Abstract:
:Type 1 diabetes (T1D) and celiac disease (CeD) cluster in families and can occur in the same individual. Genetic loci have been associated with susceptibility to both diseases. Our aim was to explore the genetic differences between individuals developing both these diseases (double autoimmunity) versus those with only one. We hypothesized that double autoimmunity individuals carry more of the genetic risk markers that are shared between the two diseases independently. SNPs were genotyped in loci associated with T1D (n=42) and CeD (n=28) in 543 subjects who developed double autoimmunity, 2,472 subjects with T1D only, and 2,223 CeD-only subjects. For identification of loci that were specifically associated with individuals developing double autoimmunity, two association analyses were conducted: double autoimmunity versus T1D and double autoimmunity versus CeD. HLA risk haplotypes were compared between the two groups. The CTLA4 and IL2RA loci were more strongly associated with double autoimmunity than with either T1D or CeD alone. HLA analyses indicated that the T1D high-risk genotype, DQ2.5/DQ8, provided the highest risk for developing double autoimmunity (odds ratio 5.22, P=2.25×10(-29)). We identified a strong HLA risk genotype (DQ2.5/DQ8) predisposing to double autoimmunity, suggesting a dominant role for HLA. Non-HLA loci, CTLA4 and IL2RA, may also confer risk to double autoimmunity. Thus, CeD patients who carry the DQ2.5/DQ8 genotype may benefit from periodic screening of autoantibodies related to T1D.
journal_name
Diabetes Carejournal_title
Diabetes careauthors
Gutierrez-Achury J,Romanos J,Bakker SF,Kumar V,de Haas EC,Trynka G,Ricaño-Ponce I,Steck A,Type 1 Diabetes Genetics Consortium.,Chen WM,Onengut-Gumuscu S,Simsek S,Diabeter.,Rewers M,Mulder CJ,Liu E,Rich SS,Wijmenga Cdoi
10.2337/dcs15-2007subject
Has Abstractpub_date
2015-10-01 00:00:00pages
S37-44eissn
0149-5992issn
1935-5548pii
38/Supplement_2/S37journal_volume
38 Suppl 2pub_type
杂志文章相关文献
DIABETES CARE文献大全abstract:OBJECTIVE:We sought to ascertain quality-of-life measures and utility values associated with visual acuity in type 2 diabetes. RESEARCH DESIGN AND METHODS:The Medical Outcome Study Short Form with 36 items (SF-36) was administered to 4,051 individuals with type 2 diabetes who were enrolled in the Lipids in Diabetes St...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc05-2150
更新日期:2006-07-01 00:00:00
abstract:OBJECTIVE:Malabsorptive bariatric surgery (biliopancreatic diversion and biliointestinal bypass [BIBP]) reduces serum cholesterol levels more than restrictive surgery (adjustable gastric banding [AGB]), and this is thought to be due to greater weight loss. Our aim was to evaluate the changes of cholesterol metabolism i...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc12-1737
更新日期:2013-06-01 00:00:00
abstract:OBJECTIVE:N-acetylglucosamine/galactosamine (GlycA) and sialic acid (GlycB) moieties of glycosylated serum proteins are nonspecific measures of inflammation, but conclusive data on their relationship with insulin resistance or insulin secretion are missing. Therefore, we aimed to examine the relation of GlycA, GlycB, a...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc16-1569
更新日期:2017-03-01 00:00:00
abstract:OBJECTIVE:To determine whether ACE inhibitors (ACEi) and angiotensin receptor blockers (ARB) protect against lower-respiratory tract infections complicating type 2 diabetes. RESEARCH DESIGN AND METHODS:Of 1,732 participants with diabetes recruited to the longitudinal observational Fremantle Diabetes Study Phase II (FD...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc20-0895
更新日期:2020-09-01 00:00:00
abstract:OBJECTIVE:To assess the relationship between the insertion (I)/deletion (D) polymorphism of the ACE gene and arterial distensibility in patients with type 2 diabetes and healthy control subjects. RESEARCH DESIGN AND METHODS:Aortic and carotid arterial distensibility were evaluated by measuring aortic pulse-wave veloci...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.22.11.1858
更新日期:1999-11-01 00:00:00
abstract:OBJECTIVE:To evaluate the feasibility and efficacy of a fully integrated hybrid closed-loop (HCL) system (Medtronic MiniMed Inc., Northridge, CA), in day and night closed-loop control in subjects with type 1 diabetes, both in an inpatient setting and during 6 days at diabetes camp. RESEARCH DESIGN AND METHODS:The Medt...
journal_title:Diabetes care
pub_type: 杂志文章,随机对照试验
doi:10.2337/dc14-3073
更新日期:2015-07-01 00:00:00
abstract:OBJECTIVE:Neonatal diabetes is a heterogeneous group of disorders with diabetes manifestation in the first 6 months of life. The most common etiology in permanent neonatal diabetes is mutations of the ATP-sensitive K(+) channel subunits; in transient neonatal diabetes, chromosome 6q24 abnormalities are the most common ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc08-0549
更新日期:2008-09-01 00:00:00
abstract:OBJECTIVE:Reductions in heart attack and stroke hospitalizations are well documented in the U.S. population with diabetes. We extended trend analyses to other cardiovascular disease (CVD) conditions, including stroke by type, and used four additional years of data. RESEARCH DESIGN AND METHODS:Using 1998-2014 National ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc17-1259
更新日期:2018-02-01 00:00:00
abstract:OBJECTIVE:Early puberty is associated with increased risk of subsequent cardiovascular disease. Low sex hormone-binding globulin (SHBG) levels are a feature of early puberty and of conditions associated with increased cardiovascular risk. The aim of the present study was to evaluate SHBG as a predictor of glucose metab...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc08-1618
更新日期:2009-05-01 00:00:00
abstract:OBJECTIVE:To determine the impact of changes to treatment on the incidence of severe hypoglycemia and its risk factors in a large population-based cohort of children with type 1 diabetes. RESEARCH DESIGN AND METHODS:The cohort consisted of 1,335 children (age at entry 9.5 +/- 4.3 years [mean +/- SD], range 0-18), yiel...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.27.10.2293
更新日期:2004-10-01 00:00:00
abstract:OBJECTIVE:Roux-en-Y gastric bypass (RYGB) ameliorates type 2 diabetes in severely obese patients through mechanisms beyond just weight loss, and it may benefit less obese diabetic patients. We determined the long-term impact of RYGB on patients with diabetes and only class I obesity. RESEARCH DESIGN AND METHODS:Sixty-...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc11-2289
更新日期:2012-07-01 00:00:00
abstract:OBJECTIVE:To determine whether using the chronic care model (CCM) in an underserved community leads to improved clinical and behavioral outcomes for people with diabetes. RESEARCH DESIGN AND METHODS:This multilevel, cluster-design, randomized controlled trial examined the effectiveness of a CCM-based intervention in a...
journal_title:Diabetes care
pub_type: 杂志文章,随机对照试验
doi:10.2337/diacare.29.04.06.dc05-1785
更新日期:2006-04-01 00:00:00
abstract:OBJECTIVE:The pharmacokinetics and glucodynamics of a new insulin analog, insulin lispro, and regular human insulin were compared and contrasted after subcutaneous administrations in femoral, deltoid, and abdominal injection sites. RESEARCH DESIGN AND METHODS:Single 0.2 U/kg doses of insulin lispro and regular insulin...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.2337/diacare.19.12.1437
更新日期:1996-12-01 00:00:00
abstract:OBJECTIVE:There is enough evidence that physical activity is an effective therapeutic tool in the management of type 2 diabetes. The present study was designed to validate a counseling strategy that could be used by physicians in their daily outpatient practice to promote the adoption and maintenance of physical activi...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.2337/diacare.26.2.404
更新日期:2003-02-01 00:00:00
abstract:OBJECTIVE:We have previously shown that 300 kcal from glucose intake induces a significant increase in reactive oxygen species (ROS) generation and nuclear factor-kappaB (NF-kappaB) binding in the circulating mononuclear cells in healthy normal subjects. We hypothesized that the intake of 300 calories as orange juice o...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc06-1458
更新日期:2007-06-01 00:00:00
abstract:OBJECTIVE:To examine trends in diabetes prevalence in the U.S. RESEARCH DESIGN AND METHODS:This study was conducted via telephone surveys in states that participated in the Behavioral Risk Factor Surveillance System between 1990 and 1998. The participants consisted of noninstitutionalized adults aged 18 years or older...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.23.9.1278
更新日期:2000-09-01 00:00:00
abstract:OBJECTIVE:Evidence that midregional fragment of pro-A-type natriuretic peptide (MR-proANP) is a marker of mortality in patients with type 2 diabetes is limited. Therefore, we aimed to investigate the capabilities of MR-proANP in predicting mortality. We also investigated whether MR-proANP influences the relationship be...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc12-0428
更新日期:2013-05-01 00:00:00
abstract::Nocturnal hypoglycemia in insulin-treated diabetic persons is often difficult to recognize clinically. It has been suggested that a useful biochemical test to demonstrate this would be the increased excretion of cortisol in the urine during the overnight period. However, of six diabetic persons who had nocturnal hypog...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.4.5.514
更新日期:1981-09-01 00:00:00
abstract:OBJECTIVE:To investigate the association of carotid atherosclerosis and serum lipoprotein(a) [Lp(a)] concentrations in subjects with NIDDM. RESEARCH DESIGN AND METHODS:We measured carotid intima-media thickness (IMT) and Lp(a) concentrations in 117 NIDDM subjects. Subjects were divided into tertiles according to IMT v...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.20.5.829
更新日期:1997-05-01 00:00:00
abstract:OBJECTIVE:Direct medical cost of diabetes in the U.S. has been estimated to be 2.3 times higher relative to individuals without diabetes. This study examines trends in health care expenditures by expenditure category in U.S. adults with diabetes between 2002 and 2011. RESEARCH DESIGN AND METHODS:We analyzed 10 years o...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc15-0369
更新日期:2015-10-01 00:00:00
abstract:OBJECTIVE:To compare the effect of morning and bedtime NPH insulin combined with daytime sulfonylurea on glycemic control in non-insulin-dependent diabetes mellitus (NIDDM) patients no longer responding to treatment with sulfonylureas alone. RESEARCH DESIGN AND METHODS:Twenty-four NIDDM patients who fulfilled these cr...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.2337/diacare.15.7.831
更新日期:1992-07-01 00:00:00
abstract::Patients with diabetes mellitus may have any one of several forms of hypertension. These include essential hypertension, systolic hypertension of three varieties, the hypertension associated with diabetic nephropathy ("diabetic hypertension"), and the hypertension associated with neuropathy (supine hypertension with o...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.5.1.50
更新日期:1982-01-01 00:00:00
abstract::We examined the clinical and epidemiologic characteristics of diabetic subjects ascertained from five different sources (hospital, private practice, specialist practice, nursing home, and prevalence survey) in a medium-sized upstate New York community. Patients were categorized using the National Diabetes Data Group c...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.8.1.s87
更新日期:1985-09-01 00:00:00
abstract:OBJECTIVE:To assess effectiveness of inpatient hybrid closed-loop control (HCLC) followed by outpatient sensor-augmented pump (SAP) therapy initiated within 7 days of diagnosis of type 1 diabetes on the preservation of β-cell function at 1 year. RESEARCH DESIGN AND METHODS:Sixty-eight individuals (mean age 13.3 ± 5.7 ...
journal_title:Diabetes care
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.2337/dc13-1074
更新日期:2013-12-01 00:00:00
abstract:OBJECTIVE:Long-term implications of childhood obesity and BMI change over the life course for risk of type 2 diabetes remain uncertain. The objective was to establish whether there are effects on adult glucose metabolism of 1) sensitive periods of BMI gain or 2) long duration of overweight and obesity. RESEARCH DESIGN...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc10-1482
更新日期:2011-09-01 00:00:00
abstract::A case-control study examining the 1-yr motor vehicle accident experiences of 158 insulin-dependent diabetes mellitus (IDDM) cases and 158 nondiabetic siblings was undertaken to evaluate the risk of motor vehicle accidents among drivers with IDDM. In multivariate analyses the overall accident risk of the cases and con...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.11.9.701
更新日期:1988-10-01 00:00:00
abstract:OBJECTIVE:To describe a glucose abnormality in AIDS that is characterized by transient NIDDM followed by hyperinsulinemic normoglycemia. RESEARCH DESIGN AND METHODS:A 36-yr-old Hispanic man with AIDS was on long-standing aerosolized pentamidine therapy in 1986. He received a course of intravenous pentamidine 5 mo befo...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.16.6.931
更新日期:1993-06-01 00:00:00
abstract:OBJECTIVE:To examine determinants of racial/ethnic differences in diabetes incidence among postmenopausal women participating in the Women's Health Initiative. RESEARCH DESIGN AND METHODS:Data on race/ethnicity, baseline diabetes prevalence, and incident diabetes were obtained from 158,833 women recruited from 1993-19...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc12-0412
更新日期:2012-11-01 00:00:00
abstract:OBJECTIVE:Of patients who are prescribed metformin, 10-30% have evidence of reduced vitamin B12 absorption. B12-intrinsic factor complex uptake by ileal cell surface receptors is known to be a process dependent on calcium availability Metformin affects calcium-dependent membrane action. The objective of this study was ...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章
doi:10.2337/diacare.23.9.1227
更新日期:2000-09-01 00:00:00
abstract:OBJECTIVE:To compare a simple meal plan emphasizing healthy food choices with a traditional exchange-based meal plan in reducing HbA(1c) levels in urban African Americans with type 2 diabetes. RESEARCH DESIGN AND METHODS:A total of 648 patients with type 2 diabetes were randomized to receive instruction in either a he...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.2337/diacare.26.6.1719
更新日期:2003-06-01 00:00:00