Microalbuminuria associated with diabetic neuropathy.

abstract：OBJECTIVE:Subjects with type 1 diabetes are at high risk for many long-term complications, including early mortality and coronary artery disease (CAD). Few data are available on which to base goal levels for two major risk factors, namely blood pressure and lipid/lipoproteins. The objective of this study was to determi...

journal_title：Diabetes care

authors： Orchard TJ,Forrest KY,Kuller LH,Becker DJ,Pittsburgh Epidemiology of Diabetes Complications Study.

更新日期：2001-06-01 00:00:00

abstract：:Serum immunoglobulin (G, A, M) levels were performed on 66 patients with non-insulin-dependent (type II) diabetes mellitus (NIDDM). When compared with 30 age-matched normal controls and 32 hospitalized controls there was no significant difference between the mean IgG and IgM levels. The IgA levels were significantly h...

journal_title：Diabetes care

authors： Gill CW,Bush WS,Burleigh WM,Cooke-Gomes D

更新日期：1981-11-01 00:00:00

abstract：OBJECTIVE:Adverse microbial exposures might contribute to diabetogenesis. We hypothesized that clinical periodontal disease (a manifestation of microbial exposures in dysbiotic biofilms) would be related to insulin resistance among diabetes-free participants. The roles of inflammatory mediation and effect modification ...

journal_title：Diabetes care

authors： Demmer RT,Squillaro A,Papapanou PN,Rosenbaum M,Friedewald WT,Jacobs DR Jr,Desvarieux M

更新日期：2012-11-01 00:00:00

abstract：OBJECTIVE:To investigate whether self-rated health profiles compiled using the EuroQol group's visual analog scale (EQ VAS) are independent predictors of vascular events and major complications in people with type 2 diabetes after controlling for standard clinical risk factors. RESEARCH DESIGN AND METHODS:The study is...

journal_title：Diabetes care

authors： Hayes AJ,Clarke PM,Glasziou PG,Simes RJ,Drury PL,Keech AC

更新日期：2008-04-01 00:00:00

abstract：OBJECTIVE:The safety of dendritic cells to selectively suppress autoimmunity, especially in type 1 diabetes, has never been ascertained. We investigated the safety of autologous dendritic cells, stabilized into an immunosuppressive state, in established adult type 1 diabetic patients. RESEARCH DESIGN AND METHODS:A ran...

journal_title：Diabetes care

authors： Giannoukakis N,Phillips B,Finegold D,Harnaha J,Trucco M

更新日期：2011-09-01 00:00:00

abstract：OBJECTIVE:There is sparse evidence for the association of suitable food substitutions for red and processed meat on the risk of type 2 diabetes. We modeled the association between replacing red and processed meat with other protein sources and the risk of type 2 diabetes and estimated its population impact. RESEARCH D...

journal_title：Diabetes care

authors： Ibsen DB,Steur M,Imamura F,Overvad K,Schulze MB,Bendinelli B,Guevara M,Agudo A,Amiano P,Aune D,Barricarte A,Ericson U,Fagherazzi G,Franks PW,Freisling H,Quiros JR,Grioni S,Heath AK,Huybrechts I,Katze V,Laouali N,

更新日期：2020-11-01 00:00:00

abstract：:Since little is known regarding the appropriate time for preprandial insulin administration, we compared the effects of 30-min subcutaneous insulin infusions started 60 min, 30 min, and immediately before meal ingestion on postprandial plasma glucose and insulin profiles in eight subjects with insulin-dependent diabet...

journal_title：Diabetes care

authors： Dimitriadis GD,Gerich JE

更新日期：1983-07-01 00:00:00

abstract：OBJECTIVE:Several national and international scoring systems are used to diagnose diabetic polyneuropathy (PNP). The variety in these scores and the lack of data on validity and predictive value has led to a comparison and validation of the scores with clinical standards for PNP to determine the most powerful measureme...

journal_title：Diabetes care

authors： Meijer JW,Smit AJ,Lefrandt JD,van der Hoeven JH,Hoogenberg K,Links TP

更新日期：2005-09-01 00:00:00

abstract：OBJECTIVE:To evaluate the role of adiposity in the relationship between specific and surrogate estimates of insulin-mediated glucose uptake (IMGU) in a large nondiabetic population. RESEARCH DESIGN AND METHODS:Healthy volunteers were classified by BMI into normal weight (<25.0 kg/m(2), n = 208), overweight (25.0-29.9 ...

journal_title：Diabetes care

authors： Kim SH,Abbasi F,Reaven GM

更新日期：2004-08-01 00:00:00

abstract：OBJECTIVE:Incidence of type 2 diabetes might be associated with preexisting hypertension. There is no information on whether incident diabetes is predicted by blood pressure control. We evaluated the hazard of diabetes in relation to blood pressure control in treated hypertensive patients. RESEARCH DESIGN AND METHODS:...

journal_title：Diabetes care

authors： Izzo R,de Simone G,Chinali M,Iaccarino G,Trimarco V,Rozza F,Giudice R,Trimarco B,De Luca N

更新日期：2009-05-01 00:00:00

abstract：OBJECTIVE:To examine the safety and efficacy of dapagliflozin, a sodium-glucose cotransporter-2 inhibitor, added on to pioglitazone in type 2 diabetes inadequately controlled on pioglitazone. RESEARCH DESIGN AND METHODS:Treatment-naive patients or those receiving metformin, sulfonylurea, or thiazolidinedione entered a...

journal_title：Diabetes care

authors： Rosenstock J,Vico M,Wei L,Salsali A,List JF

更新日期：2012-07-01 00:00:00

abstract：OBJECTIVE:HER2/ErbB2 is a member of the epidermal growth factor receptor family. It is widely used as a tumor marker, but it also has recently been associated with insulin resistance. Both ErbB2 and diabetes have been associated with cancer; however, the relationship between ErbB2 and diabetes has not been well explore...

journal_title：Diabetes care

authors： Muhammad IF,Borné Y,Bao X,Melander O,Orho-Melander M,Nilsson PM,Nilsson J,Engström G

更新日期：2019-08-01 00:00:00

abstract：OBJECTIVE:We previously showed that in patients with diabetes mellitus, glycated hemoglobin (HbA1c) monitoring outside international guidance on testing frequency is widespread. Here we examined the relationship between testing frequency and diabetes control to test the hypothesis that retest interval is linked to chan...

journal_title：Diabetes care

authors： Driskell OJ,Holland D,Waldron JL,Ford C,Scargill JJ,Heald A,Tran M,Hanna FW,Jones PW,Pemberton RJ,Fryer AA

更新日期：2014-10-01 00:00:00

abstract：OBJECTIVE:Growth deferentiation factor-15 (GDF-15) is involved in inflammation and apoptosis. Expression is induced in the heart in response to ischemia and in atherosclerotic plaques. The aim of this study was to investigate GDF-15 levels in relation to all-cause mortality, cardiovascular mortality and morbidity, decl...

journal_title：Diabetes care

authors： Lajer M,Jorsal A,Tarnow L,Parving HH,Rossing P

更新日期：2010-07-01 00:00:00

abstract：OBJECTIVE:To investigate whether insulin resistance and microalbuminuria are associated in non-insulin-dependent diabetes mellitus (NIDDM). RESEARCH DESIGN AND METHODS:Insulin sensitivity was assessed using a hyperinsulinemic euglycemic clamp in 11 normoalbuminuric and 9 microalbuminuric NIDDM patients matched for sex...

journal_title：Diabetes care

authors： Nielsen S,Schmitz O,Orskov H,Mogensen CE

更新日期：1995-06-01 00:00:00

abstract：:OBJECTIVE We tested whether average monthly glycemic burden (AMGB), a marker of hyperglycemia that is a function of the extent and duration that A1C exceeded 7%, indicated greater risk of cardiovascular disease (CVD) than traditional A1C measures. RESEARCH DESIGN AND METHODS Using a case-control design, we studied 2,4...

journal_title：Diabetes care

authors： Nichols GA,Rosales AG,Perrin NA,Fortmann SP

更新日期：2014-01-01 00:00:00

abstract：OBJECTIVE:Biomechanical studies in diabetic neuropathy have clearly demonstrated abnormal foot pressures, but information on other aspects of gait is limited. This study aimed to investigate and describe the forces transmitted through the foot during walking in diabetic subjects with varying degrees of peripheral neuro...

journal_title：Diabetes care

authors： Shaw JE,van Schie CH,Carrington AL,Abbott CA,Boulton AJ

更新日期：1998-11-01 00:00:00

abstract：OBJECTIVE:Patients with type 1 diabetes (T1D) have a higher risk of developing chronic kidney disease, cardiovascular events (CVEs), and mortality than the general population. We hypothesized that two previously published biomarkers, namely PRO-C6, a biomarker of collagen type VI formation, and C3M, a biomarker of coll...

journal_title：Diabetes care

authors： Pilemann-Lyberg S,Rasmussen DGK,Hansen TW,Tofte N,Winther SA,Holm Nielsen S,Theilade S,Karsdal MA,Genovese F,Rossing P

更新日期：2019-09-01 00:00:00

abstract：OBJECTIVE:This study aimed to assess the direct cost incurred by diabetic subjects who were in different income groups in urban and rural India, as well as to examine the changing trends of costs in the urban setting from 1998 to 2005. RESEARCH DESIGN AND METHODS:A total of 556 diabetic subjects from various urban and...

journal_title：Diabetes care

authors： Ramachandran A,Ramachandran S,Snehalatha C,Augustine C,Murugesan N,Viswanathan V,Kapur A,Williams R

更新日期：2007-02-01 00:00:00

abstract：:OBJECTIVE- We examined the influence of a moderately elevated serum ferritin level at entry to care on the risk of gestational diabetes mellitus (GDM) and a possible mechanism (increased iron stores versus inflammation). RESEARCH DESIGN AND METHODS- In a prospective observational study with 1,456 healthy pregnant wome...

journal_title：Diabetes care

authors： Chen X,Scholl TO,Stein TP

更新日期：2006-05-01 00:00:00

abstract：OBJECTIVE:This study evaluated the ability of the Building, Relating, Assessing, and Validating Outcomes (BRAVO) risk engine to accurately project cardiovascular outcomes in three major clinical trials-BI 10773 (Empagliflozin) Cardiovascular Outcome Event Trial in Type 2 Diabetes Mellitus Patients (EMPA-REG OUTCOME), C...

journal_title：Diabetes care

authors： Shao H,Shi L,Fonseca VA

更新日期：2020-07-01 00:00:00

abstract：:Given the importance of glycemic control in the development of diabetes complications, the plethora of tools now available to monitor the day-to-day trends in glycemia is remarkable. In this regard, self-monitoring of blood glucose (SMBG) has been considered a key component of patient management. Arguably, there remai...

journal_title：Diabetes care

authors： Polonsky WH,Fisher L

更新日期：2013-01-01 00:00:00

abstract：OBJECTIVE:To identify hormonal, psychological, and demographic predictors of symptom detection and accuracy of blood glucose estimation during mild hypoglycemia in adolescents and young adults with type 1 diabetes. RESEARCH DESIGN AND METHODS:During an insulin-glucose clamp study, 53 adolescents and 19 young adults es...

journal_title：Diabetes care

authors： Ryan CM,Dulay D,Suprasongsin C,Becker DJ

更新日期：2002-05-01 00:00:00

abstract：OBJECTIVE:The goal of this study was to determine whether the haptoglobin (Hp) genotype was predictive of restenosis and major adverse cardiac events (MACEs) after percutaneous transluminal coronary angioplasty (PTCA) in individuals with diabetes. RESEARCH DESIGN AND METHODS:A consecutive series of 935 diabetic patien...

journal_title：Diabetes care

authors： Roguin A,Koch W,Kastrati A,Aronson D,Schomig A,Levy AP

更新日期：2003-09-01 00:00:00

abstract：OBJECTIVE:To investigate the association of metabolic and lifestyle factors with possible diabetic polyneuropathy (DPN) and neuropathic pain in patients with early type 2 diabetes. RESEARCH DESIGN AND METHODS:We thoroughly characterized 6,726 patients with recently diagnosed diabetes. After a median of 2.8 years, we s...

journal_title：Diabetes care

authors： Christensen DH,Knudsen ST,Gylfadottir SS,Christensen LB,Nielsen JS,Beck-Nielsen H,Sørensen HT,Andersen H,Callaghan BC,Feldman EL,Finnerup NB,Jensen TS,Thomsen RW

更新日期：2020-06-01 00:00:00

abstract：:The role of hyperinsulinemia in the pathogenesis of triglyceride (TG) and VLDL over-production in insulin-resistant states remains controversial. While studies in humans and animals have generally suggested that chronic hyperinsulinemia facilitates VLDL production, particularly in the presence of an abundant supply of...

journal_title：Diabetes care

authors： Lewis GF,Steiner G

更新日期：1996-04-01 00:00:00

abstract：OBJECTIVE:The decline in C-peptide in the 5 years after diagnosis of type 1 diabetes has been well studied, but little is known about the longer-term trajectory. We aimed to examine the association between log-transformed C-peptide levels and the duration of diabetes up to 40 years after diagnosis. RESEARCH DESIGN AND...

journal_title：Diabetes care

authors： Shields BM,McDonald TJ,Oram R,Hill A,Hudson M,Leete P,Pearson ER,Richardson SJ,Morgan NG,Hattersley AT,TIGI Consortium.

更新日期：2018-07-01 00:00:00

abstract：OBJECTIVE:To investigate ethnic differences in adiponectin and leptin concentration and to determine whether these adipokines and a high-glycemic index diet account for ethnic variation in insulin resistance. RESEARCH DESIGN AND METHODS:In 1,176 South Asian, Chinese, Aboriginal, and European Canadians, fasting blood s...

journal_title：Diabetes care

authors： Mente A,Razak F,Blankenberg S,Vuksan V,Davis AD,Miller R,Teo K,Gerstein H,Sharma AM,Yusuf S,Anand SS,Study of the Health Assessment And Risk Evaluation.,Study of the Health Assessment And Risk Evaluation in Aboriginal Peoples Inv

更新日期：2010-07-01 00:00:00

abstract：OBJECTIVE:To investigate the prevalence of beta-cell autoantigen-reactive peripheral T-cells in type 1 diabetes, we developed an immunoglobulin-free enzyme-linked immunospot (ELISPOT) assay and assessed its usefulness for diagnosing this disease. RESEARCH DESIGN AND METHODS:Cellular immune responses to beta -cell auto...

journal_title：Diabetes care

authors： Kotani R,Nagata M,Moriyama H,Nakayama M,Yamada K,Chowdhury SA,Chakrabarty S,Jin Z,Yasuda H,Yokono K

更新日期：2002-08-01 00:00:00

abstract：OBJECTIVE:To evaluate the relationship of central fat distribution with gestational glucose tolerance during the usual time for screening gestational diabetes. RESEARCH DESIGN AND METHODS:This cross-sectional study investigated 1,113 consecutive women, > or = 20 years old, pregnant for approximately 21 to 28 weeks, wi...

journal_title：Diabetes care

authors： Branchtein L,Schmidt MI,Mengue SS,Reichelt AJ,Matos MC,Duncan BB

更新日期：1997-04-01 00:00:00