Dietary phylloquinone and menaquinones intakes and risk of type 2 diabetes.

Abstract:

OBJECTIVE:To investigate whether dietary phylloquinone and menaquinones intakes are related to risk of type 2 diabetes. RESEARCH DESIGN AND METHODS:We used data from a prospective cohort study in 38,094 Dutch men and women, aged 20-70 years. Dietary phylloquinone and menaquinones intakes were assessed using a validated food frequency questionnaire. Diabetes case patients were ascertained mainly via self-report and verified against medical records. RESULTS:During 10.3 years of follow-up, 918 incident cases of diabetes were documented. In a multivariate model adjusting for diabetes risk factors and dietary factors, phylloquinone intake tended to be associated (P = 0.08) with a reduced risk of type 2 diabetes with a hazard ratio (HR) of 0.81 (95% CI 0.66-0.99) for the highest versus the lowest quartile. For menaquinones intake, a linear, inverse association (P = 0.038) with risk of type 2 diabetes was observed with an HR of 0.93 (0.87-1.00) for each 10-microg increment in the multivariate model. CONCLUSIONS:This study shows that both phylloquinone and menaquinones intakes may be associated with a reduced risk of type 2 diabetes.

journal_name

Diabetes Care

journal_title

Diabetes care

authors

Beulens JW,van der A DL,Grobbee DE,Sluijs I,Spijkerman AM,van der Schouw YT

doi

10.2337/dc09-2302

subject

Has Abstract

pub_date

2010-08-01 00:00:00

pages

1699-705

issue

8

eissn

0149-5992

issn

1935-5548

pii

dc09-2302

journal_volume

33

pub_type

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