Abstract:
OBJECTIVE:Ipragliflozin, a sodium-glucose cotransporter 2 inhibitor, stimulates glycosuria and lowers glycemia in patients with type 2 diabetes (T2DM). The objective of this study was to assess the pharmacodynamics of ipragliflozin in T2DM patients with impaired renal function. RESEARCH DESIGN AND METHODS:Glycosuria was measured before and after a single ipragliflozin dose in 8 nondiabetic subjects and 57 T2DM patients (age 62 ± 9 years, fasting glucose 133 ± 39 mg/dL, mean ± SD) with normal renal function (assessed as the estimated glomerular filtration rate [eGFR]) (eGFR1 ≥90 mL · min(-1) · 1.73 m(-2)), mild (eGFR2 ≥60 to <90), moderate (eGFR3 ≥30 to <60), or severe reduction in eGFR (eGFR4 ≤15 to <30). RESULTS:Ipragliflozin significantly increased urinary glucose excretion in each eGFR class (P < 0.0001). However, ipragliflozin-induced glycosuria declined (median [IQR]) across eGFR class (from 46 mg/min [33] in eGFR1 to 8 mg/min [7] in eGFR4, P < 0.001). Ipragliflozin-induced fractional glucose excretion (excretion/filtration) was 39% [27] in the T2DM patients (pooled data), similar to that of the nondiabetic subjects (37% [17], P = ns). In bivariate analysis of the pooled data, ipragliflozin-induced glycosuria was directly related to eGFR and fasting glucose (P < 0.0001 for both, r(2) = 0.55), predicting a decrement in 24-h glycosuria of 15 g for each 20 mL/min decline in eGFR and an increase of 7 g for each 10 mg/dL increase in glucose above fasting normoglycemia. CONCLUSIONS:In T2DM patients, ipragliflozin increases glycosuria in direct, linear proportion to GFR and degree of hyperglycemia, such that its amount can be reliably predicted in the individual patient. Although absolute glycosuria decreases with declining GFR, the efficiency of ipragliflozin action (fractional glucose excretion) is maintained in patients with severe renal impairment.
journal_name
Diabetes Carejournal_title
Diabetes careauthors
Ferrannini E,Veltkamp SA,Smulders RA,Kadokura Tdoi
10.2337/dc12-1503subject
Has Abstractpub_date
2013-05-01 00:00:00pages
1260-5issue
5eissn
0149-5992issn
1935-5548pii
dc12-1503journal_volume
36pub_type
杂志文章相关文献
DIABETES CARE文献大全abstract:OBJECTIVE:To evaluate the effect of the erythromycin derivative EM523L on gastric emptying and postprandial insulin requirement in insulin-dependent diabetic patients with severe gastroparesis. RESEARCH DESIGN AND METHODS:In six IDDM patients with severe gastroparesis (two men and four women, mean age 44.5 years [rang...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章
doi:10.2337/diacare.20.7.1134
更新日期:1997-07-01 00:00:00
abstract:OBJECTIVE:The safety of dendritic cells to selectively suppress autoimmunity, especially in type 1 diabetes, has never been ascertained. We investigated the safety of autologous dendritic cells, stabilized into an immunosuppressive state, in established adult type 1 diabetic patients. RESEARCH DESIGN AND METHODS:A ran...
journal_title:Diabetes care
pub_type: 杂志文章,随机对照试验
doi:10.2337/dc11-0472
更新日期:2011-09-01 00:00:00
abstract:OBJECTIVE:We aimed to determine the effect of elevated BMI over time on the progression to type 1 diabetes in youth. RESEARCH DESIGN AND METHODS:We studied 1,117 children in the TrialNet Pathway to Prevention cohort (autoantibody-positive relatives of patients with type 1 diabetes). Longitudinally accumulated BMI abov...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc16-2331
更新日期:2017-05-01 00:00:00
abstract:OBJECTIVE:To assess the performance of the Micral-Test II immunologic test strip for the detection of microalbuminuria, a multicenter evaluation in eight European study sites was performed. RESEARCH DESIGN AND METHODS:Using both the Micral-Test II test strip and the routine method for the determination of albumin conc...
journal_title:Diabetes care
pub_type: 杂志文章,多中心研究
doi:10.2337/diacare.20.11.1642
更新日期:1997-11-01 00:00:00
abstract:OBJECTIVE:Bariatric surgery may induce remission of type 2 diabetes in obese patients. However, estimates of remission rates reported in the literature range from 25 to 81%, contributing to the uncertainty patients and physicians both face as they assess treatment options. This analysis attempts to reconcile the seemin...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc16-0954
更新日期:2016-12-01 00:00:00
abstract:OBJECTIVE:Given the transient nature of exercise-induced improvements in insulin sensitivity, it has been speculated that daily exercise is preferred to maximize the benefits of exercise for glycemic control. The current study investigates the impact of daily exercise versus exercise performed every other day on glycem...
journal_title:Diabetes care
pub_type: 杂志文章,随机对照试验
doi:10.2337/dc11-2112
更新日期:2012-05-01 00:00:00
abstract::We have developed computer programs in compiled BASIC for the IBM-PC and compatible microcomputers for use by physicians, paramedical personnel, and/or patients to assist with self-monitoring of blood glucose (SMBG) and self-adjustment of insulin dosage. The programs can potentially assist with patient education and m...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.9.1.61
更新日期:1986-01-01 00:00:00
abstract:OBJECTIVE:To investigate the association between circulating levels of hepatocyte growth factor (HGF), a mesenchymal-derived pleiotrophic factor that is elevated in obesity, and the prevalence of type 2 diabetes. RESEARCH DESIGN AND METHODS:A cross-sectional analysis among 892 postmenopausal women within the Women's H...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc10-0710
更新日期:2010-09-01 00:00:00
abstract:OBJECTIVE:To evaluate the efficacy and safety of lixisenatide versus placebo on glycemic control in older patients with type 2 diabetes uncontrolled on their current antidiabetic treatment. RESEARCH DESIGN AND METHODS:In this phase III, double-blind, randomized, placebo-controlled, two-arm, parallel-group, multicenter...
journal_title:Diabetes care
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.2337/dc16-2143
更新日期:2017-04-01 00:00:00
abstract::Once daily injection of existing intermediate/long-acting insulin preparations does not provide a 24-h basal insulinemia in most patients. High variability, pronounced insulin peaks, and (as a result) a high risk of nocturnal hypoglycemia only poorly simulate normal physiology. One principle to prolong insulin action ...
journal_title:Diabetes care
pub_type: 杂志文章,评审
doi:
更新日期:1999-03-01 00:00:00
abstract::OBJECTIVE Previous studies have demonstrated aberrant glucagon physiology in the setting of type 1 diabetes (T1D) but have not addressed the potential impact of ambient glycemia on this glucagon response. Thus, our objective was to evaluate the impact of euglycemia versus hyperglycemia on the glucagon response to an o...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc13-2339
更新日期:2014-04-01 00:00:00
abstract::Borderline hypertension, a condition in which the blood pressure oscillates between normal and high values, is a predictor of future more severe hypertension. Pathophysiologically, borderline hypertension is different from established hypertension. A large proportion of such patients have elevated cardiac output and a...
journal_title:Diabetes care
pub_type: 杂志文章,评审
doi:10.2337/diacare.14.3.249
更新日期:1991-03-01 00:00:00
abstract:OBJECTIVE:The goal of this study was to determine whether the haptoglobin (Hp) genotype was predictive of restenosis and major adverse cardiac events (MACEs) after percutaneous transluminal coronary angioplasty (PTCA) in individuals with diabetes. RESEARCH DESIGN AND METHODS:A consecutive series of 935 diabetic patien...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.26.9.2628
更新日期:2003-09-01 00:00:00
abstract:OBJECTIVE:To compare lifestyle factors, cardiovascular risk factors, and coronary artery calcium (CAC) and abdominal aortic calcium (AAC) levels in Hispanic and non-Hispanic white (NHW) individuals with type 2 diabetes. RESEARCH DESIGN AND METHODS:We recently demonstrated in a small group of nonreferred, healthy, nond...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.27.5.1115
更新日期:2004-05-01 00:00:00
abstract:OBJECTIVE:Women with preexisting (type 1 or type 2) diabetes experience an increased risk of serious adverse pregnancy outcomes. It is not known, however, how these risks change between the first and second pregnancy and whether there is an increased risk of recurrence. This study describes the absolute risks and recur...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc14-1888
更新日期:2015-04-01 00:00:00
abstract:OBJECTIVE:Various organizations have highlighted the need to examine whether abdominal obesity cut points are appropriate for identification of cardiovascular risk among ethnic minority adults, particularly Hispanic/Latino adults living in Western societies. This study aimed 1) to establish optimal definitions for abdo...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc19-1855
更新日期:2020-08-01 00:00:00
abstract:OBJECTIVE:High triglyceride (TG) levels and low HDL cholesterol (HDL-C) levels are risk factors for cardiovascular disease. It is unclear whether this relationship depends on glycemic dysregulation, sex, or LDL cholesterol (LDL-C) level. RESEARCH DESIGN AND METHODS:We studied 3,216 participants (40% men, 41% with diab...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc16-1958
更新日期:2017-04-01 00:00:00
abstract:OBJECTIVE:To assess the dose-ranging efficacy and safety of LX4211, a dual inhibitor of sodium-glucose cotransporter (SGLT) 1 and SGLT2, in type 2 diabetes. RESEARCH DESIGN AND METHODS:Type 2 diabetic patients inadequately controlled on metformin were randomly assigned to 75 mg once daily, 200 mg once daily, 200 mg tw...
journal_title:Diabetes care
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.2337/dc14-0890
更新日期:2015-03-01 00:00:00
abstract:OBJECTIVES:Obesity is a common condition in type 2 diabetic patients. Treating obesity may enhance hypoglycemic treatment and contribute to the reduction of long-term microvascular and macrovascular complications. Orlistat reduces cardiovascular risk factors in obese type 2 diabetic patients. The objectives of this stu...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.25.2.303
更新日期:2002-02-01 00:00:00
abstract:OBJECTIVE:To examine the factors that determine the blood pressure response to enalapril and nifedipine monotherapy in the treatment of hypertension associated with non-insulin-dependent diabetes mellitus (NIDDM). RESEARCH DESIGN AND METHODS:After a 6-week placebo baseline period, 102 hypertensive NIDDM patients were ...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.2337/diacare.18.7.1001
更新日期:1995-07-01 00:00:00
abstract:OBJECTIVE:To compare the efficacy and safety of glyburide versus metformin and their combination for the treatment of gestational diabetes mellitus (GDM). RESEARCH DESIGN AND METHODS:In this prospective randomized controlled study, we randomly assigned patients with GDM at 13-33 weeks gestation and whose blood glucose...
journal_title:Diabetes care
pub_type: 杂志文章,随机对照试验
doi:10.2337/dc16-2307
更新日期:2017-03-01 00:00:00
abstract:OBJECTIVE:Intensive lifestyle intervention significantly reduced diabetes incidence among the participants in the Finnish Diabetes Prevention Study. We investigated whether and to what extent risk factors for type 2 diabetes and other baseline characteristics of the study participants modified the effectiveness of the ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc07-2162
更新日期:2008-05-01 00:00:00
abstract::Two-thirds of all deaths in developed countries are caused by the major noncommunicable diseases, e.g., cardiovascular disease, cancer, and non-insulin-dependent diabetes mellitus (NIDDM). There is increasing evidence that these diseases are a consequence of life-style change, and they have a number of risk factors in...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.11.3.258
更新日期:1988-03-01 00:00:00
abstract:OBJECTIVE:To examine the evolution of the dysregulated glucagon responses to mixed-meal tolerance tests (MMTTs) in youth with recent-onset type 1 diabetes (T1D). RESEARCH DESIGN AND METHODS:MMTTs were performed in 25 youth (9-18 years of age) with 1.5-12 months disease duration (year 1); 22 subjects were restudied 1 y...
journal_title:Diabetes care
pub_type: 杂志文章,多中心研究
doi:10.2337/dc13-2612
更新日期:2014-06-01 00:00:00
abstract::This paper provides some historical aspects on the research and development of Humulin (rDNA origin), the first human health-care product derived from rDNA technology more than a decade ago. Also referred to as biosynthetic human insulin, Humulin is currently produced via the human proinsulin route, using an Escherich...
journal_title:Diabetes care
pub_type: 杂志文章,评审
doi:10.2337/diacare.16.3.133
更新日期:1993-12-01 00:00:00
abstract:OBJECTIVE:To assess the efficacy of a lifestyle intervention program that can be readily translated into clinical practice for obese patients with type 2 diabetes. RESEARCH DESIGN AND METHODS:The study consisted of a 12-month randomized controlled trial of 147 health plan members with type 2 diabetes and obesity (BMI ...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.2337/diacare.27.7.1570
更新日期:2004-07-01 00:00:00
abstract:OBJECTIVE:To determine the rheological properties of polymorphonuclear leukocytes (PMN) from non-insulin-dependent diabetes mellitus (NIDDM) patients. RESEARCH DESIGN AND METHODS:The deformability of PMN from 33 NIDDM subjects, 13 with impaired glucose tolerance (IGT), and 22 with normal glucose tolerance (NGT) was st...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.17.1.57
更新日期:1994-01-01 00:00:00
abstract:OBJECTIVE:To study the association between microalbuminuria and development of preeclampsia and preterm delivery in pregnant women with type 1 diabetes. RESEARCH DESIGN AND METHODS:This was a population-based prospective study in 846 normoalbuminuric or microalbuminuric women with type 1 diabetes without antihypertens...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc09-1219
更新日期:2010-01-01 00:00:00
abstract:OBJECTIVE:We compared the risk of cardiovascular disease (CVD) and all-cause mortality in subgroups of prediabetes defined by fasting plasma glucose (FPG), 2-h plasma glucose (2hPG), or HbA1c. RESEARCH DESIGN AND METHODS:In the Whitehall II cohort, 5,427 participants aged 50-79 years and without diabetes were followed...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc17-2530
更新日期:2018-04-01 00:00:00
abstract:OBJECTIVE:There is little information regarding the pattern of metabolic deterioration before the onset of type 1 diabetes. The goal of this study was to utilize data from the Diabetes Prevention Trial-Type 1 (DPT-1) to obtain a picture of the metabolic progression to type 1 diabetes over a period of approximately 2.5 ...
journal_title:Diabetes care
pub_type: 杂志文章,随机对照试验
doi:10.2337/diacare.29.03.06.dc05-1006
更新日期:2006-03-01 00:00:00