Abstract:
OBJECTIVE:To characterize metabolic effects of troglitazone in type 2 diabetic, obese, and lean subjects, and examine the effects of troglitazone 2-3 weeks after discontinuation. RESEARCH DESIGN AND METHODS:Nine type 2 diabetic, nine obese, and nine lean subjects underwent baseline metabolic studies including an 8-h meal-tolerance test (MTT) and a 5-h glucose clamp. Subjects then received troglitazone (600 mg/day) for 12 weeks and subsequently had repeat metabolic studies. Diabetic subjects remained off hypoglycemic agents for 2-3 weeks and then underwent a 5-h glucose clamp. RESULTS:In diabetic subjects, fasting plasma glucose was reduced (P<0.05) and insulin-stimulated glucose disposal (Rd) was enhanced by treatment (P<0.02). The area under the MTT 8-h plasma glucose curve declined with therapy (P<0.001), and its change was positively correlated with the improvement in Rd (r = 0.75, P<0.05). There was also a positive correlation between the change in fasting hepatic glucose output (HGO) and the change in fasting plasma glucose with treatment (r = 0.92, P<0.001). Discontinuation of therapy for 2-3 weeks did not significantly affect fasting plasma glucose or insulin-stimulated glucose Rd. In obese subjects, insulin-stimulated glucose Rd improved with therapy (P<0.001), allowing for maintenance of euglycemia by lower plasma insulin concentrations (P<0.05). In lean subjects, an increase in fasting HGO (P<0.001) and glucose clearance (P<0.01) was observed. CONCLUSIONS:Troglitazone lowers fasting and postprandial plasma glucose in type 2 diabetes by affecting both fasting HGO and peripheral insulin sensitivity. Its effects are evident 2-3 weeks after discontinuation. In obese subjects, its insulin sensitizing effects suggest a role for its use in the primary prevention of type 2 diabetes.
journal_name
Diabetes Carejournal_title
Diabetes careauthors
Frias JP,Yu JG,Kruszynska YT,Olefsky JMdoi
10.2337/diacare.23.1.64subject
Has Abstractpub_date
2000-01-01 00:00:00pages
64-9issue
1eissn
0149-5992issn
1935-5548journal_volume
23pub_type
临床试验,杂志文章相关文献
DIABETES CARE文献大全abstract:OBJECTIVE:To describe the association between Bacille Calmette-Guérin (BCG) vaccination and IDDM development in two different case-control series (A and B) in Montreal. RESEARCH DESIGN AND METHODS:Case-control series A comprised 93 IDDM cases and 2,903 control subjects who participated in a community-based tuberculin ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.20.5.767
更新日期:1997-05-01 00:00:00
abstract:OBJECTIVE:To investigate the relationships of serum adipocyte fatty acid-binding protein (A-FABP) and epidermal fatty acid-binding protein (E-FABP) with renal dysfunction and macrovascular complications in type 2 diabetic patients. RESEARCH DESIGN AND METHODS:The associations of serum A-FABP and E-FABP with markers of...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc08-1333
更新日期:2009-01-01 00:00:00
abstract::Diabetes has been identified as an important risk factor for mortality and rates of progression to acute respiratory distress syndrome (ARDS) in hospitalized patients with coronavirus disease 2019 (COVID-19). However, many recent reports on this topic reflect hurried approaches and have lacked careful epidemiologic de...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc20-1295
更新日期:2020-08-01 00:00:00
abstract:OBJECTIVE:There is considerable interest in identifying biomarkers that predict high risk for the development of macrovascular complications in patients with diabetes. Therefore, the longitudinal association between subclinical atherosclerosis as measured by internal carotid artery intima-media thickness (IMT) and acut...
journal_title:Diabetes care
pub_type: 杂志文章,随机对照试验
doi:10.2337/dc14-2877
更新日期:2015-07-01 00:00:00
abstract::The availability of insulin analogs has offered insulin replacement strategies that are proposed to more closely mimic normal human physiology. Specifically, there are a considerable number of reports demonstrating that prandial insulin analogs (lispro, aspart, glulisine) have pharmacokinetic and pharmacodynamic profi...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc13-2915
更新日期:2014-06-01 00:00:00
abstract::We measured plasma lipid and lipoprotein levels at baseline and at 6-mo intervals in 47 normolipidemic patients with classic insulin-dependent diabetes mellitus treated either with a conventional (n = 21) or intensive (n = 26) diabetes-treatment program. Patients were followed for a mean of 3 yr (range 1-4 yr). Intens...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.10.6.729
更新日期:1987-11-01 00:00:00
abstract:OBJECTIVE:To determine the association between serum 25-hydroxyvitamin D (25OHD) and diabetes risk and whether it varies by ethnicity. RESEARCH DESIGN AND METHODS:We performed an analysis of data from participants who attended the morning examination of the Third National Health and Nutrition Examination Survey (1988-...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.27.12.2813
更新日期:2004-12-01 00:00:00
abstract::The reality of primary and secondary prevention of cardiovascular complications in people with diabetes is alarming, even in developed countries with a well-structured medical system. Even though therapeutic targets have been more clearly defined during the last decades, their implementation is still suboptimal. Finan...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc08-s254
更新日期:2008-02-01 00:00:00
abstract::In past studies on the psychological aspects of diabetes mellitus, symptoms of depression have been identified as the most common manifestation among diabetic patients. Other psychological manifestations have been anxiety, hypochondriasis, increased dependence and passivity, and poor self-image. Ten insulin-dependent ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.3.1.117
更新日期:1980-01-01 00:00:00
abstract:OBJECTIVE:We examined the association of lactation duration with incident type 2 diabetes among women with a history of gestational diabetes mellitus (GDM). RESEARCH DESIGN AND METHODS:We monitored 4,372 women with a history of GDM participating in the Nurses' Health Study II for incident type 2 diabetes over 25 years...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc19-2237
更新日期:2020-04-01 00:00:00
abstract:OBJECTIVE:The purpose of this paper is to estimate the impact of diabetes on survival among patients with first acute myocardial infarction, using data from the World Health Organization (WHO) Monitoring Trends and Determinants of Cardiovascular Disease (MONICA) Project in Newcastle, New South Wales, Australia. RESEAR...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.20.5.704
更新日期:1997-05-01 00:00:00
abstract:OBJECTIVE:To determine the relationship between mental disorders and diabetes in a representative community sample. RESEARCH DESIGN AND METHODS:This was a cross-sectional study. Data on diabetes and HbA(1c) values were obtained by structured questionnaires and by laboratory assessments. Current psychiatric disorders w...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.26.6.1841
更新日期:2003-06-01 00:00:00
abstract:OBJECTIVE:To clarify the relationship between the angiotensin I-converting enzyme (ACE) gene polymorphism and diabetic micro- and macroangiopathy in patients with non-insulin-dependent diabetes mellitus (NIDDM). RESEARCH DESIGN AND METHODS:We examined 267 NIDDM patients with various stages of diabetic retinopathy, 61 ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.18.7.983
更新日期:1995-07-01 00:00:00
abstract:OBJECTIVE:Uncertainty remains regarding the predictive value of various glycemic measures as they relate to the risk of diabetes and its complications. Using the cutoffs recommended by the American Diabetes Association's 2010 criteria, we determined the associations of fasting plasma glucose (FPG), 2-h postload glucose...
journal_title:Diabetes care
pub_type: 杂志文章,多中心研究
doi:10.2337/dc18-1390
更新日期:2019-08-01 00:00:00
abstract:OBJECTIVE:To investigate the role of hyperglycemia in mediating the clinical association of NIDDM with hypertension and left ventricular dysfunction and hypertrophy. RESEARCH DESIGN AND METHODS:Since hyperglycemia elevates cytosolic free calcium (Cai) both in myocardial and vascular smooth muscle cells, we utilized nu...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.19.12.1393
更新日期:1996-12-01 00:00:00
abstract:OBJECTIVE:Differences in risk of erectile dysfunction (ED) by characteristics of diabetes among older men are not well understood. We examined the association of type and duration of diabetes with erectile function in men >50 years of age in a large prospective cohort study. RESEARCH DESIGN AND METHODS:Subjects includ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.25.8.1458
更新日期:2002-08-01 00:00:00
abstract:OBJECTIVE:To evaluate the prevalence of NIDDM and IGT in the urban and rural areas in southern India. RESEARCH DESIGN AND METHODS:Two populations of the same ethnic background, but different socioeconomic background were chosen for this study. Nine-hundred urban people and 1038 rural subjects were studied. Fasting and...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.15.10.1348
更新日期:1992-10-01 00:00:00
abstract:OBJECTIVE:Global usage of bariatric surgery has been dictated for the past quarter century by National Institutes of Health recommendations restricting these operations to individuals with a BMI ≥35 kg/m(2). Strong evidence now demonstrates that bariatric procedures markedly improve or cause remission of type 2 diabete...
journal_title:Diabetes care
pub_type: 杂志文章,meta分析
doi:10.2337/dc16-0350
更新日期:2016-06-01 00:00:00
abstract::OBJECTIVE The American Diabetes Association advocates insulin regimens for youth with type 1 diabetes that involve adjusting insulin dose based on carbohydrate intake and blood glucose level. Implementing these regimens requires knowledge about carbohydrate content of foods and subsequent calculations of insulin dose,...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc09-0390
更新日期:2010-03-01 00:00:00
abstract:OBJECTIVE:To validate fasting indices of insulin sensitivity and secretion in a diverse pediatric population against gold standard estimates from euglycemic and hyperglycemic clamps. RESEARCH DESIGN AND METHODS:A total of 31 children (mean BMI 25.1 +/- 4.9 kg/m(2), mean age 8.7 +/- 1.4 years, 15 girls and 16 boys, 12 ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.25.11.2081
更新日期:2002-11-01 00:00:00
abstract:OBJECTIVE:To characterize the relationship of subclinical and clinical eating disorders to HbA1c values in women with IDDM. RESEARCH DESIGN AND METHODS:Ninety women with IDDM (18-46 years of age) were recruited from diabetes clinics throughout Connecticut and Massachusetts. Subjects were categorized into one of three ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.20.2.182
更新日期:1997-02-01 00:00:00
abstract:OBJECTIVE:Our objective was to compare the performance of oral glucose tolerance tests (OGTTs) and multivariate models incorporating commonly available clinical variables in their ability to predict future cardiovascular disease (CVD). RESEARCH DESIGN AND METHODS:We randomly selected 2,662 Mexican-Americans and 1,595 ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.25.10.1851
更新日期:2002-10-01 00:00:00
abstract::To evaluate the importance of dialysis in the determination of glycosylated hemoglobin (HbA1), we studied blood glucose and HbA1 in 38 insulin-dependent diabetic children during a morning fast and again 6 h postprandially. We used two methods to determine glycosylated hemoglobin: (1) the conventional macrocolumn metho...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.4.5.551
更新日期:1981-09-01 00:00:00
abstract:OBJECTIVE:To examine ankle-brachial index (ABI) abnormalities in patients with type 2 diabetes and coronary artery disease (CAD). RESEARCH DESIGN AND METHODS:An ABI was obtained in 2,240 patients in the Bypass Angioplasty Revascularization Investigation 2 Diabetes (BARI 2D) Trial. ABIs were classified as: normal, 0.91...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc10-1734
更新日期:2011-02-01 00:00:00
abstract:OBJECTIVE:Hypertriglyceridemia is associated with cardiovascular disease in diabetes. Fibrates effectively lower, but do not always normalize, serum triglyceride levels. Fish oil supplements may then be added to lower serum triglyceride levels. Doubt remains whether the net effect of fish oil intake on glycemic control...
journal_title:Diabetes care
pub_type: 杂志文章,meta分析
doi:10.2337/diacare.21.4.494
更新日期:1998-04-01 00:00:00
abstract::Intranasal glucagon can raise blood glucose levels in healthy subjects. The aims of this study were to 1) compare the hyperglycemic effect of intranasal and intramuscular glucagon in healthy subjects and type I (insulin-dependent) diabetes patients during euglycemic conditions and 2) test the efficacy of intranasal an...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章
doi:10.2337/diacare.12.9.604
更新日期:1989-10-01 00:00:00
abstract:OBJECTIVE:In a previous study, we found observational evidence of improvement in beta-cell function when rosiglitazone was added to a failing oral antihyperglycemic regimen consisting of sulfonylureas and metformin. To confirm our previous observations, we designed and performed a prospective, randomized, and controlle...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.2337/diacare.27.11.2585
更新日期:2004-11-01 00:00:00
abstract:OBJECTIVE:Antioxidant trials have not demonstrated efficacy in slowing cardiovascular disease but could not rule out benefit for specific patient subgroups. Antioxidant therapy reduces LDL oxidizability in haptoglobin 1 allele homozygotes (Hp 1-1), but not in individuals with the haptoglobin 2 allele (Hp 2-1 or Hp 2-2)...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.2337/diacare.27.4.925
更新日期:2004-04-01 00:00:00
abstract:OBJECTIVE:This article evaluates prediction of HbA(1c) during an 18-month randomized trial of intensive therapy (IT) versus usual care (UC) for type 1 diabetes in 142 youth. RESEARCH DESIGN AND METHODS:Patients received a composite score for self-management competence (SMC) that combined standardized scores on baselin...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.2337/diacare.26.7.2043
更新日期:2003-07-01 00:00:00
abstract::To investigate vascular responses in insulin-dependent diabetic patients both with and without retinopathy, we have assessed vasodilation by forearm transcutaneous pO2 measurement after 10 min of ischemia produced by a sphygmomanometer cuff. Diabetic patients with proliferative retinopathy had a delayed vasodilatory r...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.7.1.47
更新日期:1984-01-01 00:00:00