Phase I (safety) study of autologous tolerogenic dendritic cells in type 1 diabetic patients.

abstract：OBJECTIVE:To evaluate the role of metabolic control in the progression of diabetic retinopathy during pregnancy. RESEARCH DESIGN AND METHODS:We conducted a prospective cohort study of 155 diabetic women in the Diabetes in Early Pregnancy Study followed from the periconceptional period to 1 month postpartum. Fundus pho...

journal_title：Diabetes care

authors： Chew EY,Mills JL,Metzger BE,Remaley NA,Jovanovic-Peterson L,Knopp RH,Conley M,Rand L,Simpson JL,Holmes LB

更新日期：1995-05-01 00:00:00

abstract：:Developments in fetal and placental nutrition have highlighted the interaction of the placenta and fetal liver for the exchange and metabolism of nutrients. Of particular importance is the exchange of serine and glycine and their interconversion within these two organs and the exchange of glutamine and glutamate. Plac...

journal_title：Diabetes care

authors： Battaglia FC,Thureen PJ

更新日期：1998-08-01 00:00:00

abstract：OBJECTIVE:This study uses novel methods to examine the frequency of diagnosis and treatment of prediabetes in real-world clinical settings using electronic health record (EHR) data. RESEARCH DESIGN AND METHODS:We identified a cohort of 358,120 adults with incident prediabetes (fasting plasma glucose [FPG] 100-125 mg/d...

journal_title：Diabetes care

authors： Schmittdiel JA,Adams SR,Segal J,Griffin MR,Roumie CL,Ohnsorg K,Grant RW,O'Connor PJ

更新日期：2014-02-01 00:00:00

abstract：OBJECTIVE:Ipragliflozin, a sodium-glucose cotransporter 2 inhibitor, stimulates glycosuria and lowers glycemia in patients with type 2 diabetes (T2DM). The objective of this study was to assess the pharmacodynamics of ipragliflozin in T2DM patients with impaired renal function. RESEARCH DESIGN AND METHODS:Glycosuria w...

journal_title：Diabetes care

authors： Ferrannini E,Veltkamp SA,Smulders RA,Kadokura T

更新日期：2013-05-01 00:00:00

abstract：OBJECTIVE:Global usage of bariatric surgery has been dictated for the past quarter century by National Institutes of Health recommendations restricting these operations to individuals with a BMI ≥35 kg/m(2). Strong evidence now demonstrates that bariatric procedures markedly improve or cause remission of type 2 diabete...

journal_title：Diabetes care

authors： Cummings DE,Cohen RV

更新日期：2016-06-01 00:00:00

abstract：:A film test for the rapid detection of plasma/serum 3-hydroxybutyrate (3-OHB) has been developed. The film contains NAD, nitro blue tetrazolium, 3-OHB dehydrogenase, and diaphorase, and the surface is coated with modified biomembrane and can detect 50-1500 microM 3-OHB within 2-3 min. One drop or 50 microliters of pla...

journal_title：Diabetes care

authors： Harano Y,Aoki T,Nakajima Y,Kojima H,Kosugi K,Harano A,Hidaka H,Yamada S,Uno S,Shigeta Y

更新日期：1990-05-01 00:00:00

abstract：OBJECTIVE:To assess the effects of empagliflozin, a selective sodium-glucose cotransporter 2 (SGLT2) inhibitor, on broad biological systems through proteomics. RESEARCH DESIGN AND METHODS:Aptamer-based proteomics was used to quantify 3,713 proteins in 144 paired plasma samples obtained from 72 participants across the ...

journal_title：Diabetes care

authors： Ferrannini E,Murthy AC,Lee YH,Muscelli E,Weiss S,Ostroff RM,Sattar N,Williams SA,Ganz P

更新日期：2020-09-01 00:00:00

abstract：OBJECTIVE:To investigate whether the risk for autoimmune diabetes in adults differs between socioeconomic groups and to compare such risk with that for type 2 diabetes. RESEARCH DESIGN AND METHODS:The inhabitants of the Norwegian county of Nord-Trøndelag were investigated by questionnaires and clinical examinations on...

journal_title：Diabetes care

authors： Olsson L,Ahlbom A,Grill V,Midthjell K,Carlsson S

更新日期：2011-01-01 00:00:00

abstract：:Heart rate variability (HRV) during deep breathing was studied with a neonatal heart monitor in 143 control subjects and 218 patients with diabetes (102 with IDDM and 116 with NIDDM). In the control group HRV decreased after age 20 by 4-5 beats per decade (from 29.7 +/- 5.8 beats at age 20-29 to 11.8 +/- 5.4 beats at ...

journal_title：Diabetes care

authors： Masaoka S,Lev-Ran A,Hill LR,Vakil G,Hon EH

更新日期：1985-01-01 00:00:00

abstract：:Plasma lipids and lipoproteins were studied in 26 nonobese diabetic patients, either newly diagnosed or unsatisfactorily controlled by oral antidiabetic treatment. Measurements were performed before and 3-4 mo after the institution of insulin treatment. In a subgroup of seven patients, the activities of lipoprotein li...

journal_title：Diabetes care

authors： Agardh CD,Nilsson-Ehle P,Scherstén B

更新日期：1982-05-01 00:00:00

abstract：:The clinical diagnosis of new-onset type 1 diabetes has, for many years, been considered relatively straightforward. Recently, however, there is increasing awareness that within this single clinical phenotype exists considerable heterogeneity: disease onset spans the complete age range; genetic susceptibility is compl...

journal_title：Diabetes care

authors： Battaglia M,Ahmed S,Anderson MS,Atkinson MA,Becker D,Bingley PJ,Bosi E,Brusko TM,DiMeglio LA,Evans-Molina C,Gitelman SE,Greenbaum CJ,Gottlieb PA,Herold KC,Hessner MJ,Knip M,Jacobsen L,Krischer JP,Long SA,Lundgren M

更新日期：2020-01-01 00:00:00

abstract：OBJECTIVE:To evaluate effects of vildagliptin and metformin on blood pressure (BP) and heart rate (HR) responses to intraduodenal (ID) glucose in diet-controlled type 2 diabetes. RESEARCH DESIGN AND METHODS:Study A compared vildagliptin (50 mg) and placebo, given 60 min before a 120-min ID glucose infusion at 2 or 4 k...

journal_title：Diabetes care

authors： Wu T,Trahair LG,Little TJ,Bound MJ,Zhang X,Wu H,Sun Z,Horowitz M,Rayner CK,Jones KL

更新日期：2017-05-01 00:00:00

abstract：OBJECTIVE:Biomechanical studies in diabetic neuropathy have clearly demonstrated abnormal foot pressures, but information on other aspects of gait is limited. This study aimed to investigate and describe the forces transmitted through the foot during walking in diabetic subjects with varying degrees of peripheral neuro...

journal_title：Diabetes care

authors： Shaw JE,van Schie CH,Carrington AL,Abbott CA,Boulton AJ

更新日期：1998-11-01 00:00:00

abstract：OBJECTIVE:To assess performance of nonfasting tests to screen children for dysglycemia (prediabetes or diabetes). RESEARCH DESIGN AND METHODS:This was a cross-sectional study of 254 overweight or obese (BMI ≥85th percentile) children aged 10-17 years. Subjects came for two visits to a clinical research unit. For visit...

journal_title：Diabetes care

authors： Lee JM,Gebremariam A,Wu EL,LaRose J,Gurney JG

更新日期：2011-12-01 00:00:00

abstract：OBJECTIVE:We assessed the association between early increases in albumin excretion and cardiovascular (CV) and renal markers in a large cohort of young people with type 1 diabetes. RESEARCH DESIGN AND METHODS:As part of preliminary screening for a multicenter, randomized controlled trial of statins/ACE inhibitors, we ...

journal_title：Diabetes care

authors： Marcovecchio ML,Woodside J,Jones T,Daneman D,Neil A,Prevost T,Dalton RN,Deanfield J,Dunger DB,AdDIT Investigators.

更新日期：2014-01-01 00:00:00

abstract：OBJECTIVE:In patients with type 2 diabetes, microalbuminuria is associated with an increase in predominantly cardiovascular mortality. Considerable interindividual variability in the rate of progression of microalbuminuria exists. The prognostic significance of rate of progression of microalbuminuria with regard to car...

journal_title：Diabetes care

authors： Spoelstra-de Man AM,Brouwer CB,Stehouwer CD,Smulders YM

更新日期：2001-12-01 00:00:00

abstract：OBJECTIVE:To investigate the possibility that leptin levels may be predictive of the risk of ischemic heart disease (IHD) through the relationship of leptin to body fat. RESEARCH DESIGN AND METHODS:The Quebec Cardiovascular Study cohort consisted of 2,103 French-Canadian men without IHD in 1985 who were followed until...

journal_title：Diabetes care

authors： Couillard C,Lamarche B,Mauriège P,Cantin B,Dagenais GR,Moorjani S,Lupien PJ,Després JP

更新日期：1998-05-01 00:00:00

abstract：OBJECTIVE:β-Cell autoantibodies are a feature of the preclinical phase of type 1 diabetes. Here, we asked how frequently they revert in a cohort of children at risk for type 1 diabetes and whether reversion has any effect on type 1 diabetes risk. RESEARCH DESIGN AND METHODS:Children were up to 10 years of age and scre...

journal_title：Diabetes care

authors： Vehik K,Lynch KF,Schatz DA,Akolkar B,Hagopian W,Rewers M,She JX,Simell O,Toppari J,Ziegler AG,Lernmark Å,Bonifacio E,Krischer JP,TEDDY Study Group.

更新日期：2016-09-01 00:00:00

abstract：OBJECTIVE:A1C is associated with diabetes complications but does not reflect glycemic variability (GV), which may worsen outcomes by inducing inflammation, oxidative stress, and cardiac arrhythmias. We tested whether a glucagon-like peptide 1 agonist-based regimen can reduce GV and cardiometabolic risk markers while ma...

journal_title：Diabetes care

authors： FLAT-SUGAR Trial Investigators.

更新日期：2016-06-01 00:00:00

abstract：OBJECTIVE:Blood pressure ranges associated with cardiovascular disease (CVD) events in advanced type 2 diabetes are not clear. Our objective was to determine whether baseline and follow-up (On-Study) systolic blood pressure (SBP), diastolic blood pressure (DBP), and SBP combined with DBP predict CVD events in the Veter...

journal_title：Diabetes care

authors： Anderson RJ,Bahn GD,Moritz TE,Kaufman D,Abraira C,Duckworth W,VADT Study Group.

更新日期：2011-01-01 00:00:00

abstract：OBJECTIVE:To assess the efficacy and safety of initial combination therapy with sitagliptin and metformin in patients with type 2 diabetes and inadequate glycemic control on diet and exercise. RESEARCH DESIGN AND METHODS:In a 24-week, randomized, double-blind, placebo-controlled, parallel-group study, 1,091 patients w...

journal_title：Diabetes care

authors： Goldstein BJ,Feinglos MN,Lunceford JK,Johnson J,Williams-Herman DE,Sitagliptin 036 Study Group.

更新日期：2007-08-01 00:00:00

abstract：:A representative sample of 817 American women aged 20-44 yr who were not pregnant and had no medical history of diabetes were given 75-g 2-h oral glucose tolerance tests (OGTTs). Although these conditions are somewhat different from those recommended for pregnant women (100 g glucose, 3-h OGTT), 3.8% of the women migh...

journal_title：Diabetes care

authors： Harris MI

更新日期：1988-05-01 00:00:00

abstract：OBJECTIVE:To estimate real-world off-label use of sodium-glucose cotransporter 2 (SGLT2) inhibitors in patients with type 1 diabetes, estimate rates of diabetic ketoacidosis (DKA), and compare them with DKA rates observed in sotagliflozin clinical trials. RESEARCH DESIGN AND METHODS:We identified initiators of SGLT2 i...

journal_title：Diabetes care

authors： Hampp C,Swain RS,Horgan C,Dee E,Qiang Y,Dutcher SK,Petrone A,Chen Tilney R,Maro JC,Panozzo CA

更新日期：2020-01-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to determine whether overweight and obese individuals with type 2 diabetes have higher basal and 24-h energy expenditure compared with healthy control subjects before and after adjustment for body composition, spontaneous physical activity (SPA), sex, and age. RESEARCH DESIGN AND ME...

journal_title：Diabetes care

authors： Bitz C,Toubro S,Larsen TM,Harder H,Rennie KL,Jebb SA,Astrup A

更新日期：2004-10-01 00:00:00

abstract：OBJECTIVE:Defects in insulin secretion and insulin action are the major abnormalities in the development of type 2 diabetes. In middle-aged subjects, elevated plasma proinsulin has been found to predict type 2 diabetes. Therefore, our aim was to study the longitudinal relationships between baseline determinations of in...

journal_title：Diabetes care

authors： Zethelius B,Hales CN,Lithell HO,Berne C

更新日期：2004-06-01 00:00:00

abstract：OBJECTIVE:Congenital generalized lipodystrophy (CGL) is an autosomal recessive genetic disorder characterized by almost complete absence of adipose tissue, muscular appearance, and severe insulin resistance since birth. We investigated whether insulin resistance in CGL patients is associated with abnormal muscle morpho...

journal_title：Diabetes care

authors： Garg A,Stray-Gundersen J,Parsons D,Bertocci LA

更新日期：2000-10-01 00:00:00

abstract：OBJECTIVE:To investigate the prevalence of beta-cell autoantigen-reactive peripheral T-cells in type 1 diabetes, we developed an immunoglobulin-free enzyme-linked immunospot (ELISPOT) assay and assessed its usefulness for diagnosing this disease. RESEARCH DESIGN AND METHODS:Cellular immune responses to beta -cell auto...

journal_title：Diabetes care

authors： Kotani R,Nagata M,Moriyama H,Nakayama M,Yamada K,Chowdhury SA,Chakrabarty S,Jin Z,Yasuda H,Yokono K

更新日期：2002-08-01 00:00:00

abstract：:We have examined insulin and glucagon degrading activities of muscle and fat tissues in 11 subjects (4 lean controls, 3 insulin-resistant obese subjects, 2 non-insulin-dependent diabetic subjects, and 2 insulin-treated diabetic subjects) and correlated degrading activity with (1) basal insulin level and (2) state of i...

journal_title：Diabetes care

authors： Kitabchi AE,Stentz FB,Cole C,Duckworth WC

更新日期：1979-09-01 00:00:00

abstract：OBJECTIVE:To describe market trends for antidiabetic drugs, focusing on newly approved drugs, concomitant use of antidiabetic drugs, and effects of safety concerns and access restrictions on thiazolidinedione use. RESEARCH DESIGN AND METHODS:Nationally projected data on antidiabetic prescriptions for adults dispensed ...

journal_title：Diabetes care

authors： Hampp C,Borders-Hemphill V,Moeny DG,Wysowski DK

更新日期：2014-01-01 00:00:00

abstract：OBJECTIVE:To determine the prevalence of diabetes in Tohono O'odham pregnancies, and to assess the efficacy of early prenatal diabetes screening in populations with high rates of diabetes. RESEARCH DESIGN AND METHODS:All Tohono O'odham women receiving prenatal care at the Sells Service Unit who delivered a viable baby...

journal_title：Diabetes care

authors： Livingston RC,Bachman-Carter K,Frank C,Mason WB

更新日期：1993-01-01 00:00:00