Higher levels of urinary albumin excretion within the normal range predict faster decline in glomerular filtration rate in diabetic patients.

Abstract:

:OBJECTIVE To assess the relationship between albuminuria, including elevation within the normal range, and decline in glomerular filtration rate (GFR) in diabetic patients. RESEARCH DESIGN AND METHODS A total of 5,449 Japanese diabetic patients were categorized according to sex and urinary albumin-to-creatinine ratio (ACR; <5, 5-9, 10-29, 30-99, 100-299, 300-999, 1,000-2,999, and > or =3,000 mg/g) and followed for at least 5 years. The rate of change in estimated GFR (eGFR) adjusted for age and baseline eGFR was compared among ACR categories. RESULTS A higher baseline ACR predicted a faster decline in eGFR for both sexes. Even within the normal range (<30 mg/g), ACR > or =10 mg/g in women and > or =5 mg/g in men was associated with a significantly greater rate of decline in eGFR relative to subjects with ACR <5 mg/g. CONCLUSIONS Elevated ACR, even within the normal range, is associated with a faster decline in eGFR in diabetic patients.

journal_name

Diabetes Care

journal_title

Diabetes care

authors

Babazono T,Nyumura I,Toya K,Hayashi T,Ohta M,Suzuki K,Kiuchi Y,Iwamoto Y

doi

10.2337/dc08-2151

subject

Has Abstract

pub_date

2009-08-01 00:00:00

pages

1518-20

issue

8

eissn

0149-5992

issn

1935-5548

pii

dc08-2151

journal_volume

32

pub_type

杂志文章
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    abstract::Specialists in childhood diabetes in North America were queried about the need for residential facilities for their patients with recurrent hospitalizations and school deficits due to family coping problems. Of 132 respondents, 115 indicated a need for 5-12% of their patients, a total of 530, close to the estimate of ...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.5.5.545

    authors: Rosenbloom AL

    更新日期:1982-09-01 00:00:00

  • Early-morning hyperglycemia in diabetic individuals treated with continuous subcutaneous insulin infusion.

    abstract::Significantly early-morning hyperglycemia was observed in insulin-dependent diabetic individuals who were otherwise well controlled while receiving a continuous subcutaneous insulin infusion (CSII) at standard doses. We measured the levels of the five key counterregulatory hormones (CRH) throughout the night for a tot...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.6.2.135

    authors: Geffner ME,Frank HJ,Kaplan SA,Lippe BM,Levin SR

    更新日期:1983-03-01 00:00:00

  • Neural correlates of stress- and food cue-induced food craving in obesity: association with insulin levels.

    abstract:OBJECTIVE:Obesity is associated with alterations in corticolimbic-striatal brain regions involved in food motivation and reward. Stress and the presence of food cues may each motivate eating and engage corticolimibic-striatal neurocircuitry. It is unknown how these factors interact to influence brain responses and whet...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc12-1112

    authors: Jastreboff AM,Sinha R,Lacadie C,Small DM,Sherwin RS,Potenza MN

    更新日期:2013-02-01 00:00:00

  • Diabeloop DBLG1 Closed-Loop System Enables Patients With Type 1 Diabetes to Significantly Improve Their Glycemic Control in Real-Life Situations Without Serious Adverse Events: 6-Month Follow-up.

    abstract:OBJECTIVE:To analyze safety and efficacy of the Diabeloop Generation 1 (DBLG1) hybrid closed-loop artificial pancreas system in patients with type 1 diabetes in real-world conditions. RESEARCH DESIGN AND METHODS:After a 1-week run-in period with their usual pump, 25 patients were provided the commercial DBLG1 system. ...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc20-1809

    authors: Amadou C,Franc S,Benhamou PY,Lablanche S,Huneker E,Charpentier G,Penfornis A,Diabeloop Consortium.

    更新日期:2021-01-11 00:00:00

  • Determinants of racial/ethnic disparities in incidence of diabetes in postmenopausal women in the U.S.: The Women's Health Initiative 1993-2009.

    abstract:OBJECTIVE:To examine determinants of racial/ethnic differences in diabetes incidence among postmenopausal women participating in the Women's Health Initiative. RESEARCH DESIGN AND METHODS:Data on race/ethnicity, baseline diabetes prevalence, and incident diabetes were obtained from 158,833 women recruited from 1993-19...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc12-0412

    authors: Ma Y,Hébert JR,Manson JE,Balasubramanian R,Liu S,Lamonte MJ,Bird CE,Ockene JK,Qiao Y,Olendzki B,Schneider KL,Rosal MC,Sepavich DM,Wactawski-Wende J,Stefanick ML,Phillips LS,Ockene IS,Kaplan RC,Sarto GE,Garcia L,Ho

    更新日期:2012-11-01 00:00:00

  • Effect of ezetimibe on hepatic fat, inflammatory markers, and apolipoprotein B-100 kinetics in insulin-resistant obese subjects on a weight loss diet.

    abstract:OBJECTIVE:Nonalcoholic fatty liver disease is highly prevalent in obese and type 2 diabetic individuals and is strongly associated with dyslipidemia and inflammation. Weight loss and/or pharmacotherapy are commonly used to correct these abnormalities. RESEARCH DESIGN AND METHODS:We performed a 16-week intervention tri...

    journal_title:Diabetes care

    pub_type: 杂志文章,随机对照试验

    doi:10.2337/dc09-1765

    authors: Chan DC,Watts GF,Gan SK,Ooi EM,Barrett PH

    更新日期:2010-05-01 00:00:00

  • Cyclosporin therapy for prevention and cure of IDDM. Epidemiological perspective of benefits and risks.

    abstract::Cyclosporin and other immunosuppressive agents have been proposed as a preventive treatment against the development of insulin-dependent diabetes mellitus (IDDM) in relatives at increased risk for the disease, based on the understanding that its etiology is an ongoing process of autoimmune beta-cell destruction. We us...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章,评审

    doi:10.2337/diacare.13.7.776

    authors: Lipton R,LaPorte RE,Becker DJ,Dorman JS,Orchard TJ,Atchison J,Drash AL

    更新日期:1990-07-01 00:00:00

  • Increasing the accuracy of oral glucose tolerance testing and extending its application to individuals with normal glucose tolerance for the prediction of type 1 diabetes: the Diabetes Prevention Trial-Type 1.

    abstract:OBJECTIVE:We assessed the extent to which both standard and alternative indexes from 2-h oral glucose tolerance testing predict type 1 diabetes and whether oral glucose tolerance tests (OGTTs) predict type 1 diabetes in individuals with normal glucose tolerance. RESEARCH DESIGN AND METHODS:The prediction of type 1 dia...

    journal_title:Diabetes care

    pub_type: 杂志文章,多中心研究

    doi:10.2337/dc06-1615

    authors: Sosenko JM,Palmer JP,Greenbaum CJ,Mahon J,Cowie C,Krischer JP,Chase HP,White NH,Buckingham B,Herold KC,Cuthbertson D,Skyler JS,Diabetes Prevention Trial-Type 1 Study Group.

    更新日期:2007-01-01 00:00:00

  • New insulin glargine 300 units/mL versus glargine 100 units/mL in people with type 2 diabetes using basal and mealtime insulin: glucose control and hypoglycemia in a 6-month randomized controlled trial (EDITION 1).

    abstract:OBJECTIVE:To compare the efficacy and safety of new insulin glargine 300 units/mL (Gla-300) with glargine 100 units/mL (Gla-100) in people with type 2 diabetes on basal insulin (≥42 units/day) plus mealtime insulin. RESEARCH DESIGN AND METHODS:EDITION 1 (NCT01499082) was a 6-month, multinational, open-label, parallel-...

    journal_title:Diabetes care

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.2337/dc14-0991

    authors: Riddle MC,Bolli GB,Ziemen M,Muehlen-Bartmer I,Bizet F,Home PD,EDITION 1 Study Investigators.

    更新日期:2014-10-01 00:00:00

  • Microalbuminuria associated with diabetic neuropathy.

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    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.15.4.528

    authors: Bell DS,Ketchum CH,Robinson CA,Wagenknecht LE,Williams BT

    更新日期:1992-04-01 00:00:00

  • Self-management competence as a predictor of outcomes of intensive therapy or usual care in youth with type 1 diabetes.

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    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.2337/diacare.26.7.2043

    authors: Wysocki T,Harris MA,Wilkinson K,Sadler M,Mauras N,White NH

    更新日期:2003-07-01 00:00:00

  • Diabetic neuropathy examination: a hierarchical scoring system to diagnose distal polyneuropathy in diabetes.

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    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.23.6.750

    authors: Meijer JW,van Sonderen E,Blaauwwiekel EE,Smit AJ,Groothoff JW,Eisma WH,Links TP

    更新日期:2000-06-01 00:00:00

  • Influence of adiposity on insulin resistance and glycemia markers among U.K. Children of South Asian, black African-Caribbean, and white European origin: child heart and health study in England.

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    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc12-1726

    authors: Nightingale CM,Rudnicka AR,Owen CG,Wells JC,Sattar N,Cook DG,Whincup PH

    更新日期:2013-06-01 00:00:00

  • Diabetes Epidemiology in the COVID-19 Pandemic.

    abstract::Diabetes has been identified as an important risk factor for mortality and rates of progression to acute respiratory distress syndrome (ARDS) in hospitalized patients with coronavirus disease 2019 (COVID-19). However, many recent reports on this topic reflect hurried approaches and have lacked careful epidemiologic de...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc20-1295

    authors: Selvin E,Juraschek SP

    更新日期:2020-08-01 00:00:00

  • Prevalence of Candida glabrata and its response to boric acid vaginal suppositories in comparison with oral fluconazole in patients with diabetes and vulvovaginal candidiasis.

    abstract:OBJECTIVE:A large proportion of vulvovaginal candidiasis (VVC) in diabetes is due to non-albicans Candida species such as C. glabrata and C. tropicalis. Observational studies indicate that diabetic patients with C. glabrata VVC respond poorly to azole drugs. We evaluated the response to oral fluconazole and boric acid ...

    journal_title:Diabetes care

    pub_type: 杂志文章,随机对照试验

    doi:10.2337/dc06-1469

    authors: Ray D,Goswami R,Banerjee U,Dadhwal V,Goswami D,Mandal P,Sreenivas V,Kochupillai N

    更新日期:2007-02-01 00:00:00

  • Whole-body glycolysis measured by the deuterated-glucose disposal test correlates highly with insulin resistance in vivo.

    abstract:OBJECTIVE:The purpose of this study was to compare an in vivo test of whole-body glycolysis, the deuterated-glucose disposal test (2H-GDT), with insulin sensitivity measured by the euglycemic-hyperinsulinemic glucose clamp and the steady-state plasma glucose (SSPG) test. RESEARCH DESIGN AND METHODS:The 2H-GDT consists...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc06-1809

    authors: Beysen C,Murphy EJ,McLaughlin T,Riiff T,Lamendola C,Turner HC,Awada M,Turner SM,Reaven G,Hellerstein MK

    更新日期:2007-05-01 00:00:00

  • Decreased skin wrinkling in diabetes mellitus.

    abstract::Skin wrinkling, which may be dependent on peripheral autonomic innervation, was assessed in 100 normal and 42 diabetic subjects using a temperature-controlled water bath with immersion of the hands for 30 min. Markedly decreased skin wrinkling was observed in diabetic subjects and in manual workers, but did not correl...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.7.3.224

    authors: Clark CV,Pentland B,Ewing DJ,Clarke BF

    更新日期:1984-05-01 00:00:00

  • 14. Management of Diabetes in Pregnancy: Standards of Medical Care in Diabetes-2019.

    abstract::The American Diabetes Association (ADA) "Standards of Medical Care in Diabetes" includes ADA's current clinical practice recommendations and is intended to provide the components of diabetes care, general treatment goals and guidelines, and tools to evaluate quality of care. Members of the ADA Professional Practice Co...

    journal_title:Diabetes care

    pub_type: 杂志文章,评审

    doi:10.2337/dc19-S014

    authors: American Diabetes Association.

    更新日期:2019-01-01 00:00:00

  • Glucagon response to oral glucose challenge in type 1 diabetes: lack of impact of euglycemia.

    abstract::OBJECTIVE Previous studies have demonstrated aberrant glucagon physiology in the setting of type 1 diabetes (T1D) but have not addressed the potential impact of ambient glycemia on this glucagon response. Thus, our objective was to evaluate the impact of euglycemia versus hyperglycemia on the glucagon response to an o...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc13-2339

    authors: Kramer CK,Borgoño CA,Van Nostrand P,Retnakaran R,Zinman B

    更新日期:2014-04-01 00:00:00

  • Mortality and morbidity associated with body weight in people with IDDM. The WHO Multinational Study of Vascular Disease in Diabetes.

    abstract:OBJECTIVE:Strict glycemic control in people with insulin-dependent diabetes mellitus (IDDM) reduces the risk of microvascular complications, but improvements in control are also associated with weight gain. Fears about the mortality risks of obesity may limit the acceptability of tight control. Therefore, we examined m...

    journal_title:Diabetes care

    pub_type: 杂志文章,多中心研究

    doi:10.2337/diacare.18.6.761

    authors: Chaturvedi N,Stevens LK,Fuller JH

    更新日期:1995-06-01 00:00:00

  • Altered hierarchy of protective responses against severe hypoglycemia in normal aging in healthy men.

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    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.20.2.135

    authors: Matyka K,Evans M,Lomas J,Cranston I,Macdonald I,Amiel SA

    更新日期:1997-02-01 00:00:00

  • Twenty-Year Progression Rate to Clinical Onset According to Autoantibody Profile, Age, and HLA-DQ Genotype in a Registry-Based Group of Children and Adults With a First-Degree Relative With Type 1 Diabetes.

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    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc16-2228

    authors: Gorus FK,Balti EV,Messaaoui A,Demeester S,Van Dalem A,Costa O,Dorchy H,Mathieu C,Van Gaal L,Keymeulen B,Pipeleers DG,Weets I,Belgian Diabetes Registry.

    更新日期:2017-08-01 00:00:00

  • Genetically Driven Hyperglycemia Increases Risk of Coronary Artery Disease Separately From Type 2 Diabetes.

    abstract:OBJECTIVE:This study tested the hypothesis that genetically raised hyperglycemia increases coronary artery disease (CAD) risk separately from the risk conferred by type 2 diabetes as a whole. RESEARCH DESIGN AND METHODS:We conducted a Mendelian randomization (MR) analysis using summary-level statistics from the larges...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc16-2625

    authors: Merino J,Leong A,Posner DC,Porneala B,Masana L,Dupuis J,Florez JC

    更新日期:2017-05-01 00:00:00

  • Reduced coronary artery and abdominal aortic calcification in Hispanics with type 2 diabetes.

    abstract:OBJECTIVE:To compare lifestyle factors, cardiovascular risk factors, and coronary artery calcium (CAC) and abdominal aortic calcium (AAC) levels in Hispanic and non-Hispanic white (NHW) individuals with type 2 diabetes. RESEARCH DESIGN AND METHODS:We recently demonstrated in a small group of nonreferred, healthy, nond...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.27.5.1115

    authors: Reaven PD,Sacks J,Investigators for the Veterans Affairs Cooperative Study of Glycemic Control and Complications in Diabetes Mellitus Type 2.

    更新日期:2004-05-01 00:00:00

  • Similar insulin sensitivity in NIDDM patients with normo- and microalbuminuria.

    abstract:OBJECTIVE:To investigate whether insulin resistance and microalbuminuria are associated in non-insulin-dependent diabetes mellitus (NIDDM). RESEARCH DESIGN AND METHODS:Insulin sensitivity was assessed using a hyperinsulinemic euglycemic clamp in 11 normoalbuminuric and 9 microalbuminuric NIDDM patients matched for sex...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.18.6.834

    authors: Nielsen S,Schmitz O,Orskov H,Mogensen CE

    更新日期:1995-06-01 00:00:00

  • Bimodal distribution of glucose is not universally useful for diagnosing diabetes.

    abstract:OBJECTIVE:Bimodality in the distribution of glucose has been used to define the cut point for the diagnosis of diabetes. Previous studies on bimodality have primarily been in populations with a high prevalence of type 2 diabetes, including one study in a white Caucasian population. All studies included participants wit...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc08-0867

    authors: Vistisen D,Colagiuri S,Borch-Johnsen K,DETECT-2 Collaboration.

    更新日期:2009-03-01 00:00:00

  • Comparison of A1C and fasting glucose criteria to diagnose diabetes among U.S. adults.

    abstract:OBJECTIVE:To compare A1C and fasting glucose for the diagnosis of diabetes among U.S. adults. RESEARCH DESIGN AND METHODS:This study included 6,890 adults (> or =20 years of age) from the 1999-2006 National Health and Nutrition Examination Survey without a self-reported history of diabetes who had fasted > or =9 h. A1...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc09-1227

    authors: Carson AP,Reynolds K,Fonseca VA,Muntner P

    更新日期:2010-01-01 00:00:00

  • Impact of oral antihyperglycemic therapy on all-cause mortality among patients with diabetes in the Veterans Health Administration.

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    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc06-2272

    authors: Kahler KH,Rajan M,Rhoads GG,Safford MM,Demissie K,Lu SE,Pogach LM

    更新日期:2007-07-01 00:00:00

  • Aspirin use and counseling about aspirin among patients with diabetes.

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    journal_title:Diabetes care

    pub_type: 杂志文章,多中心研究

    doi:10.2337/diacare.25.6.965

    authors: Krein SL,Vijan S,Pogach LM,Hogan MM,Kerr EA

    更新日期:2002-06-01 00:00:00

  • An analysis of dynamic forces transmitted through the foot in diabetic neuropathy.

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    doi:10.2337/diacare.21.11.1955

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    更新日期:1998-11-01 00:00:00