The prevalence and predictors of an abnormal ankle-brachial index in the Bypass Angioplasty Revascularization Investigation 2 Diabetes (BARI 2D) trial.

Abstract:

OBJECTIVE:To examine ankle-brachial index (ABI) abnormalities in patients with type 2 diabetes and coronary artery disease (CAD). RESEARCH DESIGN AND METHODS:An ABI was obtained in 2,240 patients in the Bypass Angioplasty Revascularization Investigation 2 Diabetes (BARI 2D) Trial. ABIs were classified as: normal, 0.91-1.3; low, ≤ 0.9; high, >1.3; or noncompressible artery (NC). Baseline characteristics were examined according to ABI and by multivariate analysis. RESULTS ABI was normal in 66%, low in 19%, and high in 8% of patients, and 6% of patients had NC. Of the low ABI patients, 68% were asymptomatic. Using normal ABI as referent, low ABI was independently associated with smoking, female sex, black race, hypertension, age, C-reactive protein, diabetes duration, and lower BMI. High ABI was associated with male sex, nonblack race, and higher BMI; and NC artery was associated with diabetes duration, higher BMI, and hypertension. CONCLUSIONS:ABI abnormalities are common and often asymptomatic in patients with type 2 diabetes and CAD.

journal_name

Diabetes Care

journal_title

Diabetes care

authors

Singh PP,Abbott JD,Lombardero MS,Sutton-Tyrrell K,Woodhead G,Venkitachalam L,Tsapatsaris NP,Piemonte TC,Lago RM,Rutter MK,Nesto RW,Bypass Angioplasty Revascularization Investigation 2 Diabetes Study Group.

doi

10.2337/dc10-1734

subject

Has Abstract

pub_date

2011-02-01 00:00:00

pages

464-7

issue

2

eissn

0149-5992

issn

1935-5548

pii

34/2/464

journal_volume

34

pub_type

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