Abstract:
:OBJECTIVE To assess the relationship between albuminuria, including elevation within the normal range, and decline in glomerular filtration rate (GFR) in diabetic patients. RESEARCH DESIGN AND METHODS A total of 5,449 Japanese diabetic patients were categorized according to sex and urinary albumin-to-creatinine ratio (ACR; <5, 5-9, 10-29, 30-99, 100-299, 300-999, 1,000-2,999, and > or =3,000 mg/g) and followed for at least 5 years. The rate of change in estimated GFR (eGFR) adjusted for age and baseline eGFR was compared among ACR categories. RESULTS A higher baseline ACR predicted a faster decline in eGFR for both sexes. Even within the normal range (<30 mg/g), ACR > or =10 mg/g in women and > or =5 mg/g in men was associated with a significantly greater rate of decline in eGFR relative to subjects with ACR <5 mg/g. CONCLUSIONS Elevated ACR, even within the normal range, is associated with a faster decline in eGFR in diabetic patients.
journal_name
Diabetes Carejournal_title
Diabetes careauthors
Babazono T,Nyumura I,Toya K,Hayashi T,Ohta M,Suzuki K,Kiuchi Y,Iwamoto Ydoi
10.2337/dc08-2151subject
Has Abstractpub_date
2009-08-01 00:00:00pages
1518-20issue
8eissn
0149-5992issn
1935-5548pii
dc08-2151journal_volume
32pub_type
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