Abstract:
OBJECTIVE:Diabetes Prevention Program (DPP) participants randomized to the intensive lifestyle intervention (ILS) had significantly reduced risk of diabetes compared with placebo participants. We explored the contribution of changes in weight, diet, and physical activity on the risk of developing diabetes among ILS participants. RESEARCH DESIGN AND METHODS:For this study, we analyzed one arm of a randomized trial using Cox proportional hazards regression over 3.2 years of follow-up. RESULTS:A total of 1,079 participants were aged 25-84 years (mean 50.6 years, BMI 33.9 kg/m(2)). Weight loss was the dominant predictor of reduced diabetes incidence (hazard ratio per 5-kg weight loss 0.42 [95% CI 0.35-0.51]; P < 0.0001). For every kilogram of weight loss, there was a 16% reduction in risk, adjusted for changes in diet and activity. Lower percent of calories from fat and increased physical activity predicted weight loss. Increased physical activity was important to help sustain weight loss. Among 495 participants not meeting the weight loss goal at year 1, those who achieved the physical activity goal had 44% lower diabetes incidence. CONCLUSIONS:Interventions to reduce diabetes risk should primarily target weight reduction.
journal_name
Diabetes Carejournal_title
Diabetes careauthors
Hamman RF,Wing RR,Edelstein SL,Lachin JM,Bray GA,Delahanty L,Hoskin M,Kriska AM,Mayer-Davis EJ,Pi-Sunyer X,Regensteiner J,Venditti B,Wylie-Rosett Jdoi
10.2337/dc06-0560subject
Has Abstractpub_date
2006-09-01 00:00:00pages
2102-7issue
9eissn
0149-5992issn
1935-5548pii
29/9/2102journal_volume
29pub_type
杂志文章,随机对照试验相关文献
DIABETES CARE文献大全abstract::Medications may contain significant amounts of various sugars. Data provided by 67 manufacturers have been tabulated to provide specific qualitative and quantitative information on sugar content of selected drug products. Since diabetic individuals may tolerate various sugar forms differently, it is useful to know spe...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.6.3.231
更新日期:1983-05-01 00:00:00
abstract:OBJECTIVE:Statins may reduce the risk of diabetic polyneuropathy (DPN) as a result of lipid-lowering and anti-inflammatory effects, but statins have also been associated with neurotoxicity. We examined whether statin therapy affects the risk of DPN. RESEARCH DESIGN AND METHODS:We identified all Danish patients with in...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc20-1004
更新日期:2020-12-01 00:00:00
abstract:OBJECTIVE:To examine β-cell function across a spectrum of glycemia among Asian Indians, a population experiencing type 2 diabetes development at young ages despite low BMI. RESEARCH DESIGN AND METHODS:One-thousand two-hundred sixty-four individuals without known diabetes in the Diabetes Community Lifestyle Improvement...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc12-2290
更新日期:2013-09-01 00:00:00
abstract:OBJECTIVE:To examine the contribution of nerve-axon reflex-related vasodilation to total acetylcholine-induced vasodilation in the skin of normal and diabetic subjects. RESEARCH DESIGN AND METHODS:The skin microcirculation was evaluated at the forearm level in 69 healthy subjects and 42 nonneuropathic diabetic patient...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.24.2.344
更新日期:2001-02-01 00:00:00
abstract::Adjustment algorithms for conventional insulin therapy must be tested for safety and efficacy before clinical implementation. We did this by computer simulation. Accordingly, a computer simulator of human intermediary metabolism created 10 randomly chosen diabetic subjects for study. All were well defined with respect...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.13.4.393
更新日期:1990-04-01 00:00:00
abstract:OBJECTIVE:To determine whether adults diagnosed with type 2 diabetes from age 18 to 44 years more aggressively develop clinical complications after diagnosis than adults diagnosed at >or=45 years of age. RESEARCH DESIGN AND METHODS:We compared outcomes among 7844 adults in a health maintenance organization who were ne...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.26.11.2999
更新日期:2003-11-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to determine the effect of 24 weeks of treatment with 45 mg/day pioglitazone on peripheral skin blood flow (SkBF) and skin nitric oxide (NO) production in vivo in patients with type 2 diabetes. RESEARCH DESIGN AND METHODS:This was a randomized, parallel, cross-over, double-blind...
journal_title:Diabetes care
pub_type: 杂志文章,随机对照试验
doi:10.2337/diacare.29.04.06.dc05-0517
更新日期:2006-04-01 00:00:00
abstract:OBJECTIVE:To compare pharmacokinetics (PK) and pharmacodynamics (PD) of insulin glargine in type 2 diabetes mellitus (T2DM) after evening versus morning administration. RESEARCH DESIGN AND METHODS:Ten T2DM insulin-treated persons were studied during 24-h euglycemic glucose clamp, after glargine injection (0.4 units/kg...
journal_title:Diabetes care
pub_type: 杂志文章,随机对照试验
doi:10.2337/dc14-0649
更新日期:2015-03-01 00:00:00
abstract:OBJECTIVE:Little evidence exists regarding long-term diet quality and the risk of type 2 diabetes among Asian populations, who have undergone a nutrition transition and a diabetes epidemic. RESEARCH DESIGN AND METHODS:A total of 117,919 Chinese men and women, 40-74 years old, free of diabetes, cardiovascular disease, ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc17-1626
更新日期:2018-04-01 00:00:00
abstract:OBJECTIVE:To study the effect of birth weight on risk of type 2 diabetes in the schoolchildren in Taiwan. RESEARCH DESIGN AND METHODS:From 1992 to 1997, all schoolchildren aged 6-18 years were screened for diabetes in Taiwan Province. This cohort consisted of 1,966 patients with diabetes and 1,780 randomly selected su...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.26.2.343
更新日期:2003-02-01 00:00:00
abstract::This paper provides some historical aspects on the research and development of Humulin (rDNA origin), the first human health-care product derived from rDNA technology more than a decade ago. Also referred to as biosynthetic human insulin, Humulin is currently produced via the human proinsulin route, using an Escherich...
journal_title:Diabetes care
pub_type: 杂志文章,评审
doi:10.2337/diacare.16.3.133
更新日期:1993-12-01 00:00:00
abstract:OBJECTIVE:To determine the risk of frequent and severe hypoglycemia and the associated demographic and clinical risk factors. RESEARCH DESIGN AND METHODS:Demographic and diabetes self-management factors were measured in 415 subjects followed prospectively for 4-6.5 years of type 1 diabetes duration as participants in ...
journal_title:Diabetes care
pub_type: 杂志文章,多中心研究
doi:10.2337/diacare.24.11.1878
更新日期:2001-11-01 00:00:00
abstract:OBJECTIVE:The sulfonylurea (SU) glyburide may cause severe and prolonged episodes of hypoglycemia. We aimed at investigating the impact of glyburide on glucose counterregulatory hormones during stepwise hypoglycemic clamp studies. RESEARCH DESIGN AND METHODS:We performed stepwise hypoglycemic clamp studies in 16 healt...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.2337/diacare.25.1.107
更新日期:2002-01-01 00:00:00
abstract::A survey of the entire population of Israel revealed 392 newly diagnosed type I diabetic children and adolescents aged 0-20 for the period of 1975-80. The mean annual age specific incidence of type I (insulin-dependent) diabetes mellitus was 3.8/10(5) for the age group 0-14 yr and 4.2/10(5) for the age group 0-20 yr. ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.8.1.s24
更新日期:1985-09-01 00:00:00
abstract::Twenty-eight patients with type I diabetes mellitus, legally blind as a result of proliferative retinopathy, were recruited into a program designed to teach and evaluate tactile methods for self-monitoring of blood glucose (SMBG). Vision ranged from "blind" to "able to read large print." Techniques with wipe-off strip...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.7.4.313
更新日期:1984-07-01 00:00:00
abstract::We report the occurrence of the adult respiratory distress syndrome (ARDS) in association with uncontrolled diabetes in nine patients. In reviewing the literature we found nine similar cases reported in little over a decade. In most cases no condition known to precipitate ARDS was discovered. The evidence suggests tha...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.5.6.574
更新日期:1982-11-01 00:00:00
abstract:OBJECTIVE:To evaluate the efficacy and safety of taspoglutide (R1583/BIM51077), a human once-weekly glucagon-like peptide-1 analog, in patients with type 2 diabetes inadequately controlled with metformin. RESEARCH DESIGN AND METHODS:Type 2 diabetic (n = 306) patients who failed to obtain glycemic control (A1C 7-9.5%) ...
journal_title:Diabetes care
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.2337/dc08-1961
更新日期:2009-07-01 00:00:00
abstract:OBJECTIVE:To measure well-being and treatment satisfaction and their correlates in older people with diabetes. RESEARCH DESIGN AND METHODS:A postal survey was conducted of 1,000 diabetic patients aged > or = 60 years, representing 56% of the resident older diabetic population in an inner-city health district with a la...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.21.6.930
更新日期:1998-06-01 00:00:00
abstract:OBJECTIVE:Cases of acute pancreatitis have been reported in association with exenatide, sitagliptin, and type 2 diabetes without use of these medications. It remains unknown whether exenatide or sitagliptin increase the risk of acute pancreatitis. RESEARCH DESIGN AND METHODS:A retrospective cohort study of a large med...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc10-0482
更新日期:2010-11-01 00:00:00
abstract:OBJECTIVE:To evaluate safety and efficacy of DiaPep277 in preserving β-cell function in type 1 diabetic patients. RESEARCH DESIGN AND METHODS:DIA-AID 1 is a multinational, phase 3, balanced-randomized, double-blind, placebo-controlled, parallel-group clinical study. Newly diagnosed patients (N = 457, aged 16-45 years)...
journal_title:Diabetes care
pub_type: 杂志文章,收录出版
doi:10.2337/dc13-1391
更新日期:2014-01-01 00:00:00
abstract:OBJECTIVE:Observational studies have associated metformin use with a decreased risk of lung cancer incidence in patients with type 2 diabetes, but the studies had important methodological shortcomings. The objective of this study was to determine whether metformin use is associated with a decreased risk of lung cancer ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc12-0740
更新日期:2013-01-01 00:00:00
abstract:OBJECTIVE:To examine trends in diabetes prevalence in the U.S. RESEARCH DESIGN AND METHODS:This study was conducted via telephone surveys in states that participated in the Behavioral Risk Factor Surveillance System between 1990 and 1998. The participants consisted of noninstitutionalized adults aged 18 years or older...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.23.9.1278
更新日期:2000-09-01 00:00:00
abstract:OBJECTIVE:To study how type 2 diabetes adversely affects brain volumes, changes in volume, and cognitive function. RESEARCH DESIGN AND METHODS:Regional brain volumes and ischemic lesion volumes in 1,366 women, aged 72-89 years, were measured with structural brain magnetic resonance imaging (MRI). Repeat scans were col...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc12-0555
更新日期:2013-01-01 00:00:00
abstract:OBJECTIVE:To determine the fatty acid composition of serum phospholipid, triglyceride, and cholesterol ester fractions and to analyze the lipid profile of microalbuminuric type 2 diabetic patients. RESEARCH DESIGN AND METHODS:A case-control study was conducted with 72 patients: 37 were normoalbuminuric (urinary albumi...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.26.3.613
更新日期:2003-03-01 00:00:00
abstract:OBJECTIVE:To assess the performance of the Micral-Test II immunologic test strip for the detection of microalbuminuria, a multicenter evaluation in eight European study sites was performed. RESEARCH DESIGN AND METHODS:Using both the Micral-Test II test strip and the routine method for the determination of albumin conc...
journal_title:Diabetes care
pub_type: 杂志文章,多中心研究
doi:10.2337/diacare.20.11.1642
更新日期:1997-11-01 00:00:00
abstract:OBJECTIVE:To compare the efficacy of the diabetic retinopathy (DR) screening with digital camera by endocrinologists with that by specialist and resident ophthalmologists in terms of sensitivity, specificity, and level of "loss of chance." RESEARCH DESIGN AND METHODS:In a cross-sectional study, 500 adult diabetic pati...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc10-1373
更新日期:2011-03-01 00:00:00
abstract::OBJECTIVE To assess the relationship between albuminuria, including elevation within the normal range, and decline in glomerular filtration rate (GFR) in diabetic patients. RESEARCH DESIGN AND METHODS A total of 5,449 Japanese diabetic patients were categorized according to sex and urinary albumin-to-creatinine ratio ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc08-2151
更新日期:2009-08-01 00:00:00
abstract:OBJECTIVE:The racial impact on graft outcome is not well defined in diabetic recipients. The purpose of this study is to analyze our experience with kidney-alone (A) and kidney-pancreas (KP) transplantation in type 1 diabetic recipients and evaluate the impact of racial disparity on outcome. RESEARCH DESIGN AND METHOD...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.20.8.1310
更新日期:1997-08-01 00:00:00
abstract:OBJECTIVE:To examine patients' views of the acceptability of and satisfaction with telephone care center support provided to improve blood glucose control in type 2 diabetes. RESEARCH DESIGN AND METHODS:The Pro-Active Call-Center Treatment Support (PACCTS) Trial randomized patients from 47 general practices in a depri...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.2337/diacare.28.2.283
更新日期:2005-02-01 00:00:00
abstract::Once daily injection of existing intermediate/long-acting insulin preparations does not provide a 24-h basal insulinemia in most patients. High variability, pronounced insulin peaks, and (as a result) a high risk of nocturnal hypoglycemia only poorly simulate normal physiology. One principle to prolong insulin action ...
journal_title:Diabetes care
pub_type: 杂志文章,评审
doi:
更新日期:1999-03-01 00:00:00