Accelerated insulin degradation: an alternate mechanism for insulin resistance.

abstract：:Coronary heart disease is the leading cause of death among patients with non-insulin-dependent diabetes mellitus (NIDDM). NIDDM patients have a high frequency of dyslipidemia, which along with obesity, hypertension, and hyperglycemia may contribute significantly to accelerated coronary atherosclerosis. Because risk fa...

journal_title：Diabetes care

authors： Garg A,Grundy SM

更新日期：1990-02-01 00:00:00

abstract：OBJECTIVE:Insulin pump therapy (continuous subcutaneous insulin infusion [CSII]) and multiple daily injections (MDIs) with insulin glargine as basal insulin and mealtime insulin lispro have not been prospectively compared in people naïve to either regimen in a multicenter study. We aimed to help close that deficiency. ...

journal_title：Diabetes care

authors： Bolli GB,Kerr D,Thomas R,Torlone E,Sola-Gazagnes A,Vitacolonna E,Selam JL,Home PD

更新日期：2009-07-01 00:00:00

abstract：OBJECTIVE:Regular physical activity (PA) reduces the risk of developing type 2 diabetes, and different subtypes of dysglycemia have shown different associations with PA. To better understand the associations of PA and glucose homeostasis, we examined the association of objectively measured PA energy expenditure (PAEE) ...

journal_title：Diabetes care

authors： Hansen AL,Carstensen B,Helge JW,Johansen NB,Gram B,Christiansen JS,Brage S,Lauritzen T,Jørgensen ME,Aadahl M,Witte DR,ADDITION-Denmark Steering Committee.

更新日期：2013-10-01 00:00:00

abstract：:OBJECTIVE--To assess kidney function and AER in patients with PD. RESEARCH DESIGN AND METHODS--Thirty-three patients with PD (age 52 +/- 7 yr, duration of disease 11 +/- 6 yr, BMI 24 +/- 3 kg/m2) and 33 patients with IDDM were matched for sex, BMI, and duration of disease. GFR and RPF were determined by single injecti...

journal_title：Diabetes care

authors： Tiengo A,Briani G,Scaldaferri E,Riva F,Jori E,Sgnaolin E,Fenato R,D'Ambrosio M,Fioretto P,Nosadini R

更新日期：1992-11-01 00:00:00

abstract：OBJECTIVE:To assess the relationship between subclinical cardiac dysfunction and aerobic exercise capacity (peak VO2) in adults with type 2 diabetes (T2D), a group at high risk of developing heart failure. RESEARCH DESIGN AND METHODS:Cross-sectional study. We prospectively enrolled a multiethnic cohort of asymptomatic...

journal_title：Diabetes care

authors： Gulsin GS,Henson J,Brady EM,Sargeant JA,Wilmot EG,Athithan L,Htike ZZ,Marsh AM,Biglands JD,Kellman P,Khunti K,Webb D,Davies MJ,Yates T,McCann GP

更新日期：2020-09-01 00:00:00

abstract：OBJECTIVE:A long-term health economic analysis was performed to establish the cost-effectiveness of real-time continuous glucose monitoring (RT-CGM) (Dexcom G6) versus self-monitoring of blood glucose (SMBG) alone in U.K.-based patients with type 1 diabetes (T1D). RESEARCH DESIGN AND METHODS:The analysis used the IQVI...

journal_title：Diabetes care

authors： Roze S,Isitt J,Smith-Palmer J,Javanbakht M,Lynch P

更新日期：2020-10-01 00:00:00

abstract：OBJECTIVE:To compare lifestyle factors, cardiovascular risk factors, and coronary artery calcium (CAC) and abdominal aortic calcium (AAC) levels in Hispanic and non-Hispanic white (NHW) individuals with type 2 diabetes. RESEARCH DESIGN AND METHODS:We recently demonstrated in a small group of nonreferred, healthy, nond...

journal_title：Diabetes care

authors： Reaven PD,Sacks J,Investigators for the Veterans Affairs Cooperative Study of Glycemic Control and Complications in Diabetes Mellitus Type 2.

更新日期：2004-05-01 00:00:00

abstract：OBJECTIVE:This double-blind, placebo-controlled, randomized, multicenter, parallel-group study compared the efficacy, safety, and tolerability of Technosphere insulin with Technosphere powder as placebo in insulin-naive type 2 diabetic patients whose diabetes was suboptimally controlled with oral antidiabetic agents. ...

journal_title：Diabetes care

authors： Rosenstock J,Bergenstal R,Defronzo RA,Hirsch IB,Klonoff D,Boss AH,Kramer D,Petrucci R,Yu W,Levy B,0008 Study Group.

更新日期：2008-11-01 00:00:00

abstract：OBJECTIVE:Compare differences in health-related quality of life among blacks and whites to examine if race, diabetes, and visual impairment (VI) present a triple disadvantage in terms of quality-adjusted life expectancy. RESEARCH DESIGN AND METHODS:Data were analyzed from the 2000-2003 Medical Expenditure Panel Survey...

journal_title：Diabetes care

authors： McCollister KE,Zheng DD,Fernandez CA,Lee DJ,Lam BL,Arheart KL,Galor A,Ocasio M,Muennig P

更新日期：2012-08-01 00:00:00

abstract：:Twenty-eight patients with type I diabetes mellitus, legally blind as a result of proliferative retinopathy, were recruited into a program designed to teach and evaluate tactile methods for self-monitoring of blood glucose (SMBG). Vision ranged from "blind" to "able to read large print." Techniques with wipe-off strip...

journal_title：Diabetes care

authors： Prior JC,Alojado NC,Hunt JA,Begg IS

更新日期：1984-07-01 00:00:00

abstract：OBJECTIVE:To date no clinical trials have evaluated the role of dietary patterns on the incidence of microvascular diabetes complications. We hypothesized that a nutritional intervention based on the Mediterranean diet (MedDiet) would have greater protective effect on diabetic retinopathy and nephropathy than a low-fat...

journal_title：Diabetes care

authors： Díaz-López A,Babio N,Martínez-González MA,Corella D,Amor AJ,Fitó M,Estruch R,Arós F,Gómez-Gracia E,Fiol M,Lapetra J,Serra-Majem L,Basora J,Basterra-Gortari FJ,Zanon-Moreno V,Muñoz MÁ,Salas-Salvadó J,PREDIMED Study Inves

更新日期：2015-11-01 00:00:00

abstract：OBJECTIVE:To examine the comparative effectiveness of the sodium-glucose cotransporter 2 inhibitor (SGLT2i) empagliflozin and other non-SGLT2i antihyperglycemics on the risk of major adverse kidney events (MAKE) of estimated glomerular filtration rate (eGFR) decline >50%, end-stage kidney disease, or all-cause mortalit...

journal_title：Diabetes care

authors： Xie Y,Bowe B,Gibson AK,McGill JB,Yan Y,Maddukuri G,Al-Aly Z

更新日期：2020-11-01 00:00:00

abstract：OBJECTIVE:To examine cross-sectional associations of serum vitamin D [25-hydroxyvitamin D, 25(OH)D] concentration with insulin resistance (IR) and beta-cell dysfunction in 712 subjects at risk for type 2 diabetes. RESEARCH DESIGN AND METHODS:Serum 25(OH)D was determined using a chemiluminescence immunoassay. Insulin s...

journal_title：Diabetes care

authors： Kayaniyil S,Vieth R,Retnakaran R,Knight JA,Qi Y,Gerstein HC,Perkins BA,Harris SB,Zinman B,Hanley AJ

更新日期：2010-06-01 00:00:00

abstract：OBJECTIVE:The purpose of this paper is to estimate the impact of diabetes on survival among patients with first acute myocardial infarction, using data from the World Health Organization (WHO) Monitoring Trends and Determinants of Cardiovascular Disease (MONICA) Project in Newcastle, New South Wales, Australia. RESEAR...

journal_title：Diabetes care

authors： Chun BY,Dobson AJ,Heller RF

更新日期：1997-05-01 00:00:00

abstract：:In a patient with hyperthyroidism and newly diagnosed insulin-dependent diabetes mellitus (IDDM), insulin action and clearance were studied before the initiation of antithyroid treatment and at 3-mo intervals for 1 yr thereafter. The sequential euglycemic clamp technique (5 mM) was used with insulin infusion rates of ...

journal_title：Diabetes care

authors： Nijs HG,Radder JK,Frölich M,Krans HM

更新日期：1989-05-01 00:00:00

abstract：:The American Diabetes Association (ADA) "Standards of Medical Care in Diabetes" includes ADA's current clinical practice recommendations and is intended to provide the components of diabetes care, general treatment goals and guidelines, and tools to evaluate quality of care. Members of the ADA Professional Practice Co...

journal_title：Diabetes care

authors： American Diabetes Association.

更新日期：2018-01-01 00:00:00

abstract：OBJECTIVE:Studies comparing the incidence of blindness in persons with and without diabetes are scarce worldwide. In Germany, a decline in the incidence of blindness was found during the 1990s. The aim of this study was to analyze the recent time trend. RESEARCH DESIGN AND METHODS:Data were based on administrative fil...

journal_title：Diabetes care

authors： Claessen H,Kvitkina T,Narres M,Trautner C,Zöllner I,Bertram B,Icks A

更新日期：2018-03-01 00:00:00

abstract：:Combination sulfonylurea-insulin therapy for patients with diabetes mellitus has been evaluated by numerous investigators with various experimental designs. Much of the data are conflicting, and clear conclusions do not seem justified. Insulin-sulfonylurea therapy is probably not clinically useful in most patients wit...

journal_title：Diabetes care

authors： Lebovitz HE,Pasmantier R

更新日期：1990-06-01 00:00:00

abstract：OBJECTIVE:In patients with type 2 diabetes, microalbuminuria is associated with an increase in predominantly cardiovascular mortality. Considerable interindividual variability in the rate of progression of microalbuminuria exists. The prognostic significance of rate of progression of microalbuminuria with regard to car...

journal_title：Diabetes care

authors： Spoelstra-de Man AM,Brouwer CB,Stehouwer CD,Smulders YM

更新日期：2001-12-01 00:00:00

abstract：:Use of continuous subcutaneous insulin infusion requires continuing available care by skilled professionals, careful selection of patients, meticulous patient monitoring, and provisions for recording and reporting experiences. Insulin pumps prescribed by a physician within these guidelines are a part of treatment and ...

journal_title：Diabetes care

authors：

更新日期：1985-09-01 00:00:00

abstract：OBJECTIVE:We sought to compare the effects of combined calcium and vitamin D supplementation versus placebo on blood glucose and markers of inflammation in nondiabetic adults aged > or =65 years. RESEARCH DESIGN AND METHODS:A total of 314 Caucasian adults without diabetes received either 500 mg calcium citrate and 700...

journal_title：Diabetes care

authors： Pittas AG,Harris SS,Stark PC,Dawson-Hughes B

更新日期：2007-04-01 00:00:00

abstract：OBJECTIVE:To investigate the association of carotid atherosclerosis and serum lipoprotein(a) [Lp(a)] concentrations in subjects with NIDDM. RESEARCH DESIGN AND METHODS:We measured carotid intima-media thickness (IMT) and Lp(a) concentrations in 117 NIDDM subjects. Subjects were divided into tertiles according to IMT v...

journal_title：Diabetes care

authors： Yamamoto M,Egusa G,Yamakido M

更新日期：1997-05-01 00:00:00

abstract：OBJECTIVE:There is little information regarding the pattern of metabolic deterioration before the onset of type 1 diabetes. The goal of this study was to utilize data from the Diabetes Prevention Trial-Type 1 (DPT-1) to obtain a picture of the metabolic progression to type 1 diabetes over a period of approximately 2.5 ...

journal_title：Diabetes care

authors： Sosenko JM,Palmer JP,Greenbaum CJ,Mahon J,Cowie C,Krischer JP,Chase HP,White NH,Buckingham B,Herold KC,Cuthbertson D,Skyler JS

更新日期：2006-03-01 00:00:00

abstract：OBJECTIVE:To clarify the contribution of the Asp905Tyr polymorphism of the muscle-specific glycogen-targeting subunit of protein phosphatase 1 (PP1G) to insulin resistance and related diseases. RESEARCH DESIGN AND METHODS:We investigated the Asp905Tyr polymorphism of the PPP1R3 gene, which encodes the muscle-specific ...

journal_title：Diabetes care

authors： Shen GQ,Ikegami H,Kawaguchi Y,Fujisawa T,Hamada Y,Ueda H,Shintani M,Nojima K,Kawabata Y,Yamada K,Babaya N,Ogihara T

更新日期：1998-07-01 00:00:00

abstract：:OBJECTIVE Cross-sectional and longitudinal associations among regimen distress (RD), self-management, and glycemic control were undertaken to explore mechanisms of operation among these variables. RESEARCH DESIGN AND METHODS In a behavioral randomized control trial (RCT) to reduce RD, 392 adults with type 2 diabetes w...

journal_title：Diabetes care

authors： Hessler D,Fisher L,Glasgow RE,Strycker LA,Dickinson LM,Arean PA,Masharani U

更新日期：2014-01-01 00:00:00

abstract：OBJECTIVE:We examined the effects of metformin on diabetes prevention and the subgroups that benefited most over 15 years in the Diabetes Prevention Program (DPP) and its follow-up, the Diabetes Prevention Program Outcomes Study (DPPOS). RESEARCH DESIGN AND METHODS:During the DPP (1996-2001), adults at high risk of de...

journal_title：Diabetes care

authors： Diabetes Prevention Program Research Group.

更新日期：2019-04-01 00:00:00

abstract：OBJECTIVE:Our objective was to analyze the prevalence, incidence, and mortality of diabetes in a population of 280,539 inhabitants. RESEARCH DESIGN AND METHODS:The incidence, prevalence, and deaths from diabetes at all ages of a population have been prospectively followed in the county of Skaraborg, Sweden, since 1991...

journal_title：Diabetes care

authors： Berger B,Stenström G,Sundkvist G

更新日期：1999-05-01 00:00:00

abstract：OBJECTIVE:To investigate the association of metabolic and lifestyle factors with possible diabetic polyneuropathy (DPN) and neuropathic pain in patients with early type 2 diabetes. RESEARCH DESIGN AND METHODS:We thoroughly characterized 6,726 patients with recently diagnosed diabetes. After a median of 2.8 years, we s...

journal_title：Diabetes care

authors： Christensen DH,Knudsen ST,Gylfadottir SS,Christensen LB,Nielsen JS,Beck-Nielsen H,Sørensen HT,Andersen H,Callaghan BC,Feldman EL,Finnerup NB,Jensen TS,Thomsen RW

更新日期：2020-06-01 00:00:00

abstract：OBJECTIVE:To examine the relationship between disordered eating attitudes and behaviors, BMI, and glycemic control in adolescents with type 1 diabetes. RESEARCH DESIGN AND METHODS:In a cross-sectional design, 152 adolescents (ages 11-19 years) completed three scales from the Eating Disorders Inventory (EDI): Body Diss...

journal_title：Diabetes care

authors： Meltzer LJ,Johnson SB,Prine JM,Banks RA,Desrosiers PM,Silverstein JH

更新日期：2001-04-01 00:00:00

abstract：OBJECTIVE:To determine the role of height and glycosylated hemoglobin in abnormal nerve conduction in pediatric patients with insulin-dependent (type I) diabetes mellitus. RESEARCH DESIGN AND METHODS:Sixty-six pediatric patients (aged 6.3-18.2 yr) with a duration of diabetes from 4 to 8.5 yr but free of clinical neuro...

journal_title：Diabetes care

authors： Duck SC,Wei FF,Parke J,Swick HM

更新日期：1991-05-01 00:00:00