The hypertensions of diabetes.

Abstract:

:Patients with diabetes mellitus may have any one of several forms of hypertension. These include essential hypertension, systolic hypertension of three varieties, the hypertension associated with diabetic nephropathy ("diabetic hypertension"), and the hypertension associated with neuropathy (supine hypertension with orthostatic hypotension). Because there are differences in the hypertensive mechanisms in each of these hypertensions, the use of antihypertensive medications should be tailored to the type of hypertension present. In this review, the rationale for treating hypertension in the diabetic will be discussed, the mechanisms of action and potential side effects of antihypertensive drugs peculiar to the diabetic will be outlined, and specific antihypertensive therapy programs based on the mechanisms involved in producing each of the hypertensions will be detailed.

journal_name

Diabetes Care

journal_title

Diabetes care

authors

Christlieb AR

doi

10.2337/diacare.5.1.50

subject

Has Abstract

pub_date

1982-01-01 00:00:00

pages

50-8

issue

1

eissn

0149-5992

issn

1935-5548

journal_volume

5

pub_type

杂志文章
  • Low prevalence of islet autoantibodies in patients with gestational diabetes mellitus.

    abstract:OBJECTIVE:To determine the proportion of patients with gestational diabetes mellitus (GDM) who have serological characteristics typical of IDDM. RESEARCH DESIGN AND METHODS:Islet cell antibodies (ICAs), insulin autoantibodies (IAAs), GAD65, and IA-2 antibodies were measured in 145 pregnant women with GDM, 33 with impa...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.20.1.81

    authors: Dozio N,Beretta A,Belloni C,Castiglioni M,Rosa S,Bosi E,Bonifacio E

    更新日期:1997-01-01 00:00:00

  • Beta-score: an assessment of beta-cell function after islet transplantation.

    abstract:OBJECTIVE:Success after islet transplantation can be defined in terms of insulin independence, C-peptide secretion, or glycemic control. These measures are interdependent and all need to be considered in evaluating beta-cell function after islet transplantation. For the current study, a composite beta-score was develop...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.28.2.343

    authors: Ryan EA,Paty BW,Senior PA,Lakey JR,Bigam D,Shapiro AM

    更新日期:2005-02-01 00:00:00

  • Intra-individual variability of the metabolic effect of inhaled insulin together with an absorption enhancer.

    abstract:OBJECTIVE:To study the metabolic effect and the variability of the effect elicited by inhalation of 87.2 U insulin powder combined with an absorption enhancer. The metabolic effect was compared with that of 10.2 U regular insulin injected subcutaneously and of 5.5 U regular insulin given intravenously RESEARCH DESIGN ...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.2337/diacare.23.9.1343

    authors: Heinemann L,Klappoth W,Rave K,Hompesch B,Linkeschowa R,Heise T

    更新日期:2000-09-01 00:00:00

  • Asp905Tyr polymorphism of the gene for the skeletal muscle-specific glycogen-targeting subunit of protein phosphatase 1 in NIDDM.

    abstract:OBJECTIVE:To clarify the contribution of the Asp905Tyr polymorphism of the muscle-specific glycogen-targeting subunit of protein phosphatase 1 (PP1G) to insulin resistance and related diseases. RESEARCH DESIGN AND METHODS:We investigated the Asp905Tyr polymorphism of the PPP1R3 gene, which encodes the muscle-specific ...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.21.7.1086

    authors: Shen GQ,Ikegami H,Kawaguchi Y,Fujisawa T,Hamada Y,Ueda H,Shintani M,Nojima K,Kawabata Y,Yamada K,Babaya N,Ogihara T

    更新日期:1998-07-01 00:00:00

  • Validation of the WHO-5 Well-Being Index in adolescents with type 1 diabetes.

    abstract:OBJECTIVE:It is recommended that the psychological status of adolescents with diabetes be assessed periodically as part of ongoing care. The World Health Organization-Five Well-Being Index (WHO-5) is a short self-report instrument that appears suitable for this purpose. This study is the first to assess the reliability...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc07-0447

    authors: de Wit M,Pouwer F,Gemke RJ,Delemarre-van de Waal HA,Snoek FJ

    更新日期:2007-08-01 00:00:00

  • Intranasal glucagon as remedy for hypoglycemia. Studies in healthy subjects and type I diabetic patients.

    abstract::Intranasal glucagon can raise blood glucose levels in healthy subjects. The aims of this study were to 1) compare the hyperglycemic effect of intranasal and intramuscular glucagon in healthy subjects and type I (insulin-dependent) diabetes patients during euglycemic conditions and 2) test the efficacy of intranasal an...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章

    doi:10.2337/diacare.12.9.604

    authors: Pontiroli AE,Calderara A,Pajetta E,Alberetto M,Pozza G

    更新日期:1989-10-01 00:00:00

  • Combined heart rate- and accelerometer-assessed physical activity energy expenditure and associations with glucose homeostasis markers in a population at high risk of developing diabetes: the ADDITION-PRO study.

    abstract:OBJECTIVE:Regular physical activity (PA) reduces the risk of developing type 2 diabetes, and different subtypes of dysglycemia have shown different associations with PA. To better understand the associations of PA and glucose homeostasis, we examined the association of objectively measured PA energy expenditure (PAEE) ...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc12-2671

    authors: Hansen AL,Carstensen B,Helge JW,Johansen NB,Gram B,Christiansen JS,Brage S,Lauritzen T,Jørgensen ME,Aadahl M,Witte DR,ADDITION-Denmark Steering Committee.

    更新日期:2013-10-01 00:00:00

  • Progression of lower-extremity disability in older women with diabetes: the Women's Health and Aging Study.

    abstract:OBJECTIVE:Older patients with diabetes are more likely to have a higher prevalence of multiple risk factors for physical disability, as a result of diabetic complications. We evaluated the pace of decline in lower-extremity function and the risk for progression of disability in older women with diabetes. RESEARCH DESI...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.26.1.70

    authors: Volpato S,Ferrucci L,Blaum C,Ostir G,Cappola A,Fried LP,Fellin R,Guralnik JM

    更新日期:2003-01-01 00:00:00

  • Heterogeneous Contribution of Insulin Sensitivity and Secretion Defects to Gestational Diabetes Mellitus.

    abstract:OBJECTIVE:To characterize physiologic subtypes of gestational diabetes mellitus (GDM). RESEARCH DESIGN AND METHODS:Insulin sensitivity and secretion were estimated in 809 women at 24-30 weeks' gestation, using oral glucose tolerance test-based indices. In women with GDM (8.3%), defects in insulin sensitivity or secret...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc15-2672

    authors: Powe CE,Allard C,Battista MC,Doyon M,Bouchard L,Ecker JL,Perron P,Florez JC,Thadhani R,Hivert MF

    更新日期:2016-06-01 00:00:00

  • Self-monitoring of blood glucose in noninsulin-using type 2 diabetic patients: right answer, but wrong question: self-monitoring of blood glucose can be clinically valuable for noninsulin users.

    abstract::Given the importance of glycemic control in the development of diabetes complications, the plethora of tools now available to monitor the day-to-day trends in glycemia is remarkable. In this regard, self-monitoring of blood glucose (SMBG) has been considered a key component of patient management. Arguably, there remai...

    journal_title:Diabetes care

    pub_type: 评论,杂志文章

    doi:10.2337/dc12-0731

    authors: Polonsky WH,Fisher L

    更新日期:2013-01-01 00:00:00

  • Metformin as an adjunct therapy in adolescents with type 1 diabetes and insulin resistance: a randomized controlled trial.

    abstract:OBJECTIVE:To evaluate whether, in adolescents with type 1 diabetes, the addition of metformin to insulin and standard diabetes management results in 1) higher insulin sensitivity and 2) lower HbA1c, fasting glucose, insulin dosage (units per kilogram per day) and BMI. RESEARCH DESIGN AND METHODS:This was a randomized,...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.2337/diacare.26.1.138

    authors: Hamilton J,Cummings E,Zdravkovic V,Finegood D,Daneman D

    更新日期:2003-01-01 00:00:00

  • Epidemiology and treatment of diabetic ketoacidosis in a community population.

    abstract::We evaluated the epidemiology of diabetic ketoacidosis in the period 1960-1979. In Frederiksborg County, Denmark, the incidence of ketoacidosis at the county hospital increased from 60 per 100,000 in the period 1943-1963 to 120 per 100,000 in the period 1960-1979. In the investigation period we found an increasing inc...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.7.6.528

    authors: Ellemann K,Soerensen JN,Pedersen L,Edsberg B,Andersen OO

    更新日期:1984-11-01 00:00:00

  • Time in Range in Relation to All-Cause and Cardiovascular Mortality in Patients With Type 2 Diabetes: A Prospective Cohort Study.

    abstract:OBJECTIVE:There is growing evidence linking time in range (TIR), an emerging metric for assessing glycemic control, to diabetes-related outcomes. We aimed to investigate the association between TIR and mortality in patients with type 2 diabetes. RESEARCH DESIGN AND METHODS:A total of 6,225 adult patients with type 2 d...

    journal_title:Diabetes care

    pub_type: 评论,杂志文章

    doi:10.2337/dc20-1862

    authors: Lu J,Wang C,Shen Y,Chen L,Zhang L,Cai J,Lu W,Zhu W,Hu G,Xia T,Zhou J

    更新日期:2021-02-01 00:00:00

  • Expression of matrix metalloproteinases, cytokines, and connexins in diabetic and nondiabetic human keratinocytes before and after transplantation into an ex vivo wound-healing model.

    abstract:OBJECTIVE:Wound healing is known to require a well-organized balance of numerous factors, e.g., cytokines, matrix metalloproteinases (MMPs), and their inhibitors, as well as direct cell-cell communication (connexins). Disruption of this balance may lead to the formation of chronic wounds such as diabetic foot ulcers. T...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc07-1304

    authors: Brandner JM,Zacheja S,Houdek P,Moll I,Lobmann R

    更新日期:2008-01-01 00:00:00

  • Erythromycin derivative improves gastric emptying and insulin requirement in diabetic patients with gastroparesis.

    abstract:OBJECTIVE:To evaluate the effect of the erythromycin derivative EM523L on gastric emptying and postprandial insulin requirement in insulin-dependent diabetic patients with severe gastroparesis. RESEARCH DESIGN AND METHODS:In six IDDM patients with severe gastroparesis (two men and four women, mean age 44.5 years [rang...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章

    doi:10.2337/diacare.20.7.1134

    authors: Ishii M,Nakamura T,Kasai F,Baba T,Takebe K

    更新日期:1997-07-01 00:00:00

  • Diabetes and cause-specific mortality in a prospective cohort of one million U.S. adults.

    abstract:OBJECTIVE:Diabetes is a major predictor of death from heart disease and stroke; its impact on nonvascular mortality, including specific cancers, is less understood. We examined the association of diabetes with cause-specific mortality, including deaths from specific cancers. RESEARCH DESIGN AND METHODS:A prospective c...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc12-0002

    authors: Campbell PT,Newton CC,Patel AV,Jacobs EJ,Gapstur SM

    更新日期:2012-09-01 00:00:00

  • High prevalence of glucose abnormalities in patients with hepatitis C virus infection: a multivariate analysis considering the liver injury.

    abstract:OBJECTIVE:The aim of this study was to compare the prevalence of both impaired fasting glucose (IFG) and diabetes between hepatitis C virus (HCV)-infected patients and patients with other liver diseases but anti-HCV-, taking into account the degree of liver damage. RESEARCH DESIGN AND METHODS:A total of 642 consecutiv...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.27.5.1171

    authors: Lecube A,Hernández C,Genescà J,Esteban JI,Jardí R,Simó R

    更新日期:2004-05-01 00:00:00

  • Lipid, glycemic, and insulin responses to meals rich in saturated, cis-monounsaturated, and polyunsaturated (n-3 and n-6) fatty acids in subjects with type 2 diabetes.

    abstract:OBJECTIVE:The recommendations for dietary fats in patients with type 2 diabetes are based largely on the impact of fatty acids on fasting serum lipid and glucose concentrations. How fatty acids affect postprandial insulin, glucose, and triglyceride concentrations, however, remains unclear. The objective of this study w...

    journal_title:Diabetes care

    pub_type: 杂志文章,随机对照试验

    doi:10.2337/dc07-1026

    authors: Shah M,Adams-Huet B,Brinkley L,Grundy SM,Garg A

    更新日期:2007-12-01 00:00:00

  • Metabolic effects of troglitazone therapy in type 2 diabetic, obese, and lean normal subjects.

    abstract:OBJECTIVE:To characterize metabolic effects of troglitazone in type 2 diabetic, obese, and lean subjects, and examine the effects of troglitazone 2-3 weeks after discontinuation. RESEARCH DESIGN AND METHODS:Nine type 2 diabetic, nine obese, and nine lean subjects underwent baseline metabolic studies including an 8-h m...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章

    doi:10.2337/diacare.23.1.64

    authors: Frias JP,Yu JG,Kruszynska YT,Olefsky JM

    更新日期:2000-01-01 00:00:00

  • Family history of diabetes in relation to different types of obesity and change of obesity during 12-yr period. Results from prospective population study of women in Göteborg, Sweden.

    abstract::OBJECTIVE--To assess the relationship between family history and different types of obesity and change in obesity in a longitudinal population study. RESEARCH DESIGN AND METHODS--A longitudinal population study of 1462 randomly selected women (38-60 yr old) was conducted in Göteborg, Sweden, in 1968-69. The women were...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.15.11.1455

    authors: Lapidus L,Bengtsson C,Lissner L,Smith U

    更新日期:1992-11-01 00:00:00

  • More impact of microalbuminuria on retinopathy than moderately reduced GFR among type 2 diabetic patients.

    abstract:OBJECTIVE:The current study aimed to investigate whether microalbuminuria or moderately decreased glomerular filtration rate (GFR) is a better predictor for the development and progression of retinopathy in type 2 diabetic patients. RESEARCH DESIGN AND METHODS:Type 2 diabetic patients without cardiovascular diseases, ...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc11-1955

    authors: Chen YH,Chen HS,Tarng DC

    更新日期:2012-04-01 00:00:00

  • Dietary phylloquinone and menaquinones intakes and risk of type 2 diabetes.

    abstract:OBJECTIVE:To investigate whether dietary phylloquinone and menaquinones intakes are related to risk of type 2 diabetes. RESEARCH DESIGN AND METHODS:We used data from a prospective cohort study in 38,094 Dutch men and women, aged 20-70 years. Dietary phylloquinone and menaquinones intakes were assessed using a validate...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc09-2302

    authors: Beulens JW,van der A DL,Grobbee DE,Sluijs I,Spijkerman AM,van der Schouw YT

    更新日期:2010-08-01 00:00:00

  • Effect of drinking on adiponectin in healthy men and women: a randomized intervention study of water, ethanol, red wine, and beer with or without alcohol.

    abstract:OBJECTIVE:Moderate alcohol consumption is associated with reduced incidence of type 2 diabetes and cardiovascular mortality and increases adiponectin concentrations, but effects might differ according to sex and beverage consumed. RESEARCH DESIGN AND METHODS:A total of 72 healthy individuals (22-56 years) were enrolle...

    journal_title:Diabetes care

    pub_type: 杂志文章,随机对照试验

    doi:10.2337/dc08-1723

    authors: Imhof A,Plamper I,Maier S,Trischler G,Koenig W

    更新日期:2009-06-01 00:00:00

  • Randomized prospective trial of pure porcine and conventional bovine/porcine insulin.

    abstract::Use of pure porcine insulin versus partially purified insulin of bovine/porcine origin might be expected to have certain clinical benefits, e.g., a lower incidence of skin reactions, a lower insulin dosage, better diabetes regulation, and greater preservation of endogenous insulin secretion. To test this hypothesis, w...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.2337/diacare.10.3.337

    authors: Asplin C,Raghu P,Clemons P,Lyen K,Tatpati O,McKnight B,Baker L,Guthrie R,Sperling M,Palmer J

    更新日期:1987-05-01 00:00:00

  • Absorption kinetics and biologic effects of subcutaneously injected insulin preparations.

    abstract::This paper describes systematic studies on the absorption kinetics of exogenous insulin from its subcutaneous tissue depot in 52 male nonobese volunteers (age 20-30 yr). Five experimental protocols were used: effect of changing injection site, effect of temperature change and local massage, effect of aprotinin and hum...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.5.2.77

    authors: Berger M,Cüppers HJ,Hegner H,Jörgens V,Berchtold P

    更新日期:1982-03-01 00:00:00

  • A highly successful and novel model for treatment of chronic painful diabetic peripheral neuropathy.

    abstract:OBJECTIVE:To investigate why, in spite of a vast variety of treatment agents, the alleviation of pain in patients with diabetic neuropathy is difficult. Previous studies have not used a treatment algorithm based on anatomic site and neuropathophysiological source of the neuropathic pain. RESEARCH DESIGN AND METHODS:A ...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章

    doi:10.2337/diacare.16.8.1103

    authors: Pfeifer MA,Ross DR,Schrage JP,Gelber DA,Schumer MP,Crain GM,Markwell SJ,Jung S

    更新日期:1993-08-01 00:00:00

  • Effect of treatment of gestational diabetes mellitus on obesity in the next generation.

    abstract:OBJECTIVE:Gestational diabetes mellitus (GDM) may cause obesity in the offspring. The objective was to assess the effect of treatment for mild GDM on the BMI of 4- to 5-year-old children. RESEARCH DESIGN AND METHODS:Participants were 199 mothers who participated in a randomized controlled trial of the treatment of mil...

    journal_title:Diabetes care

    pub_type: 杂志文章,随机对照试验

    doi:10.2337/dc09-1810

    authors: Gillman MW,Oakey H,Baghurst PA,Volkmer RE,Robinson JS,Crowther CA

    更新日期:2010-05-01 00:00:00

  • Nutrition of the fetus and the premature infant.

    abstract::Developments in fetal and placental nutrition have highlighted the interaction of the placenta and fetal liver for the exchange and metabolism of nutrients. Of particular importance is the exchange of serine and glycine and their interconversion within these two organs and the exchange of glutamine and glutamate. Plac...

    journal_title:Diabetes care

    pub_type: 杂志文章,评审

    doi:

    authors: Battaglia FC,Thureen PJ

    更新日期:1998-08-01 00:00:00

  • Impact of BMI and the metabolic syndrome on the risk of diabetes in middle-aged men.

    abstract:OBJECTIVE:The existence of an obese subgroup with a healthy metabolic profile and low diabetes risk has been proposed; yet long-term data are lacking. We aimed to investigate associations between combinations of BMI categories and metabolic syndrome and risk of type 2 diabetes in middle-aged men. RESEARCH DESIGN AND M...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc10-0955

    authors: Arnlöv J,Sundström J,Ingelsson E,Lind L

    更新日期:2011-01-01 00:00:00

  • Diabetes Distress, Intentional Hyperglycemia at Work, and Glycemic Control Among Workers With Type 1 Diabetes.

    abstract:OBJECTIVE:The aim was to explore relationships between work-related factors, work-related diabetes distress (WRDD), diabetes distress (measured by Problem Areas in Diabetes [PAID]-5 scale), intentional hyperglycemia at work (IHW), and glycemic control. RESEARCH DESIGN AND METHODS:A cross-sectional survey was conducted...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc18-1426

    authors: Hansen UM,Skinner T,Olesen K,Willaing I

    更新日期:2019-05-01 00:00:00