The effect of beta-adrenergic and peroxisome proliferator-activated receptor-gamma stimulation on target genes related to lipid metabolism in human subcutaneous adipose tissue.

abstract：OBJECTIVE:Identifying maturity-onset diabetes of the young (MODY) in pediatric populations close to diabetes diagnosis is difficult. Misdiagnosis and unnecessary insulin treatment are common. We aimed to identify the discriminatory clinical features at diabetes diagnosis of patients with glucokinase (GCK), hepatocyte n...

journal_title：Diabetes care

authors： Carlsson A,Shepherd M,Ellard S,Weedon M,Lernmark Å,Forsander G,Colclough K,Brahimi Q,Valtonen-Andre C,Ivarsson SA,Elding Larsson H,Samuelsson U,Örtqvist E,Groop L,Ludvigsson J,Marcus C,Hattersley AT

更新日期：2020-01-01 00:00:00

abstract：:The association of obesity with hypertension has been amply demonstrated in cross-sectional, longitudinal, and dietary-intervention studies, but the mechanisms remain enigmatic. Both conditions are independently characterized by similar metabolic alterations, i.e., glucose intolerance, dyslipoproteinemia, elevated ser...

journal_title：Diabetes care

authors： Modan M,Halkin H

更新日期：1991-06-01 00:00:00

abstract：OBJECTIVE:Anti-programmed cell death-1 (anti-PD-1) antibodies have revolutionized advanced cancer therapy. Anti-PD-1 therapy is responsible for immune-related adverse events, with frequent endocrine manifestations, including acute-onset type 1 diabetes. Acquired generalized lipodystrophy (AGL) is a rare disease, believ...

journal_title：Diabetes care

authors： Jehl A,Cugnet-Anceau C,Vigouroux C,Legeay AL,Dalle S,Harou O,Marchand L,Lascols O,Caussy C,Thivolet C,Laville M,Disse E

更新日期：2019-10-01 00:00:00

abstract：OBJECTIVE:In this prospective, randomized, open trial, we compared the efficacy and safety of aspart insulin given subcutaneously at different time intervals to a standard low-dose intravenous (IV) infusion protocol of regular insulin in patients with uncomplicated diabetic ketoacidosis (DKA). RESEARCH DESIGN AND METH...

journal_title：Diabetes care

authors： Umpierrez GE,Cuervo R,Karabell A,Latif K,Freire AX,Kitabchi AE

更新日期：2004-08-01 00:00:00

abstract：:One-third of men with obesity or type 2 diabetes have subnormal free testosterone concentrations. The lower free testosterone concentrations are observed in obese men at all ages, including adolescents at completion of puberty. The gonadotropin concentrations in these males are inappropriately normal; thus, these pati...

journal_title：Diabetes care

authors： Dhindsa S,Ghanim H,Batra M,Dandona P

更新日期：2018-07-01 00:00:00

abstract：OBJECTIVE:To explore the possible link between diabetic nephropathy and the enhanced activity of the polyol pathway, known to occur in IDDM subjects. RESEARCH DESIGN AND METHODS:We studied the effects of the aldose reductase inhibitor tolrestat (200 mg/day) on urinary albumin excretion rate and glomerular filtration r...

journal_title：Diabetes care

authors： Passariello N,Sepe J,Marrazzo G,De Cicco A,Peluso A,Pisano MC,Sgambato S,Tesauro P,D'Onofrio F

更新日期：1993-05-01 00:00:00

abstract：OBJECTIVE:To test whether diabetic polyneuropathies (DPNs), retinopathy, or nephropathy is more prevalent in subjects with impaired glycemia (IG) (abnormality of impaired fasting glucose [IFG], impaired glucose tolerance [IGT], or impaired HbA(1c) [IA1C]) than in healthy subjects (non-IG). RESEARCH DESIGN AND METHODS:...

journal_title：Diabetes care

authors： Dyck PJ,Clark VM,Overland CJ,Davies JL,Pach JM,Dyck PJ,Klein CJ,Rizza RA,Melton LJ 3rd,Carter RE,Klein R,Litchy WJ

更新日期：2012-03-01 00:00:00

abstract：OBJECTIVE:To determine the prevalence of type 2 diabetes and impaired fasting glycemia (IFG) in a tribal population of Bangladesh. RESEARCH DESIGN AND METHODS:A cluster sampling of 1,287 tribal subjects of age > or =20 years was investigated. They live in a hilly area of Khagrachari in the far northeast of Bangladesh....

journal_title：Diabetes care

authors： Abu Sayeed M,Mahtab H,Akter Khanam P,Abul Ahsan K,Banu A,Rashid AN,Azad Khan AK

更新日期：2004-05-01 00:00:00

abstract：OBJECTIVE:To examine the association of stage of change with diet and exercise behaviors in response to a lifestyle intervention for Native Hawaiians (NHs). RESEARCH DESIGN AND METHODS:A family ('ohana) support lifestyle intervention was compared with a standard intervention in NHs with or at risk for diabetes in two ...

journal_title：Diabetes care

authors： Mau MK,Glanz K,Severino R,Grove JS,Johnson B,Curb JD

更新日期：2001-10-01 00:00:00

abstract：OBJECTIVE:To determine the association between triglyceride levels and lower-extremity amputation (LEA) risk in a large diabetic cohort. RESEARCH DESIGN AND METHODS:This is a 10-year survey follow-up study (from 1995-2006) of 28,701 diabetic patients with a baseline triglyceride measure. All patients were fully insure...

journal_title：Diabetes care

authors： Callaghan BC,Feldman E,Liu J,Kerber K,Pop-Busui R,Moffet H,Karter AJ

更新日期：2011-03-01 00:00:00

abstract：OBJECTIVE:To identify the clinical and genetic factors that explain why the rate of diabetes progression is highly variable between individuals following diagnosis of type 2 diabetes. RESEARCH DESIGN AND METHODS:We studied 5,250 patients with type 2 diabetes using comprehensive electronic medical records in Tayside, S...

journal_title：Diabetes care

authors： Zhou K,Donnelly LA,Morris AD,Franks PW,Jennison C,Palmer CN,Pearson ER

更新日期：2014-01-01 00:00:00

abstract：OBJECTIVE:We assessed the extent to which both standard and alternative indexes from 2-h oral glucose tolerance testing predict type 1 diabetes and whether oral glucose tolerance tests (OGTTs) predict type 1 diabetes in individuals with normal glucose tolerance. RESEARCH DESIGN AND METHODS:The prediction of type 1 dia...

journal_title：Diabetes care

authors： Sosenko JM,Palmer JP,Greenbaum CJ,Mahon J,Cowie C,Krischer JP,Chase HP,White NH,Buckingham B,Herold KC,Cuthbertson D,Skyler JS,Diabetes Prevention Trial-Type 1 Study Group.

更新日期：2007-01-01 00:00:00

abstract：:This commentary/review briefly considers the diverse criteria recommended for classification of overweight infants. Macrosomia continues to be a vexing problem for both obstetricians and pediatricians. Among the various techniques possible for use in assessing body composition, none are more practical than body weight...

journal_title：Diabetes care

authors： Schwartz R,Teramo KA

更新日期：1999-07-01 00:00:00

abstract：:Given the importance of glycemic control in the development of diabetes complications, the plethora of tools now available to monitor the day-to-day trends in glycemia is remarkable. In this regard, self-monitoring of blood glucose (SMBG) has been considered a key component of patient management. Arguably, there remai...

journal_title：Diabetes care

authors： Polonsky WH,Fisher L

更新日期：2013-01-01 00:00:00

abstract：:We studied the reliability of the Chemstrip system in the self-monitoring of blood glucose by diabetic patients. A total of 453 blood glucose values obtained by 38 diabetic patients using Chemstrip were compared with the glucose values of the same blood samples measured with a conventional laboratory method. We found ...

journal_title：Diabetes care

authors： Birch K,Hildebrandt P,Marshall MO,Sestoft L

更新日期：1981-05-01 00:00:00

abstract：:To examine the clinical role of BAYm 1099, 15 diet-treated non-insulin-dependent diabetic (NIDDM) subjects were randomized to start drug (50 mg 3 times/day) or placebo after a 4-wk run-in period in a double-blind crossover study. Treatment periods (4 wk) were separated by a 2-wk washout period. During the last week of...

journal_title：Diabetes care

authors： Samad AH,Ty Willing TS,Alberti KG,Taylor R

更新日期：1988-04-01 00:00:00

abstract：OBJECTIVE:To determine the pharmacokinetic (PK) and glucodynamic (GD) dose response of human insulin inhalation powder (HIIP) delivered via AIR particle technology and dose equivalence to subcutaneous (SC) insulin lispro. RESEARCH DESIGN AND METHODS:Twenty healthy, nonsmoking, male or female subjects (aged 29.6 +/- 6....

journal_title：Diabetes care

authors： Rave KM,Nosek L,de la Peña A,Seger M,Ernest CS 2nd,Heinemann L,Batycky RP,Muchmore DB

更新日期：2005-10-01 00:00:00

abstract：OBJECTIVE:Women with preexisting (type 1 or type 2) diabetes experience an increased risk of serious adverse pregnancy outcomes. It is not known, however, how these risks change between the first and second pregnancy and whether there is an increased risk of recurrence. This study describes the absolute risks and recur...

journal_title：Diabetes care

authors： Tennant PW,Bilous RW,Prathapan S,Bell R

更新日期：2015-04-01 00:00:00

abstract：:OBJECTIVE--To assess the relationship between family history and different types of obesity and change in obesity in a longitudinal population study. RESEARCH DESIGN AND METHODS--A longitudinal population study of 1462 randomly selected women (38-60 yr old) was conducted in Göteborg, Sweden, in 1968-69. The women were...

journal_title：Diabetes care

authors： Lapidus L,Bengtsson C,Lissner L,Smith U

更新日期：1992-11-01 00:00:00

abstract：:OBJECTIVE To examine the efficacy and safety of rimonabant, a selective cannabinoid receptor type-1 antagonist, in patients with type 2 diabetes receiving insulin monotherapy. RESEARCH DESIGN AND METHODS Patients (n = 368; A1C > or =7%) were randomized to 20 mg/day rimonabant or placebo in this 48-week, double-blind, ...

journal_title：Diabetes care

authors： Hollander PA,Amod A,Litwak LE,Chaudhari U,ARPEGGIO Study Group.

更新日期：2010-03-01 00:00:00

abstract：:Type 1 diabetes (T1D) and celiac disease (CeD) cluster in families and can occur in the same individual. Genetic loci have been associated with susceptibility to both diseases. Our aim was to explore the genetic differences between individuals developing both these diseases (double autoimmunity) versus those with only...

journal_title：Diabetes care

authors： Gutierrez-Achury J,Romanos J,Bakker SF,Kumar V,de Haas EC,Trynka G,Ricaño-Ponce I,Steck A,Type 1 Diabetes Genetics Consortium.,Chen WM,Onengut-Gumuscu S,Simsek S,Diabeter.,Rewers M,Mulder CJ,Liu E,Rich SS,Wijmenga C

更新日期：2015-10-01 00:00:00

abstract：OBJECTIVE:The efficacy of topical phenytoin in the treatment of diabetic foot ulcers was evaluated in a controlled inpatient study. RESEARCH DESIGN AND METHODS:Fifty patients were treated with topical phenytoin, and 50 patients matched for age, sex, and ulcer areas, depth, chronicity, and infection were dressed with d...

journal_title：Diabetes care

authors： Muthukumarasamy MG,Sivakumar G,Manoharan G

更新日期：1991-10-01 00:00:00

abstract：OBJECTIVE:The purpose of this study was to compare an in vivo test of whole-body glycolysis, the deuterated-glucose disposal test (2H-GDT), with insulin sensitivity measured by the euglycemic-hyperinsulinemic glucose clamp and the steady-state plasma glucose (SSPG) test. RESEARCH DESIGN AND METHODS:The 2H-GDT consists...

journal_title：Diabetes care

authors： Beysen C,Murphy EJ,McLaughlin T,Riiff T,Lamendola C,Turner HC,Awada M,Turner SM,Reaven G,Hellerstein MK

更新日期：2007-05-01 00:00:00

abstract：OBJECTIVE:Recent survey evidence suggests that sensory ataxia due to diabetic neuropathy may be a more frequent and serious problem than is commonly recognized. This view is further supported by research that confirms the major contribution of the somatosensory system to the control of posture. We therefore sought to d...

journal_title：Diabetes care

authors： Simoneau GG,Ulbrecht JS,Derr JA,Becker MB,Cavanagh PR

更新日期：1994-12-01 00:00:00

abstract：OBJECTIVE:To evaluate statin use in the U.S. before and after the 2015 American Diabetes Association position statement, which expanded statin therapy recommendations to include all adults 40-75 years old with diabetes. RESEARCH DESIGN AND METHODS:The National Health and Nutrition Examination Survey (NHANES) was used ...

journal_title：Diabetes care

authors： Leino AD,Dorsch MP,Lester CA

更新日期：2020-12-01 00:00:00

abstract：:Core Outcome Sets (COS) contain an agreed minimum set of outcomes to be measured and reported in all studies in a specific area, with the objective of standardizing outcome reporting. COS may minimize research waste by identifying outcomes important to key stakeholders, allowing for improved evidence synthesis, and fa...

journal_title：Diabetes care

authors： Egan AM,Bogdanet D,Biesty L,Kgosidialwa O,McDonagh C,O'Shea C,O'Shea PM,Devane D,Dunne FP,INSPIRED research group.

更新日期：2020-12-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to evaluate the frequency of sympathetic versus parasympathetic neuropathy among type 1 and type 2 diabetic patients. RESEARCH DESIGN AND METHODS:There were 43 patients with type 1 and 17 with type 2 diabetes who were investigated. Sympathetic nerve function was assessed by measurem...

journal_title：Diabetes care

authors： Freccero C,Svensson H,Bornmyr S,Wollmer P,Sundkvist G

更新日期：2004-12-01 00:00:00

abstract：OBJECTIVE:Biomechanical studies in diabetic neuropathy have clearly demonstrated abnormal foot pressures, but information on other aspects of gait is limited. This study aimed to investigate and describe the forces transmitted through the foot during walking in diabetic subjects with varying degrees of peripheral neuro...

journal_title：Diabetes care

authors： Shaw JE,van Schie CH,Carrington AL,Abbott CA,Boulton AJ

更新日期：1998-11-01 00:00:00

abstract：OBJECTIVE:The objective of this study was to evaluate the association between foot ulcers (DFU) and lower-extremity amputation (LEA) and chronic kidney disease (CKD) in patients with diabetes. RESARCH DESIGN AND METHODS: This was a retrospective cohort study of individuals enrolled between 2002 and 2006 who were aged >...

journal_title：Diabetes care

authors： Margolis DJ,Hofstad O,Feldman HI

更新日期：2008-07-01 00:00:00

abstract：OBJECTIVE:To explore the nature of functional impairment in older people with diabetes. RESEARCH DESIGN AND METHODS:A population-based case-control study with detailed assessment of diabetes and functional status was undertaken. RESULTS:Altogether, 403 case subjects and 403 matched control subjects were studied (medi...

journal_title：Diabetes care

authors： Sinclair AJ,Conroy SP,Bayer AJ

更新日期：2008-02-01 00:00:00