Abstract:
OBJECTIVE:The levels of the surrogate markers of cholesterol absorption (cholestanol and plant sterols) and synthesis (cholesterol precursors) in serum have suggested that in adult type 1 diabetes, cholesterol absorption is high and synthesis is low compared with type 2 diabetic or control subjects. Accordingly, these findings were further studied in children with type 1 diabetes. RESEARCH DESIGN AND METHODS:Forty-eight children with diabetes were compared with 79 age- and sex-matched control subjects. The serum ratios of cholesterol absorption and synthesis markers were measured with gas-liquid chromatography. The study population was divided into triads (combining the two lowest triads) by serum cholestanol ratios of the control subjects indicating low to high cholesterol absorption efficiency. RESULTS:The ratios of the absorption and synthesis markers were similar in case and control subjects, and they were negatively related to each other in control subjects, being less consistent in diabetic patients. Thus, high cholesterol absorption was associated with low synthesis. Plant sterol ratios increased significantly with increasing cholestanol triads in both groups, but the values in the lowest triads were higher in case versus control subjects. CONCLUSIONS:Homeostasis between cholesterol absorption and synthesis is maintained in control children and somewhat less consistently in those with diabetes. The higher plant sterol ratios in diabetic versus control subjects in the lowest cholestanol triads suggest that cholesterol absorption is higher in children with diabetes versus control subjects but only within the range of low cholesterol absorption.
journal_name
Diabetes Carejournal_title
Diabetes careauthors
Järvisalo M,Raitakari O,Gylling H,Miettinen TAdoi
10.2337/dc05-2235subject
Has Abstractpub_date
2006-10-01 00:00:00pages
2300-4issue
10eissn
0149-5992issn
1935-5548pii
29/10/2300journal_volume
29pub_type
杂志文章相关文献
DIABETES CARE文献大全abstract:OBJECTIVE:To study the relationship between exposure to antibiotic treatment and risk of subsequent myocardial infarction (MI) in patients with diabetes. RESEARCH DESIGN AND METHODS:A case-control design was used to assess the effect of previous antibiotic exposure in diabetes patients with acute, nonfatal or fatal MI...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.26.7.2100
更新日期:2003-07-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to determine whether objectively measured physical activity and dietary macronutrient intake differentially predict body fat in adolescent girls with type 1 diabetes and control girls. RESEARCH DESIGN AND METHODS:This study comprised 23 girls (12-19 years) with type 1 diabetes a...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc05-2318
更新日期:2006-06-01 00:00:00
abstract:OBJECTIVE:Numerous publications have already demonstrated that diabetes is a risk factor for the development of periodontal diseases and various inflammatory lesions in the oral mucosa. A possible correlation between diabetes and oral premalignancies and tumors was examined in this study, as no literature data are avai...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.27.3.770
更新日期:2004-03-01 00:00:00
abstract:OBJECTIVE:Under the auspices of the National Institutes of Health, American Diabetes Association, and World Health Organization, expert committees lowered the fasting plasma glucose (FPG) concentration diagnostic for diabetes from 7.8 to 7.0 mmol/l and defined 6.1-6.9 mmol/l as impaired fasting glucose (IFG) and <6.1 m...
journal_title:Diabetes care
pub_type: 杂志文章,评审
doi:10.2337/diacare.28.11.2626
更新日期:2005-11-01 00:00:00
abstract:OBJECTIVE:To evaluate the relationship of central fat distribution with gestational glucose tolerance during the usual time for screening gestational diabetes. RESEARCH DESIGN AND METHODS:This cross-sectional study investigated 1,113 consecutive women, > or = 20 years old, pregnant for approximately 21 to 28 weeks, wi...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.20.4.509
更新日期:1997-04-01 00:00:00
abstract:OBJECTIVE:Diabetes is one of the most common chronic diseases and a leading cause of morbidity and mortality in the U.S. Although our ability to treat diabetes and its associated complications has significantly improved, presentation with uncontrolled diabetes leading to ketoacidosis remains a significant problem. RES...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc17-1379
更新日期:2018-08-01 00:00:00
abstract::The reality of primary and secondary prevention of cardiovascular complications in people with diabetes is alarming, even in developed countries with a well-structured medical system. Even though therapeutic targets have been more clearly defined during the last decades, their implementation is still suboptimal. Finan...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc08-s254
更新日期:2008-02-01 00:00:00
abstract:OBJECTIVE:To describe an etiologic approach to classification of diabetes types in youth based on the 1997 American Diabetes Association (ADA) framework, using data from the SEARCH for Diabetes in Youth Study. RESEARCH DESIGN AND METHODS:SEARCH conducted a comprehensive assessment of 2,291 subjects aged <20 years with...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc10-2324
更新日期:2011-07-01 00:00:00
abstract:OBJECTIVE:Approximately 25% of patients who undergo percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG) have diabetes, and the diagnosis of diabetes roughly doubles the mortality risk associated with coronary artery disease. However, the impact of diabetes may differ according to ethnicit...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc11-1547
更新日期:2012-03-01 00:00:00
abstract:OBJECTIVE:Ipragliflozin, a sodium-glucose cotransporter 2 inhibitor, stimulates glycosuria and lowers glycemia in patients with type 2 diabetes (T2DM). The objective of this study was to assess the pharmacodynamics of ipragliflozin in T2DM patients with impaired renal function. RESEARCH DESIGN AND METHODS:Glycosuria w...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc12-1503
更新日期:2013-05-01 00:00:00
abstract:OBJECTIVE:The sympathetic nervous system and thiazolidinediones control lipid metabolism and have been implicated in body weight regulation. This study was conducted to determine whether the simultaneous activation of these two signaling systems might synergize to exert beneficial effects on the expression of key genes...
journal_title:Diabetes care
pub_type: 杂志文章,随机对照试验
doi:10.2337/dc06-1962
更新日期:2007-05-01 00:00:00
abstract:OBJECTIVE:To project the number of people with diagnosed diabetes in the U.S. through 2050, accounting for changing demography and diabetes prevalence rates. RESEARCH DESIGN AND METHODS:We combined age-, sex-, and race-specific diagnosed diabetes prevalence rates-predicted from 1980-1998 trends in prevalence data from...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.24.11.1936
更新日期:2001-11-01 00:00:00
abstract::We measured hemoglobin A1 (HbA1) and performed clean-catch urine cultures in 752 patients (411 men and 341 women) with non-insulin-dependent diabetes mellitus (NIDDM) attending an outpatient diabetes clinic. Prevalence of bacteriuria was significantly greater in diabetic women than in controls (9.1 vs. 5.0%, P less th...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.9.5.518
更新日期:1986-09-01 00:00:00
abstract:OBJECTIVE:Patients with diabetes have a higher case fatality rate in myocardial infarction (MI) or stroke than those without diabetes: that is, MI and stroke are more often fatal if diabetes is present. We investigated whether the risk of MI or stroke being fatal in type 2 diabetes can be estimated using information av...
journal_title:Diabetes care
pub_type: 杂志文章,多中心研究
doi:10.2337/diacare.27.1.201
更新日期:2004-01-01 00:00:00
abstract::There is increasing evidence that an ongoing cytokine-induced acute-phase response (sometimes called low-grade inflammation, but part of a widespread activation of the innate immune system) is closely involved in the pathogenesis of type 2 diabetes and associated complications such as dyslipidemia and atherosclerosis....
journal_title:Diabetes care
pub_type: 杂志文章,评审
doi:10.2337/diacare.27.3.813
更新日期:2004-03-01 00:00:00
abstract::The role of hyperinsulinemia in the pathogenesis of triglyceride (TG) and VLDL over-production in insulin-resistant states remains controversial. While studies in humans and animals have generally suggested that chronic hyperinsulinemia facilitates VLDL production, particularly in the presence of an abundant supply of...
journal_title:Diabetes care
pub_type: 杂志文章,评审
doi:10.2337/diacare.19.4.390
更新日期:1996-04-01 00:00:00
abstract:OBJECTIVE:High plasma adiponectin is associated with reduced risk of type 2 diabetes, probably a consequence of its insulin-sensitizing properties. In vivo data in rodents suggest that the insulin-sensitization responsible for improvement of glycemia occurs in muscle and liver. Whereas associations of plasma adiponecti...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.26.12.3315
更新日期:2003-12-01 00:00:00
abstract::In seven type II (non-insulin-dependent) diabetic patients, given either 50 g glucose or a mixed meal potentially containing 61 g glucose as starch and sucrose, the postmeal plasma glucose area integrated over 4 h was less after the mixed meal. The insulin area was considerably greater (2.1-fold). The greater increase...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.11.1.72
更新日期:1988-01-01 00:00:00
abstract:OBJECTIVE:We prospectively investigated in hypertensive patients with type 2 diabetes if bedtime treatment with ≥1 hypertension medications exerts better blood pressure control and cardiovascular risk reduction than conventional therapy, in which all medications are ingested in the morning. RESEARCH DESIGN AND METHODS...
journal_title:Diabetes care
pub_type: 杂志文章,随机对照试验
doi:10.2337/dc11-0297
更新日期:2011-06-01 00:00:00
abstract:OBJECTIVE:The primary outcome is to evaluate the relationship between diabetes distress and decisional conflict regarding diabetes care in patients with diabetes and two or more comorbidities. Secondary outcomes include the relationships between diabetes distress and quality of life and patient perception of chronic il...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc18-1256
更新日期:2019-07-01 00:00:00
abstract:OBJECTIVE:The cholesteryl ester transfer protein (CETP) plays a key role in the remodeling of triglyceride (TG)-rich and HDL particles. Sequence variations in the CETP gene may interfere with the effect of lipid-lowering treatment in type 2 diabetes. RESEARCH DESIGN AND METHODS:We performed a 30-week randomized double...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.2337/diacare.26.4.1216
更新日期:2003-04-01 00:00:00
abstract::In a 10-yr prospective population study 406 subjects who were 70 yr old received an oral glucose tolerance test. Of these subjects 169 were retested at 80. Three sets of diagnostic criteria were evaluated, of which the WHO criteria are recommended for screening studies in this age group. The prevalences of diabetes me...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.5.6.600
更新日期:1982-11-01 00:00:00
abstract:OBJECTIVE:The purpose of this article was to compare the effects of cod protein to those of other animal proteins on insulin sensitivity in insulin-resistant human subjects. RESEARCH DESIGN AND METHODS:Insulin sensitivity (M/I) was assessed using a hyperinsulinemic-euglycemic clamp in 19 insulin-resistant subjects fed...
journal_title:Diabetes care
pub_type: 杂志文章,随机对照试验
doi:10.2337/dc07-0273
更新日期:2007-11-01 00:00:00
abstract:OBJECTIVE:To investigate the effects of trans fatty acids (TFAs) on type 2 diabetes mellitus (DM) by specific TFA subtype or method of assessment. RESEARCH DESIGN AND METHODS:In the Cardiovascular Health Study, plasma phospholipid trans (t)-16:1n9, t-18:1, and cis (c)/t-, t/c-, and t/t-18:2 were measured in blood draw...
journal_title:Diabetes care
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.2337/dc14-2101
更新日期:2015-06-01 00:00:00
abstract:OBJECTIVE:To determine the risk of frequent and severe hypoglycemia and the associated demographic and clinical risk factors. RESEARCH DESIGN AND METHODS:Demographic and diabetes self-management factors were measured in 415 subjects followed prospectively for 4-6.5 years of type 1 diabetes duration as participants in ...
journal_title:Diabetes care
pub_type: 杂志文章,多中心研究
doi:10.2337/diacare.24.11.1878
更新日期:2001-11-01 00:00:00
abstract:OBJECTIVE:To examine determinants of racial/ethnic differences in diabetes incidence among postmenopausal women participating in the Women's Health Initiative. RESEARCH DESIGN AND METHODS:Data on race/ethnicity, baseline diabetes prevalence, and incident diabetes were obtained from 158,833 women recruited from 1993-19...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc12-0412
更新日期:2012-11-01 00:00:00
abstract:OBJECTIVE:Success after islet transplantation can be defined in terms of insulin independence, C-peptide secretion, or glycemic control. These measures are interdependent and all need to be considered in evaluating beta-cell function after islet transplantation. For the current study, a composite beta-score was develop...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.28.2.343
更新日期:2005-02-01 00:00:00
abstract:OBJECTIVE:To determine whether women with pregestational diabetes obtained long-term benefits from an intensive diabetes management program during pregnancy. RESEARCH DESIGN AND METHODS:Women with pregestational diabetes who had attended an intensive diabetes management program in pregnancy between 1991 and 1999 were ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.29.03.06.dc05-1731
更新日期:2006-03-01 00:00:00
abstract:OBJECTIVE:To determine the effect of metformin on the acute metabolic response to submaximal exercise, the effect of exercise on plasma metformin concentrations, and the interaction between metformin and exercise on the subsequent response to a standardized meal. RESEARCH DESIGN AND METHODS:Ten participants with type ...
journal_title:Diabetes care
pub_type: 杂志文章,随机对照试验
doi:10.2337/dc10-2207
更新日期:2011-07-01 00:00:00
abstract:OBJECTIVE:Type 1 diabetes mellitus causes increased carotid intima-media thickness (IMT) in adults. We evaluated IMT in young subjects with type 1 diabetes. RESEARCH DESIGN AND METHODS:Participants with type 1 diabetes (N = 402) were matched to controls (N = 206) by age, sex, and race or ethnicity. Anthropometric and ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc12-2024
更新日期:2013-09-01 00:00:00