Heterogeneous Contribution of Insulin Sensitivity and Secretion Defects to Gestational Diabetes Mellitus.

Abstract:

OBJECTIVE:To characterize physiologic subtypes of gestational diabetes mellitus (GDM). RESEARCH DESIGN AND METHODS:Insulin sensitivity and secretion were estimated in 809 women at 24-30 weeks' gestation, using oral glucose tolerance test-based indices. In women with GDM (8.3%), defects in insulin sensitivity or secretion were defined below the 25th percentile in women with normal glucose tolerance (NGT). GDM subtypes were defined based on the defect(s) present. RESULTS:Relative to women with NGT, women with predominant insulin sensitivity defects (51% of GDM) had higher BMI and fasting glucose, larger infants (birth weight z score 0.57 [-0.01 to 1.37] vs. 0.03 [-0.53 to 0.52], P = 0.001), and greater risk of GDM-associated adverse outcomes (57.6 vs. 28.2%, P = 0.003); differences were independent of BMI. Women with predominant insulin secretion defects (30% of GDM) had BMI, fasting glucose, infant birth weights, and risk of adverse outcomes similar to those in women with NGT. CONCLUSIONS:Heterogeneity of physiologic processes underlying hyperglycemia exists among women with GDM. GDM with impaired insulin sensitivity confers a greater risk of adverse outcomes.

journal_name

Diabetes Care

journal_title

Diabetes care

authors

Powe CE,Allard C,Battista MC,Doyon M,Bouchard L,Ecker JL,Perron P,Florez JC,Thadhani R,Hivert MF

doi

10.2337/dc15-2672

subject

Has Abstract

pub_date

2016-06-01 00:00:00

pages

1052-5

issue

6

eissn

0149-5992

issn

1935-5548

pii

dc15-2672

journal_volume

39

pub_type

杂志文章
  • Acute hypoglycemia impairs executive cognitive function in adults with and without type 1 diabetes.

    abstract:OBJECTIVE:Acute hypoglycemia impairs cognitive function in several domains. Executive cognitive function governs organization of thoughts, prioritization of tasks, and time management. This study examined the effect of acute hypoglycemia on executive function in adults with and without diabetes. RESEARCH DESIGN AND ME...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc13-0194

    authors: Graveling AJ,Deary IJ,Frier BM

    更新日期:2013-10-01 00:00:00

  • Food insecurity and glycemic control among low-income patients with type 2 diabetes.

    abstract:OBJECTIVE:To determine whether food insecurity--the inability to reliably afford safe and nutritious food--is associated with poor glycemic control and whether this association is mediated by difficulty following a healthy diet, diabetes self-efficacy, or emotional distress related to diabetes. RESEARCH DESIGN AND MET...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc11-1627

    authors: Seligman HK,Jacobs EA,López A,Tschann J,Fernandez A

    更新日期:2012-02-01 00:00:00

  • Hormone replacement therapy and its relationship to lipid and glucose metabolism in diabetic and nondiabetic postmenopausal women: results from the Third National Health and Nutrition Examination Survey (NHANES III).

    abstract:OBJECTIVE:Among postmenopausal women, those with diabetes experience more cardiovascular diseases than those without diabetes. We examine the relationship of hormone replacement therapy (HRT) with indicators of lipid and glucose metabolism using a national sample of diabetic and nondiabetic postmenopausal women. RESEA...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.25.10.1675

    authors: Crespo CJ,Smit E,Snelling A,Sempos CT,Andersen RE,NHANES III.

    更新日期:2002-10-01 00:00:00

  • Impact of HbA1c, followed from onset of type 1 diabetes, on the development of severe retinopathy and nephropathy: the VISS Study (Vascular Diabetic Complications in Southeast Sweden).

    abstract:OBJECTIVE:HbA1c is strongly related to the development of diabetes complications, but it is still controversial which HbA1c level to strive for in the treatment of type 1 diabetes. The aim of the current study was to evaluate HbA1c, followed from diagnosis, as a predictor of severe microvascular complications and to fo...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc14-1203

    authors: Nordwall M,Abrahamsson M,Dhir M,Fredrikson M,Ludvigsson J,Arnqvist HJ

    更新日期:2015-02-01 00:00:00

  • Circulating 25-hydroxyvitamin D concentrations are correlated with cardiometabolic risk among American black and white adolescents living in a year-round sunny climate.

    abstract:OBJECTIVE:Low vitamin D status is common among healthy black and white adolescents residing at southern U.S. latitudes with a year-round sunny climate. Thus we aimed to study the relationships between circulating 25-hydroxyvitamin D [25(OH)D] and cardiometabolic risk factors in this population. RESEARCH DESIGN AND MET...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc11-1944

    authors: Parikh S,Guo DH,Pollock NK,Petty K,Bhagatwala J,Gutin B,Houk C,Zhu H,Dong Y

    更新日期:2012-05-01 00:00:00

  • Dose response of inhaled dry-powder insulin and dose equivalence to subcutaneous insulin lispro.

    abstract:OBJECTIVE:To determine the pharmacokinetic (PK) and glucodynamic (GD) dose response of human insulin inhalation powder (HIIP) delivered via AIR particle technology and dose equivalence to subcutaneous (SC) insulin lispro. RESEARCH DESIGN AND METHODS:Twenty healthy, nonsmoking, male or female subjects (aged 29.6 +/- 6....

    journal_title:Diabetes care

    pub_type: 杂志文章,随机对照试验

    doi:10.2337/diacare.28.10.2400

    authors: Rave KM,Nosek L,de la Peña A,Seger M,Ernest CS 2nd,Heinemann L,Batycky RP,Muchmore DB

    更新日期:2005-10-01 00:00:00

  • Changes in inflammatory cytokines are related to impaired glucose tolerance in offspring of type 2 diabetic subjects.

    abstract:OBJECTIVE:We sought to determine whether levels of inflammatory markers and different cytokines are abnormal in nondiabetic offspring of type 2 diabetic subjects. RESEARCH DESIGN AND METHODS:Cytokine levels were measured in 19 healthy control subjects and 129 offspring of patients with type 2 diabetes (109 with normal...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc06-0147

    authors: Ruotsalainen E,Salmenniemi U,Vauhkonen I,Pihlajamäki J,Punnonen K,Kainulainen S,Laakso M

    更新日期:2006-12-01 00:00:00

  • Long-acting insulin analogs.

    abstract::Once daily injection of existing intermediate/long-acting insulin preparations does not provide a 24-h basal insulinemia in most patients. High variability, pronounced insulin peaks, and (as a result) a high risk of nocturnal hypoglycemia only poorly simulate normal physiology. One principle to prolong insulin action ...

    journal_title:Diabetes care

    pub_type: 杂志文章,评审

    doi:

    authors: Rosskamp RH,Park G

    更新日期:1999-03-01 00:00:00

  • Diet-quality scores and the risk of type 2 diabetes in men.

    abstract:OBJECTIVE:To 1) compare associations of diet-quality scores, which were inversely associated with cardiovascular disease, with incident type 2 diabetes and 2) test for differences in absolute-risk reduction across various strata. RESEARCH DESIGN AND METHODS:Men from the Health Professionals Follow-Up Study, who were i...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc10-2352

    authors: de Koning L,Chiuve SE,Fung TT,Willett WC,Rimm EB,Hu FB

    更新日期:2011-05-01 00:00:00

  • Racial differences in the correlation between gonadal androgens and serum insulin levels.

    abstract:OBJECTIVE:We previously demonstrated a direct correlation between serum insulin levels and gonadal androgens (testosterone and androstenedione) in a group of obese hyperandrogenic predominantly black women. Subsequent work by others in predominantly white women showed conflicting results. To examine these potentially i...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章

    doi:10.2337/diacare.22.9.1524

    authors: Kitabchi AE,Imseis RE,Bush AJ,Williams-Cleaves B,Pourmotabbed G

    更新日期:1999-09-01 00:00:00

  • High Blood Pressure and Its Association With Incident Diabetes Over 10 Years in the Korean Genome and Epidemiology Study (KoGES).

    abstract:OBJECTIVE:No prospective, community-based cohort studies have investigated the association between blood pressure and diabetes in Asian ethnicity. We investigated this issue in a 10-year prospective, community-based study of Koreans. RESEARCH DESIGN AND METHODS:We studied whether high blood pressure was associated wit...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc14-1931

    authors: Cho NH,Kim KM,Choi SH,Park KS,Jang HC,Kim SS,Sattar N,Lim S

    更新日期:2015-07-01 00:00:00

  • Impact of iron deficiency anemia on prevalence of gestational diabetes mellitus.

    abstract:OBJECTIVE:Increased Hb and ferritin have been associated with gestational diabetes mellitus (GDM). This study was performed to determine whether the prevalence of GDM is influenced by iron deficiency anemia. RESEARCH DESIGN AND METHODS:In a retrospective case-control study, 242 women with iron deficiency anemia (Hb<10...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.27.3.650

    authors: Lao TT,Ho LF

    更新日期:2004-03-01 00:00:00

  • Valsartan improves {beta}-cell function and insulin sensitivity in subjects with impaired glucose metabolism: a randomized controlled trial.

    abstract:OBJECTIVE:Recently, the Nateglinide and Valsartan in Impaired Glucose Tolerance Outcomes Research Trial demonstrated that treatment with the angiotensin receptor blocker (ARB) valsartan for 5 years resulted in a relative reduction of 14% in the incidence of type 2 diabetes in subjects with impaired glucose metabolism (...

    journal_title:Diabetes care

    pub_type: 杂志文章,随机对照试验

    doi:10.2337/dc10-2224

    authors: van der Zijl NJ,Moors CC,Goossens GH,Hermans MM,Blaak EE,Diamant M

    更新日期:2011-04-01 00:00:00

  • Bariatric/Metabolic Surgery to Treat Type 2 Diabetes in Patients With a BMI

    abstract:OBJECTIVE:Global usage of bariatric surgery has been dictated for the past quarter century by National Institutes of Health recommendations restricting these operations to individuals with a BMI ≥35 kg/m(2). Strong evidence now demonstrates that bariatric procedures markedly improve or cause remission of type 2 diabete...

    journal_title:Diabetes care

    pub_type: 杂志文章,meta分析

    doi:10.2337/dc16-0350

    authors: Cummings DE,Cohen RV

    更新日期:2016-06-01 00:00:00

  • Predicting future cardiovascular disease: do we need the oral glucose tolerance test?

    abstract:OBJECTIVE:Our objective was to compare the performance of oral glucose tolerance tests (OGTTs) and multivariate models incorporating commonly available clinical variables in their ability to predict future cardiovascular disease (CVD). RESEARCH DESIGN AND METHODS:We randomly selected 2,662 Mexican-Americans and 1,595 ...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.25.10.1851

    authors: Stern MP,Fatehi P,Williams K,Haffner SM

    更新日期:2002-10-01 00:00:00

  • Efficacy of metformin in the treatment of NIDDM. Meta-analysis.

    abstract:OBJECTIVE:The results differ concerning randomized controlled trials of the effects of metformin on blood glucose regulation and body weight. To get a systematic overview, a meta-analysis of the efficacy of metformin was performed by comparing metformin with placebo and sulfonylurea. RESEARCH DESIGN AND METHODS:All ra...

    journal_title:Diabetes care

    pub_type: 杂志文章,meta分析

    doi:10.2337/diacare.22.1.33

    authors: Johansen K

    更新日期:1999-01-01 00:00:00

  • Glucosuria in children with diabetes: advantages of the 2-drop Clinitest method.

    abstract::In order to assess the actual and theoretical limitations of using the traditional urinary glucose determinations as an indicator of plasma glucose concentration, we have measured plasma and urine glucose concentrations in 37 children with diabetes mellitus. A constant blood withdrawal system enabled an accurate estim...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.2.4.349

    authors: Winter RJ,Traisman HS,Green OC

    更新日期:1979-07-01 00:00:00

  • Pioglitazone Improves Left Ventricular Diastolic Function in Subjects With Diabetes.

    abstract:OBJECTIVE:To examine the effect of pioglitazone on myocardial insulin sensitivity and left ventricular (LV) function in patients with type 2 diabetes (T2D). RESEARCH DESIGN AND METHODS:Twelve subjects with T2D and 12 with normal glucose tolerance received a euglycemic insulin clamp. Myocardial glucose uptake (MGU) and...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc17-0078

    authors: Clarke GD,Solis-Herrera C,Molina-Wilkins M,Martinez S,Merovci A,Cersosimo E,Chilton RJ,Iozzo P,Gastaldelli A,Abdul-Ghani M,DeFronzo RA

    更新日期:2017-11-01 00:00:00

  • Exercise therapy in type 2 diabetes: is daily exercise required to optimize glycemic control?

    abstract:OBJECTIVE:Given the transient nature of exercise-induced improvements in insulin sensitivity, it has been speculated that daily exercise is preferred to maximize the benefits of exercise for glycemic control. The current study investigates the impact of daily exercise versus exercise performed every other day on glycem...

    journal_title:Diabetes care

    pub_type: 杂志文章,随机对照试验

    doi:10.2337/dc11-2112

    authors: van Dijk JW,Tummers K,Stehouwer CD,Hartgens F,van Loon LJ

    更新日期:2012-05-01 00:00:00

  • Nonselective loss of contrast sensitivity in visual system testing in early type I diabetes.

    abstract:OBJECTIVE:Psychophysical methods in patients with diabetes mellitus reveal deficits of central or foveal vision. Our aim was to evaluate the contrast-sensitivity thresholds in 24 insulin-dependent (type I) diabetic patients with a short disease duration and without retinopathy, taking into account metabolic control. R...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.15.5.620

    authors: Di Leo MA,Caputo S,Falsini B,Porciatti V,Minnella A,Greco AV,Ghirlanda G

    更新日期:1992-05-01 00:00:00

  • Phase I (safety) study of autologous tolerogenic dendritic cells in type 1 diabetic patients.

    abstract:OBJECTIVE:The safety of dendritic cells to selectively suppress autoimmunity, especially in type 1 diabetes, has never been ascertained. We investigated the safety of autologous dendritic cells, stabilized into an immunosuppressive state, in established adult type 1 diabetic patients. RESEARCH DESIGN AND METHODS:A ran...

    journal_title:Diabetes care

    pub_type: 杂志文章,随机对照试验

    doi:10.2337/dc11-0472

    authors: Giannoukakis N,Phillips B,Finegold D,Harnaha J,Trucco M

    更新日期:2011-09-01 00:00:00

  • Effects and correlates of blood glucose awareness training among patients with IDDM.

    abstract::Whereas self-monitoring of blood glucose (SMBG) is the recommended source of information on which to make self-care decisions, patients frequently use estimates of their own blood glucose (BG). This study evaluated whether patients with insulin-dependent diabetes mellitus (IDDM) could learn to improve accuracy of BG e...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.12.5.313

    authors: Cox DJ,Gonder-Frederick LA,Lee JH,Julian DM,Carter WR,Clarke WL

    更新日期:1989-05-01 00:00:00

  • Uric Acid Is an Independent Risk Factor for Decline in Kidney Function, Cardiovascular Events, and Mortality in Patients With Type 1 Diabetes.

    abstract:OBJECTIVE:Previous studies have provided inconclusive results on the role of uric acid (UA) in risk prediction. Here we aimed to improve the power and precision of the predictive value of UA for the risk of decline in kidney function, cardiovascular events (CVEs), and mortality in patients with type 1 diabetes (T1D). ...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc18-2173

    authors: Pilemann-Lyberg S,Hansen TW,Tofte N,Winther SA,Theilade S,Ahluwalia TS,Rossing P

    更新日期:2019-06-01 00:00:00

  • Impaired glycemia and diabetic polyneuropathy: the OC IG Survey.

    abstract:OBJECTIVE:To test whether diabetic polyneuropathies (DPNs), retinopathy, or nephropathy is more prevalent in subjects with impaired glycemia (IG) (abnormality of impaired fasting glucose [IFG], impaired glucose tolerance [IGT], or impaired HbA(1c) [IA1C]) than in healthy subjects (non-IG). RESEARCH DESIGN AND METHODS:...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc11-1421

    authors: Dyck PJ,Clark VM,Overland CJ,Davies JL,Pach JM,Dyck PJ,Klein CJ,Rizza RA,Melton LJ 3rd,Carter RE,Klein R,Litchy WJ

    更新日期:2012-03-01 00:00:00

  • Plasma adiponectin plays an important role in improving insulin resistance with glimepiride in elderly type 2 diabetic subjects.

    abstract:OBJECTIVE:We investigated the effect of glimepiride, a third-generation sulfonylurea hypoglycemic agent, on insulin resistance in elderly patients with type 2 diabetes, in connection with plasma adiponectin and 8-epi-prostagrandin F2alpha (8-epi-PGF2alpha), an oxidative stress marker. RESEARCH DESIGN AND METHODS:A tot...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.2337/diacare.26.2.285

    authors: Tsunekawa T,Hayashi T,Suzuki Y,Matsui-Hirai H,Kano H,Fukatsu A,Nomura N,Miyazaki A,Iguchi A

    更新日期:2003-02-01 00:00:00

  • A Multidisciplinary Evaluation of a Virtually Supervised Home-Based High-Intensity Interval Training Intervention in People With Type 1 Diabetes.

    abstract:OBJECTIVE:Adopt a multidisciplinary approach to evaluate a virtually supervised home-based high-intensity interval training (Home-HIT) intervention in people with type 1 diabetes. RESEARCH DESIGN AND METHODS:Eleven individuals with type 1 diabetes (seven women; age 30 ± 3 years; [Formula: see text] 2.5 ± 0.2 L/min; du...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc19-0871

    authors: Scott SN,Shepherd SO,Andrews RC,Narendran P,Purewal TS,Kinnafick F,Cuthbertson DJ,Atkinson-Goulding S,Noon T,Wagenmakers AJM,Cocks M

    更新日期:2019-12-01 00:00:00

  • Increased risk of childhood type 1 diabetes in children born after 1985.

    abstract:OBJECTIVE:The incidence rate of childhood type 1 diabetes is thought to be increasing; however, Danish studies have not confirmed this. Using a national diabetes register initiated in 1996 and two previous regional incidence studies, we studied the age-specific incidence of type 1 diabetes over 30 years. Here, we descr...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.25.12.2197

    authors: Svensson J,Carstensen B,Mølbak A,Christau B,Mortensen HB,Nerup J,Borch-Johnsen K

    更新日期:2002-12-01 00:00:00

  • Serum 25-hydroxyvitamin D, diabetes, and ethnicity in the Third National Health and Nutrition Examination Survey.

    abstract:OBJECTIVE:To determine the association between serum 25-hydroxyvitamin D (25OHD) and diabetes risk and whether it varies by ethnicity. RESEARCH DESIGN AND METHODS:We performed an analysis of data from participants who attended the morning examination of the Third National Health and Nutrition Examination Survey (1988-...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.27.12.2813

    authors: Scragg R,Sowers M,Bell C,Third National Health and Nutrition Examination Survey.

    更新日期:2004-12-01 00:00:00

  • Dietary cod protein improves insulin sensitivity in insulin-resistant men and women: a randomized controlled trial.

    abstract:OBJECTIVE:The purpose of this article was to compare the effects of cod protein to those of other animal proteins on insulin sensitivity in insulin-resistant human subjects. RESEARCH DESIGN AND METHODS:Insulin sensitivity (M/I) was assessed using a hyperinsulinemic-euglycemic clamp in 19 insulin-resistant subjects fed...

    journal_title:Diabetes care

    pub_type: 杂志文章,随机对照试验

    doi:10.2337/dc07-0273

    authors: Ouellet V,Marois J,Weisnagel SJ,Jacques H

    更新日期:2007-11-01 00:00:00

  • Health outcomes of severely obese type 2 diabetic subjects 1 year after laparoscopic adjustable gastric banding.

    abstract:OBJECTIVE:To prospectively examine the effect of weight loss 1 year after laparoscopic adjustable gastric band surgery on a broad range of health outcomes in 50 diabetic subjects. RESEARCH DESIGN AND METHODS:A total of 50 (17 men, 33 women) of 51 patients with type 2 diabetes, from a total of 500 consecutive patients,...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.25.2.358

    authors: Dixon JB,O'Brien PE

    更新日期:2002-02-01 00:00:00