Abstract:
OBJECTIVE:To investigate whether dietary phylloquinone and menaquinones intakes are related to risk of type 2 diabetes. RESEARCH DESIGN AND METHODS:We used data from a prospective cohort study in 38,094 Dutch men and women, aged 20-70 years. Dietary phylloquinone and menaquinones intakes were assessed using a validated food frequency questionnaire. Diabetes case patients were ascertained mainly via self-report and verified against medical records. RESULTS:During 10.3 years of follow-up, 918 incident cases of diabetes were documented. In a multivariate model adjusting for diabetes risk factors and dietary factors, phylloquinone intake tended to be associated (P = 0.08) with a reduced risk of type 2 diabetes with a hazard ratio (HR) of 0.81 (95% CI 0.66-0.99) for the highest versus the lowest quartile. For menaquinones intake, a linear, inverse association (P = 0.038) with risk of type 2 diabetes was observed with an HR of 0.93 (0.87-1.00) for each 10-microg increment in the multivariate model. CONCLUSIONS:This study shows that both phylloquinone and menaquinones intakes may be associated with a reduced risk of type 2 diabetes.
journal_name
Diabetes Carejournal_title
Diabetes careauthors
Beulens JW,van der A DL,Grobbee DE,Sluijs I,Spijkerman AM,van der Schouw YTdoi
10.2337/dc09-2302subject
Has Abstractpub_date
2010-08-01 00:00:00pages
1699-705issue
8eissn
0149-5992issn
1935-5548pii
dc09-2302journal_volume
33pub_type
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