDDM patients were treated for 8 weeks with ginseng (100 or 200 mg) or placebo. Efficacy was evaluated with psychoph...

journal_title：Diabetes care

authors： Sotaniemi EA,Haapakoski E,Rautio A

更新日期：1995-10-01 00:00:00

abstract：OBJECTIVE:The role of adiponectin in the natural history of diabetes is not well characterized. We set out to characterize prediagnosis trajectories of adiponectin in individuals who develop type 2 diabetes. RESEARCH DESIGN AND METHODS:In a case-cohort study (335 incident diabetes case and 2,474 noncase subjects) nest...

journal_title：Diabetes care

authors： Tabák AG,Carstensen M,Witte DR,Brunner EJ,Shipley MJ,Jokela M,Roden M,Kivimäki M,Herder C

更新日期：2012-12-01 00:00:00

abstract：OBJECTIVE:The levels of the surrogate markers of cholesterol absorption (cholestanol and plant sterols) and synthesis (cholesterol precursors) in serum have suggested that in adult type 1 diabetes, cholesterol absorption is high and synthesis is low compared with type 2 diabetic or control subjects. Accordingly, these ...

journal_title：Diabetes care

authors： Järvisalo M,Raitakari O,Gylling H,Miettinen TA

更新日期：2006-10-01 00:00:00